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    • 8. 发明申请
    • ANTIBACTERIAL OR BACTERICIDE COMPRISING 2-AMINOTHIAZOLE DERIVATIVE AND SALTS THEREOF
    • 含有2-氨基噻唑衍生物及其盐的抗菌素或杀菌剂
    • WO1996016650A1
    • 1996-06-06
    • PCT/JP1995002347
    • 1995-11-16
    • HISAMITSU PHARMACEUTICAL CO., INC.HASHIGUCHI, TerushiYOSHIDA, ToshioITOYAMA, ToshioTANIGUCHI, Yasuaki
    • HISAMITSU PHARMACEUTICAL CO., INC.
    • A61K31/425
    • C07D401/12C07D277/46C07D277/52C07D277/56C07D417/04C07D417/12
    • An antibacterial or bactericide comprising a 2-aminothiazole derivative represented by general formula (I) or a salt thereof, wherein R and R represent each hydrogen, halogeno, lower alkyl, lower cycloalkyl, (un)substituted phenyl, thiophene, benzoyl, benzoylmethyl, optionally substituted benzyl, p-pivoloyloxyphenyl, -COOR3 (wherein R3 represents hydrogen or lower alkyl) or -CH2COOR4 (wherein R4 represents hydrogen, lower alkyl or optionally substituted benzyl); and A and A represent each hydrogen, lower alkanesulfonyl, halogenated lower alkanesulfonyl, optionally substituted phenyl, substituted benzoyl, substituted benzyl, (un)substituted benzenesulfonyl, (un)substituted lower alkanoyl, amidino, -CO-R5 (wherein R5 represents lower alkyl, optionally substituted phenyl, -(CH2)m-COOH (wherein m represents an integer of 1 to 5), -(CH2)n-NH-R6 (wherein n represents an integer of 1 to 5, and R6 represents hydrogen, tert-butoxycarbonyl or benzyloxycarbonyl) or -(CH2)Q-R7 (wherein Q represents an integer of 0 to 5, and R7 represents lower alkoxy, optionally substituted phenyl, optionally substituted pyridyl or cyclic amino), or A and A are combined with each other to represent cyclic amino.
    • 一种抗菌剂或杀菌剂,其包含由通式(I)表示的2-氨基噻唑衍生物或其盐,其中R 1和R 2各自代表氢,卤代,低级烷基,低级环烷基,(取代的)取代的苯基, 噻吩,苯甲酰基,苯甲酰基甲基,任选取代的苄基,对甲氧基苯基,-COOR 3(其中R 3表示氢或低级烷基)或-CH 2 COOR 4(其中R 4表示氢,低级烷基或任选取代的苄基); 并且A 1和A 2分别表示氢,低级链烷磺酰基,卤代低级链烷磺酰基,任选取代的苯基,取代的苯甲酰基,取代的苄基,(取代的)取代的苯磺酰基,(取代的)取代的低级烷酰基,脒基,-CO-R 5 (其中R 5表示低级烷基,任选取代的苯基, - (CH 2)m -COOH(其中m表示1至5的整数), - (CH 2)n -NH-R 6(其中n表示1至5的整数, 或者R 1表示氢,叔丁氧基羰基或苄氧基羰基)或 - (CH 2)Q -R 7(其中Q表示0〜5的整数,并且R 7表示低级烷氧基,任意取代的苯基,任意取代的吡啶基或环状氨基)或A <1>和A <2>相互结合以表示环状氨基。