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1. 发明公开

EP1568785A2 Method for detecting oligonucleotides and determining base sequence of nucleic acids 审中-公开
标题翻译：一种用于检测的核酸的碱基序列的寡核苷酸和确定方法
公开(公告)号：EP1568785A2
公开(公告)日：2005-08-31
申请号：EP05075875.4
申请日：1999-07-16
申请人： THE INSTITUTE OF PHYSICAL & CHEMICAL RESEARCH , Kabushiki Kaisha Dnaform
发明人： Hayashizaki, Yoshihide
IPC分类号： C12Q1/68 , B01L3/00 , G01N21/64 , G01N27/00
CPC分类号： G01N27/44721 , C12Q1/6869 , Y10S436/80 , C12Q2565/125 , C12Q2565/102 , C12Q2537/143
摘要： Disclosed are a method which can simultaneously analyze a plurality of analytes and can realize the determination of the base sequence of a large quantity of gene information in a short time, and an apparatus for the method. The method comprises the steps of: preparing four samples, for each of a plurality of nucleic acid analytes, containing analyte nucleic acid-derived oligonucleotide fragments with the end bases having been base-specifically fragmented; labeling the oligonucleotide fragments with a different label for each of the analyte nucleic acids; and subjecting the four samples to an analytical method which can distinguish oligonucleotide fragments based on a difference in length of one base, thereby determining the base sequence of the target nucleic acids.

2. 发明授权

EP0690125B1 Process for induction culture of cytotoxic T lymphocytes having killing activity against tumor cells 失效
标题翻译：一种用于细胞毒性T淋巴细胞的诱导培养过程与肿瘤细胞杀伤活性
公开(公告)号：EP0690125B1
公开(公告)日：2003-04-23
申请号：EP95109803.7
申请日：1995-06-23
申请人： THE INSTITUTE OF PHYSICAL & CHEMICAL RESEARCH
发明人： Ohno, Tadao, c/o The Inst.of Physic. and Chem.Res. , Tsurushima, Hideo , Liu, Shu Qin , Todoroki, Takeshi
IPC分类号： C12N5/08 , A61K35/14
CPC分类号： A61K39/0011 , A61K2039/5158 , C12N5/0636 , C12N2501/23 , C12N2501/24

3. 发明授权

EP0792089B1 Ultraviolet electroluminescent element and laser luminescent element 失效
标题翻译：紫外线发射电致发光元件和激光
公开(公告)号：EP0792089B1
公开(公告)日：2002-11-06
申请号：EP97301036.6
申请日：1997-02-18
申请人： THE INSTITUTE OF PHYSICAL & CHEMICAL RESEARCH
发明人： Koshihara, Shinya , Ebihara,Kenzo , Miyazawa, Takashi , Kira, Mitsuo, The Institute of Physical and Chem. , Suzuki, Toshihiro
IPC分类号： H05B33/14 , H01S3/06
CPC分类号： H01S3/0632 , C09K11/06 , H01L51/0032 , H01L51/0094 , H01L51/42

4. 发明公开

EP1004301A1 PROTECTING AND SURVIVAL PROMOTING AGENT FOR CENTRAL NERVOUS CELL 失效
标题翻译：资源保护中枢神经系统的细胞的推广和生存
公开(公告)号：EP1004301A1
公开(公告)日：2000-05-31
申请号：EP98933970.0
申请日：1998-07-28
申请人： THE INSTITUTE OF PHYSICAL & CHEMICAL RESEARCH , TAISHO PHARMACEUTICAL CO. LTD
发明人： MITOMA, Jyunya , FURUYA, Shigeki , HIRABAYASHI, Yoshio
IPC分类号： A61K31/195 , A61K31/23 , C12N5/16
CPC分类号： A61K31/198
摘要： A cell survival promoting agent for central nervous cells, containing as the active ingredient a compound selected from the group consisting of L-serine, glycine, and fatty acid derivatives thereof; and an agent for prevention and/or treatment of a lowering in the function of brains, containing the compound as the active ingredient. The cell survival promoting agent functions to protect brain cells to inhibit cell death and, at the same time, to prolong the life of the cells. It can inhibit the death of brain cells induced, for example, by cerebral hemorrhage, cerebral infarction, and cerebral edema and the rise of the intracranial temperature caused by cephalic lesion or the like.
摘要翻译：的细胞存活促进剂廷中枢神经细胞，含有作为活性成分的选自L-丝氨酸，甘氨酸，以及它们的脂肪酸衍生物中选择的化合物; 和用于预防和/或治疗中的大脑的功能的降低，含有该化合物作为活性成分的试剂。细胞存活促进剂婷功能，保护脑细胞，抑制细胞死亡，并在同一时间，以延长电池的使用寿命。它可以抑制诱导的，例如脑细胞的死亡，由脑出血，脑梗塞，脑水肿和头侧病变等引起颅内温度的升高。

5. 发明公开

EP0979878A2 Method for detecting oligonucleotides and determining base sequence of nucleic acids 审中-公开
标题翻译：一种用于检测的核酸的碱基序列的寡核苷酸和确定方法
公开(公告)号：EP0979878A2
公开(公告)日：2000-02-16
申请号：EP99305648.0
申请日：1999-07-16
申请人： THE INSTITUTE OF PHYSICAL & CHEMICAL RESEARCH , Hayashizaki, Yoshihide
发明人： Hayashizaki, Yoshihide
IPC分类号： C12Q1/68 , B01D57/02 , G01N21/64 , G01N27/447
CPC分类号： G01N27/44721 , C12Q1/6869 , Y10S436/80 , C12Q2565/125 , C12Q2565/102 , C12Q2537/143
摘要： Disclosed are a method which can simultaneously analyze a plurality of analytes and can realize the determination of the base sequence of a large quantity of gene information in a short time, and an apparatus for the method. The method comprises the steps of: preparing four samples, for each of a plurality of nucleic acid analytes, containing analyte nucleic acid-derived oligonucleotide fragments with the end bases having been base-specifically fragmented; labeling the oligonucleotide fragments with a different label for each of the analyte nucleic acids; and subjecting the four samples to an analytical method which can distinguish oligonucleotide fragments based on a difference in length of one base, thereby determining the base sequence of the target nucleic acids.
摘要翻译：所公开的是可以同时分析的分析物的多个部分并加以可以实现基因的大量信息的碱基序列的确定，在短时间内，以及用于该方法装置的方法。该方法包括以下步骤：制备四个样品，对每个核酸分析物的多个，含有分析物的核酸衍生的寡核苷酸片段与末端碱基已被碱基特异性片段化; 对于每个的分析物核酸的不同的标签标记所述寡核苷酸片段; 和对所述四个样品到哪个分析方法可以基于在一个基站，从而确定性挖掘的靶核酸的碱基序列的长度的差区分寡核苷酸片段。

6. 发明公开

EP0967219A1 COMPOUNDS HAVING ENERGY TRANSFER FUNCTION AND METHOD FOR DNA BASE SEQUENCING BY USING THE SAME 失效
标题翻译：具有能量传递函数和DNA碱基测序使用这些化合物的方法LINKS
公开(公告)号：EP0967219A1
公开(公告)日：1999-12-29
申请号：EP98931037.0
申请日：1998-07-10
申请人： THE INSTITUTE OF PHYSICAL & CHEMICAL RESEARCH , Wako Pure Chemical Industies, Ltd. , Hayashizaki, Yoshihide
发明人： HAYASHIZAKI, Yoshihide, The Inst. Physical Chemi.
IPC分类号： C07H19/10 , C07H19/14 , C07H19/20 , C12Q1/68
CPC分类号： C07H21/00 , C07H19/10 , C07H19/20 , C12Q1/6869 , C12Q2565/1015 , C12Q2521/119
摘要： Disclosed are compounds having two kinds of reporters that can be a donor and an acceptor for energy transfer, for example, fluorescent groups, and having a 2 ' ,3 ' -dideoxyribonucleotide residue or a 3 ' -deoxyribonucleotide residue. These compounds can be used as terminators for the chain terminator method. The two kinds of reporters are arranged with a distance sufficient for causing energy transfer from the donor to the acceptor. Also disclosed are methods for determining DNA sequences based on the chain terminator method wherein the chain termination reaction is performed by using the above terminators. Also disclosed are compounds having two kinds of reporters that can be a donor and an acceptor for energy transfer, which can be used as a primer or an initiator in methods for determining DNA sequences utilizing the chain terminator method, and methods for determining DNA sequences utilizing the compounds.
摘要翻译：本发明公开了具有2种记者的化合物做了可以在用于能量传输，例如，荧光基团，和具有2”，3'-双脱氧核糖核苷酸残基或3'-脱氧核糖核苷酸残基的供体和受体。这些化合物可以用作终止子为链终止法。这两种记者被布置成足以使从供体到受体的能量转移的距离。所以光盘游离缺失是基于所述链终止法worin链终止反应进行通过使用上述的终止子用于确定性采矿DNA序列的方法。所以盘游离缺失是具有2种记者的化合物也可以是一个供体和受主能量转移，其可以被用作引物或在利用链终止方法确定的采矿的DNA序列的方法来引发剂，以及用于确定性采矿DNA序列的方法利用的化合物。

7. 发明公开

EP0931620A1 Laser machining method and apparatus 有权
标题翻译： Verfahren und Vorrichtung zur Laserbearbeitung
公开(公告)号：EP0931620A1
公开(公告)日：1999-07-28
申请号：EP99100818.6
申请日：1999-01-18
申请人： THE INSTITUTE OF PHYSICAL & CHEMICAL RESEARCH
发明人： Sugioka, Koji, C/O The Inst. of Phys. & Chem. Res. , Zhang, Jie, C/O The Inst. of Phys. & Chem. Res. , Midorikawa, Katsumi, C/O The Inst. of Phys. & Chem
IPC分类号： B23K26/00
CPC分类号： B23K26/18 , B23K26/066
摘要： In order to form a fine pattern at high speed with respect to a material (18) such as quartz glass exhibiting a remarkable band gap, having a short wavelength at absorption edge of light, and having high bond energy between constituent atoms, laser beam being transparent as to a material to be worked is irradiated thereupon, at the same time, plasma is produced at a place close to an objective surface of the material to be worked, and ablation is generated on the objective surface (A) of the material to be worked by means of interactions between the plasma and laser beam irradiated upon the material to be worked, thereby to work the material.
摘要翻译：为了相对于呈现显着带隙的石英玻璃（18）的材料（18）形成高精度图案，在光的吸收边缘具有短波长，并且在构成原子之间具有高的键能，激光束在其上照射待加工材料透明的同时，等离子体在靠近待加工材料的物镜表面的地方产生，并且在材料的物镜表面（A）上产生烧蚀通过等离子体和照射在待加工材料上的激光束之间的相互作用来加工，从而对材料进行加工。

8. 发明公开

EP0916342A1 A medicament for treating obesity and improving lipid metabolism 有权
标题翻译： Ein Arzneimittel zur Behandlung von Fettleibigkeit und Verbesserung des lipidmetabolismus
公开(公告)号：EP0916342A1
公开(公告)日：1999-05-19
申请号：EP98121049.5
申请日：1998-11-06
申请人： THE INSTITUTE OF PHYSICAL & CHEMICAL RESEARCH , Suzuki, Kunio
发明人： Suzuki, Kunio , Shimizu, Takeshi c/o The Inst. of Ph. & Chem. Res. , Nakata, Tadashi c/o The Inst. of Ph. & Chem. Resea
IPC分类号： A61K31/575
CPC分类号： A61K31/575 , Y10S514/824 , Y10S514/909
摘要： A medicament for preventive and therapeutic treatment of obesity and a disease with abnormal lipid metabolism which comprises as an active ingredient a compound selected from the group consisting of 24-alkylcholestan-3-ones and 24-alkylcholesten-3-ones such as 24-alkylcholestan-3-ones, 24-alkylcholestmonoen-3-ones, 24-alkylcholestdien-3-ones, 24-alkylcholesttrien-3-ones and 24-alkylcholesttetraen-3-ones.
摘要翻译：一种用于预防和治疗肥胖症和脂代谢异常的疾病的药物，其包含选自24-烷基胆甾烷-3-酮和24-烷基胆甾烯-3-酮的化合物作为活性成分，例如24-烷基胆甾烷 2-烷基胆甾烯-3-酮，24-烷基胆甾烯-3-酮，24-烷基胆甾烯-3-酮和24-烷基胆甾四烯-3-酮。

9. 发明公开

EP0898247A2 Method of synthesizing measurement data of free-form surface 审中-公开
标题翻译：维也纳自治大学
公开(公告)号：EP0898247A2
公开(公告)日：1999-02-24
申请号：EP98115196.2
申请日：1998-08-12
申请人： THE INSTITUTE OF PHYSICAL & CHEMICAL RESEARCH
发明人： Kase, Kiwamu
IPC分类号： G06T17/30
CPC分类号： G06T17/30 , Y02P90/265
摘要： (a) A surface shape of an object 1 is measured from different positions and/or different directions and plural partial measurement data 2 including common part 1a is obtained. (b) A parametric surface showing the surface shape of each measurement range is formed from the data. (c) A plurality of sampling points are set at a predetermined pitch in the common part and the Gaussian curvature K and/or an average curvature H are calculated from the principal curvatures (κ 1 ,κ 2 ) in the points. (d) Three or more characteristic points are selected in accordance with the order from larger absolute values of K or H in the common part and a normal vector of a plane constructed by three points among the points is calculated. (e) The common parts are made coincide with each other by moving the parametric surfaces so as to coincide the three characteristic points with each other and to coincide the directions of the normal vectors with each other. Consequently, the synthesis data can be formed from the partial measurement data obtained from the free-form surface.
摘要翻译：（a）从不同的位置和/或不同的方向测量物体1的表面形状，并且获得包括公共部分1a的多个部分测量数据2。（b）从数据形成表示各测量范围的表面形状的参数表面。（c）在公共部分中以预定间距设置多个采样点，并且从点的主曲率（kappa1，kappa2）计算高斯曲率K和/或平均曲率H. （d）根据在公共部分中较大的K或H的绝对值的顺序选择三个或更多个特征点，并且计算由点中的三个点构成的平面的法线矢量。（e）通过移动参数表面使公共部分彼此重合，以使三个特征点彼此重合，并使法向量的方向彼此一致。因此，合成数据可以由从自由曲面获得的部分测量数据形成。

10. 发明公开

EP0873754A1 AMINO ACID COMPOSITIONS 失效
标题翻译： AMINOSÄUREZUSAMMENSETZUNGEN
公开(公告)号：EP0873754A1
公开(公告)日：1998-10-28
申请号：EP97900113.8
申请日：1997-01-09
申请人： THE INSTITUTE OF PHYSICAL & CHEMICAL RESEARCH , MEIJI MILK PRODUCTS COMPANY LIMITED
发明人： ABE, Takashi, The Inst. of Phys. & Chem. Research , TSUCHITA, Hiroshi , IIDA, Koji
IPC分类号： A61K38/48 , A61K31/195 , A61K31/395 , A61K31/40
CPC分类号： A61K31/415 , A61K31/40 , A61K31/195 , A61K2300/00
摘要： An amino acid composition comprising the following amino acids at the following molar ratio: proline (12.6 to 23.4), alanine (8.4 to 15.6), glycine (13.3 to 24.9), valine (8.2 to 15.4), threonine (5.0 to 9.4), leucine (4.3 to 8.1), histidine (1.8 to 11.9), serine (1.7 to 3.3), lysine (6.0 to 11.2), isoleucine (3.1 to 5.9), glutamic acid (2.2 to 10.4), arginine (2.4 to 4.6), phenylalanine (2.6 to 5.0), tyrosine (4.2 to 7.8) and trypsin (1.5 to 2.9). The composition supplements blood amino acids reduced during hard exercise and shows effects to improve motor function, to reduce fatigue after exercise and to help recovery from the fatigue.
摘要翻译：包含以下摩尔比的以下氨基酸的氨基酸组合物：脯氨酸（12.6至23.4），丙氨酸（8.4至15.6），甘氨酸（13.3至24.9），缬氨酸（8.2至15.4），苏氨酸（5.0至9.4），亮氨酸（4.3至8.1），组氨酸（1.8至11.9），丝氨酸（1.7至3.3），赖氨酸（6.0至11.2），异亮氨酸（3.1至5.9），谷氨酸（2.2至10.4），精氨酸（2.4至4.6）苯丙氨酸（2.6〜5.0），酪氨酸（4.2〜7.8）和胰蛋白酶（1.5〜2.9）。该组合物补充了在锻炼期间减少的血液氨基酸，并且显示出改善运动功能的效果，减少运动后的疲劳并帮助恢复疲劳。

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