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1. 发明专利

AU2006252074B2 Phosphonate compounds 未知
公开(公告)号：AU2006252074B2
公开(公告)日：2010-09-30
申请号：AU2006252074
申请日：2006-12-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA SAN DIEGO
发明人： HOSTETLER KARL Y , BEADLE JAMES R , KINI GANESH D
IPC分类号： A61K47/48 , A61K31/513 , A61K31/662 , A61P3/14 , A61P9/08 , A61P19/00 , A61P19/10 , A61P31/00 , A61P31/12 , A61P35/00 , A61P43/00 , C07F9/02 , C07F9/22 , C07F9/28 , C07F9/38 , C07F9/40 , C07F9/6512 , C07F9/6561 , C07F9/6574 , C07H19/10
摘要： The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.

2. 发明专利

AU2010257309B2 Phosphonate compounds 未知
公开(公告)号：AU2010257309B2
公开(公告)日：2014-04-10
申请号：AU2010257309
申请日：2010-12-20
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA SAN DIEGO
发明人： HOSTETLER KARL Y , BEADLE JAMES R , KINI GANESH D
IPC分类号： A61K31/513 , A61K47/48 , A61K31/662 , A61P3/14 , A61P9/08 , A61P19/00 , A61P19/10 , A61P31/00 , A61P31/12 , A61P35/00 , A61P43/00 , C07F9/02 , C07F9/22 , C07F9/28 , C07F9/38 , C07F9/40 , C07F9/6512 , C07F9/6561 , C07F9/6574 , C07H19/10
摘要： Abstract The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, 5 viral infections, and the like.

3. 发明专利

AU2001285427B2 Stress proteins and peptides and methods of use thereof 未知
公开(公告)号：AU2001285427B2
公开(公告)日：2007-03-22
申请号：AU2001285427
申请日：2001-08-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA SAN DIEGO
发明人： ALBANI SALVATORE , PRAKKEN BERENT J
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/00 , A61P3/10 , A61P19/02 , A61P21/00 , A61P21/04 , A61P25/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07K7/08 , C07K14/35 , C07K14/47 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08
摘要： Provided are HLA pan DR peptides and methods of using such peptides to modulate, block, or inhibit immune responses in treatment of immune-mediated diseases and conditions, such as inflammatory and autoimmune diseases, cancer, and microbial infections. The peptides and methods are useful diagnostically to screen peptide or peptide analogs that can inhibit the pathogenic immune response or upregulate an immune response against aberrant or invading cells, to monitor efficacy or therapeutic use and to identify other agents that may be effective to inhibit or modulate the immune response.

4. 发明申请

WO2002012286A3 STRESS PROTEINS AND PEPTIDES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2002012286A3
公开(公告)日：2002-02-14
申请号：PCT/US2001/041656
申请日：2001-08-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO
发明人： ALBANI, Salvatore , PRAKKEN, Berent, J.
IPC分类号： C07K7/08
摘要： Provided are HLA pan DR peptide and methods of using such peptides to modulate, block, or inhibit immune responses in treatment of immune-mediated diseases and conditions, such as inflammatory and autoimmune diseases, cancer, and microbial infections. The peptides and methods are useful diagnostically to screen peptide or peptide analogs that can inhibit the pathogenic immune response or upregulate an immune response against aberrant or invading cells, to monitor efficacy or therapeutic use and to identify other agents that may be effective to inhibit or modulate the immune response.

5. 发明公开

EP1732581A2 POLYPEPTIDE TRANSDUCTION AND FUSOGENIC PEPTIDES 审中-公开
标题翻译：多肽转运和致癌肽
公开(公告)号：EP1732581A2
公开(公告)日：2006-12-20
申请号：EP04821562.8
申请日：2004-06-18
申请人： The Regents of The University of California San Diego
发明人： DOWDY, Stephen, F. , WADIA, Jehangir, S.
IPC分类号： A61K38/00
CPC分类号： C07K14/43581 , A61K38/162 , C07K14/005 , C07K2319/01 , C07K2319/10 , C07K2319/21 , C12N15/907 , C12N2740/16322 , C12N2760/16122 , C12N2760/16322
摘要： Due to the barrier imposed by the cell membrane, delivery of macromolecules in excess of 500 Daltons directly into cells remains problematic. However, proteins, which have been evolutionarily selected to perform specific functions, are therefore an attractive therapeutic agent to treat a variety of human diseases. In practice, the direct intracellular delivery of these proteins has, until recently, been difficult to achieve due primarily to the bioavailability barrier of the plasma membrane, which effectively prevents the uptake of the majority of peptides and proteins by limiting their passive entry. However, recent work using small cationic peptides, termed protein transduction domains (PTDs), derived from polynucleotide binding proteins, such as HIV TAT protein or the Drosophila transcription factor Antp. or synthetic poly-Arginine, have now been shown to deliver a myriad of molecules, including synthetic small molecules, peptides and proteins, into animal models in vivo.
摘要翻译：由于细胞膜所施加的屏障，将超过500道尔顿的大分子直接递送入细胞仍然存在问题。然而，进化选择用于执行特定功能的蛋白质因此是治疗各种人类疾病的有吸引力的治疗剂。实际上，直到最近，这些蛋白质的直接细胞内递送主要是由于质膜的生物利用率屏障而难以实现，其通过限制它们的被动进入而有效地阻止大部分肽和蛋白质的摄取。然而，最近使用来自多核苷酸结合蛋白（例如HIV TAT蛋白或果蝇转录因子Antp）的称为蛋白质转导结构域（PTD）的小阳离子肽的工作。或合成的聚精氨酸，现已显示将大量分子（包括合成小分子，肽和蛋白质）递送到体内动物模型中。

6. 发明公开

EP1399162A2 TREATING NEUROPATHIC/INFLAMMATORY PAIN BY TARGETING A COMPOSITION (E.G. ZD7288) TO HCN PACEMAKER CHANNELS 审中-公开
标题翻译：治疗神经性/炎性痛通过对HCN PACE CHANNELS的组合物的目标应用（例如ZD7288）
公开(公告)号：EP1399162A2
公开(公告)日：2004-03-24
申请号：EP02734581.8
申请日：2002-05-30
申请人： Ortho-McNeil Pharmaceutical, Inc. , The Regents of The University of California San Diego
发明人： CHAPLAN, Sandra , DUBIN, Adrienne , LEE, Doo, Hyun , LIU, Changlu
IPC分类号： A61K31/4965 , A61P25/00 , A61P25/02 , A61P43/00
CPC分类号： G01N33/6872 , A61K31/00 , A61K31/4168 , A61K31/485 , A61K31/4965 , A61K31/505 , A61K31/53 , A61K31/55 , A61K45/06 , A61K49/0008 , G01N2500/02 , A61K2300/00
摘要： Markedly enhanced activity of pacemaker (hyperpolarization-activated, cation-nonselective, HCN) ion channels governs spontaneous firing in sensory cells of allodynic rats. An HCN ion channel specific blocker, ZD7288, dose-dependently and completely suppresses allodynia. Nerve injury increases the population of large DRG neurons expressing a high density of Ih and modulates HCN mRNA expression. New methods of treating pain by targeting HCN pacemaker channels are developed. In addition, new methods for identifying compositions useful for treating pain are disclosed.

7. 发明公开

EP1851342A2 DETECTION OF BIOMARKERS FOR NEUROPSYCHIATRIC DISORDERS 审中-公开
标题翻译：生物标志物的精神疾病检测NEURO
公开(公告)号：EP1851342A2
公开(公告)日：2007-11-07
申请号：EP06735281.5
申请日：2006-02-15
申请人： The Regents of The University of California San Diego
发明人： TSUANG, Ming, T. , EVERALL, Ian, P. , GLATT, Stephen, J. , KREMEN, William, S.
IPC分类号： C12Q1/68 , A61K38/17
CPC分类号： A61K38/1709 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： Systems and methods provide a comprehensive high-throughput approach toward the sequential identification, prioritization, verification, and validation of etiologic factors in neuropsychiatric disorders, some of which can also be utilized as biomarkers for these illnesses. The systems and methods determine patterns of gene expression in various tissues from various samples under various experimental and non-experimental conditions, and uses the differences and similarities between the gene expression profiles observed under these conditions to delineate distinct gene expression profiles of risk and treatment of neuropsychiatric disorders.

8. 发明公开

EP1355922A2 STRESS PROTEINS AND PEPTIDES AND METHODS OF USE THEREOF 审中-公开
标题翻译：应激蛋白和多肽和使用方法
公开(公告)号：EP1355922A2
公开(公告)日：2003-10-29
申请号：EP01964589.4
申请日：2001-08-08
申请人： The Regents of The University of California San Diego
发明人： ALBANI, Salvatore , PRAKKEN, Berent, J.
IPC分类号： C07K7/08 , C07K7/06 , C07K14/35 , A61K38/10 , C07K16/18 , A61P19/02 , A61P3/10 , A61K39/04
CPC分类号： C07K14/35 , A61K38/00 , C07K14/47
摘要： Provided are HLA pan DR peptide and methods of using such peptides to modulate, block, or inhibit immune responses in treatment of immune-mediated diseases and conditions, such as inflammatory and autoimmune diseases, cancer, and microbial infections. The peptides and methods are useful diagnostically to screen peptide or peptide analogs that can inhibit the pathogenic immune response or upregulate an immune response against aberrant or invading cells, to monitor efficacy or therapeutic use and to identify other agents that may be effective to inhibit or modulate the immune response.

9. 发明公开

EP1652856A1 Stress proteins-derived peptides and method of use thereof 审中-公开
标题翻译： Stressproteine-abgeleitete Peptide und Verfahren zu deren Verwendung
公开(公告)号：EP1652856A1
公开(公告)日：2006-05-03
申请号：EP06000232.6
申请日：2001-08-08
申请人： The Regents of The University of California San Diego
发明人： PRAKKEN, Berent , ALBANI, Salvatore
IPC分类号： C07K7/08 , C07K7/06 , C07K14/35 , C07K14/47 , A61K38/10 , C07K16/18 , A61P19/02 , A61P3/10 , A61K39/04
CPC分类号： C07K7/06 , A61K38/00 , A61K39/0008 , A61K39/04 , C07K7/08 , C07K14/35
摘要： Provided are HLA pan DR peptide and methods of using such peptides to modulate, block, or inhibit immune responses in treatment of immune-mediated diseases and conditions, such as inflammatory and autoimmune diseases, cancer, and microbial infections. The peptides and methods are useful diagnostically to screen peptide analogs that can inhibit the pathogenic immune response or upregulate an immune response against aberrant or invading cells, to monitor efficacy or therapeutic use and to identify other agents that may be effective to inhibit or modulate the immune response.
摘要翻译：提供了HLA pan DR肽和使用这些肽调节，阻断或抑制免疫应答在治疗免疫介导的疾病和病症如炎症和自身免疫性疾病，癌症和微生物感染中的方法。肽和方法在诊断上用于筛选可抑制致病性免疫应答或上调针对异常或侵袭细胞的免疫应答的肽类似物，以监测功效或治疗用途，并鉴定可能有效抑制或调节免疫的其它试剂响应。

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