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1. 发明专利

SG11201705195WA METHOD AND KIT FOR PATHOLOGIC GRADING OF BREAST NEOPLASM 未知
公开(公告)号：SG11201705195WA
公开(公告)日：2017-07-28
申请号：SG11201705195W
申请日：2015-10-04
申请人： TEH BIN TEAN , TAN BOON OOI PATRICK , TAN PUAY HOON
发明人： TAN JING , TEH BIN TEAN , TAN BOON OOI PATRICK , ONG CHOON KIAT , LIM WENG KHONG , TAN PUAY HOON , NG CHUAN YOUNG CEDRIC
IPC分类号： C12Q1/68 , C12N15/09
摘要： The present disclosure is a method comprising the steps of performing one or more nucleic-acid based assays to identify mutations present in the breast tissue acquired from the subject corresponding to a first test module and a second test module associated with detection of at least one predetermined mutation of one or more genes, wherein each test module is configured to provide a positive outcome corresponding to at least one predetermined mutation detected in the tissue or a negative outcome corresponding to absence of detectable predetermined mutation in the sample; and identifying the type of neoplasm of the breast tissue based upon the provided outcome of the both test modules. Preferably, the first test module is associated with detection of mutation in MED12 gene and/or RARA gene, while the second test module is associated with detection of mutation in FLNA gene, SETD2 gene and/or MLL2 gene.

2. 发明申请

WO2016118078A1 METHOD AND KIT FOR PATHOLOGIC GRADING OF BREAST NEOPLASM 审中-公开
标题翻译：乳腺癌的病理学分级方法和工具包
公开(公告)号：WO2016118078A1
公开(公告)日：2016-07-28
申请号：PCT/SG2015/050368
申请日：2015-10-04
申请人： TEH, Bin Tean , TAN, Boon Ooi Patrick , TAN, Puay Hoon
发明人： TEH, Bin Tean , TAN, Boon Ooi Patrick , TAN, Puay Hoon , TAN, Jing , ONG, Choon Kiat , LIM, Weng Khong , NG, Chuan Young Cedric
IPC分类号： C12Q1/68 , C12N15/09
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/156
摘要： The present disclosure is a method comprising the steps of performing one or more nucleic-acid based assays to identify mutations present in the breast tissue acquired from the subject corresponding to a first test module and a second test module associated with detection of at least one predetermined mutation of one or more genes, wherein each test module is configured to provide a positive outcome corresponding to at least one predetermined mutation detected in the tissue or a negative outcome corresponding to absence of detectable predetermined mutation in the sample; and identifying the type of neoplasm of the breast tissue based upon the provided outcome of the both test modules. Preferably, the first test module is associated with detection of mutation in MED12 gene and/or RARA gene, while the second test module is associated with detection of mutation in FLNA gene, SETD2 gene and/or MLL2 gene.
摘要翻译：本公开是一种方法，其包括以下步骤：执行一个或多个基于核酸的测定，以鉴定从与第一测试模块相对应的从受试者获得的乳腺组织中存在的突变，以及与检测至少一个预定的一个或多个基因的突变，其中每个测试模块被配置为提供对应于组织中检测到的至少一个预定突变的阳性结果或对应于样品中不可检测到的预定突变的否定结果; 并且基于两个测试模块的提供的结果来识别乳腺组织的肿瘤的类型。优选地，第一测试模块与检测MED12基因和/或RARA基因中的突变相关，而第二测试模块与FLNA基因，SETD2基因和/或MLL2基因中的突变的检测相关。

4. 发明申请

WO2012167112A2 GASTRIC CANCER BIOMARKERS 审中-公开
标题翻译：胃癌生物标志物
公开(公告)号：WO2012167112A2
公开(公告)日：2012-12-06
申请号：PCT/US2012040501
申请日：2012-06-01
申请人： ILLUMINA INC , UNIV SINGAPORE , GROCOCK RUSSELL , SOONG RICHIE CHUAN TECK , BECQ JENNIFER , FAN JIAN-BING , MACARTHUR STEWART , CHEETHAM KEIRA , SILVENTOINEN VILLE , EVERS DIRK , WU MENGCHU , YEOH KHAY GUAN , SO BOK YAN JIMMY , TAN BOON OOI PATRICK
发明人： GROCOCK RUSSELL , SOONG RICHIE CHUAN TECK , BECQ JENNIFER , FAN JIAN-BING , MACARTHUR STEWART , CHEETHAM KEIRA , SILVENTOINEN VILLE , EVERS DIRK , WU MENGCHU , YEOH KHAY GUAN , SO BOK YAN JIMMY , TAN BOON OOI PATRICK
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/156 , G01N33/57446
摘要： The present disclosure provides biomarkers and methods of their use in determining the presence or absence of gastric cancer. In preferred embodiments, biomarkers identified comprise mutational hot spots which can be correlated with the presence of gastric cancer in a sample from an individual.
摘要翻译：本公开提供了其用于确定胃癌存在或不存在的生物标志物及其方法。在优选的实施方案中，鉴定的生物标志物包括可与来自个体的样品中胃癌存在相关的突变性热点。

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