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1. 发明授权

US08420120B2 Oral drug delivery system 有权
公开(公告)号：US08420120B2
公开(公告)日：2013-04-16
申请号：US13366168
申请日：2012-02-03
申请人： Su Il Yum , Grant Schoenhard , Arthur J. Tipton , John W. Gibson , John C. Middleton
发明人： Su Il Yum , Grant Schoenhard , Arthur J. Tipton , John W. Gibson , John C. Middleton
IPC分类号： A61K9/64 , A61K31/44 , A61K47/00
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/4458 , A61K47/14 , A61K47/26 , A61K47/38 , Y10S514/96
摘要： Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.

2. 发明授权

US08354124B2 Oral drug delivery system 有权
公开(公告)号：US08354124B2
公开(公告)日：2013-01-15
申请号：US13366164
申请日：2012-02-03
申请人： Su Il Yum , Grant Schoenhard , Arthur J. Tipton , John W. Gibson , John C. Middleton
发明人： Su Il Yum , Grant Schoenhard , Arthur J. Tipton , John W. Gibson , John C. Middleton
IPC分类号： A61K9/64 , A61K31/44 , A61K47/00
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/4458 , A61K47/14 , A61K47/26 , A61K47/38 , Y10S514/96
摘要： Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.

3. 发明授权

US08133507B2 Oral drug delivery system 有权
公开(公告)号：US08133507B2
公开(公告)日：2012-03-13
申请号：US10737144
申请日：2003-12-15
申请人： Su Il Yum , Grant Schoenhard , Arthur J. Tipton , John W. Gibson , John C. Middleton
发明人： Su Il Yum , Grant Schoenhard , Arthur J. Tipton , John W. Gibson , John C. Middleton
IPC分类号： A61K9/64 , A61K31/44 , A61K47/00
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/4458 , A61K47/14 , A61K47/26 , A61K47/38 , Y10S514/96
摘要： Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.

4. 发明授权

US07438701B2 Local concentration management system 失效
标题翻译：本地集中管理制度
公开(公告)号：US07438701B2
公开(公告)日：2008-10-21
申请号：US09917181
申请日：2001-07-26
申请人： Felix Theeuwes , Su Il Yum
发明人： Felix Theeuwes , Su Il Yum
IPC分类号： A61M29/00
CPC分类号： A61M25/00 , A61M25/0043 , A61M2025/0057 , A61M2025/105 , A61M2025/1086
摘要： The invention provides a local concentration management system (LCMS) for delivery of highly concentrated therapeutic agent formulations. The LCMS comprises a device comprising an elongate body defining a lumen between its proximal and distal ends, and a diffuser element, a dilutor element, or both. The diffuser element, which is selectively permeable to the agent, is operatively associated with the elongate body so that agent flows through the elongate body, and into and through the diffuser element to exit the system. The dilutor element can be operatively associated with the system to be in fluid communication with the elongate body lumen, a diffusion space defined by a diffuser element inner wall, or both. The dilutor element is selectively water permeable, but substantially impermeable to agent, to provide for dilution of the agent during transit through the system. The LCMS system is designed to disperse and/or dilute the drug delivery stream.
摘要翻译：本发明提供了用于递送高度浓缩的治疗剂制剂的局部浓度管理系统（LCMS）。 LCMS包括装置，其包括在其近端和远端之间限定内腔的细长主体，以及扩散器元件，稀释元件或两者。对试剂选择性渗透的扩散器元件可与细长体可操作地连接，使得试剂流过细长体并进入并通过扩散器元件以离开系统。稀释元件可以与系统可操作地相关联以与细长体腔流体连通，由扩散器元件内壁或两者限定的扩散空间。稀释剂元件选择性地是水可渗透的，但是对试剂基本上是不可渗透的，以便在通过系统运输期间提供试剂的稀释。 LCMS系统被设计成分散和/或稀释药物输送流。

5. 发明申请

US20080206321A1 Oral drug delivery system 有权
标题翻译：口服药物输送系统
公开(公告)号：US20080206321A1
公开(公告)日：2008-08-28
申请号：US11888652
申请日：2007-07-31
申请人： Su Il Yum , Grant Schoenhard , Arthur J. Tipton , John W. Gibson , John C. Middleton
发明人： Su Il Yum , Grant Schoenhard , Arthur J. Tipton , John W. Gibson , John C. Middleton
IPC分类号： A61K31/4748 , A61K9/48
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/4458 , A61K47/14 , A61K47/26 , A61K47/38 , Y10S514/96
摘要： Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
摘要翻译：适用于药物化合物和组合物施用的剂型和药物递送装置，包括化合物的口服药物施用。

6. 发明授权

US06960353B2 Formulations for the transdermal administration of fenoldopam 有权
标题翻译：芬太尔康透皮给药制剂
公开(公告)号：US06960353B2
公开(公告)日：2005-11-01
申请号：US10675715
申请日：2003-09-29
申请人： William W. van Osdol , Nieves M. Crisologo , Su Il Yum
发明人： William W. van Osdol , Nieves M. Crisologo , Su Il Yum
IPC分类号： A61K9/70 , A61K31/55 , A61K47/12 , A61K47/14 , A61K47/18
CPC分类号： A61K9/7084 , A61K9/0014 , A61K31/55 , A61K47/12 , A61K47/14 , A61K47/18
摘要： Composition of matter for application to skin to administer fenoldopam by permeation through the skin, the composition comprising fenoldopam to be administered, at a therapeutically effective rate, in combination with a permeation enhancer or mixture. Also disclosed are drug delivery devices and methods for the transdermal administration of fenoldopam for the treatment of hypertension, congestive heart failure, and chronic and acute renal failure.
摘要翻译：通过渗透通过皮肤施用于非诺多泮的物质的组合物，所述组合物包含要施用的非诺多泮，以治疗有效率与渗透增强剂或混合物组合。还公开了药物递送装置和用于透皮给药芬太尔康用于治疗高血压，充血性心力衰竭和慢性和急性肾衰竭的方法。

7. 发明授权

US5686097A Monoglyceride/lactate ester permeation enhancer for codelivery of steroids 失效
标题翻译：单体甘油酯/乳酸酯渗透促进剂用于交付类固醇
公开(公告)号：US5686097A
公开(公告)日：1997-11-11
申请号：US401593
申请日：1995-03-09
申请人： Lina Tormen Taskovich , Su Il Yum , Nieves Marzan Crisologo
发明人： Lina Tormen Taskovich , Su Il Yum , Nieves Marzan Crisologo
IPC分类号： A61K9/00 , A61K9/70 , A61K31/215 , A61K31/216 , A61K31/57 , A61K47/14 , A61K47/32 , A61P13/02 , A61P15/00 , A61P17/00 , A61P21/00 , A61F13/02
CPC分类号： A61K9/7053 , A61K31/215 , A61K31/216 , A61K31/57 , A61K47/14 , A61K9/0014 , A61K9/7084 , Y10S514/946 , Y10S514/947
摘要： A composition of matter for application to a body surface or membrane to coadminister an estrogen and progesterone by permeation through the body surface or membrane, the composition comprising, in combination, the estrogen and progesterone to be administered, in a therapeutically effective amount; and a permeation-enhancing mixture comprising a monoglyceride or a mixture of monoglycerides, and a lactate ester or a mixture of lactate esters at specific concentrations. The composition of matter is used to provide hormone replacement therapy to a woman.
摘要翻译：一种用于施用于身体表面或膜的物质组合物，其通过渗透身体表面或膜来共同施用雌激素和孕酮，所述组合物以治疗有效量组合包含待施用的雌激素和孕酮; 以及包含单酸甘油酯或单酸甘油酯和乳酸酯或特定浓度的乳酸酯混合物的混合物的渗透增强混合物。物质的组成用于为女性提供激素替代疗法。

8. 发明授权

US5641504A Skin permeation enhancer compositions using glycerol monolinoleate 失效
标题翻译：使用甘油单烯酸酯的皮肤渗透促进剂组合物
公开(公告)号：US5641504A
公开(公告)日：1997-06-24
申请号：US162026
申请日：1993-10-21
申请人： Eun Soo Lee , Diane E. Nedberge , Su Il Yum
发明人： Eun Soo Lee , Diane E. Nedberge , Su Il Yum
IPC分类号： A61K9/00 , A61K9/127 , A61K9/70 , A61K47/10 , A61K47/14 , A61L15/16
CPC分类号： A61K9/7053 , A61K47/10 , A61K47/14 , A61K9/0014 , A61K9/1274 , A61K9/7084 , Y10S514/946 , Y10S514/947
摘要： The present invention provides compositions and systems for the transdermal administration of a drug together with glycerol monolinoleate as a permeation enhancer. An example of a delivery system of the invention is a system (20) having a drug reservoir (22) containing together a drug to be delivered and glycerol monolinoleate permeation enhancer. Reservoir is sandwiched between a backing layer (24) and an in-line contact adhesive layer (28).
摘要翻译： PCT No.PCT / US92 / 04255 Sec。 371日期：1993年10月21日 102（e）日期1993年10月21日PCT提交1992年5月20日PCT公布。出版物WO92 / 20377 日期：1992年11月26日本发明提供了用于透明给药药物与甘油单烯酸酯作为渗透促进剂的组合物和系统。本发明的递送系统的实例是具有药物储存器（22）的系统（20），所述药物储存器（22）将待递送的药物和甘油单烯酸酯渗透增强剂包含在一起。储存器夹在背衬层（24）和直列式接触粘合剂层（28）之间。

9. 发明授权

US5284660A Delayed onset transdermal delivery device 失效
标题翻译：延迟发作透皮递送装置
公开(公告)号：US5284660A
公开(公告)日：1994-02-08
申请号：US933423
申请日：1992-08-21
申请人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
发明人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
IPC分类号： A61K9/00 , A61K9/22 , A61K9/70 , A61F13/00
CPC分类号： A61K9/7084 , A61K9/7069 , A61K9/7092
摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir, which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in predetermined temporal patterns at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.
摘要翻译：描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。合适的方法包括设置在释放表面和药剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初不能渗透到试剂中，然后变得可渗透。可以提供由一种或多种这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

10. 发明申请

US20120225033A1 Biodegradable Drug Delivery Composition 审中-公开
标题翻译：可生物降解的药物输送组合物
公开(公告)号：US20120225033A1
公开(公告)日：2012-09-06
申请号：US13304174
申请日：2011-11-23
申请人： William W. van Osdol , Su il Yum , Felix Theeuwes , Michael Sekar , John Gibson , Keith Branham , Huey-Ching Su
发明人： William W. van Osdol , Su il Yum , Felix Theeuwes , Michael Sekar , John Gibson , Keith Branham , Huey-Ching Su
IPC分类号： A61K38/27 , A61K38/16 , A61K38/26 , A61K38/21 , A61K31/7105
CPC分类号： A61K38/212 , A61K9/0019 , A61K31/7052 , A61K38/26 , A61K38/27 , A61K47/14 , A61K47/26 , A61K47/34 , A61K47/52 , A61K47/541 , A61K47/64
摘要： The present disclosure provides a biodegradable drug delivery composition including a vehicle and an insoluble component comprising beneficial agent dispersed in the vehicle. Typically, the composition is not an emulsion, but has a low viscosity and further provides for minimized initial burst and sustained release of the beneficial agent over time. Also provided, are kits including the biodegradable drug delivery composition or components thereof, as well as methods of making and using the biodegradable drug delivery composition.
摘要翻译：本公开提供了包含载体和包含分散在载体中的有益剂的不溶性组分的生物可降解药物递送组合物。通常，组合物不是乳液，而是具有低粘度，并进一步提供有益剂随时间的最小化的初始爆发和持续释放。还提供了包括可生物降解的药物递送组合物或其组分的试剂盒，以及制备和使用可生物降解的药物递送组合物的方法。

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