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1. 发明申请

WO2002101056A3 CONJUGATED LINOLEIC ACID ISOMERASE AND A PROCESS FOR THE PRODUCTION OF CONJUGATED LINOLEIC ACID 审中-公开
公开(公告)号：WO2002101056A3
公开(公告)日：2002-12-19
申请号：PCT/EP2002/006341
申请日：2002-06-10
申请人： TEAGASC DAIRY PRODUCTS RESEARCH CENTRE , STANTON, Catherine , ROSS, R., Paul , ZELDER, Oskar
发明人： STANTON, Catherine , ROSS, R., Paul , ZELDER, Oskar
IPC分类号： C12N15/61
摘要： The present invention relates to a process for the production of conjugated linoleic acid and a process for the production of triglycerides with an increased content of conjugated linoleic acid. Moreover, the invention relates to a nucleic acid sequence; a nucleic acid construct, a vector and transgenic organisms comprising at least one nucleic acid sequence or one nucleic acid construct which encodes a polypeptide with conjugated linoleic isomerase activity. Furthermore, the invention relates to the use of a microorganism of the genus Bifidobacterium as a probiotic.

2. 发明申请

WO2002101056A2 CONJUGATED LINOLEIC ACID ISOMERASE AND A PROCESS FOR THE PRODUCTION OF CONJUGATED LINOLEIC ACID 审中-公开
标题翻译：连接的亚油酸异构体和一种生产连结的亚油酸的方法
公开(公告)号：WO2002101056A2
公开(公告)日：2002-12-19
申请号：PCT/EP2002/006341
申请日：2002-06-10
申请人： TEAGASC DAIRY PRODUCTS RESEARCH CENTRE , STANTON, Catherine , ROSS, R., Paul , ZELDER, Oskar
发明人： STANTON, Catherine , ROSS, R., Paul , ZELDER, Oskar
IPC分类号： C12N15/61
CPC分类号： C12P7/6427 , A23K10/18 , A23L29/065 , A23V2002/00 , A23Y2300/59 , C12P7/6472 , A23V2250/1866
摘要： The present invention relates to a process for the production of conjugated linoleic acid and a process for the production of triglycerides with an increased content of conjugated linoleic acid. Moreover, the invention relates to a nucleic acid sequence; a nucleic acid construct, a vector and transgenic organisms comprising at least one nucleic acid sequence or one nucleic acid construct which encodes a polypeptide with conjugated linoleic isomerase activity. Furthermore, the invention relates to the use of a microorganism of the genus Bifidobacterium as a probiotic.
摘要翻译：本发明涉及一种生产共轭亚油酸的方法和一种生产具有增加共轭亚油酸含量的甘油三酯的方法。此外，本发明涉及核酸序列; 核酸构建体，载体和转基因生物体，其包含编码具有共轭亚油酸异构酶活性的多肽的至少一个核酸序列或一个核酸构建体。此外，本发明涉及双歧杆菌属的微生物作为益生菌的用途。

3. 发明公开

EP1963517A1 PROCESS FOR THE PRODUCTION OF TRANS-10, CIS 12 OCTADECADIENOIC ACID 审中-公开
标题翻译：用于生产TRANS-10-CIS-12-十八
公开(公告)号：EP1963517A1
公开(公告)日：2008-09-03
申请号：EP06830179.5
申请日：2006-11-29
申请人： Teagasc Dairy Products Research Centre
发明人： STANTON, Catherine
IPC分类号： C12P7/64 , C12N9/90 , C12N1/20 , A23L1/03 , A61K31/201 , C11C3/14
CPC分类号： C12N9/90 , A23L33/12 , A23V2002/00 , C11C3/14 , C12P7/6427 , C12P7/6463 , C12P7/6472 , A23V2250/1866
摘要： The present application is directed to a process for the production of trans-10, cis-12 conjugated linoleic acid in a transgenic microorganism comprising the steps of: (a) introducing into said microorganism at least one nucleic acid molecule encoding a trans-10, cis-12 conjugated linoleic acid isomerase, (b) culturing the transgenic microorganism obtained under (a), (c) inducing the production of trans-10, cis-12 conjugated linoleic acid by adding linoleic acid to the culture, (d) incubating the induced culture for at least 12 hours, and (e) isolating the conjugated linoleic acid from the culturemedia and/or transgenic microorganism.

4. 发明公开

EP1399569A2 CONJUGATED LINOLEIC ACID ISOMERASE AND A PROCESS FOR THE PRODUCTION OF CONJUGATED LINOLEIC ACID 有权
标题翻译：共轭亚油酸异构酶，AND METHOD FOR PRODUCING共轭亚油酸
公开(公告)号：EP1399569A2
公开(公告)日：2004-03-24
申请号：EP02747365.1
申请日：2002-06-10
申请人： Teagasc Dairy Products Research Centre
发明人： STANTON, Catherine,Teagasc Dairy Prod Resch Cent. , ROSS, R. Paul,Teagasc Dairy Products Resch Centre , ZELDER, Oskar
IPC分类号： C12N15/61 , C12N9/90 , C12P7/64 , A61K35/74 , A23L1/03 , A23K1/00
CPC分类号： C12P7/6427 , A23K10/18 , A23L29/065 , A23V2002/00 , A23Y2300/59 , C12P7/6472 , A23V2250/1866
摘要： The present invention relates to a process for the production of conjugated linoleic acid and a process for the production of triglycerides with an increased content of conjugated linoleic acid. Moreover, the invention relates to a nucleic acid sequence; a nucleic acid construct, a vector and transgenic organisms comprising at least one nucleic acid sequence or one nucleic acid construct which encodes a polypeptide with conjugated linoleic isomerase activity. Furthermore, the invention relates to the use of a microorganism of the genus Bifidobacterium as a probiotic.

5. 发明公开

EP1951745A2 CASEIN-DERIVED ANTIMICROBIAL PEPTIDES AND LACTOBACILLUS STRAINS THAT PRODUCE THEM 审中-公开
标题翻译：酪蛋白衍生抗菌肽和乳酸菌菌株这些农产品
公开(公告)号：EP1951745A2
公开(公告)日：2008-08-06
申请号：EP06809742.7
申请日：2006-11-20
申请人： Teagasc Dairy Products Research Centre
发明人： ROSS, Paul , STANTON, Catherine , HILL, Colin , FITZGERALD, Ger
IPC分类号： C07K7/06 , C07K7/08 , A61K35/74 , A61K38/08 , A61K38/10 , A23L1/305 , A23J3/34 , A61P31/00
CPC分类号： C07K14/4732 , A23C9/1322 , A23C9/1585 , A23C19/11 , A23L2/52 , A23L33/135 , A23L33/18 , A23L33/40 , A23V2002/00 , A61K38/556 , C07K14/335 , C12N9/52 , C12R1/23 , Y02A50/473 , A23V2200/324 , A23V2250/546
摘要： The present invention relates generally to the field of health promoting agents, in particular antimicrobial agents and provides antimicrobial peptides and bacterial strains that provide the antimicrobial peptides. In one aspect, the invention provides a biologically pure culture of Lactobacillus acidophilus, strain DPC6026, a sample of which has been deposited at the National Collection of Industrial and Marine Bacteria, Aberdeen, Scotland on 18th Nov. 2005 under the accession number NCIMB 41354, or a derivative or mutant thereof capable of producing from milk or a milk product, peptides having antimicrobial activity.

6. 发明公开

EP1264893A1 CLA biosynthesis by bifidobacteria 审中-公开
标题翻译：生物合成
公开(公告)号：EP1264893A1
公开(公告)日：2002-12-11
申请号：EP01113962.3
申请日：2001-06-08
申请人： Teagasc Dairy Products Research Centre
发明人： The designation of the inventor has not yet been filed
IPC分类号： C12P7/64 , A61K35/74 , A23L1/03 , A23K1/00
CPC分类号： C12P7/6427 , A23K10/18 , A23L29/065 , A23V2002/00 , A23Y2300/59 , C12P7/6472 , A23V2250/1866
摘要： Nineteen strains of Lactobacillus , 2 strains of Lactococcus , 1 strain of Pediococcus, 4 strains of Propionibacterium and 23 strains of Bifidobacterium were screened for their ability to produce conjugated linoleic acid (CLA) from linoleic acid. Of these, 7 strains of Bifidobacterium , as well as 2 strains of Propionibacterium produced the cis-9, trans -11 CLA isomer from linoleic acid. In contrast, strains of Lactobacillus, Lactococcus and Pediococcus lacked the ability to synthesise CLA. CLA ( cis -9, trans- 11 isomer) production by the genus Bifidobacterium was shown to exhibit considerable interspecies variation, with B . breve and B . dentium being the most efficient producers among the strains tested, yielding up to 65 % conversion of linoleic acid to CLA at linoleic acid concentrations of 0.2-1.0 mg/ml in MRS medium. The growth of B. breve strains was inhibited by increasing concentrations of linoleic acid. Viability of B. breve 2257 was unaffected in the presence of up to 0.5 mg/ml linoleic acid for 48 h but was dramatically reduced to 1.5% survival at 1 mg/ml linoleic acid. However, viability of the B . breve strains NCFB2258, NCTC 11815, NCIMB 8815 and NCIMB 8807 was reduced to
摘要翻译：从亚油酸中筛选出19株乳酸杆菌，2株乳杆菌属，1株菌种，4种丙酸杆菌和23株双歧杆菌，产生共轭亚油酸（CLA）的能力。其中7种双歧杆菌以及2种丙酸杆菌从亚油酸产生顺式-9，反式-11 CLA异构体。相比之下，乳酸杆菌，乳球菌和小球菌的菌株缺乏合成CLA的能力。显示双歧杆菌属的CLA（顺式-9，反式-11异构体）产生显示出相当大的种间变异，B. breve和B. dentium是所测试菌株中最有效的生产者，产生高达65％的亚油酸转化在MRS培养基中亚油酸浓度为0.2-1.0mg / ml的CLA对CLA的影响。通过增加亚油酸的浓度来抑制短双歧杆菌菌株的生长。在高达0.5mg / ml亚油酸存在下，短双歧杆菌2257的活力不受影响48小时，但在1mg / ml亚油酸下显着降低至1.5％存活。然而，短链子短杆菌NCFB2258，NCTC 11815，NCIMB 8815和NCIMB 8807的活力在亚油酸浓度为0.2mg / ml时降低至<60％。这些数据表明，某些双歧杆菌菌株可能有提高食物中CLA含量和CLA在人体内的应用。

7. 发明授权

EP1399569B1 CONJUGATED LINOLEIC ACID ISOMERASE AND A PROCESS FOR THE PRODUCTION OF CONJUGATED LINOLEIC ACID 有权
标题翻译：共轭亚油酸异构酶，AND METHOD FOR PRODUCING共轭亚油酸
公开(公告)号：EP1399569B1
公开(公告)日：2008-09-10
申请号：EP02747365.1
申请日：2002-06-10
申请人： Teagasc Dairy Products Research Centre
发明人： STANTON, Catherine, Teagasc Dairy Products Research Centre , ROSS, R. Paul, Teagasc Dairy Products Research Centre , ZELDER, Oskar , KAESLER, Bruno
IPC分类号： C12N15/61 , C12N9/90 , C12P7/64 , A61K35/74 , A23L1/03 , A23K1/00
CPC分类号： C12P7/6427 , A23K10/18 , A23L29/065 , A23V2002/00 , A23Y2300/59 , C12P7/6472 , A23V2250/1866
摘要： The present invention relates to a process for the production of conjugated linoleic acid and a process for the production of triglycerides with an increased content of conjugated linoleic acid. Moreover, the invention relates to a nucleic acid sequence; a nucleic acid construct, a vector and transgenic organisms comprising at least one nucleic acid sequence or one nucleic acid construct which encodes a polypeptide with conjugated linoleic isomerase activity. Furthermore, the invention relates to the use of a microorganism of the genus Bifidobacterium as a probiotic.

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