专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20150218262A1 Method for In-Vivo Binding of Chromatin Fragments 审中-公开
标题翻译：染色质片段的体内结合方法
公开(公告)号：US20150218262A1
公开(公告)日：2015-08-06
申请号：US14688736
申请日：2015-04-16
申请人： TATA MEMORIAL CENTRE
发明人： Indraneel MITTRA , Rekha Mannemcherril RAMESAN , Chandra Prakash SHARMA , Gopichettipalayam Subbaratnam BHUVANESHWAR , Kavita Anirban PAL
IPC分类号： C07K16/18 , A61K47/48
CPC分类号： C07K16/18 , A61K47/61 , A61K47/6939 , A61K2039/505 , C07K16/08 , Y10T428/2982
摘要： A process for substantially reducing levels of circulating chromatin fragments (CCFs) from a medium using binding agents such as antibodies or antibodies complexed with haemocompatible natural polymer substrates like as alginates, chitosan and pullulan to form complexed antibodysubstrate nano-particulates (CNP) to bind and/or inactivate CCFs is disclosed. The amount of antibody bound to the polymer varies from 30% to 100% of activated sites in the polymer. Elevated levels of CCFs can be substantially reduced following administration of tissue damaging agents that generate apoptotic chromatin fragments by the concomitant administration of CNPs or concomitant administration of H4 antibody alone. A method of treatment is disclosed wherein therapeutic dose of CNPs, or H4 antibody alone, are administered systematically, or orally, in a delivery system to curb pathological conditions that are associated with increased burden of circulating chromatin fragments.
摘要翻译：使用结合剂（例如抗体或抗体与诸如藻酸盐，壳聚糖和支链淀粉等血液相容性天然聚合物底物复合的抗体）从培养基中显着降低循环染色质片段（CCF）的水平的方法，以形成复合的抗生物碱性纳米颗粒（CNP）结合和 /或灭活CCF。与聚合物结合的抗体的量在聚合物中的活化位点的30％至100％不等。在施用组合损伤剂后，CCF的升高水平可以显着降低，所述组织损伤剂通过伴随施用CNP或单独施用H4抗体产生凋亡染色质片段。公开了一种治疗方法，其中治疗剂量的CNP或单独的H4抗体在递送系统中系统地或口服地施用以遏制与循环染色质片段的负担增加相关的病理状况。

2. 发明申请

US20140099293A1 METHOD FOR EX-VIVO SEPARATION OF APOPTOTIC CHROMATIN FRAGMENTS FROM BLOOD OR PLASMA FOR PREVENTION AND TREATMENT OF DIVERSE HUMAN DISEASES 审中-公开
标题翻译：用于预防和治疗多发性人类疾病的血液或血浆中的细胞色素片段的分离方法
公开(公告)号：US20140099293A1
公开(公告)日：2014-04-10
申请号：US14100950
申请日：2013-12-09
申请人： Tata Memorial Centre
发明人： Indraneel MITTRA , Urmila Chandrashekhar SAMANT , Gopesh Kumar MODI , Pradyumna Kumar MISHRA , Gobichettipalayam Subbaratnam BHUVANESHWAR
IPC分类号： A61K35/16 , C12N5/078
CPC分类号： A61K35/16 , A61M1/3472 , A61M1/3486 , A61M1/3496 , A61M1/3693 , A61M1/3695 , C12N5/0634
摘要： A method of prevention/treatment of pathological consequences of DNA damage triggered by incorporation of circulating apoptotic chromatin fragments into healthy cells of individuals/patients in need therefore, said method comprising ex vivo or extra corporeal treatment of blood/plasma for removal of circulating chromatin fragments released from apoptotic cells which apoptotic chromatin fragments are capable of triggering DNA damage leading to genomic instability, senescence, apoptosis and cancerous transformation of healthy cells on being integrated into their genomes
摘要翻译：一种预防/治疗因需要将循环凋亡染色质片段并入健康细胞引起的DNA损伤的病理学后果的方法，所述方法包括用于去除循环染色质片段的血液/血浆的离体或额外体外处理从凋亡细胞释放，凋亡染色质片段能够引发DNA损伤，导致融合到其基因组中的健康细胞的基因组不稳定性，衰老，凋亡和癌性转化

3. 发明申请

WO2020188596A1 A METHOD FOR DETECTION OF PROTEIN ACTIVATION USING PHOSPHOBRET IMAGING SENSOR AND METHODS THEREOF 审中-公开
公开(公告)号：WO2020188596A1
公开(公告)日：2020-09-24
申请号：PCT/IN2020/050237
申请日：2020-03-16
申请人： ADVANCED CENTRE FOR TREATMENT, RESEARCH AND EDUCATION IN CANCER, TATA MEMORIAL CENTRE
发明人： DE, Abhijit , RAY, Pritha , DIMRI, Shalini , BISHNU, Aniketh
IPC分类号： G01N33/52
摘要： A fusion construct comprising sequence encoding Nanoluciferase and a flurophore selected from list of TurboFP635, TagRFP and mOrange to form a bioluminescence resonance energy transfer (BRET) sensor-based donor-acceptor pair is provided. The system and methods to detect phosphorylation of STAT3 and AKT protein is provided.

4. 发明申请

WO2011092715A2 METHOD FOR IN-VIVO BINDING OF CHROMATIN FRAGMENTS 审中-公开
标题翻译：色氨酸片段的体内结合方法
公开(公告)号：WO2011092715A2
公开(公告)日：2011-08-04
申请号：PCT/IN2011/000052
申请日：2011-01-24
申请人： TATA MEMORIAL CENTRE , MITTRA, Indraneel , RAMESAN, Rekha, Mannemcherril , SHARMA, Chandra, Prakash , BHUVANESHWAR, Gopichettipalayam, Subbaratnam , PAL, Kavita, Anirban
发明人： MITTRA, Indraneel , RAMESAN, Rekha, Mannemcherril , SHARMA, Chandra, Prakash , BHUVANESHWAR, Gopichettipalayam, Subbaratnam , PAL, Kavita, Anirban
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K47/61 , A61K47/6939 , A61K2039/505 , C07K16/08 , Y10T428/2982
摘要： A process for substantially reducing levels of circulating chromatin fragments (CCFs) from a medium using binding agents such as antibodies or antibodies complexed with haemocompatible natural polymer substrates like as alginates, chitosan and pullulan to form complexed antibody-substrate nano-particulates (CNP) to bind and / or inactivate CCFs is disclosed. The amount of antibody bound to the polymer varies from 30% to 100% of activated sites in the polymer. Elevated levels of CCFs can be substantially reduced following administration of tissue damaging agents that generate apoptotic chromatin fragments by the concomitant administration of CNPs or concomitant administration of H4 antibody alone. A method of treatment is disclosed wherein therapeutic dose of CNPs, or H4 antibody alone, are administered systematically, or orally, in a delivery system to curb pathological conditions that are associated with increased burden of circulating chromatin fragments.
摘要翻译：使用结合剂（例如抗体或抗体与诸如藻酸盐，壳聚糖和支链淀粉等血液相容性天然聚合物底物复合的抗体）从培养基中显着降低循环染色质片段（CCF）的水平的方法，以形成复合的抗体 - 底物纳米颗粒（CNP）公开了结合和/或灭活CCF。与聚合物结合的抗体的量在聚合物中的活化位点的30％至100％不等。在施用组合损伤剂后，CCF的升高水平可以显着降低，所述组织损伤剂通过伴随施用CNP或单独施用H4抗体产生凋亡染色质片段。公开了一种治疗方法，其中治疗剂量的CNP或单独的H4抗体在递送系统中系统地或口服地施用以遏制与循环染色质片段的负担增加相关的病理状况。

5. 发明申请

WO2017115381A1 DEGRADABLE OR TRANSFORMABLE GOLD COATED LIPOSOMAL NANO-CONSTRUCT AND A PROCESS FOR ITS PREPARATION 审中-公开
标题翻译：可降解或可转化的金涂覆的脂质体纳米结构体及其制备方法
公开(公告)号：WO2017115381A1
公开(公告)日：2017-07-06
申请号：PCT/IN2016/000296
申请日：2016-12-27
申请人： INDIAN INSTITUTE OF TECHNOLOGY, BOMBAY , TATA MEMORIAL CENTRE
发明人： SRIVASTAVA, Rohit , BANERJEE, Rinti , RENGAN, Aravind Kumar , PRADHAN, Arpan , DE, Abhijit , BUKHARI, Amirali Bakarali
IPC分类号： A61K9/27
摘要： The present invention provides a degradable or transformable gold coated liposomal nano- construct which is multifunctional. More particularly, the present invention provides a degradable nano-construct comprising gold coated lipid liposome, wherein said lipid liposome is made up of phosphatidylcholine and cholesterol and wherein said nano-construct is degraded either by enzyme, increase in temperature or photo-thermal. The present invention also provides a transformed nano-construct comprising gold coated lipid liposome, wherein said lipid liposome is made up of phosphatidylcholine and cholesterol and co-entraps at least one drug and wherein said nano-construct is in a dendrimer form, branched form or mesh form. Further, the present invention provides a process for preparing the afore- mentioned degradable and/or transformed nano-construct.
摘要翻译：本发明提供了一种多功能的可降解或可转化的金涂覆的脂质体纳米构建体。更具体地说，本发明提供了包含金涂布的脂质脂质体的可降解的纳米构建体，其中所述脂质体由磷脂酰胆碱和胆固醇构成，并且其中所述纳米构建体通过酶降解，温度升高或光热降解。本发明还提供了包含金涂布的脂质脂质体的转化的纳米构建体，其中所述脂质脂质体由磷脂酰胆碱和胆固醇构成，并共同包载至少一种药物，并且其中所述纳米构建体为树枝状聚合物形式，枝化形式或网格形式。此外，本发明提供了制备上述可降解和/或转化的纳米构建体的方法。

6. 发明申请

WO2015011732A3 PLANT POLY-PHENOL AND COPPER (II) MEDIATED DEGRADATION OF DNA AND RNA 审中-公开
公开(公告)号：WO2015011732A3
公开(公告)日：2015-01-29
申请号：PCT/IN2014/000491
申请日：2014-07-25
申请人： TATA MEMORIAL CENTRE
发明人： MITTRA, Indraneel
IPC分类号： A61K45/06 , A61K31/015 , A61K31/05 , A61K31/12 , A61K33/34 , A61P35/00 , A61P31/18
摘要： A composition comprising a plant polyphenol, especially Resveratrol, and copper (II) for the degradation of or preventing or reducing a rise in the level of one or more of circulating fragments of chromatin, DNA and RNA. The molar ratio of plant polyphenol to copper (II) is in the range 1 :1 to 10 -10 Higher levels of degradation of chromatin fragments, DNA and RNA occur as the molar ratio of the copper to plant polyphenol to copper (II) is reduced to an optimum level depending on the material to be degraded. The composition provides therapeutic treatment for conditions associated with raised levels of chromatin fragments including cancer and HIV, may enhance cell destruction therapies and, reduce the incidence of death of live cells in the presence of dead cells or fragments of chromatin from dead cells.

7. 发明申请

WO2007049286A1 A SYSTEM FOR EX-VIVO SEPARATION OF APOPTOTIC CHROMATIN PARTICLES FROM BLOOD OR PLASMA 审中-公开
标题翻译：用于从血液或血浆中分离细胞色素颗粒的系统
公开(公告)号：WO2007049286A1
公开(公告)日：2007-05-03
申请号：PCT/IN2005/000353
申请日：2005-10-27
申请人： TATA MEMORIAL CENTRE , MITTRA, Indraneel , SAMANT, Urmila, Chandrashekhar , MODI, Gopesh, Kumar , MISHRA, Pradyumna, Kumar , BHUVANESHWAR, Gobichettipalayam, Subbaratnam
发明人： MITTRA, Indraneel , SAMANT, Urmila, Chandrashekhar , MODI, Gopesh, Kumar , MISHRA, Pradyumna, Kumar , BHUVANESHWAR, Gobichettipalayam, Subbaratnam
IPC分类号： A61M1/34 , A61M1/36
CPC分类号： A61K35/16 , A61M1/3472 , A61M1/3486 , A61M1/3496 , A61M1/3693 , A61M1/3695 , C12N5/0634
摘要： A system for ex vivo or extra corporeal treatment of blood or plasma for removal of chromatin fragments released from apoptotic cells. The said chromatin fragments are capable of triggering genomic instability leading to pathological consequences including cancerous transformation of recipient cells on being integrated in their genomes The said system comprises means adapted for removal of platelets and apoptotic chromatin fragments rich plasma (PCRP) or chromatin rich plasma (CRP) from blood cells; separating means adapted to remove apoptotic chromatin fragments from PCRP / CRP; means adapted to reconstitute blood after removal of the apoptotic chromatin fragments; means adapted to communicating and guiding of blood or plasma from body to the said separating means through the means for removal of PCRP / CRP from blood cells, to means to reconstitute blood and direct the treated blood back into the body.
摘要翻译：用于血液或血浆离体或额外体外处理以去除从细胞凋亡细胞释放的染色质片段的系统。所述染色质片段能够引发基因组不稳定性，导致病理学后果，包括被融合在其基因组中的受体细胞的癌转化。所述系统包括适于除去血小板和富含血浆（PCRP）或富含染色质的血浆的凋亡染色质片段 CRP）用于从PCRP / CRP中去除凋亡染色质片段的分离装置; 意味着去除细胞凋亡染色质片段后重建血液; 用于通过用于从血液细胞中除去PCRP / CRP的装置将血液或血浆从身体传达到所述分离装置的装置，用于重建血液并将经处理的血液引导回到体内的装置。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式