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1. 发明授权

US09120711B2 Carboxylation catalysts 有权
标题翻译：羧化催化剂
公开(公告)号：US09120711B2
公开(公告)日：2015-09-01
申请号：US13702886
申请日：2011-06-09
申请人： Steven P. Nolan , Catherine Cazin
发明人： Steven P. Nolan , Catherine Cazin
IPC分类号： C07B41/08 , C07D233/02 , C07D233/04 , C07D233/90 , C07D207/04 , C07D207/18 , B01J23/66 , B01J23/72 , B01J31/22 , B01J31/18 , B01J31/24 , C07B59/00 , C07D235/24 , C07D237/24 , C07D249/10 , C07D253/07 , C07D261/18 , C07D263/34 , C07D263/58 , C07D275/03 , C07D277/56 , C07D277/68 , C07D307/68 , C07D473/00 , C07F1/08 , C07F1/10
CPC分类号： C07B41/08 , B01J31/185 , B01J31/2226 , B01J31/2265 , B01J31/2269 , B01J31/2273 , B01J31/24 , B01J2531/16 , B01J2531/17 , B01J2531/18 , C07B59/002 , C07D233/90 , C07D235/24 , C07D237/24 , C07D249/10 , C07D253/07 , C07D261/18 , C07D263/34 , C07D263/58 , C07D275/03 , C07D277/56 , C07D277/68 , C07D307/68 , C07D473/00 , C07F1/08 , C07F1/10
摘要： The use of a complex of the form Z—M—OR in the carboxylation of a substrate is described. The group Z is a two-electron donor ligand, M is a metal and OR is selected from the group consisting of OH, alkoxy and aryloxy. The substrate may be carboxylated at a C—H or N—H bond. The metal M may be copper, silver or gold. The two-electron donor ligand may be a phosphine, a carbene or a phosphite ligand. Also described are methods of manufacture of the complexes and methods for preparing isotopically labelled caboxylic acids and carboxylic acid derivatives.
摘要翻译：描述了在底物羧化中使用Z-M-OR形式的络合物。基团Z是双电子供体配体，M是金属，OR选自OH，烷氧基和芳氧基。底物可以在C-H或N-H键被羧化。金属M可以是铜，银或金。双电子供体配体可以是膦，卡宾或亚磷酸酯配体。还描述了制备复合物的方法和用于制备同位素标记的木糖酸和羧酸衍生物的方法。

2. 发明授权

US07622590B1 Catalyst complex with carbene ligand 有权
标题翻译：催化剂配合物与卡宾配体
公开(公告)号：US07622590B1
公开(公告)日：2009-11-24
申请号：US09392869
申请日：1999-09-09
申请人： Steven P. Nolan , Jinkun Huang
发明人： Steven P. Nolan , Jinkun Huang
IPC分类号： C07F15/00 , B01J31/00 , C08F4/44
CPC分类号： B01J31/2278 , B01J31/2265 , B01J31/2273 , B01J31/2295 , B01J31/2404 , B01J2231/10 , B01J2231/4205 , B01J2231/54 , B01J2231/543 , B01J2531/821 , B01J2531/825 , C07C6/04 , C07C67/30 , C07C2531/22 , C07D207/46 , C07D223/04 , C07D225/02 , C07D313/00 , C07D498/04 , C07F15/00 , C07F15/002 , C07F15/0046
摘要： Catalytic complexes including a metal atom having anionic ligands, at least one nucleophilic carbene ligand, and an alkylidene, vinylidene, or allenylidene ligand. The complexes are highly stable to air, moisture and thermal degradation. The complexes are designed to efficiently carry out a variety of olefin metathesis reactions.
摘要翻译：包括具有阴离子配体的金属原子，至少一个亲核卡宾配体和亚烷基，亚乙烯基或亚烯基亚基配体的催化络合物。该配合物对空气，水分和热降解高度稳定。复合物被设计为有效地进行各种烯烃复分解反应。

3. 发明授权

US07205424B2 Preparation of ruthenium-based olefin metathesis catalysts 有权
标题翻译：钌基烯烃复分解催化剂的制备
公开(公告)号：US07205424B2
公开(公告)日：2007-04-17
申请号：US10873026
申请日：2004-06-21
申请人： Steven P. Nolan
发明人： Steven P. Nolan
IPC分类号： B01J31/00
CPC分类号： B01J31/2265 , B01J31/2273 , B01J31/2404 , B01J2231/54 , B01J2231/543 , B01J2531/821
摘要： A synthetic method leading to the isolation of ruthenium-based olefin metathesis catalysts relies on the cross metathesis reaction between (L1)Ru(L2)(3-phenylindenylid-1-ene)Cl2 (where L1 and L2 can be two-electron donors) and an olefin. This method leads to the isolation of numerous ruthenium olefin metathesis catalysts.
摘要翻译：导致分离钌基烯烃复分解催化剂的合成方法依赖于（L 1 H 2）Ru（L 2 N 2）（3-苯基茚基）-1 烯）Cl 2（其中L 1和L 2可以是双电子给体）和烯烃。这种方法导致许多钌烯烃复分解催化剂的分离。

4. 发明授权

US06774274B2 Metal complexes for hydrogenation of unsaturated compounds 失效
标题翻译：用于氢化不饱和化合物的金属络合物
公开(公告)号：US06774274B2
公开(公告)日：2004-08-10
申请号：US10011680
申请日：2001-12-04
申请人： Steven P. Nolan , Hon Man Lee , Anna C. Hillier
发明人： Steven P. Nolan , Hon Man Lee , Anna C. Hillier
IPC分类号： C07C500
CPC分类号： C07F15/0033 , B01J31/181 , B01J31/2273 , B01J31/2291 , B01J31/2295 , B01J2231/645 , B01J2531/0288 , B01J2531/827 , C07C5/03 , C07C2531/22
摘要： The cationic iridium carbene complexes [Ir(cod)(N)(L)]X have been synthesized by reaction of [Ir(cod)(py)2]PF6 with L or NL ligands. Complexes of this type are active hydrogenation catalysts capable of hydrogenating simple olefins at room temperature and atmospheric pressure of hydrogen or by transfer hydrogenation.
摘要翻译：通过[Ir（cod）（py）2] PF6与L或NL配体的反应合成了阳离子铱卡宾配合物[Ir（cod）（N）（L）] X。这种类型的络合物是能够在室温和氢气的大气压下或通过转移氢化使单烯烃氢化的活性氢化催化剂。

5. 发明授权

US09464097B2 Gold complexes 有权
标题翻译：金色复合体
公开(公告)号：US09464097B2
公开(公告)日：2016-10-11
申请号：US13580772
申请日：2011-03-02
申请人： Steven P. Nolan
发明人： Steven P. Nolan
IPC分类号： C07F1/12 , B01J31/22 , B01J31/02 , B01J31/24
CPC分类号： C07F1/12 , B01J31/0211 , B01J31/181 , B01J31/2273 , B01J31/24 , B01J2531/18 , C07C45/26 , C07C67/333 , C07C231/065 , C07C231/10 , C07C2601/08 , C07C2601/10 , C07D207/06 , C07D213/81 , C07F1/00
摘要： Gold (I) hydroxide complexes of the form Z—Au—OH and digold complexes of the form Z—Au-(μOH)—Au—Z where groups Z are two electron donors are provided. The groups Z may be carbenes, for example nitrogen containing heterocyclic carbenes (NHCs), phosphines or phosphites. The complexes can be used as catalysts, for example in reactions such as hydration of nitriles, skeletal arrangement of enynes, alkoxycyclization of enynes, alkyne hydration, the Meyer-Shuster reaction, 3,3′ rearrangement of allylic acetates, cyclization of propargylic acetates, Beckman rearrangements and hydroamination. The complexes can be used in medicine, for example in the treatment of cancer.
摘要翻译：提供Z-Au-OH形式的金（I）氢氧化物络合物和Z-Au-（μOH）-Au-Z形式的二价配合物，其中基团Z是两个电子给体。基团Z可以是卡宾，例如含氮杂环卡宾（NHC），膦或亚磷酸酯。络合物可以用作催化剂，例如在诸如腈水合，烯炔的骨架排列，烯炔的烷基环化，炔烃水合，Meyer-Shuster反应，烯丙基乙酸酯的3,3'重排，炔丙基乙酸酯的环化，贝克曼重排和水文。该复合物可用于医学中，例如用于治疗癌症。

6. 发明申请

US20130085276A1 CARBOXYLATION CATALYSTS 有权
标题翻译：羧氧化催化剂
公开(公告)号：US20130085276A1
公开(公告)日：2013-04-04
申请号：US13702886
申请日：2011-06-09
申请人： Steven P. Nolan , Catherine Cazin
发明人： Steven P. Nolan , Catherine Cazin
IPC分类号： C07B41/08 , C07D263/34 , C07D261/18 , C07D263/58 , C07D277/56 , C07D275/03 , C07D277/68 , C07D233/90 , C07D235/24 , C07D237/24 , C07D249/10 , C07D253/07 , C07D473/00 , C07F1/08 , C07F1/10 , C07B59/00 , C07D307/68
CPC分类号： C07B41/08 , B01J31/185 , B01J31/2226 , B01J31/2265 , B01J31/2269 , B01J31/2273 , B01J31/24 , B01J2531/16 , B01J2531/17 , B01J2531/18 , C07B59/002 , C07D233/90 , C07D235/24 , C07D237/24 , C07D249/10 , C07D253/07 , C07D261/18 , C07D263/34 , C07D263/58 , C07D275/03 , C07D277/56 , C07D277/68 , C07D307/68 , C07D473/00 , C07F1/08 , C07F1/10
摘要： The use of a complex of the form Z—M—OR in the carboxylation of a substrate is described. The group Z is a two-electron donor ligand, M is a metal and OR is selected from the group consisting of OH, alkoxy and aryloxy. The substrate may be carboxylated at a C—H or N—H bond. The metal M may be copper, silver or gold. The two-electron donor ligand may be a phosphine, a carbene or a phosphite ligand. Also described are methods of manufacture of the complexes and methods for preparing isotopically labelled caboxylic acids and carboxylic acid derivatives.
摘要翻译：描述了在底物羧化中使用Z-M-OR形式的络合物。基团Z是双电子供体配体，M是金属，OR选自OH，烷氧基和芳氧基。底物可以在C-H或N-H键被羧化。金属M可以是铜，银或金。双电子供体配体可以是膦，卡宾或亚磷酸酯配体。还描述了制备复合物的方法和用于制备同位素标记的木糖酸和羧酸衍生物的方法。

7. 发明授权

US07767841B1 Gold complexes for catalysIS and preparation thereof 有权
标题翻译：用于催化的金络合物及其制备
公开(公告)号：US07767841B1
公开(公告)日：2010-08-03
申请号：US12098863
申请日：2008-04-07
申请人： Steven P. Nolan , Pierre de Fremont
发明人： Steven P. Nolan , Pierre de Fremont
IPC分类号： C07F1/12 , C01F1/00
CPC分类号： C07F1/00
摘要： A number of cationic gold(I) and neutral gold(III) complexes have been synthesized and found to be stabilized by the use of N-heterocyclic carbene ligands. These species are often employed as in situ-generated reactive intermediates in gold catalyzed organic transformations. An isolated, well-defined cationic species was tested in gold mediated carbene transfer reactions from ethyl diazoacetate.
摘要翻译：已经合成了许多阳离子金（I）和中性金（III）络合物，发现通过使用N-杂环卡宾配体来稳定。这些物质通常用作金催化有机转化中的原位产生的反应中间体。在乙基重氮乙酸酯的金介导的卡宾转移反应中测试了分离的，明确定义的阳离子物质。

8. 发明申请

US20130035322A1 GOLD COMPLEXES 有权
标题翻译：金复合体
公开(公告)号：US20130035322A1
公开(公告)日：2013-02-07
申请号：US13580772
申请日：2011-03-02
申请人： Steven P. Nolan
发明人： Steven P. Nolan
IPC分类号： A61K31/555 , C07F15/00 , C07D207/16 , A61P35/00 , C07C231/06 , C07C45/26 , C07C17/37 , C07D213/81 , C07C69/74
CPC分类号： C07F1/12 , B01J31/0211 , B01J31/181 , B01J31/2273 , B01J31/24 , B01J2531/18 , C07C45/26 , C07C67/333 , C07C231/065 , C07C231/10 , C07C2601/08 , C07C2601/10 , C07D207/06 , C07D213/81 , C07F1/00
摘要： Gold (I) hydroxide complexes of the form Z-Au-OH and digold complexes of the form Z—Au-(μOH)—Au—Z where groups Z are two electron donors are provided. The groups Z may be carbenes, for example nitrogen containing heterocyclic carbenes (NHCs), phosphines or phosphites. The complexes can be used as catalysts, for example in reactions such as hydration of nitriles, skeletal arrangement of enynes, alkoxycyclisation of enynes, alkyne hydration, the Meyer-Shuster reaction, 3,3′ rearrangement of allylic acetates, cyclisation of propargylic acetates, Beckman rearrangements and hydroamination. The complexes can be used in medicine, for example in the treatment of cancer.
摘要翻译：提供Z-Au-OH形式的金（I）氢氧化物络合物和Z-Au-（μOH）-Au-Z形式的二价配合物，其中基团Z是两个电子给体。基团Z可以是卡宾，例如含氮杂环卡宾（NHC），膦或亚磷酸酯。络合物可以用作催化剂，例如在诸如腈水合，烯炔的骨架排列，烯炔的烷基环化，炔烃水合，Meyer-Shuster反应，烯丙基乙酸酯的3,3'重排，炔丙基乙酸酯的环化，贝克曼重排和水文。该复合物可用于医学中，例如用于治疗癌症。

9. 发明申请

US20120004418A1 Catalyst Complex With Carbene Ligand 审中-公开
标题翻译：催化剂配合物与卡宾配体
公开(公告)号：US20120004418A1
公开(公告)日：2012-01-05
申请号：US13041573
申请日：2011-03-07
申请人： Steven P. Nolan , Jinkun Huang
发明人： Steven P. Nolan , Jinkun Huang
IPC分类号： C07F15/00
CPC分类号： B01J31/2278 , B01J31/2265 , B01J31/2273 , B01J31/2295 , B01J31/2404 , B01J2231/10 , B01J2231/4205 , B01J2231/54 , B01J2231/543 , B01J2531/821 , B01J2531/825 , C07C6/04 , C07C67/30 , C07C2531/22 , C07D207/46 , C07D223/04 , C07D225/02 , C07D313/00 , C07D498/04 , C07F15/00 , C07F15/002 , C07F15/0046
摘要： Catalytic complexes including a metal atom having anionic ligands, at least one nucleophilic carbine ligand, and an alkylidene, vinylidene, or allenylidene ligand. The complexes are highly stable to air, moisture and thermal degradation. The complexes are designed to efficiently carry out a variety of olefin metathesis reactions.
摘要翻译：包括具有阴离子配体的金属原子，至少一个亲核卡宾配体和亚烷基，亚乙烯基或亚烯基亚基配位体的催化络合物。该配合物对空气，水分和热降解高度稳定。复合物被设计为有效地进行各种烯烃复分解反应。

10. 发明授权

US07109348B1 Synthesis of 1,3 distributed imidazolium salts 失效
标题翻译： 1,3分散咪唑鎓盐的合成
公开(公告)号：US07109348B1
公开(公告)日：2006-09-19
申请号：US10653688
申请日：2003-09-02
申请人： Steven P. Nolan
发明人： Steven P. Nolan
IPC分类号： C07D233/54
CPC分类号： C07D233/56
摘要： Imidazolium salts are the immediate precursors to N-heterocyclic carbenes (NHC) yet a simple, general synthetic route to a wide variety of imidazolium salts is not yet available. Such a straightforward route is described for two specific members of this family of ligand precursor: 1,3-Bis(2,4,6-trimethylphenyl)imidazolium chloride (IMes.HCl) and 1,3-Bis(2,6-diispropylphenyl)imidazolium chloride (IPr.HCl). The procedure appears general and similar protocols can be used to isolate various imidazolium salts.
摘要翻译：咪唑盐是N-杂环卡宾（NHC）的直接前体，但是尚未提供到各种咪唑鎓盐的简单的通用合成途径。对这种配体前体家族的两个特定成员描述了这种简单的途径：1,3-双（2,4,6-三甲基苯基）氯化咪唑（IMes.HCl）和1,3-双（2,6-二）氯化咪唑（IPr.HCl）。该方法看起来通用，并且可以使用类似的方案来分离各种咪唑鎓盐。

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