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1. 发明公开

EP2355852A1 CHEMICALLY MODIFIED CELL-PENETRATING PEPTIDES FOR IMPROVED DELIVERY OF GENE MODULATING COMPOUNDS 审中-公开
标题翻译：化学修饰的细胞穿透肽供应改善GENMODULIERENDER CONNECTIONS
公开(公告)号：EP2355852A1
公开(公告)日：2011-08-17
申请号：EP09818057.3
申请日：2009-09-16
申请人： Ahmed, Kariem , El Andaloussi, Samir , Guterstam, Peter , Hällbrink, Mattias , Johansson, Henrik , Langel, Ülo , Lehto, Taavi , Lindgren, Maria , Mäger, Imre , Sillard, Rannar , Rosenthal Aizman, Katri , Tedebark, Ulf , Lundin, Per
发明人： Ahmed, Kariem , El Andaloussi, Samir , Guterstam, Peter , Hällbrink, Mattias , Johansson, Henrik , Langel, Ülo , Lehto, Taavi , Lindgren, Maria , Mäger, Imre , Sillard, Rannar , Rosenthal Aizman, Katri , Tedebark, Ulf , Lundin, Per
IPC分类号： A61K47/48 , A61K31/00 , A61K31/20 , A61K38/16 , C07K1/107 , C07K14/00 , C07K7/08
CPC分类号： A61K49/0004 , A61K31/20 , A61K38/00 , A61K47/543 , A61K47/641 , A61K47/6455 , C07K7/06 , C07K7/08 , C07K9/00 , C07K14/001 , C12N15/87 , Y02P20/582
摘要： The present invention relates to a system for intracellular delivery of a cargo comprising at least one component A chosen from aliphatic linear or branched moieties with at least 4 carbon atoms and/or cyclic ring systems comprising 2-4 rings which may contain several hetero atoms chosen from N, S, O and P, wherein component(s) A is (are) attached to a cell penetrating peptide B and/or a non-peptide analogue thereof. It also relates to methods of using the system in diagnosis of diseases, as research tool and as a targeting system, a composition comprising the system and especially a pharmaceutical composition a material covered with the system and a material having the delivery systems into the material. Finally it relates to novel peptides.

2. 发明申请

WO2010039088A1 CHEMICALLY MODIFIED CELL-PENETRATING PEPTIDES FOR IMPROVED DELIVERY OF GENE MODULATING COMPOUNDS 审中-公开
标题翻译：用于改进基因调节化合物递送的化学改性细胞培养基
公开(公告)号：WO2010039088A1
公开(公告)日：2010-04-08
申请号：PCT/SE2009/051032
申请日：2009-09-16
申请人： AHMED, Kariem , EL ANDALOUSSI, Samir , GUTERSTAM, Peter , HÄLLBRINK, Mattias , JOHANSSON, Henrik , LANGEL, Ülo , LEHTO, Taavi , LINDGREN, Maria , MÄGER, Imre , SILLARD, Rannar , ROSENTHAL AIZMAN, Katri , TEDEBARK, Ulf , LUNDIN, Per
发明人： AHMED, Kariem , EL ANDALOUSSI, Samir , GUTERSTAM, Peter , HÄLLBRINK, Mattias , JOHANSSON, Henrik , LANGEL, Ülo , LEHTO, Taavi , LINDGREN, Maria , MÄGER, Imre , SILLARD, Rannar , ROSENTHAL AIZMAN, Katri , TEDEBARK, Ulf , LUNDIN, Per
IPC分类号： A61K47/48 , A61K31/00 , A61K31/20 , A61K38/16 , C07K1/107 , C07K14/00 , C07K7/08
CPC分类号： A61K49/0004 , A61K31/20 , A61K38/00 , A61K47/543 , A61K47/641 , A61K47/6455 , C07K7/06 , C07K7/08 , C07K9/00 , C07K14/001 , C12N15/87 , Y02P20/582
摘要： The present invention relates to a system for intracellular delivery of a cargo comprising at least one component A chosen from aliphatic linear or branched moieties with at least 4 carbon and/or cyclic ring systems comprising 2-4 rings which may contain several hetero atoms chosen from N, S, O and P, wherein component(s) A is (are) attached to a cell penetrating peptide B and/or a non-peptide analogue thereof. It also relates to the use of the system in diagnosis of deceases, as research tool and as a targeting system, a composition comprising the system and especially a pharmaceutical composition a material covered with the system and a material having the delivery systems into the material. Finally it relates to novel peptides.
摘要翻译：本发明涉及一种用于细胞内递送货物的系统，其包含至少一种选自脂族直链或支链部分的组分A和至少4个碳环和/或环环系统，其包含2-4个环，其可以含有选自以下的多个杂原子 N，S，O和P，其中组分A连接到穿透肽B的细胞和/或其非肽类似物。它还涉及该系统在诊断死亡中的用途，作为研究工具和作为靶向系统的组合物，包含该系统的组合物，特别是药物组合物包含在该系统中的材料以及具有输送系统进入该材料的材料。最后涉及新型肽。

3. 发明申请

WO2011115555A1 SYSTEM FOR IMPROVED DELIVERY OF GENE MODULATING COMPOUNDS 审中-公开
标题翻译：改进基因调节化合物的方法
公开(公告)号：WO2011115555A1
公开(公告)日：2011-09-22
申请号：PCT/SE2011/050279
申请日：2011-03-15
申请人： GE HEALTHCARE BIO-SCIENCES AB , TEDEBARK, Ulf
发明人： TEDEBARK, Ulf
IPC分类号： A61K47/48 , A61K48/00 , A61K49/00
CPC分类号： C12N15/111 , A61K47/543 , A61K47/545 , A61K48/0025 , C12N2310/14 , C12N2320/32
摘要： The present invention relates to a system for intracellular cargo delivery comprising: D (n) BAC wherein: Component D is a amine-containing compound; n is a number of amines between 2-6, Component B is a di-, tri or tetra ring system,such as quinoline or naphthalene derivatives which may contain several hetero atoms chosen from N, S, O and P; Component A is an aliphatic linear or branched hydrophobic chain of at least 4 carbon atoms preferably an epoxide, alkyl halide or an acrylamide with 6-30 carbon atoms or a derivative thereof;and Component C is an optional targeting moiety, such as homing peptide or aptamer, wherein components D, B, A and C may be coupled to each other via spacer(s). It also relates to the use of the system in diagnosis of diseases, as research tool and as a targeting system, a composition comprising the system and especially a pharmaceutical composition,a material covered with the system and a material having the delivery systems within the material.
摘要翻译：本发明涉及一种用于细胞内货物递送的系统，其包括：D（n）BAC，其中：组分D是含胺化合物; n是2-6之间的多个胺，组分B是二，三或四环体系，例如喹啉或萘衍生物，其可以含有选自N，S，O和P的几个杂原子; 组分A是具有至少4个碳原子的脂族直链或支链疏水链，优选环氧化物，烷基卤化物或具有6-30个碳原子的丙烯酰胺或其衍生物;组分C是任选的靶向部分，例如归巢肽或适体，其中组分D，B，A和C可以通过间隔物彼此偶联。它还涉及该系统在诊断疾病中的用途，作为研究工具和靶向系统，包含该系统，特别是药物组合物的组合物，被该系统覆盖的材料以及在该材料内具有递送系统的材料。

4. 发明申请

WO2004076475A1 A METHOD OF GENERATING METAL CHELATING AFFINITY LIGANDS 审中-公开
标题翻译：一种生成金属螯合亲和力配体的方法
公开(公告)号：WO2004076475A1
公开(公告)日：2004-09-10
申请号：PCT/SE2003/001903
申请日：2003-12-08
申请人： AMERSHAM BIOSCIENCES AB , ANDERSSON, Lars, C. , AXÉN, Andreas , GEBRU, Tesfai , MALOISEL, Jean-Luc , TEDEBARK, Ulf
发明人： ANDERSSON, Lars, C. , AXÉN, Andreas , GEBRU, Tesfai , MALOISEL, Jean-Luc , TEDEBARK, Ulf
IPC分类号： C07K1/22
CPC分类号： B01J45/00 , B01D15/3828 , B01J20/286 , B01J20/3251 , B01J20/3265 , C07C323/58 , C07D333/36
摘要： The present invention relates to a method of generating polydentate metal chelating affinity ligands, which method comprises the steps of providing a cyclic scaffold comprising a carbonyl, an adjacent sulphur and a nucleophile; providing a polydentate metal chelating affinity ligand arm on each scaffold by derivatisation of said nucleophile; ring-opening of the scaffold by adding a reagent that adds more metal chelating affinity ligand arm(s) to the scaffold; and, if required, deprotecting the functionalities of the ligand arm(s) so provided. In the most preferred embodiment of the method, the ring-opening and the deprotection steps are performed in a single step.
摘要翻译：本发明涉及产生多齿金属螯合亲和配体的方法，该方法包括提供包含羰基，相邻硫和亲核体的环状支架的步骤; 通过所述亲核试剂的衍生化在每个支架上提供多齿金属螯合亲和配体臂; 通过添加向支架中添加更多金属螯合亲和配体臂的试剂来开环支架; 并且如果需要，使如此提供的配体臂的功能脱保护。在该方法的最优选实施方案中，开环和脱保护步骤在单步中进行。

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