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1. 发明专利

DE3117560A1 未知
公开(公告)号：DE3117560A1
公开(公告)日：1982-06-24
申请号：DE3117560
申请日：1981-05-04
申请人： BRIDGESTONE TIRE CO LTD , HAYAKAWA RUBBER , FUJII YOSHIHIKO , SHINOGAYA TOSHIKAZU , KAWAGOE TAKAHIRO , TANAKA HIDEO , ISHIDO YOSHINOBU , KIMURA TAKESHI , IRAKO KOICHI
发明人： FUJII YOSHIHIKO , SHINOGAYA TOSHIKAZU , KAWAGOE TAKAHIRO , TANAKA HIDEO , ISHIDO YOSHINOBU , KIMURA TAKESHI , IRAKO KOICHI
IPC分类号： C08K3/34 , C09J123/16 , C09J123/22 , C09J123/28 , C09K3/10 , C08L21/00

2. 发明专利

DE3152459A1 未知
公开(公告)号：DE3152459A1
公开(公告)日：1982-12-02
申请号：DE3152459
申请日：1981-10-28
申请人： SUKA KAGAKU YAKUHIN KK , AKADA MITSUO , TORII SHIGERU , MASATOMI TSUNEHIKO , TANAKA HIDEO , SHIMIZU YASUO
发明人： AKADA MITSUO , TORII SHIGERU , MASATOMI TSUNEHIKO , TANAKA HIDEO , SHIMIZU YASUO
IPC分类号： C07C41/48 , C07C43/30 , C07C43/315 , C07C49/587 , C07C49/753 , C25B3/02

3. 发明申请

WO2011093524A9 DI - SUBSTITUTED PYRIDINE DERIVATIVES AS ANTICANCERS 审中-公开
标题翻译： DI - 取代的吡啶衍生物作为反应物
公开(公告)号：WO2011093524A9
公开(公告)日：2011-12-01
申请号：PCT/JP2011052302
申请日：2011-01-28
申请人： OTSUKA PHARMA CO LTD , TAKASU HIDEKI , FUJITA SHIGEKAZU , OHTSUKA SHINYA , HIROSE TOSHIYUKI , SATO YOSUKE , YAMADA SATOSHI , MIYAJIMA KEISUKE , SAKAI KOJI , KOJIMA YUTAKA , SEKIGUCHI KAZUO , YANAGIHARA YASUO , SUZUKI TAKASHI , TANAKA HIDEO , SUGIYAMA KAZUHISA , OKUNO MITSUHIRO , SUMIDA TAKUMI
发明人： TAKASU HIDEKI , FUJITA SHIGEKAZU , OHTSUKA SHINYA , HIROSE TOSHIYUKI , SATO YOSUKE , YAMADA SATOSHI , MIYAJIMA KEISUKE , SAKAI KOJI , KOJIMA YUTAKA , SEKIGUCHI KAZUO , YANAGIHARA YASUO , SUZUKI TAKASHI , TANAKA HIDEO , SUGIYAMA KAZUHISA , OKUNO MITSUHIRO , SUMIDA TAKUMI
IPC分类号： C07D213/69 , A61K31/44 , A61K31/443 , A61K31/4439 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61P35/00 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
CPC分类号： C07D213/69 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is -NH-G2-, -N(lower alkyl)-G2-, -NH-CH2-G2-, -N(lower alkyl)-CH2-G2- or -CH2-G2-, [wherein G2 binds to R2, G2-R2 is bond-R2, phenylene-G3-R2, phenylene-G4-O-R2, phenylene-G5-NH-R2, phenylene-G6-N(lower alkyl)-R2 or quinolinediyl-O-R2, the phenylene of said phenylene-cotnaining groups being optionally substituted with one or more substituents; G3-R2 is -O-lower alkylene-R2 or the like; G4-O- is lower alkylene-O- or the like; G5 is lower alkylene; G6 is lower alkylene].
摘要翻译：本发明提供具有优异抗肿瘤效果的新型化合物。本发明的化合物由以下通式（1）表示，其中R 1和R 2是芳基等; A是低级亚烷基; 环X是任选取代的亚芳基; E是键或低级亚烯基; 环Y是含有一个或多个氮原子的任选取代的杂环亚烷基，其中一个氮原子连接到相邻的羰基上; G是-NH-G2-，-N（低级烷基）-G2-，-NH-CH2-G2-，-N（低级烷基）-CH2-G2-或-CH2-G2-，其中G2与R2结合，G2-R2是键-R2，亚苯基-G3-R2，亚苯基-G4-O-R2，亚苯基-G5-NH-R2，亚苯基-G6-N（低级烷基）-R2或喹啉二基-O-R2，所述亚苯基连接基团的亚苯基任选被一个或多个取代基取代; G3-R2是-O-低级亚烷基-R2等; G4-O-是低级亚烷基-O-等; G5为低级亚烷基; G6为低级亚烷基]。

4. 发明申请

WO2011093524A1 DI - SUBSTITUTED PYRIDINE DERIVATIVES AS ANTICANCERS 审中-公开
标题翻译：二取代的吡啶衍生物作为抗癌剂
公开(公告)号：WO2011093524A1
公开(公告)日：2011-08-04
申请号：PCT/JP2011/052302
申请日：2011-01-28
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , TAKASU, Hideki , FUJITA, Shigekazu , OHTSUKA, Shinya , HIROSE, Toshiyuki , SATO, Yosuke , YAMADA, Satoshi , MIYAJIMA, Keisuke , SAKAI, Koji , KOJIMA, Yutaka , SEKIGUCHI, Kazuo , YANAGIHARA, Yasuo , SUZUKI, Takashi , TANAKA, Hideo , SUGIYAMA, Kazuhisa , OKUNO, Mitsuhiro , SUMIDA, Takumi
发明人： TAKASU, Hideki , FUJITA, Shigekazu , OHTSUKA, Shinya , HIROSE, Toshiyuki , SATO, Yosuke , YAMADA, Satoshi , MIYAJIMA, Keisuke , SAKAI, Koji , KOJIMA, Yutaka , SEKIGUCHI, Kazuo , YANAGIHARA, Yasuo , SUZUKI, Takashi , TANAKA, Hideo , SUGIYAMA, Kazuhisa , OKUNO, Mitsuhiro , SUMIDA, Takumi
IPC分类号： C07D213/69 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , A61K31/44 , A61K31/4439 , A61K31/4545 , A61K31/4725 , A61K31/443 , A61K31/496 , A61P35/00
CPC分类号： C07D213/69 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R 1 and R 2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is -NH-G 2 -, -N(lower alkyl)-G 2 -, -NH-CH 2 -G 2 -, -N(lower alkyl)-CH 2 -G 2 - or -CH 2 -G 2 -, [wherein G 2 binds to R 2 , G 2 -R 2 is bond-R 2 , phenylene-G 3 -R 2 , phenylene-G 4 -O-R 2 , phenylene-G 5 -NH-R 2 , phenylene-G 6 -N(lower alkyl)-R 2 or quinolinediyl-O-R 2 , the phenylene of said phenylene-cotnaining groups being optionally substituted with one or more substituents; G 3 -R 2 is -O-lower alkylene-R 2 or the like; G 4 -O- is lower alkylene-O- or the like; G 5 is lower alkylene; G 6 is lower alkylene].
摘要翻译：本发明提供了具有优异抗肿瘤效果的新型化合物。本发明的化合物由以下通式（1）表示：其中R1和R2是芳基等; A是低级亚烷基; 环X是任选取代的亚芳基; E是键或低级亚烯基; 环Y是含有一个或多个氮原子的任选取代的杂环亚烷基，其中一个与相邻的羰基连接; G是-NH-G 2 - ， - N（低级烷基）-G 2 - ， - NH-CH 2 -G

5. 发明申请

WO2004109381A1 METHOD FOR MANUFACTURING LIQUID CRYSTAL DISPLAY DEVICE 审中-公开
标题翻译：制造液晶显示装置的方法
公开(公告)号：WO2004109381A1
公开(公告)日：2004-12-16
申请号：PCT/IB2004/050834
申请日：2004-06-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , TANAKA, Hideo
发明人： TANAKA, Hideo
IPC分类号： G02F1/1368
CPC分类号： G02F1/133553 , G02F1/136227 , G02F1/1368 , G02F2001/136231 , G02F2001/136236 , G02F2001/13685
摘要： A semiconductor film is formed in a gap between a source electrode and a drain electrode of a thin film transistor in an active-matrix type liquid crystal display device. A metal film for a gate electrode is formed on said semiconductor film via a gate insulating film. A photo-resist film, having a thick portion in region including the gap and having an opening portion in contact-hole forming region, is formed on the metal film. A contact-hole is formed in the gate insulating film by using the organic material film as a mask. The organic material film is left on the region including the gap. A gate electrode is formed on the region including the gap by etching the first metal film by using the remained organic material film as a mask. An organic material film, having projections and depressions, is formed on a reflective region except the contact-hole forming region. A reflective electrode is formed on the organic material film having projections and depressions
摘要翻译：半导体膜形成在有源矩阵型液晶显示装置中的薄膜晶体管的源极和漏极之间的间隙中。通过栅极绝缘膜在所述半导体膜上形成用于栅电极的金属膜。在金属膜上形成具有包含该间隙的区域中具有厚度部分并且在接触孔形成区域中具有开口部分的光致抗蚀剂膜。通过使用有机材料膜作为掩模在栅极绝缘膜中形成接触孔。有机材料膜留在包括间隙的区域上。通过使用剩余的有机材料膜作为掩模，通过蚀刻第一金属膜，在包括间隙的区域上形成栅电极。在除了接触孔形成区域之外的反射区域上形成具有凹凸的有机材料膜。在具有凹凸的有机材料膜上形成反射电极

6. 发明申请

WO2010047603A1 A WATER PURIFYING AND ACTIVATING DEVICE 审中-公开
标题翻译：水净化和激活装置
公开(公告)号：WO2010047603A1
公开(公告)日：2010-04-29
申请号：PCT/PH2008/000010
申请日：2008-10-24
申请人： TANAKA, Hideo , COMMANDANTE, Bonifacio
发明人： TANAKA, Hideo , COMMANDANTE, Bonifacio
IPC分类号： C02F3/22
CPC分类号： C02F3/16 , B01F3/04531 , B01F7/163 , B01F13/0035 , Y02W10/15
摘要： A water purifying and activating apparatus comprising: a drive mechanism being supported above the surface of a stagnated water; and means to generate the surface flow of water radially from the center of rotation of said drive mechanism to induce the water flow from the bottom to the surface by generating surface flow with the use of minimal energy.
摘要翻译：一种净水和启动装置，包括：驱动机构，其被支撑在停滞水表面上; 以及用于从所述驱动机构的旋转中心径向产生水的表面流的装置，以通过使用最小的能量产生表面流而引起水从底部流到表面的装置。

7. 发明申请

WO2008044667A1 STAT3/5 ACTIVATION INHIBITOR 审中-公开
标题翻译： STAT3 / 5激活抑制剂
公开(公告)号：WO2008044667A1
公开(公告)日：2008-04-17
申请号：PCT/JP2007/069645
申请日：2007-10-02
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , SEKIGUCHI, Kazuo , SUZUKI, Takashi , OHBUCHI, Yutaka , OKUNO, Mitsuhiro , OHI, Naoto , OHNISHI, Kenji , MOTOYAMA, Masaaki , YOSHIDA, Kenji , KODAMA, Takeshi , SUGIYAMA, Kazuhisa , AKAMATSU, Seiji , KIYONO, Kunihiko , YANAGIHARA, Yasuo , WATANABE, Takashi , HAYASHI, Kazuhiko , TANAKA, Hideo , SUMIDA, Takumi
发明人： SEKIGUCHI, Kazuo , SUZUKI, Takashi , OHBUCHI, Yutaka , OKUNO, Mitsuhiro , OHI, Naoto , OHNISHI, Kenji , MOTOYAMA, Masaaki , YOSHIDA, Kenji , KODAMA, Takeshi , SUGIYAMA, Kazuhisa , AKAMATSU, Seiji , KIYONO, Kunihiko , YANAGIHARA, Yasuo , WATANABE, Takashi , HAYASHI, Kazuhiko , TANAKA, Hideo , SUMIDA, Takumi
IPC分类号： C07D317/58 , C07D405/12
CPC分类号： C07D401/12 , C07D213/38 , C07D401/04 , C07D405/12 , C07D405/14
摘要： An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein X1 represents a nitrogen atom or a group -CH=, R1 represents a group -Z-R 6 , in which Z represents a group -CO-, a group -CH(OH)- or the like, R 6 represents a 5-to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R 2 represents a hydrogen atom or a halogen atom, Y represents a group -O-, a group -CO-, a group -CH(OH)-or a lower alkylene group, and A represents a group wherein R 3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R 4 represents an imidazolyl lower alkyl group or the like.
摘要翻译：本发明的目的是提供一种STAT3 / 5激活抑制剂。本发明提供含有通式所示的芳香族化合物或其盐作为有效成分的STAT3 / 5活化抑制剂，其中，X1表示氮原子或-CH =，R1表示-ZR < 6，其中Z表示-CO-基团，基团-CH（OH） - 等，R 6表示5至15元单环，二环或三环具有1至4个氮原子，氧原子或硫原子的饱和或不饱和杂环基，R 2表示氢原子或卤素原子，Y表示基团-O-，基团-CO-，基团-CH（OH） - 或低级亚烷基，A表示R 3表示氢原子，低级烷氧基等，p表示1或2的基团， SUP> 4 代表咪唑基低级烷基等。

8. 发明申请

WO1996014734A1 ORGANISM WITH INHIBITED EXPRESSION OF S-ADENOSYLHOMOCYSTEINE HYDROLASE GENE 审中-公开
标题翻译：具有抑制性表达S-腺嘧啶羟基水解酶基因的有机体
公开(公告)号：WO1996014734A1
公开(公告)日：1996-05-23
申请号：PCT/JP1995002333
申请日：1995-11-15
申请人： JAPAN TOBACCO INC. , MASUTA, Chikara , UEHARA, Kyoko , TANAKA, Hideo , KUWATA, Shigeru
发明人： JAPAN TOBACCO INC.
IPC分类号： A01H05/00
CPC分类号： C12N15/8283 , C12N9/14 , C12N15/8243
摘要： A transgenic organism with a substantially inhibited expression of SAHH genes present in genomic genes and with excellent characteristics including the resistance to viruses.
摘要翻译：具有基本上抑制基因组基因中存在的SAHH基因表达并具有优异特征（包括对病毒的抗性）的转基因生物。

9. 发明申请

WO1993011769A1 CARCINOSTATIC 审中-公开
标题翻译：抗癌
公开(公告)号：WO1993011769A1
公开(公告)日：1993-06-24
申请号：PCT/JP1992001597
申请日：1992-12-07
申请人： OTSUKA PHARMACEUTICAL CO., LTD , NAKAI, Satoru , AIHARA, Koutoku , TANAKA, Hideo , MORI, Hitomi , KAWAI, Kazuyoshi , TOMINAGA, Michiaki , ADACHI, Masakazu
发明人： OTSUKA PHARMACEUTICAL CO., LTD
IPC分类号： A61K31/47
CPC分类号： A61K31/495 , A61K38/19 , A61K31/07 , A61K2300/00
摘要： A carcinostatic containing a carbostyril derivative, represented by general formula (1), and/or a pharmaceutically acceptable salt thereof and a cytokine and/or a retinoid as active ingredients, and a cancer therapy by administering the carcinostatic to patients. In the formula (1), R represents benzoyl optionally having 1 to 3 groups selected among lower alkoxy and lower alkyl groups on the benzene ring, and the carbon-to-carbon bond between the 3- and 4-positions of the carbostyril skeleton represents either a single or a double bond. The carcinostatic has an excellent carcinostatic effect based on the effects of inhibiting tumor growth and promoting cell differenciation.
摘要翻译：含有由通式（1）表示的喹诺酮衍生物和/或其药学上可接受的盐和细胞因子和/或类视黄醇作为活性成分的制癌剂，以及通过向患者施用制癌剂的癌症治疗。式（1）中，R表示苯环上具有1-3个选自苯环中的低级烷氧基和低级烷基的苯甲酰基，喹诺酮骨架的3-位和4-位之间的碳 - 碳键表示单键或双键。基于抑制肿瘤生长和促进细胞分化的作用，制癌具有优异的抗癌作用。

10. 发明申请

WO1992016532A1 HALOGENATED 'beta'-LACTAM COMPOUND AND PRODUCTION OF 3-HYDROXYCEPHEM DERIVATIVE THEREFROM 审中-公开
标题翻译：低分子化合物β-LACTAM化合物和3-羟基吡啶衍生物的生产
公开(公告)号：WO1992016532A1
公开(公告)日：1992-10-01
申请号：PCT/JP1992000126
申请日：1992-02-10
申请人： OTSUKA KAGAKU KABUSHIKI KAISHA , TORII, Shigeru , TANAKA, Hideo , TANIGUCHI, Masatoshi , SASAOKA, Mitio , SHIROI, Takashi , KAMEYAMA, Yutaka , KIKUCHI, Ryo
发明人： OTSUKA KAGAKU KABUSHIKI KAISHA
IPC分类号： C07D501/08
CPC分类号： C07D205/095 , C07D501/00 , Y02P20/55
摘要： A halogenated β-lactam compound represented by general formula (III), wherein Ar represents optionally substituted aryl; R1 represents optionally protected amino; R2 represents hydrogen or a carboxyl blocking group; R3 represents hydrogen or a hydroxyl blocking group; and X represents halogen. A process for producing a 3-hydroxycephem derivative is represented by general formula (I) in an industrially advantageous manner by reducing the compound (III) either with a metallic reducing agent or electrolytically. In formula (I), R?1, R2 and R3¿ are as defined above.

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