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1. 发明授权

US06833237B1 Genes involved in stroke response and/or regulated by FK506, proteins encoded thereby, and methods of use 失效
标题翻译：涉及卒中反应和/或由FK506调节的基因，由此编码的蛋白质和使用方法
公开(公告)号：US06833237B1
公开(公告)日：2004-12-21
申请号：US10021338
申请日：2001-12-12
申请人： Elena Feinstein , Igor Mett , Sylvia G. Kachalsky , Svetlana Gorodin
发明人： Elena Feinstein , Igor Mett , Sylvia G. Kachalsky , Svetlana Gorodin
IPC分类号： C12Q100
CPC分类号： C07K14/705 , G01N2500/00
摘要： Genes and the proteins encoded thereby that are involved in stroke response and/or are regulated by FK506 are disclosed. These genes were discovered using in vivo or in vitro stroke models by determining which genes were differentially upregulated or downregulated upon treatment of the model with FK506. They were also found by a functional assay of genes specifically selected for conferring to cells resistance to hypoxia, dopamine or glutamate treatment. The disclosure includes such genes and proteins as well as analogs, salts and functional derivatives of such proteins, and DNA encoding such analogs, and methods of use. Methods for treating the effects of stroke, hypoxia and/or ischemia by regulating such genes or proteins are disclosed. Methods for screening for compounds capable of regulating the genes and proteins of the invention are also disclosed.
摘要翻译：公开了基因和由其编码的涉及中风反应和/或由FK506调节的蛋白质。使用体内或体外卒中模型，通过确定哪些基因在用FK506处理模型时差异上调或下调，发现这些基因。它们也通过功能性测定法发现，其特异性选择用于赋予细胞对缺氧，多巴胺或谷氨酸处理的抗性。本公开包括此类基因和蛋白质以及此类蛋白质的类似物，盐和功能性衍生物，以及编码此类类似物的DNA及其使用方法。公开了通过调节这些基因或蛋白质来治疗中风，缺氧和/或缺血的作用的方法。还公开了能够调节本发明的基因和蛋白质的化合物的筛选方法。

2. 发明授权

US07202211B2 Methods of preventing or treating brain ischemia or brain injury 有权
标题翻译：预防或治疗脑缺血或脑损伤的方法
公开(公告)号：US07202211B2
公开(公告)日：2007-04-10
申请号：US10371725
申请日：2003-02-20
申请人： Alexander Faerman , Sylvia G. Kachalsky , Gregory Hirsch Idelson
发明人： Alexander Faerman , Sylvia G. Kachalsky , Gregory Hirsch Idelson
IPC分类号： A61K38/00 , A61K49/00
CPC分类号： G01N33/5008 , A61K38/1703 , G01N33/502 , G01N33/5041 , G01N33/5058 , G01N33/5088 , G01N33/6896
摘要： The present invention relates to use of Narp inhibitor in order to promote or enhance recovery from ischemic events, particularly focal ischemia of the central nervous system, as well as for preventing or diminishing chronic degenerative changes.
摘要翻译：本发明涉及使用Narp抑制剂以促进或增强从缺血事件，特别是中枢神经系统的局部缺血以及预防或减少慢性退行性变化的恢复。

3. 发明申请

US20090029456A1 STR50 and uses thereof 审中-公开
标题翻译： STR50及其用途
公开(公告)号：US20090029456A1
公开(公告)日：2009-01-29
申请号：US12151774
申请日：2008-05-08
申请人： Sylvia G. Kachalsky , Alexander Faerman , Yehuda Per-Or
发明人： Sylvia G. Kachalsky , Alexander Faerman , Yehuda Per-Or
IPC分类号： C12N5/06 , C07H21/00 , C07K16/18 , C07K14/435 , C12N15/64
CPC分类号： C07K14/47 , C07H21/04
摘要： The present invention relates to use of a novel gene, STR50 and to STR50 modulators in diagnostic, therapeutic and screening aspects related to neurotoxic events. More particularly, the present invention concerns diagnosing and treating neurodegenerative diseases, and screening for species which can be useful in treating the same.
摘要翻译：本发明涉及新型基因STR50和STR50调节剂在与神经毒性事件有关的诊断，治疗和筛选方面的用途。更具体地，本发明涉及诊断和治疗神经变性疾病，以及筛选可用于治疗它们的物种。

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