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1. 发明申请

WO2012089222A2 A DURABLE HAEMOSTATIC SCAFFOLD 审中-公开
标题翻译：持久的止血支架
公开(公告)号：WO2012089222A2
公开(公告)日：2012-07-05
申请号：PCT/EE2011/000011
申请日：2011-12-29
申请人： TARTU ÜLIKOOL (UNIVERSITY OF TARTU) , JANMEY, Paul , UIBO, Raivo , VESKI, Peep , LAIDMÄE, Ivo
发明人： JANMEY, Paul , UIBO, Raivo , VESKI, Peep , LAIDMÄE, Ivo
IPC分类号： A61L27/20 , A61L27/22 , A61L27/50
CPC分类号： A61L27/225 , A61K31/722 , A61K38/363 , A61L27/20 , A61L27/50 , A61L27/56 , A61L27/58 , A61L2300/404 , A61L2300/418 , A61L2400/04 , A61L2430/00 , C08L5/08
摘要： A haemostatic and adhesive durable scaffold useful for promoting wound healing is provided. A scaffold made of fibrinogen and chitosan is produced by electrospinning techniques, resulting in a material with enhanced endurance, applicable in various medical purposes including surgery, tissue regeneration, burns, injuries, etc. Scaffold is produced in the absence of biocatalysts, in particular thrombin.
摘要翻译：提供了用于促进伤口愈合的止血和粘合剂耐用支架。由纤维蛋白原和壳聚糖制成的支架通过静电纺丝技术生产，产生耐久性增强的材料，适用于各种医疗目的，包括手术，组织再生，烧伤，损伤等。在没有生物催化剂的情况下生成支架，特别是凝血酶

2. 发明申请

WO2008071201A1 TRANSGENIC ANIMAL MODEL FOR MODELLING PATHOLOGICAL ANXIETY, A METHOD FOR IDENTIFYING COMPOUNDS FOR TREATMENT OF DISEASES OR DISORDERS CAUSED BY PATHOLOGICAL ANXIETY AND A METHOD FOR USING WFSL PROTEIN AS A TARGET FOR IDENTIFYING EFFECTIVE COMPOUNDS AGAINST PATHOLOGICAL ANXIETY 审中-公开
标题翻译：用于建立病理学变异的转基因动物模型，鉴定用于治疗由病理学变异引起的疾病或病症的化合物的方法和使用WFSL蛋白作为目标鉴定有效化合物的方法A
公开(公告)号：WO2008071201A1
公开(公告)日：2008-06-19
申请号：PCT/EE2007/000025
申请日：2007-12-10
申请人： TARTU ÜLIKOOL (UNIVERSITY OF TARTU) , VASAR, Eero , KÖKS, Sulev , LUUK, Hendrik , RAUD, Sirli , PLAAS, Mario
发明人： VASAR, Eero , KÖKS, Sulev , LUUK, Hendrik , RAUD, Sirli , PLAAS, Mario
IPC分类号： C07K14/705 , A01K67/027 , G01N33/50 , G01N33/68
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0356 , A01K2267/0393 , C07K14/705
摘要： The invention discloses the transgenic animal model for pathological anxiety, the method to generate this model, the method to test drugs and drug candidates for the treatment of pathological anxiety and the method to use Wfsl as target for screening of new anxiolytic drugs to treat pathological anxiety. This animal model is useful to test potential drug candidates for the treatment of diseases caused by pathological anxiety and to screen therapeutic compounds for the psychiatric disorders caused by reduces stress-tolerance and deficiency in adaptation to environmental challenges.
摘要翻译：本发明公开了用于病理性焦虑的转基因动物模型，产生该模型的方法，用于治疗病理性焦虑的药物和候选药物的测试方法以及使用Wfsl作为筛选新的抗焦虑药物以治疗病理性焦虑的靶标的方法。这种动物模型可用于测试潜在的药物候选物，用于治疗由病理性焦虑引起的疾病，并筛选治疗化合物，以减轻因适应环境挑战而导致的压力耐受性和缺陷所引起的精神疾病。

3. 发明申请

WO2009033490A1 A METHOD FOR CREATING A VIRAL GENOMIC LIBRARY, A VIRAL GENOMIC LIBRARY AND A KIT FOR CREATING THE SAME 审中-公开
标题翻译：一种用于创建病毒基因组图书馆的方法，一种病毒基因组图书馆及其创建工具包
公开(公告)号：WO2009033490A1
公开(公告)日：2009-03-19
申请号：PCT/EE2008/000020
申请日：2008-08-29
申请人： TARTU ÜLIKOOL (UNIVERSITY OF TARTU) , RAUASALU, Kai , IOFIK, Anna , LULLA, Valeria , KARO-ASTOVER, Liis , TAMM, Kristi , ÜLPER, Liane , SARAND, Inga , MERITS, Andres
发明人： RAUASALU, Kai , IOFIK, Anna , LULLA, Valeria , KARO-ASTOVER, Liis , TAMM, Kristi , ÜLPER, Liane , SARAND, Inga , MERITS, Andres
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C12N15/1027 , C12N15/1034 , C12N2770/36143
摘要： A method for creating an alphavirus-based genomic library, comprising a) ligation of foreign sequence (s) from an expression library or a random library into plasmids containing cloned alphaviral cDNA, b) multiplication of the obtained plasmid constructs in bacterial cells, c) direct transfection of the obtained plasmid constructs into mammalian or arthropod cells, characterized in that the sequence of an intron or sequences of introns are inserted into the respective genome of an alphavirus or into the cDNA of an expression vector based on an alphavirus, - the sequence of a viral subgenomic promoter, which is larger than minimal functional promoter is inserted immediately to the 3' end of the sequences coding the structural proteins of the named alphavirus, - and ribozyme sequence is inserted for creating correct 3' ends of the alphavirus.
摘要翻译：一种用于产生基于甲病毒的基因组文库的方法，包括：a）将外来序列从表达文库或随机文库连接到含有克隆的甲病毒cDNA的质粒中，b）将获得的质粒构建体在细菌细胞中增殖，c）将获得的质粒构建体直接转染到哺乳动物或节肢动物细胞中，其特征在于将内含子或内含子序列的序列插入甲病毒的各自基因组或基于甲病毒的表达载体的cDNA中，将大于最小功能性启动子的病毒亚基因组启动子立即插入编码所述甲病毒属的结构蛋白的序列的3'末端，并插入核酶序列以产生甲病毒的正确3'端。

4. 发明申请

WO2011091804A1 AN APPARATUS FOR QUANTITATIVE CATARACT DIAGNOSTICS 审中-公开
标题翻译：定量诊断诊断的设备
公开(公告)号：WO2011091804A1
公开(公告)日：2011-08-04
申请号：PCT/EE2010/000003
申请日：2010-01-29
申请人： TARTU ÜLIKOOL (UNIVERSITY OF TARTU) , KIKAS, Jaak , ANIJALG, Agu , MAURING, Koit
发明人： KIKAS, Jaak , ANIJALG, Agu , MAURING, Koit
IPC分类号： A61B3/117
CPC分类号： A61B3/1176 , A61B3/10
摘要： A portative apparatus for quantitative cataract diagnostics has been disclosed. That apparatus comprises a modulated light source, a photodetector, an illumination optics, means for lock-in detection of the electrical current from the photodetector and a distance meter. The photodetector may be with or without a central hole; it can be designed from a bundle of optical fibres. The photodetector having a central hole is arranged so that the patient's eye lens is illuminated with the light beam through the hole of the photodetector and the back- scattered light is measured by the photodetector. If the photodetector has no hole, then the light beam is directed to the lens by a central mirror situated in front of the photodetector. The photodetector has area extending in all directions from the optical axis of the eye, resulting in high sensitivity and uniform (in all azimuthal directions) detection of back-scattered light.
摘要翻译：已经公开了用于定量白内障诊断的便携式装置。该装置包括调制光源，光电检测器，照明光学器件，用于锁定检测来自光电检测器的电流和距离计的装置。光电检测器可以具有或不具有中心孔; 它可以由一束光纤设计。具有中心孔的光电检测器被布置成使得患者的眼睛透镜被光束照射通过光电检测器的孔，并且后向散射光由光电检测器测量。如果光电检测器没有孔，则光束通过位于光电检测器前面的中央反射镜被引导到透镜。光检测器具有从眼睛的光轴向所有方向延伸的区域，导致反射散射光的高灵敏度和均匀（在所有方位角方向上）检测。

5. 发明申请

WO2010142301A1 METHOD FOR THE DETECTION OF MASTITIS AND MILK QUALITY, AND MASTITIS SENSOR 审中-公开
标题翻译：用于检测主体和奶酪质量的方法，以及MASTITIS传感器
公开(公告)号：WO2010142301A1
公开(公告)日：2010-12-16
申请号：PCT/EE2009/000009
申请日：2009-06-09
申请人： TARTU ÜLIKOOL (UNIVERSITY OF TARTU) , RINKEN, Toonika , JAANISOO, Raivo
发明人： RINKEN, Toonika , JAANISOO, Raivo
IPC分类号： G01N33/04 , A01J5/013
CPC分类号： G01N33/04 , A01J5/0131
摘要： The present invention discloses a mastitis sensor and a method for detection of mastitis and determination of milk quality in real time ( on-line ). The invention comprises a rapid non-invasive determination of the concentration of dissolved molecular oxygen in milked milk. Mastitis sensor comprises a fiberoptic, amperometric or potentiometric device for the determination of oxygen concentration, a device for data acquisition and processing, mastitis indicator and a device, generating a signal for the automatic on-line elimination of substandard milk of infected animals to prevent the pollution of bigger quantities of milk.
摘要翻译：本发明公开了一种实时（在线）乳腺炎传感器和乳腺炎检测方法及牛奶质量测定方法。本发明包括快速非侵入性测定挤奶中溶解分子氧的浓度。乳腺炎传感器包括用于确定氧浓度的光纤，电流或电位装置，用于数据采集和处理的装置，乳腺炎指示器和装置，产生用于自动在线消除感染动物的不合格牛奶的信号，以防止污染更多的牛奶。

6. 发明申请

WO2008080413A2 AN ANTISENSE OLIGONUCLEOTIDE, PHARMACEUTICAL COMPOSITION AND A METHOD FOR DOWNREGULATION OF PERIPHERAL NEURONAL NITRIC OXIDE SYNTHASE AND MU-OPIOID RECEPTORS AND USE OF AN ANTISENSE OLIGONUCLEOTIDE FOR DRUG PRODUCTION 审中-公开
标题翻译：反义寡核苷酸，药物组合物和下调外周神经元一氧化氮合酶和多阿片受体的方法以及使用反义寡核苷酸用于药物生产
公开(公告)号：WO2008080413A2
公开(公告)日：2008-07-10
申请号：PCT/EE2007/000026
申请日：2007-12-21
申请人： TARTU ÜLIKOOL (UNIVERSITY OF TARTU) , KOLESNIKOV, Yuri
发明人： KOLESNIKOV, Yuri
IPC分类号： C12N15/11 , A61K31/7105
CPC分类号： C12N15/1137 , C12N15/111 , C12N2310/11 , C12N2320/32
摘要： An antisense-oligonucleotides (AS-OND), that specifically and selectively downregulate peripheral neuronal nitric oxide synthase (nNOS) or peripheral mu-opioid receptors (MOR), and a pharmaceutical composition comprising antisense-oligonucleotides, and a method of downregulation nNOS and MOR are disclosed. Current invention allows for direct targeting of genes with antisense oligonucleotides - mRNA of peripheral neuronal nitric oxide synthase (nNOS), involved in causing inflammatory and neuropatic pain, and mRNA of peripheral mu-opioid receptors (MOR), involved in opioid analgesia. Antisense oligonucleotides can be used for the manufacture of a medicament for treating chronic neuropathic pain and for (topical) medicament for treating chronic skin diseases such as psoriasis.
摘要翻译：特异性和选择性下调外周神经元一氧化氮合酶（nNOS）或外周μ阿片受体（MOR）的反义寡核苷酸（AS-OND）和包含反义寡核苷酸的药物组合物，并公开了下调nNOS和MOR的方法。本发明允许用反义寡核苷酸（参与引起炎性和神经性疼痛的外周神经元一氧化氮合酶（nNOS）mRNA）和外周μ-阿片受体（MOR）的mRNA直接靶向基因，参与阿片类镇痛。反义寡核苷酸可用于制造治疗慢性神经性疼痛的药物和用于治疗慢性皮肤疾病如牛皮癣的（局部）药物。

7. 发明申请

WO2012159638A1 NON-CYTOTOXIC ALPHA VIRAL CONSTRUCT, CELL LINE AND COMPOSITION AND A METHOD FOR THE ASSESSMENT OF THE EFFECT OF ANTIVIRAL AGENTS. 审中-公开
标题翻译：非细胞毒素病毒构建体，细胞系和组成以及评估抗病毒药物作用的方法。
公开(公告)号：WO2012159638A1
公开(公告)日：2012-11-29
申请号：PCT/EE2012/000003
申请日：2012-05-23
申请人： TARTU ÜLIKOOL (UNIVERSITY OF TARTU) , LULLA, Aleksei , MERITS, Andres , UTT, Age , VARJAK, Margus
发明人： LULLA, Aleksei , UTT, Age , VARJAK, Margus
IPC分类号： G01N33/00 , C07K14/18
CPC分类号： C07K14/005 , C12N2770/36121 , C12N2770/36122 , C12N2770/36141
摘要： The invention relates to the field of molecular biology and comprises constructs based on non-cytotoxic alphaviral mutants capable to replicate in a stable manner ant to be maintained in mammalian cells as well as cell lines capable to replicate said constructs in a stable manner. The invention provides new constructs based on an alphavirus, in particular Chikungunya virus, which are feasible to apply in the creation of expression systems and research for and analysis of antiviral substances due to their non-cytotoxic nature. The invention enables the assessment of drug candidates for the screening of anti-alphaviral substances. Also, the invention can be applied for expressing recombinant proteins in genetic engineering systems.
摘要翻译：本发明涉及分子生物学领域，并且包含能够以稳定的方式复制的非细胞毒性甲基病毒突变体的构建体，以保持哺乳动物细胞以及能够以稳定的方式复制所述构建体的细胞系。本发明提供了基于甲病毒，特别是基孔肯雅病毒的新构建体，其可应用于创建表达系统以及由于其非细胞毒性而对抗病毒物质的研究和分析。本发明使得能够评估候选药物用于筛选抗角膜病毒物质。此外，本发明可用于在基因工程系统中表达重组蛋白。

8. 发明申请

WO2011144216A8 METHOD AND KIT FOR IDENTIFYING COMPOUNDS CAPABLE OF INHIBITING HUMAN PAPILLOMA VIRUS REPLICATION 审中-公开
公开(公告)号：WO2011144216A8
公开(公告)日：2011-11-24
申请号：PCT/EE2010/000010
申请日：2010-05-19
申请人： TARTU ÜLIKOOL (UNIVERSITY OF TARTU) , USTAV, Mart , USTAV, Ene , GEIMANEN, Jelizaveta , PIPITŠ, Regina , ISOK-PAAS, Helen , REINSON, Tormi , USTAV, Mart Jr. , LAOS, Triin , ORAV, Marit , SALK, Kristiina , MÄNNIK, Andres , REMM, Anu
发明人： USTAV, Mart , USTAV, Ene , GEIMANEN, Jelizaveta , PIPITŠ, Regina , ISOK-PAAS, Helen , REINSON, Tormi , USTAV, Mart Jr. , LAOS, Triin , ORAV, Marit , SALK, Kristiina , MÄNNIK, Andres , REMM, Anu
IPC分类号： C12Q1/68 , C12Q1/70
摘要： The invention provides a method and a kit for identifying compounds capable of inhibiting Human Papilloma Virus (HPV) replication. HPV genomic or subgenomic DNA is inserted into a cell line, wherein HPV DNA replication is supported, and further the influence of a compound on the replication of HPV DNA is determined. The U2OS cell line was identified as a feasible host cell line to support HPV DNA replication, and U2OS cells were identified as a suitable host for the propagation of genomes of mucosal and cutaneous tissue specific HPVs and for the HPV genome-related constructs. The method enables screening for factors inhibiting the replication of HPV DNA at different replication phases of HPV life cycle. The method can be used in pharmacological research and screening for new potential drug candidates for prevention or therapy of infections caused by various subtypes of HPV.

9. 发明申请

WO2008043368A2 METHOD FOR OBTAINING ENDOSPORES OF SPOROGENOUS FERMENTABLE THERMOPHILIC STRAINS OF MICROORGANISM AND USE OF THE OBTAINED ENDOSPORES TO INOCULATE FERMENTATION 审中-公开
标题翻译：获得嗜菌性可发酵热微生物菌株内生微生物的方法和使用获得的内生菌接种发酵
公开(公告)号：WO2008043368A2
公开(公告)日：2008-04-17
申请号：PCT/EE2007/000019
申请日：2007-10-05
申请人： TARTU ÜLIKOOL (UNIVERSITY OF TARTU) , JÖGI, Eerik , NURK, Allan , KASK, Karin , MICHELSON, Tiina , OTS, Mari-Liis
发明人： JÖGI, Eerik , NURK, Allan , KASK, Karin , MICHELSON, Tiina , OTS, Mari-Liis
IPC分类号： C12N3/00 , C12N1/00
CPC分类号： C12N3/00
摘要： The present invention relates to the method of producing endospores of thermophilic sporogenic microbial strains and the use thereof for inoculation of fermentation process. Unimmobilized endospores will be proposed for inoculation of fermentation whereas the obtained culture will be synchronized by activation of endospores before outgrowth. The strain, used in the examples of implementation for production of endospores, has been previously described and patented is Bacillus coagulans SIM7 DSM 14043.
摘要翻译：本发明涉及生产嗜热产孢微生物菌株的内生孢子的方法及其用于接种发酵过程的用途。未固定化的内生孢子将被提议用于接种发酵，而获得的培养物将在生长前通过内生孢子的活化同步化。用于生产内生孢子的实施例中使用的菌株之前已经描述并且获得专利是凝结芽孢杆菌SIM7 DSM 14043。

10. 发明申请

WO2011091805A1 ON-LINE SYSTEM, METHOD OF ITS CALIBRATION AND SIMULTANEOUS DETECTION OF ANTIBIOTIC RESIDUES AND THEIR CONCENTRATION IN MILK 审中-公开
标题翻译：在线系统，其校准方法及同时检测抗生素残留及其浓度
公开(公告)号：WO2011091805A1
公开(公告)日：2011-08-04
申请号：PCT/EE2010/000004
申请日：2010-01-29
申请人： TARTU ÜLIKOOL (UNIVERSITY OF TARTU) , RINKEN, Toonika , JAANISOO, Raivo
发明人： RINKEN, Toonika , JAANISOO, Raivo
IPC分类号： G01N33/04
CPC分类号： C12Q1/005 , G01N33/04
摘要： The present invention discloses an on-line system, a method for its calibration and simultaneous detection of antibiotic residues and their concentrations in milk. The system comprises a device for lactose hydrolysis to increase the concentrations of glucose and galactose in milk samples at least 10 times to obtain their equal concentrations in all investigated samples and a biosensor array to measure the transient phase decrease of dissolved oxygen concentration caused by the enzymatic oxidation of glucose and galactose. Parameters, characterising the oxidation of glucose and galactose, are calculated for each biosensor on the basis of the transient phase decrease of dissolved oxygen concentration and initial oxygen concentration in milk sample. The combination of different parameters of different biosensors forms a pattern of milk sample and in the presence of antibiotics this combination forms the fingerprints of particular antibiotics.
摘要翻译：本发明公开了一种在线系统，其校准和同时检测牛奶中抗生素残留及其浓度的方法。该系统包括用于乳糖水解的装置，以将乳样中的葡萄糖和半乳糖的浓度增加至少10倍，以便在所有研究的样品中获得相等的浓度，以及生物传感器阵列，以测量酶促引起的溶解氧浓度的瞬时相减少葡萄糖和半乳糖的氧化。基于牛奶样品中溶解氧浓度和初始氧浓度的瞬时相位降低，为每个生物传感器计算表征葡萄糖和半乳糖氧化的参数。不同生物传感器的不同参数的组合形成了牛奶样本的模式，并且在抗生素存在下，这种组合形成特定抗生素的指纹。

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