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1. 发明申请

US20050175694A1 Long acting compositions comprising zidovudine and lamivudine 审中-公开
标题翻译：包含齐多夫定和拉米夫定的长效组合物
公开(公告)号：US20050175694A1
公开(公告)日：2005-08-11
申请号：US10512464
申请日：2002-04-23
申请人： Himadri Sen , Surva Jayanthi
发明人： Himadri Sen , Surva Jayanthi
IPC分类号： A61K9/20 , A61K9/22 , A61K31/7068 , A61K31/7072 , A61P31/18
CPC分类号： A61K9/205 , A61K9/2054 , A61K9/2059 , A61K31/7068 , A61K31/7072 , A61K2300/00
摘要： A pharmaceutical composition in the form of a tablet for controlled release of active ingredient(s) comprises lamivudione, zidovudine or combination of lamivudine and zidovudine or their pharmaceutically acceptable derivatives, and a mixture of hydrophilic polymers selected from the group consisting of at least one hydroxypropyl methylcellulose, at least one sodium alginate and at least one guar gum as controlled release matrix and a pharmaceutically acceptable calcium salt as a matrix stabilizer. The composition may also contain one or more of a water soluble and/or water dispersible diluent, wherein the quantities of the hydrophilic polymers, the calcium salt and water soluble and/or water dispersible diluents are such that the therapeutically effective active ingredient(s) is released at a rate suitable for once daily administration of the pharmaceutical composition. The tablets may be coated with a water soluble polymeric film coat.
摘要翻译：用于控制释放活性成分的片剂形式的药物组合物包括拉米夫定，齐多夫定或拉米夫定和齐多夫定或其药学上可接受的衍生物的组合，以及选自至少一种羟丙基甲基纤维素，至少一种藻酸钠和至少一种瓜尔胶作为控释基质和药学上可接受的钙盐作为基质稳定剂。组合物还可以含有一种或多种水溶性和/或水分散性稀释剂，其中亲水性聚合物，钙盐和水溶性和/或水分散性稀释剂的量使得治疗有效的活性成分以适合于每日一次给予药物组合物的速率释放。片剂可以用水溶性聚合物膜包衣包衣。

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