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1. 发明授权

US08828322B2 Device and method for measuring prothrombin time and hematocrit by analyzing change in reactance in a sample 有权
标题翻译：通过分析样品中电抗的变化来测量凝血酶原时间和血细胞比容的装置和方法
公开(公告)号：US08828322B2
公开(公告)日：2014-09-09
申请号：US13156693
申请日：2011-06-09
申请人： Sz-Hau Chen , Yueh-Hui Lin , Ching-Yuan Chu , Chu-Ming Cheng , Guan-Ting Chen , Yi-Chen Lu , Thomas Y.S. Shen
发明人： Sz-Hau Chen , Yueh-Hui Lin , Ching-Yuan Chu , Chu-Ming Cheng , Guan-Ting Chen , Yi-Chen Lu , Thomas Y.S. Shen
IPC分类号： G01N15/06
CPC分类号： G01N33/4905 , G01N27/447 , G01N2800/224 , Y10T436/11
摘要： Devices and methods for measuring prothrombin time (PT) and hematocrit (HCT) by analyzing the change in reactance in a sample are presented. A diagnostic device for measuring HCT and PT of a fluid includes a relative electrode-type sensor device and a blood test card assembly including one or more pairs of electrodes, wherein alternating current (AC) provided by the sensor device is used to measure and calculate HCT and PT of blood test using the reactance analysis.
摘要翻译：提出了通过分析样品电抗变化来测量凝血酶原时间（PT）和血细胞比容（HCT）的装置和方法。用于测量流体的HCT和PT的诊断装置包括相对电极型传感器装置和包括一对或多对电极的血液测试卡组件，其中由传感器装置提供的交流电（AC）用于测量和计算 HCT和PT血液检测采用电抗分析。

2. 发明授权

US08236154B2 Composite modified electrode strip 有权
标题翻译：复合改性电极条
公开(公告)号：US08236154B2
公开(公告)日：2012-08-07
申请号：US12139883
申请日：2008-06-16
申请人： Sz-Hau Chen , Chih-Sheng Lin , Guan-Tin Chen , Yueh-Hui Lin , Thomas Y. S. Shen
发明人： Sz-Hau Chen , Chih-Sheng Lin , Guan-Tin Chen , Yueh-Hui Lin , Thomas Y. S. Shen
IPC分类号： G01N27/327
CPC分类号： B82Y15/00 , B82Y30/00 , G01N27/3272
摘要： The present invention provides a surface-modified electrode strip for measuring an electrochemical signal that is synergistically amplified by means of a nano-scaled gold particle layer and a lipid-soluble electron mediator layer. A biosensor comprising the electrode strip is also provided.
摘要翻译：本发明提供一种用于测量电化学信号的表面改性电极条，其通过纳米级金颗粒层和脂溶性电子介体层协同放大。还提供了包括电极条的生物传感器。

3. 发明申请

US20110303556A1 DEVICE AND METHOD FOR MEASURING PROTHROMBIN TIME AND HEMATOCRIT BY ANALYZING CHANGE IN REACTANCE IN A SAMPLE 有权
标题翻译：通过分析样品在样品中的变化来测量丙泊酚时间和HEMATOCRIT的装置和方法
公开(公告)号：US20110303556A1
公开(公告)日：2011-12-15
申请号：US13156693
申请日：2011-06-09
申请人： Sz-Hau Chen , Yueh-Hui Lin , Ching-Yuan Chu , Chu-Ming Cheng , Guan-Ting Chen , Yi-Chen Lu , Thomas Y.S, Shen
发明人： Sz-Hau Chen , Yueh-Hui Lin , Ching-Yuan Chu , Chu-Ming Cheng , Guan-Ting Chen , Yi-Chen Lu , Thomas Y.S, Shen
IPC分类号： G01N33/86 , G01N27/26
CPC分类号： G01N33/4905 , G01N27/447 , G01N2800/224 , Y10T436/11
摘要： Devices and methods for measuring prothrombin time (PT) and hematocrit (HCT) by analyzing the change in reactance in a sample are presented. A diagnostic device for measuring HCT and PT of a fluid includes a relative electrode-type sensor device and a blood test card assembly including one or more pairs of electrodes, wherein alternating current (AC) provided by the sensor device is used to measure and calculate HCT and PT of blood test using the reactance analysis.
摘要翻译：提出了通过分析样品电抗变化来测量凝血酶原时间（PT）和血细胞比容（HCT）的装置和方法。用于测量流体的HCT和PT的诊断装置包括相对电极型传感器装置和包括一对或多对电极的血液测试卡组件，其中由传感器装置提供的交流电（AC）用于测量和计算 HCT和PT血液检测采用电抗分析。

4. 发明申请

US20100089775A1 ELECTROCHEMICAL TEST STRIP, ELECTROCHEMICAL TEST SYSTEM, AND MEASUREMENT METHOD USING THE SAME 有权
标题翻译：电化学测试条，电化学测试系统及其测量方法
公开(公告)号：US20100089775A1
公开(公告)日：2010-04-15
申请号：US12641406
申请日：2009-12-18
申请人： Guan-Ting CHEN , Yueh-Hui Lin , Kai-Tsung Teng , Sz-Hau Chen , Thomas Y. S. Shen
发明人： Guan-Ting CHEN , Yueh-Hui Lin , Kai-Tsung Teng , Sz-Hau Chen , Thomas Y. S. Shen
IPC分类号： G01N27/26
CPC分类号： G01N27/3274
摘要： An electrochemical test strip, an electrochemical test system, and a measurement method using the same are provided. The electrochemical test strip includes an insulating substrate, an electrode system formed on the insulating substrate, and an insulating layer formed on the electrode system. The electrode system includes a set of measurement electrodes, a set of identifying electrodes, and a resistive path having a predetermined resistance value. The set of identifying electrodes is made of metal material, and the resistive path is made of non-metal material. The set of measurement electrodes includes a reference electrode and a working electrode insulated from each other, and the set of identifying electrodes includes a first identifying electrode and a second identifying electrode connected with each other through the resistive path. The insulating layer covers a part of the electrode system, wherein a part of the electrode system not covered by the insulating layer forms a reaction region with a supply port. When a sample is injected into the supply port of the reaction region, the injected sample reaches the set of measurement electrodes and the set of identifying electrodes in sequence.
摘要翻译：提供电化学测试条，电化学测试系统以及使用其的测量方法。电化学测试条包括绝缘基板，形成在绝缘基板上的电极系统和形成在电极系统上的绝缘层。电极系统包括一组测量电极，一组识别电极和具有预定电阻值的电阻路径。该组识别电极由金属材料制成，电阻路径由非金属材料制成。该组测量电极包括彼此绝缘的参考电极和工作电极，并且该组识别电极包括通过电阻路径彼此连接的第一识别电极和第二识别电极。绝缘层覆盖电极系统的一部分，其中未被绝缘层覆盖的电极系统的一部分与供给端口形成反应区域。当将样品注入反应区域的供给口时，注入的样品依次到达测量电极组和识别电极组。

5. 发明申请

US20090008247A1 Composite Modified Electrode Strip 有权
标题翻译：复合改性电极带
公开(公告)号：US20090008247A1
公开(公告)日：2009-01-08
申请号：US12139883
申请日：2008-06-16
申请人： Sz-Hau Chen , Chih-Sheng Lin , Guan-Tin Chen , Yueh-Hui Lin , Thomas Y.S. Shen
发明人： Sz-Hau Chen , Chih-Sheng Lin , Guan-Tin Chen , Yueh-Hui Lin , Thomas Y.S. Shen
IPC分类号： G01N27/26
CPC分类号： B82Y15/00 , B82Y30/00 , G01N27/3272
摘要： The present invention provides a surface-modified electrode strip for measuring an electrochemical signal that is synergistically amplified by means of a nano-scaled gold particle layer and a lipid-soluble electron mediator layer. A biosensor comprising the electrode strip is also provided.
摘要翻译：本发明提供一种用于测量电化学信号的表面改性电极条，其通过纳米级金颗粒层和脂溶性电子介体层协同放大。还提供了包括电极条的生物传感器。

6. 发明授权

US09000770B2 Electrochemical blood test strips and diagnosis systems using the same 有权
标题翻译：电化学血液测试条和诊断系统使用相同
公开(公告)号：US09000770B2
公开(公告)日：2015-04-07
申请号：US13530868
申请日：2012-06-22
申请人： Sz-Hau Chen , Yi-Chen Lu , Chun-Yi Yen
发明人： Sz-Hau Chen , Yi-Chen Lu , Chun-Yi Yen
IPC分类号： G01N27/02 , G01N33/86 , G01N27/28 , G01N27/327
CPC分类号： G01N27/3272
摘要： Electrochemical blood test strips and diagnosis systems are presented. An electrochemical blood test strip for measuring HCT% and prothrombin time includes an electrode plate having electrode circuit patterns on an insulator substrate; a separation plate disposed on the electrode plate defining a blood sample region, a channel and three reaction regions; and a cover plate disposed on the separation plate having a blood sample inlet and vents. In measuring, one of the three reaction regions is used for detecting hemoglobin and hematocrit and the other two reaction regions are biochemical reaction regions and used for detecting prothrombin time.
摘要翻译：介绍了电化学血液测试条和诊断系统。用于测量HCT％和凝血酶原时间的电化学血液测试条包括在绝缘体基底上具有电极电路图案的电极板; 设置在所述电极板上的限定血液样本区域，通道和三个反应区域的分离板; 以及设置在分离板上的盖板，其具有血液样本入口和排气口。在测量中，三个反应区域之一用于检测血红蛋白和血细胞比容，其他两个反应区域是生化反应区域，用于检测凝血酶原时间。

7. 发明授权

US08409424B2 Electrochemical test strip, electrochemical test system, and measurement method using the same 有权
标题翻译：电化学试片，电化学试验系统及使用其的测量方法
公开(公告)号：US08409424B2
公开(公告)日：2013-04-02
申请号：US12641406
申请日：2009-12-18
申请人： Guan-Ting Chen , Yueh-Hui Lin , Kai-Tsung Teng , Sz-Hau Chen , Thomas Y. S. Shen
发明人： Guan-Ting Chen , Yueh-Hui Lin , Kai-Tsung Teng , Sz-Hau Chen , Thomas Y. S. Shen
IPC分类号： G01N27/327
CPC分类号： G01N27/3274
摘要： An electrochemical test strip, an electrochemical test system, and a measurement method using the same are provided. The electrochemical test strip includes an insulating substrate, an electrode system formed on the insulating substrate, and an insulating layer formed on the electrode system. The electrode system includes a set of measurement electrodes, a set of identifying electrodes, and a resistive path having a predetermined resistance value. The set of identifying electrodes is made of metal material, and the resistive path is made of non-metal material. The set of measurement electrodes includes a reference electrode and a working electrode insulated from each other, and the set of identifying electrodes includes a first identifying electrode and a second identifying electrode connected with each other through the resistive path. The insulating layer covers a part of the electrode system, wherein a part of the electrode system not covered by the insulating layer forms a reaction region with a supply port. When a sample is injected into the supply port of the reaction region, the injected sample reaches the set of measurement electrodes and the set of identifying electrodes in sequence.
摘要翻译：提供电化学测试条，电化学测试系统以及使用其的测量方法。电化学测试条包括绝缘基板，形成在绝缘基板上的电极系统和形成在电极系统上的绝缘层。电极系统包括一组测量电极，一组识别电极和具有预定电阻值的电阻路径。该组识别电极由金属材料制成，电阻路径由非金属材料制成。该组测量电极包括彼此绝缘的参考电极和工作电极，并且该组识别电极包括通过电阻路径彼此连接的第一识别电极和第二识别电极。绝缘层覆盖电极系统的一部分，其中未被绝缘层覆盖的电极系统的一部分与供给端口形成反应区域。当将样品注入反应区域的供给口时，注入的样品依次到达测量电极组和识别电极组。

8. 发明申请

US20130118899A1 ELECTROCHEMICAL BLOOD TEST STRIPS AND DIAGNOSIS SYSTEMS USING THE SAME 有权
标题翻译：电化学血液测试条和诊断系统
公开(公告)号：US20130118899A1
公开(公告)日：2013-05-16
申请号：US13530868
申请日：2012-06-22
申请人： Sz-Hau CHEN , Yi-Chen LU , Chun-Yi YEN
发明人： Sz-Hau CHEN , Yi-Chen LU , Chun-Yi YEN
IPC分类号： G01N27/28
CPC分类号： G01N27/3272
摘要： Electrochemical blood test strips and diagnosis systems are presented. An electrochemical blood test strip for measuring HCT % and prothrombin time includes an electrode plate having electrode circuit patterns on an insulator substrate; a separation plate disposed on the electrode plate defining a blood sample region, a channel and three reaction regions; and a cover plate disposed on the separation plate having a blood sample inlet and vents. In measuring, one of the three reaction regions is used for detecting hemoglobin and hematocrit and the other two reaction regions are biochemical reaction regions and used for detecting prothrombin time.
摘要翻译：介绍了电化学血液测试条和诊断系统。用于测量HCT％和凝血酶原时间的电化学血液测试条包括在绝缘体基底上具有电极电路图案的电极板; 设置在所述电极板上的限定血液样本区域，通道和三个反应区域的分离板; 以及设置在分离板上的盖板，其具有血液样本入口和排气口。在测量中，三个反应区域之一用于检测血红蛋白和血细胞比容，其他两个反应区域是生化反应区域，用于检测凝血酶原时间。

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