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1. 发明申请

US20090036794A1 METHOD AND APPARATUS FOR DETERMINING LOCAL TISSUE IMPEDANCE FOR POSITIONING OF A NEEDLE 审中-公开
标题翻译：用于确定针状物定位的局部组织阻力的方法和装置
公开(公告)号：US20090036794A1
公开(公告)日：2009-02-05
申请号：US12159359
申请日：2006-12-28
申请人： Audun Stubhaug , Orjan Grottem Martinsen , Sverre Joran Grimnes
发明人： Audun Stubhaug , Orjan Grottem Martinsen , Sverre Joran Grimnes
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/416 , A61B5/4519
摘要： The invention relates to apparatus and methods for measuring local tissue impedance for subcutaneous tissue surrounding a needle tip inserted into a subject, impedance spectra and/or complex impedance values are determined. The invention applies a monopolar impedance measuring setup with a needle, a current-carrying electrode, an optional reference electrode. The setup is configured to eliminate contributions from the current-carrying electrode in order to measure local impedance of tissue in the close neighbourhood of the needle tip instead of an averaged value over the volume or current path between the needle and the electrode(s). The determined impedance can be correlated with either a tissue type or state, or with a position of the needle tip in the subject, and can thereby provide an insertion history to the operator in the form of impedance or corresponding tissue type as a function of insertion depth or time.
摘要翻译：本发明涉及用于测量局部组织阻抗的装置和方法，用于测量插入到受试者中的针尖周围的皮下组织，阻抗谱和/或复阻抗值。本发明应用具有针，载流电极，可选参考电极的单极阻抗测量装置。该设置被配置为消除载流电极的贡献，以便测量针尖附近的组织的局部阻抗，而不是在针和电极之间的体积或电流路径上的平均值。确定的阻抗可以与组织类型或状态相关联，或与针尖在受试者中的位置相关联，并且因此可以以阻抗或相应组织类型的形式向操作者提供作为插入的函数的插入历史深度或时间。

2. 发明申请

US20100179403A1 METHOD AND KIT FOR SWEAT ACTIVITY MEASUREMENT 有权
标题翻译： SWEAT活动测量方法和工具包
公开(公告)号：US20100179403A1
公开(公告)日：2010-07-15
申请号：US12666050
申请日：2008-07-01
申请人： Orjan Grottem Martinsen , Sverre Joran Grimnes , Erik Fosse
发明人： Orjan Grottem Martinsen , Sverre Joran Grimnes , Erik Fosse
IPC分类号： A61B5/05
CPC分类号： A61B5/0531 , A61B5/0002 , A61B5/0537 , A61B5/4035 , A61B5/4266 , A61B2562/0217
摘要： The invention relates to sweat activity measurement, e.g. for determining a physiological state of a subject, embodied by a method as well as a kit with an immittance measuring circuit and electrodes with contact electrolyte. Sweat activity is considered a transport phenomenon and can be defined as a flux, e.g. gram water per skin area per second. Prior art methods determining water absorbed per gram dry stratum corneum measures skin moisture and do not truly reflect sweat activity. A periodic signal with frequency of 60 Hz or lower is applied to reduce contribution from complex admittance of the skin, and skin conductance is measured as a degree of sweat activity. The contact electrolyte allows filling of sweat ducts with sweat from sweat glands, this may be characterized in that it does not substantially fill the sweat ducts when being positioned on the skin and/or in that it has a re-absorption time constant from the sweat ducts into the Epidermis of less than 15 min.
摘要翻译：本发明涉及汗液活性测量，例如，用于确定受试者的生理状态，通过方法体现，以及具有导纳测量电路和具有接触电解质的电极的试剂盒。汗液活性被认为是运输现象，可以定义为助焊剂，例如，克水每皮肤面积每秒。确定每克干性角质层吸收水的现有技术方法测量皮肤水分，并且不能真正反映汗液活性。应用频率为60Hz或更低的周期性信号以减少皮肤复杂导纳的贡献，并且测量皮肤电导度作为汗液活性的程度。接触电解质允许从汗腺填充汗管，这可能的特征在于，当其定位在皮肤上时并且/或其具有来自汗液的再吸收时间常数基本上不填充汗管导管进入表皮不到15分钟。

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