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1. 发明申请

WO2013039854A1 COMPOSITIONS AND METHODS FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：WO2013039854A1
公开(公告)日：2013-03-21
申请号：PCT/US2012/054554
申请日：2012-09-11
申请人： MERCK SHARP & DOHME CORP. , SHUMWAY, Stuart Denham , TONIATTI, Carlo , ROBERTS, Brian Scott , MARTIN, Melissa M.
发明人： SHUMWAY, Stuart Denham , TONIATTI, Carlo , ROBERTS, Brian Scott , MARTIN, Melissa M.
IPC分类号： A01N43/54
CPC分类号： A61K31/519 , A61K31/506 , A61K45/06 , A61K2300/00
摘要： The instant invention provides a method of treating a cancer, selected from the group consisting of breast cancer, melanoma, colorectal cancer, non-small cell lung cancer and ovarian cancer, by administering a combination of a WEE1 inhibitor and a CHK1 inhibitor, wherein the WEE1 inhibitor is MK-1775 or a pharmaceutically acceptable salt thereof, or MK-3652 or a pharmaceutically acceptable salt thereof, and the CHK1 inhibitor is MK-8776 or a pharmaceutically acceptable salt thereof, or SCH900444 or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了通过施用WEE1抑制剂和CHK1抑制剂的组合来治疗选自乳腺癌，黑素瘤，结肠直肠癌，非小细胞肺癌和卵巢癌的癌症的方法，其中 WEE1抑制剂是MK-1775或其药学上可接受的盐或MK-3652或其药学上可接受的盐，CHK1抑制剂是MK-8776或其药学上可接受的盐或SCH900444或其药学上可接受的盐。

2. 发明申请

WO2014085216A1 COMPOSITIONS AND METHODS FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：WO2014085216A1
公开(公告)日：2014-06-05
申请号：PCT/US2013/071377
申请日：2013-11-22
申请人： MERCK SHARP & DOHME CORP. , SHUMWAY, Stuart Denham
发明人： SHUMWAY, Stuart Denham
IPC分类号： C12Q1/68
CPC分类号： A61K31/519 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/573 , G01N2333/91011
摘要： The instant invention relates to methods for the treatment of WEE1 kinase associated cancer by administering a WEE1 inhibitor, wherein the WEE1 inhibitor is WEE1-1 or a pharmaceutically acceptable salt thereof, or WEE1-2 or a pharmaceutically acceptable salt thereof. In another embodiment, the invention relates to a method for treating a WEE1 kinase associated cancer patient, comprising administering a WEE1 inhibitor, wherein the cancer cells of said patient to be treated are characterized by low expression levels of PKMYT1.
摘要翻译：本发明涉及通过施用WEE1抑制剂治疗WEE1激酶相关癌症的方法，其中WEE1抑制剂是WEE1-1或其药学上可接受的盐，或WEE1-2或其药学上可接受的盐。在另一个实施方案中，本发明涉及治疗WEE1激酶相关癌症患者的方法，包括施用WEE1抑制剂，其中所述待治疗患者的癌细胞的特征在于PKMYT1的低表达水平。

3. 发明申请

WO2014062454A1 COMPOSITIONS AND METHODS FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：WO2014062454A1
公开(公告)日：2014-04-24
申请号：PCT/US2013/064193
申请日：2013-10-10
申请人： MERCK SHARP & DOHME CORP. , CHILDREN'S HOSPITAL OF PHILADELPHIA , COLE, Kristina , MARIS, John , RUSSELL, Michael , BENITA, Yair , KUBICA, Jamie , SHUMWAY, Stuart Denham
发明人： COLE, Kristina , MARIS, John , RUSSELL, Michael , BENITA, Yair , KUBICA, Jamie , SHUMWAY, Stuart Denham
IPC分类号： A61K31/501
CPC分类号： A61K31/503 , A61K31/5025 , A61K2300/00
摘要： The instant invention relates to methods for the treatment of neuroblastoma by administering a combination of a WEE1 inhibitor and a CHK1 inhibitor, wherein the WEE1 inhibitor is WEE1-1 or a pharmaceutically acceptable salt thereof, or WEE1-2 or a pharmaceutically acceptable salt thereof, and the CHK1 inhibitor is CHK1-1 or a pharmaceutically acceptable salt thereof. In another embodiment, the invention relates to a method for treating a neuroblastoma patient, comprising administering a WEE1 inhibitor and a CHK1 inhibitor, wherein the cancer cells of said patient to be treated are characterized by amplified expression levels of MYCN.
摘要翻译：本发明涉及通过施用WEE1抑制剂和CHK1抑制剂的组合来治疗神经母细胞瘤的方法，其中WEE1抑制剂是WEE1-1或其药学上可接受的盐，或WEE1-2或其药学上可接受的盐， CHK1抑制剂是CHK1-1或其药学上可接受的盐。在另一个实施方案中，本发明涉及治疗神经母细胞瘤患者的方法，包括施用WEE1抑制剂和CHK1抑制剂，其中所述待治疗患者的癌细胞的特征在于MYCN的扩增表达水平。

4. 发明申请

US20110304259A1 COILS FOR ELECTRON DISCHARGE DEVICES 有权
标题翻译：电子放电装置线圈
公开(公告)号：US20110304259A1
公开(公告)日：2011-12-15
申请号：US12815960
申请日：2010-06-15
申请人： Richard Speer , Stuart Denham , Henry Hall , Brian Jones
发明人： Richard Speer , Stuart Denham , Henry Hall , Brian Jones
IPC分类号： H01J61/36 , H01J1/88
CPC分类号： H01J61/0672
摘要： A mount (30) for a fluorescent lamp (32) has a glass flare (34) with a first portion (36) penetrating the fluorescent lamp (32) and a second portion (38) the fluorescent lamp (32). Two spaced-apart lead-in wires (40, 42) are sealed in the glass flare (34): and an electron emitter (12) is fixed between the spaced-apart lead-in wires (40, 42) and mated thereto by an electrical connection (46). The electron emitter (12) comprises a substrate (10) of a first material having an electron emitting material (11) thereon and two ends (20,22) and an element (23) mechanically and electrically fixed to each of the ends (20, 22), the element (23) comprising a second material different from the first material and is used to make the electrical connection (46) between the ends (20, 22) and the lead-in wires (40, 42).
摘要翻译：用于荧光灯（32）的安装座（30）具有玻璃光阑（34），其中穿过荧光灯（32）的第一部分（36）和荧光灯（32）的第二部分（38）。两个间隔开的引入线（40,42）被密封在玻璃光阑（34）中，并且电子发射器（12）固定在间隔开的引入线（40,42）之间，并通过电连接（46）。电子发射器（12）包括其上具有电子发射材料（11）的第一材料的基底（10）和两端（20,22）以及机械和电气固定到每个端部（20）的元件（23），22），所述元件（23）包括与所述第一材料不同的第二材料，并且用于在所述端部（20,22）和所述引入线（40,42）之间形成所述电连接（46）。

5. 发明申请

US20140343071A1 COMPOSITIONS AND METHODS FOR TREATING CANCER 有权
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：US20140343071A1
公开(公告)日：2014-11-20
申请号：US14344190
申请日：2012-09-11
申请人： Stuart Denham Shumway , Carlo Toniatti , Brian Scott Roberts , Melissa M. Martin
发明人： Stuart Denham Shumway , Carlo Toniatti , Brian Scott Roberts , Melissa M. Martin
IPC分类号： A61K31/519 , A61K45/06
CPC分类号： A61K31/519 , A61K31/506 , A61K45/06 , A61K2300/00
摘要： The instant invention provides a method of treating a cancer, selected from the group consisting of breast cancer, melanoma, colorectal cancer, non-small cell lung cancer and ovarian cancer, by administering a combination of a WEE1 inhibitor and a CHK1 inhibitor, wherein the WEE1 inhibitor is MK-1775 or a pharmaceutically acceptable salt thereof, or MK-3652 or a pharmaceutically acceptable salt thereof, and the CHK1 inhibitor is MK-8776 or a pharmaceutically acceptable salt thereof, or SCH900444 or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了通过施用WEE1抑制剂和CHK1抑制剂的组合来治疗选自乳腺癌，黑素瘤，结肠直肠癌，非小细胞肺癌和卵巢癌的癌症的方法，其中 WEE1抑制剂是MK-1775或其药学上可接受的盐或MK-3652或其药学上可接受的盐，CHK1抑制剂是MK-8776或其药学上可接受的盐或SCH900444或其药学上可接受的盐。

6. 发明授权

US09345705B2 Compositions and methods for treating cancer 有权
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：US09345705B2
公开(公告)日：2016-05-24
申请号：US14344190
申请日：2012-09-11
申请人： Stuart Denham Shumway , Carlo Toniatti , Brian Scott Roberts , Melissa M. Martin
发明人： Stuart Denham Shumway , Carlo Toniatti , Brian Scott Roberts , Melissa M. Martin
IPC分类号： A61K31/519 , C07D487/02 , A61K31/506 , A61K45/06
CPC分类号： A61K31/519 , A61K31/506 , A61K45/06 , A61K2300/00
摘要： The instant invention provides a method of treating a cancer, selected from the group consisting of breast cancer, melanoma, colorectal cancer, non-small cell lung cancer and ovarian cancer, by administering a combination of a WEE1 inhibitor and a CHK1 inhibitor, wherein the WEE1 inhibitor is MK-1775 or a pharmaceutically acceptable salt thereof, or MK-3652 or a pharmaceutically acceptable salt thereof, and the CHK1 inhibitor is MK-8776 or a pharmaceutically acceptable salt thereof, or SCH900444 or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了通过施用WEE1抑制剂和CHK1抑制剂的组合来治疗选自乳腺癌，黑素瘤，结肠直肠癌，非小细胞肺癌和卵巢癌的癌症的方法，其中 WEE1抑制剂是MK-1775或其药学上可接受的盐或MK-3652或其药学上可接受的盐，CHK1抑制剂是MK-8776或其药学上可接受的盐或SCH900444或其药学上可接受的盐。

7. 发明授权

US08183760B2 Coils for electron discharge devices 有权
标题翻译：线圈用于电子放电装置
公开(公告)号：US08183760B2
公开(公告)日：2012-05-22
申请号：US12815960
申请日：2010-06-15
申请人： Richard Speer , Stuart Denham , Henry Hall , Brian Jones
发明人： Richard Speer , Stuart Denham , Henry Hall , Brian Jones
IPC分类号： H01J63/04
CPC分类号： H01J61/0672
摘要： A mount (30) for a fluorescent lamp (32) has a glass flare (34) with a first portion (36) penetrating the fluorescent lamp (32) and a second portion (38) the fluorescent lamp (32). Two spaced-apart lead-in wires (40, 42) are sealed in the glass flare (34): and an electron emitter (12) is fixed between the spaced-apart lead-in wires (40, 42) and mated thereto by an electrical connection (46). The electron emitter (12) comprises a substrate (10) of a first material having an electron emitting material (11) thereon and two ends (20,22) and an element (23) mechanically and electrically fixed to each of the ends (20, 22), the element (23) comprising a second material different from the first material and is used to make the electrical connection (46) between the ends (20, 22) and the lead-in wires (40, 42).
摘要翻译：用于荧光灯（32）的安装座（30）具有玻璃光阑（34），其中穿过荧光灯（32）的第一部分（36）和荧光灯（32）的第二部分（38）。两个间隔开的引入线（40,42）被密封在玻璃光阑（34）中，并且电子发射器（12）固定在间隔开的引入线（40,42）之间，并通过电连接（46）。电子发射器（12）包括其上具有电子发射材料（11）的第一材料的基底（10）和两端（20,22）以及机械和电气固定到每个端部（20）的元件（23），22），所述元件（23）包括与所述第一材料不同的第二材料，并且用于在所述端部（20,22）和所述引入线（40,42）之间形成所述电连接（46）。

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