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1. 发明申请

US20050043549A1 Novel diterpene compounds 失效
标题翻译：新型二萜化合物
公开(公告)号：US20050043549A1
公开(公告)日：2005-02-24
申请号：US10767436
申请日：2004-01-30
申请人： Susumu Kitanaka , Syohei Miyata , Liyan Wang , Naili Wang , Xinsheng Yao
发明人： Susumu Kitanaka , Syohei Miyata , Liyan Wang , Naili Wang , Xinsheng Yao
IPC分类号： C07D493/08 , A61K31/34 , A61P35/00 , C07D493/04
CPC分类号： C07D493/08
摘要： The present invention provides a novel diterpene compounds with antineoplastic activities. The novel diterpene compounds of the present invention are represented by the general formula (I). R1 to R6 in the formula represent an aliphatic group, or a radical represented by the general formula RCO—, wherein R represents an aliphatic, an aromatic or a heteroaromatic group. The compounds of the present invention may be prepared by extracting roots of Euphorbia kansui L. with an organic solvent such as chloroform, ethyl acetate and butanol. These extracted compounds may be used as starting materials for the preparation of the compounds represented by the general formula (I). The compounds of the present invention have antineoplastic activities, and therefore, useful as antineoplastic agents.
摘要翻译：本发明提供具有抗肿瘤活性的新型二萜化合物。本发明的新颖的二萜化合物由通式（I）表示。式中的R 1至R 6表示脂族基，或由通式RCO-表示的基团，其中R表示脂族，芳族或杂芳族基团。本发明的化合物可以通过用有机溶剂如氯仿，乙酸乙酯和丁醇萃取大戟属的根而制备。这些提取的化合物可以用作制备由通式（I）表示的化合物的起始原料。本发明的化合物具有抗肿瘤活性，因此可用作抗肿瘤剂。

2. 发明授权

US07009061B2 Diterpene compounds 失效
标题翻译：双萜化合物
公开(公告)号：US07009061B2
公开(公告)日：2006-03-07
申请号：US10767436
申请日：2004-01-30
申请人： Susumu Kitanaka , Syohei Miyata , Liyan Wang , Naili Wang , Xinsheng Yao
发明人： Susumu Kitanaka , Syohei Miyata , Liyan Wang , Naili Wang , Xinsheng Yao
IPC分类号： C07D313/00
CPC分类号： C07D493/08
摘要： The present invention provides a novel diterpene compounds with antineoplastic activities.The novel diterpene compounds of the present invention are represented by the general formula (I). R1 to R6 in the formula represent an aliphatic group, or a radical represented by the general formula RCO—, wherein R represents an aliphatic, an aromatic or a heteroaromatic group. The compounds of the present invention may be prepared by extracting roots of Euphorbia kansui L. with an organic solvent such as chloroform, ethyl acetate and butanol. These extracted compounds may be used as starting materials for the preparation of the compounds represented by the general formula (I). The compounds of the present invention have antineoplastic activities, and therefore, useful as antineoplastic agents.
摘要翻译：本发明提供具有抗肿瘤活性的新型二萜化合物。本发明的新颖的二萜化合物由通式（I）表示。式中的R 1至R 6表示脂族基，或由通式RCO-表示的基团，其中R表示脂族，芳族或杂芳族基团。本发明的化合物可以通过用有机溶剂如氯仿，乙酸乙酯和丁醇萃取大戟属的根而制备。这些提取的化合物可以用作制备由通式（I）表示的化合物的起始原料。本发明的化合物具有抗肿瘤活性，因此可用作抗肿瘤剂。

3. 发明授权

US5942231A Method of treatment of atopic dermatitis with dried guava leaves 失效
标题翻译：用番石榴叶干燥处理特应性皮炎的方法
公开(公告)号：US5942231A
公开(公告)日：1999-08-24
申请号：US664920
申请日：1996-06-18
申请人： Sadao Hamada , Susumu Kitanaka
发明人： Sadao Hamada , Susumu Kitanaka
IPC分类号： A61K9/06 , A61K8/00 , A61K8/97 , A61K36/00 , A61K36/18 , A61K36/61 , A61P17/00 , A61P37/08 , A61P43/00 , A61Q19/10 , A01N65/00
CPC分类号： A61K36/61 , Y10S514/826 , Y10S514/861 , Y10S514/863 , Y10S514/864 , Y10S514/885
摘要： A method of treating a patient suffering from allergic diseases, comprises administering to said patient an effective amount of a pharmaceutical composition in dosage unit form comprising a dry powder of guava leaves.
摘要翻译：治疗患有过敏性疾病的患者的方法包括向所述患者施用有效量的包含番石榴叶干粉的剂量单位形式的药物组合物。

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