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1. 发明授权

US07651974B2 Adsorbent for oral administration 有权
标题翻译：用于口服的吸附剂
公开(公告)号：US07651974B2
公开(公告)日：2010-01-26
申请号：US10948314
申请日：2004-09-24
申请人： Naohiro Sonobe , Susumu Morimoto , Hideyuki Yoshihara , Hiroyuki Hanatsuka , Makoto Arakawa
发明人： Naohiro Sonobe , Susumu Morimoto , Hideyuki Yoshihara , Hiroyuki Hanatsuka , Makoto Arakawa
IPC分类号： C01B31/08 , A61K47/02
CPC分类号： A61K33/44
摘要： An adsorbent for oral administration, characterized by comprising a surface-modified spherical activated carbon, having a diameter of 0.01 to 1 mm, a specific surface area determined by Langmuir's adsorption equation of 1000 m2/g or more, a total amount of acidic groups of 0.40 to 1.00 meq/g, a total amount of basic groups of 0.40 to 1.10 meq/g, and a diffraction intensity ratio, an R value, determined by equation (1) of 1.4 or more. The adsorbents for oral administration exhibit a useful selective adsorbability; that is, a lesser adsorbability of useful substances, and a greater adsorbability of toxic substances, in a body.
摘要翻译：一种用于口服给药的吸附剂，其特征在于包括直径为0.01至1mm的表面改性的球形活性炭，朗格米尔的吸附方程式为1000m 2 / g以上的比表面积， 0.40〜1.00meq / g，碱性基团的总量为0.40〜1.10meq / g，衍射强度比，R值由式（1）确定为1.4以上。用于口服给药的吸附剂表现出有用的选择性吸附性; 即有毒物质的吸附性较小，有毒物质的吸附性较高。

2. 发明申请

US20050152890A1 Adsorbent for oral administration 有权
标题翻译：用于口服的吸附剂
公开(公告)号：US20050152890A1
公开(公告)日：2005-07-14
申请号：US10948314
申请日：2004-09-24
申请人： Naohiro Sonobe , Susumu Morimoto , Hideyuki Yoshihara , Hiroyuki Hanatsuka , Makoto Arakawa
发明人： Naohiro Sonobe , Susumu Morimoto , Hideyuki Yoshihara , Hiroyuki Hanatsuka , Makoto Arakawa
IPC分类号： A61K33/44 , C01B31/08
CPC分类号： A61K33/44
摘要： An adsorbent for oral administration, characterized by comprising a spherical activated carbon, wherein a diameter is 0.01 to 1 mm, a specific surface area determined by Langmuir's adsorption equation is 1000 m2/g or more, and a diffraction intensity ratio, an R value, determined by an equation (1): R=(I15−I35)/(I24−I35) (1) wherein I15 is a diffraction intensity when a diffraction angle (2θ) of an X-ray diffractometry is 15°, I35 is a diffraction intensity when a diffraction angle (2θ) of an X-ray diffractometry is 35°, and I24 is a diffraction intensity when a diffraction angle (2θ) of an X-ray diffractometry is 24°, is 1.4 or more; and an adsorbent for an oral administration, characterized by comprising a surface-modified spherical activated carbon, wherein a diameter is 0.01 to 1 mm, a specific surface area determined by Langmuir's adsorption equation is 1000 m2/g or more, a total amount of acidic groups is 0.40 to 1.00 meq/g, a total amount of basic groups is 0.40 to 1.10 meq/g, and a diffraction intensity ratio, an R value, determined by equation (1) is 1.4 or more. The adsorbents for oral administration exhibit a useful selective adsorbability, that is, a less adsorbability of useful substances in a body, and a greater adsorbability of toxic substances.
摘要翻译：一种用于口服给药的吸附剂，其特征在于包含直径为0.01至1mm的球形活性炭，由Langmuir吸附方程确定的比表面积为1000m 2 / g以上，衍射强度比，由等式（1）确定的R值：<？in-line-formula description =“In-line Formulas”end =“lead”？> R =（I < （1）＆lt;＆lt; 35＆gt; 35＆gt;）（1）<？in-line-formula description =“In-line Formulas “end =”tail“？>其中I <15>是当X射线衍射的衍射角（2θ）为15°时的衍射强度，I 35为 X射线衍射的衍射角（2θ）为35°时的衍射强度，X射线衍射的衍射角（2θ）为24°时的衍射强度，是1.4以上; 和口服给药用吸附剂，其特征在于，包含表面改性的球状活性炭，其直径为0.01〜1mm，由Langmuir吸附式测定的比表面积为1000m 2 / g 以上，酸性基团的总量为0.40〜1.00meq / g，碱性基团的总量为0.40〜1.10meq / g，由式（1）求出的衍射强度比R值为1.4或更多。用于口服给药的吸附剂表现出有用的选择性吸附性，即有用物质在体内的吸附性较差，并且有毒物质的吸附性更高。

3. 发明授权

US08309130B2 Adsorbent for oral administration 有权
标题翻译：用于口服的吸附剂
公开(公告)号：US08309130B2
公开(公告)日：2012-11-13
申请号：US12630581
申请日：2009-12-03
申请人： Naohiro Sonobe , Susumu Morimoto , Hideyuki Yoshihara , Hiroyuki Hanatsuka , Makoto Arakawa
发明人： Naohiro Sonobe , Susumu Morimoto , Hideyuki Yoshihara , Hiroyuki Hanatsuka , Makoto Arakawa
IPC分类号： A61K9/18 , A61K33/44 , A61P1/16 , A61P31/12
CPC分类号： A61K33/44
摘要： An adsorbent for oral administration, characterized by comprising a spherical activated carbon, wherein a diameter is 0.01 to 1 mm, a specific surface area determined by Langmuir's adsorption equation is 1000 m2/g or more, and a diffraction intensity ratio, an R value, determined by an equation (1): R=(I15−I35)/(I24−I35) (1) wherein I15 is a diffraction intensity when a diffraction angle (2θ) of an X-ray diffractometry is 15°, I35 is a diffraction intensity when a diffraction angle (2θ) of an X-ray diffractometry is 35°, and I24 is a diffraction intensity when a diffraction angle (2θ) of an X-ray diffractometry is 24°, is 1.4 or more; and an adsorbent for an oral administration, characterized by comprising a surface-modified spherical activated carbon, wherein a diameter is 0.01 to 1 mm, a specific surface area determined by Langmuir's adsorption equation is 1000 m2/g or more, a total amount of acidic groups is 0.40 to 1.00 meq/g, a total amount of basic groups is 0.40 to 1.10 meq/g, and a diffraction intensity ratio, an R value, determined by equation (1) is 1.4 or more. The adsorbents for oral administration exhibit a useful selective adsorbability, that is, a less adsorbability of useful substances in a body, and a greater adsorbability of toxic substances.
摘要翻译：一种用于口服给药的吸附剂，其特征在于包含球形活性炭，其直径为0.01至1mm，由Langmuir吸附方程确定的比表面积为1000m 2 / g以上，衍射强度比R值，由式（1）确定：R =（I15-I35）/（I24-I35）（1）其中I15是当X射线衍射的衍射角（2θ）为15°时的衍射强度，I35为 X射线衍射的衍射角（2θ）为35°时的衍射强度，I24为X射线衍射的衍射角（2θ）为24°时的衍射强度为1.4以上。和口服给药用吸附剂，其特征在于，包含直径为0.01〜1mm的表面改性球形活性炭，朗缪尔吸附方程式测定的比表面积为1000m 2 / g以上，酸性总量基团为0.40〜1.00meq / g，碱性基团的总量为0.40〜1.10meq / g，衍生强度比（R值）为1.4以上。用于口服给药的吸附剂表现出有用的选择性吸附性，即有用物质在体内的吸附性较差，并且有毒物质的吸附性更高。

4. 发明申请

US20050079167A1 Adsorbent for oral administration, and agent for treating or preventing renal or liver disease 审中-公开
标题翻译：用于口服的吸附剂和用于治疗或预防肾或肝脏疾病的药剂
公开(公告)号：US20050079167A1
公开(公告)日：2005-04-14
申请号：US10948334
申请日：2004-09-24
申请人： Naohiro Sonobe , Susumu Morimoto , Hideyuki Yoshihara , Hiroyuki Hanatsuka , Makoto Arakawa
发明人： Naohiro Sonobe , Susumu Morimoto , Hideyuki Yoshihara , Hiroyuki Hanatsuka , Makoto Arakawa
IPC分类号： A61K33/44 , A61P1/16 , A61P13/12 , A61P39/02
CPC分类号： A61K33/44
摘要： An adsorbent for oral administration, characterized by comprising a spherical activated carbon prepared from a thermosetting resin as a carbon source, wherein a diameter is 0.01 to 1 mm, and a specific surface area determined by Langmuir's adsorption equation is 1000 m2/g or more; and an adsorbent for oral administration, characterized by comprising a surface-modified spherical activated carbon prepared from a thermosetting resin as a carbon source, wherein a diameter is 0.01 to 1 mm, a specific surface area determined by Langmuir's adsorption equation is 1000 m2/g or more, a total amount of acidic groups is 0.40 to 1.00 meq/g, and a total amount of basic groups is 0.40 to 1.10 meq/g. The adsorbents for oral administration exhibit a useful selective adsorbability, that is, a less adsorbability of useful substances in a body, and a greater adsorbability of toxic substances.
摘要翻译：一种用于口服给药的吸附剂，其特征在于包含由作为碳源的热固性树脂制备的球形活性炭，其直径为0.01至1mm，并且由Langmuir吸附方程确定的比表面积为1000m 2 / g 或者更多; 和用于口服的吸附剂，其特征在于包含由作为碳源的热固性树脂制备的表面改性的球形活性炭，其直径为0.01至1mm，由Langmuir吸附方程确定的比表面积为1000m 2 > g以上，酸性基团的总量为0.40〜1.00meq / g，碱性基团的总量为0.40〜1.10meq / g。用于口服给药的吸附剂表现出有用的选择性吸附性，即有用物质在体内的吸附性较差，并且有毒物质的吸附性更高。

5. 发明授权

US06830753B2 Adsorbent for oral administration 有权
标题翻译：用于口服的吸附剂
公开(公告)号：US06830753B2
公开(公告)日：2004-12-14
申请号：US10267795
申请日：2002-10-10
申请人： Naohiro Sonobe , Michihito Ise , Susumu Morimoto , Hideyuki Yamato , Satoshi Mitsuhashi , Haruhisa Hayashi
发明人： Naohiro Sonobe , Michihito Ise , Susumu Morimoto , Hideyuki Yamato , Satoshi Mitsuhashi , Haruhisa Hayashi
IPC分类号： A61K900
CPC分类号： A61K33/44 , A61K9/143
摘要： An adsorbent for an oral administration, comprising a porous spherical carbonaceous substance wherein a diameter is 0.01 to 1 mm, a specific surface area determined by a BET method is 700 m2/g or more, a volume of pores having a pore diameter of 20 to 15000 nm is from not less than 0.04 mL/g to less than 0.10 mL/g, a total amount of acidic groups is 0.30 to 1.20 meq/g, and a total amount of basic groups is 0.20 to 1.00 meq/g, is disclosed.
摘要翻译：一种用于口服给药的吸附剂，其包含直径为0.01至1mm的多孔球形碳质物质，通过BET法测定的比表面积为700m 2 / g以上，具有孔径的孔的体积 20至15000nm的范围为不小于0.04mL / g至小于0.10mL / g，酸性基团的总量为0.30至1.20meq / g，碱性基团的总量为0.20至1.00meq / g ，被披露。

6. 发明申请

US20100074954A1 ADSORBENT FOR ORAL ADMINISTRATION 有权
标题翻译：对口腔管理的吸引力
公开(公告)号：US20100074954A1
公开(公告)日：2010-03-25
申请号：US12630581
申请日：2009-12-03
申请人： Naohiro Sonobe , Susumu Morimoto , Hideyuki Yoshihara , Hiroyuki Hanatsuka , Makoto Arakawa
发明人： Naohiro Sonobe , Susumu Morimoto , Hideyuki Yoshihara , Hiroyuki Hanatsuka , Makoto Arakawa
IPC分类号： A61K9/18 , A61K33/44 , A61P1/16 , A61P13/12
CPC分类号： A61K33/44
摘要： An adsorbent for oral administration, characterized by comprising a spherical activated carbon, wherein a diameter is 0.01 to 1 mm, a specific surface area determined by Langmuir's adsorption equation is 1000 m2/g or more, and a diffraction intensity ratio, an R value, determined by an equation (1): R=(I15−I35)/(I24−I35) (1) wherein I15 is a diffraction intensity when a diffraction angle (2θ) of an X-ray diffractometry is 15°, I35 is a diffraction intensity when a diffraction angle (2θ) of an X-ray diffractometry is 35°, and I24 is a diffraction intensity when a diffraction angle (2θ) of an X-ray diffractometry is 24°, is 1.4 or more; and an adsorbent for an oral administration, characterized by comprising a surface-modified spherical activated carbon, wherein a diameter is 0.01 to 1 mm, a specific surface area determined by Langmuir's adsorption equation is 1000 m2/g or more, a total amount of acidic groups is 0.40 to 1.00 meq/g, a total amount of basic groups is 0.40 to 1.10 meq/g, and a diffraction intensity ratio, an R value, determined by equation (1) is 1.4 or more. The adsorbents for oral administration exhibit a useful selective adsorbability, that is, a less adsorbability of useful substances in a body, and a greater adsorbability of toxic substances.
摘要翻译：一种用于口服给药的吸附剂，其特征在于包含球形活性炭，其直径为0.01至1mm，由Langmuir吸附方程确定的比表面积为1000m 2 / g以上，衍射强度比R值，由式（1）确定：R =（I15-I35）/（I24-I35）（1）其中I15是当X射线衍射的衍射角（2θ）为15°时的衍射强度，I35为 X射线衍射的衍射角（2θ）为35°时的衍射强度，I24为X射线衍射的衍射角（2θ）为24°时的衍射强度为1.4以上。和口服给药用吸附剂，其特征在于，包含直径为0.01〜1mm的表面改性球形活性炭，朗缪尔吸附方程式测定的比表面积为1000m 2 / g以上，酸性总量基团的总量为0.40〜1.00meq / g，碱性基团的总量为0.40〜1.10meq / g，衍生强度比，R值由式（1）确定为1.4以上。用于口服给药的吸附剂表现出有用的选择性吸附性，即有用物质在体内的吸附性较差，并且有毒物质的吸附性更高。

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