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1. 发明授权

US08399647B2 Alpha5-beta1 antibodies and their uses 失效
标题翻译： Alpha5-beta1抗体及其用途
公开(公告)号：US08399647B2
公开(公告)日：2013-03-19
申请号：US13237502
申请日：2011-09-20
申请人： Steven L. Bender , Gerald F. Casperson , Dana D. Hu-Lowe , Xin Jiang , Gang Li , Michael A. North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
发明人： Steven L. Bender , Gerald F. Casperson , Dana D. Hu-Lowe , Xin Jiang , Gang Li , Michael A. North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
IPC分类号： C07H21/04 , C12P21/06 , C12N15/87 , C12N1/20 , C12N15/74
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-α5β1 antibodies or antigen binding portions thereof described herein.
摘要翻译：本公开提供以高亲和力特异性结合整联蛋白α5和bgr1的分离的单克隆抗体，特别是人单克隆抗体或其抗原结合部分。还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。还提供了免疫偶联物，双特异性分子和包含抗体或其抗原结合部分的药物组合物。本公开还提供了使用本文所述的抗α5和bgr1抗体或其抗原结合部分治疗各种癌症的方法。

2. 外观设计

USD643161S1 Retractable pet leash housing 有权
标题翻译：伸缩宠物皮带外壳
公开(公告)号：USD643161S1
公开(公告)日：2011-08-09
申请号：US29380558
申请日：2010-12-07
申请人： Caroline Leedom , Steven L. Bender
设计人： Caroline Leedom , Steven L. Bender

3. 发明申请

US20100330078A1 ALPHA 5 - BETA 1 ANTIBODIES AND THEIR USES 失效
标题翻译： ALPHA 5 - BETA 1抗体及其用途
公开(公告)号：US20100330078A1
公开(公告)日：2010-12-30
申请号：US12365638
申请日：2009-02-04
申请人： STEVEN L. BENDER , GERALD F. CASPERSON , DANA D. HU-LOWE , XIN JIANG , GANG LI , MICHAEL A. NORTH , JIANYING WANG , GRANT WICKMAN , PETER BRAMS , HAICHUN HUANG , BRIGITTE DEVAUX , HAIBIN CHEN , DAWN M. TANAMACHI , KRISTOPHER TOY , LAN YANG , TIM W. SPROUL , MARK YAMANAKA
发明人： STEVEN L. BENDER , GERALD F. CASPERSON , DANA D. HU-LOWE , XIN JIANG , GANG LI , MICHAEL A. NORTH , JIANYING WANG , GRANT WICKMAN , PETER BRAMS , HAICHUN HUANG , BRIGITTE DEVAUX , HAIBIN CHEN , DAWN M. TANAMACHI , KRISTOPHER TOY , LAN YANG , TIM W. SPROUL , MARK YAMANAKA
IPC分类号： A61K39/395 , C07K16/28 , C07K16/00 , A61P35/00
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-α5β1 antibodies or antigen binding portions thereof described herein.
摘要翻译：本公开提供以高亲和力特异性结合整联蛋白α5和bgr1的分离的单克隆抗体，特别是人单克隆抗体或其抗原结合部分。还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。还提供了免疫偶联物，双特异性分子和包含抗体或其抗原结合部分的药物组合物。本公开还提供了使用本文所述的抗α5和bgr1抗体或其抗原结合部分治疗各种癌症的方法。

4. 发明授权

US06306892B1 Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use 失效
标题翻译：金属蛋白酶抑制剂，含有它们的药物组合物及其用途
公开(公告)号：US06306892B1
公开(公告)日：2001-10-23
申请号：US09598208
申请日：2000-06-21
申请人： Steven L. Bender , Arlindo L. Castelhano , Wesley K. M. Chong , Melwyn A. Abreo , Roland J. Billedeau , Jian Jeffrey Chen , Judith G. Deal
发明人： Steven L. Bender , Arlindo L. Castelhano , Wesley K. M. Chong , Melwyn A. Abreo , Roland J. Billedeau , Jian Jeffrey Chen , Judith G. Deal
IPC分类号： A61K31381
CPC分类号： C07D207/327 , A61K38/00 , C07D207/337 , C07D231/12 , C07D233/56 , C07D249/08 , C07D307/54 , C07D333/24 , C07D401/10 , C07D401/12 , C07D405/12 , C07D405/14 , C07D487/08 , C07K5/0606 , C07K5/06104 , C07K5/06113
摘要： The present invention is directed to compound of the formula I: wherein R1, R2, R3, R4, R 5, X, Y, and are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds.
摘要翻译：本发明涉及式I化合物：其中R 1，R 2，R 3，R 4，R 5，X，Y和如本文所定义。这些化合物可用于通过使金属蛋白酶与本发明化合物的有效量。

5. 发明授权

US06174915B1 Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses 失效
标题翻译：金属蛋白酶抑制剂，含有它们的药物组合物及其药物用途
公开(公告)号：US06174915B1
公开(公告)日：2001-01-16
申请号：US09309602
申请日：1999-05-11
申请人： Steven L. Bender , Arlindo L. Castelhano , Wesley K. M. Chong , Melwyn A. Abreo , Roland J. Billedeau , Jian Jeffrey Chen , Judith G. Deal
发明人： Steven L. Bender , Arlindo L. Castelhano , Wesley K. M. Chong , Melwyn A. Abreo , Roland J. Billedeau , Jian Jeffrey Chen , Judith G. Deal
IPC分类号： A61K31341
CPC分类号： C07D207/327 , A61K38/00 , C07D207/337 , C07D231/12 , C07D233/56 , C07D249/08 , C07D307/54 , C07D333/24 , C07D401/10 , C07D401/12 , C07D405/12 , C07D405/14 , C07D487/08 , C07K5/0606 , C07K5/06104 , C07K5/06113
摘要： The present invention is directed to compound of the formula I: wherein R1, R2, R3, R4, R5, X, Y, and are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds.
摘要翻译：本发明涉及式I化合物：其中R 1，R 2，R 3，R 4，R 5，X，Y如本文所定义。这些化合物可用于通过使金属蛋白酶与有效量的本发明化合物。

6. 发明授权

US5985900A Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses 失效
标题翻译：金属蛋白酶抑制剂，含有它们的药物组合物及其药物用途
公开(公告)号：US5985900A
公开(公告)日：1999-11-16
申请号：US49949
申请日：1998-03-30
申请人： Steven L. Bender , Melwyn A. Abreo
发明人： Steven L. Bender , Melwyn A. Abreo
IPC分类号： C07C311/29 , C07C323/58 , C07C323/60 , C07D213/32 , C07D213/64 , C07D213/68 , C07D233/54 , C07D261/08 , C07D405/12 , C07D413/12 , A01N43/40 , A01N37/28 , A01N43/50 , A01N43/80
CPC分类号： C07D213/64 , C07C311/29 , C07C323/58 , C07C323/60 , C07D213/32 , C07D213/68 , C07D233/64 , C07D261/08 , C07D405/12 , C07D413/12
摘要： Compounds of the formula I: ##STR1## wherein Y is O or S, Ar is an aryl group or a heteroaryl group, R is H, an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, a heteroaryl group, or --C(O)R.sub.1, wherein R.sub.1 is hydrogen, an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, a heteroaryl group, or NR.sub.2 R.sub.3, wherein R.sub.2 and R.sub.3 independently are hydrogen, an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, or a heteroaryl group, and X is --NH--OH or --OH. Pharmaceutically acceptable prodrugs, salts and solvates of these compounds. Methods of inhibiting the activity of metalloproteinases by administering a compound of the formula I or a prodrug, salt of solvate thereof. Pharmaceutical compositions comprising an effective amount of these compounds, prodrugs, salts, and solvates.
摘要翻译：式I化合物：其中Y是O或S，Ar是芳基或杂芳基，R是H，烷基，环烷基，杂环烷基，芳基，杂芳基或-C （O）R 1，其中R 1是氢，烷基，环烷基，杂环烷基，芳基，杂芳基或NR 2 R 3，其中R 2和R 3独立地是氢，烷基，环烷基，杂环烷基，芳基或杂芳基，X是-NH-OH或-OH。这些化合物的药学上可接受的前药，盐和溶剂合物。通过施用式I化合物或其前药，其溶剂合物的盐来抑制金属蛋白酶的活性的方法。包含有效量的这些化合物，前药，盐和溶剂合物的药物组合物。

7. 发明授权

US4368247A Photographic materials and processes comprising oxoindolizine and oxoindolizinium compounds 失效
标题翻译：摄影材料和方法，包括氧代二氢化茚和氧代吲哚啉鎓化合物
公开(公告)号：US4368247A
公开(公告)日：1983-01-11
申请号：US278013
申请日：1981-06-29
申请人： George L. Fletcher, Jr. , Steven L. Bender , Donald H. Wadsworth
发明人： George L. Fletcher, Jr. , Steven L. Bender , Donald H. Wadsworth
IPC分类号： C09B57/00 , C07D471/04 , G03C1/73 , G03C1/52
CPC分类号： C07D471/04 , G03C1/73
摘要： Oxoindolizine and oxoindolizinium dyes are useful in photographic materials and processes as image dyes. These dyes are formed in unexposed areas of photographic materials, especially photothermographic materials, by the reaction of a photosensitive cyclopropenone with a pyridine compound. Oxoindolizine and oxoindolizinium dyes are alternatively formed by (1) reaction of a photosensitive cyclopropenone with a pyridine compound and (2) reaction of the resulting product with a color forming coupler. The photographic material is imagewise exposed and then heated to a processing temperature to form a dye image. Alternatively, the oxoindolizine and oxoindolizinium dyes are produced by imbibing at least one of the reactants into the photographic material comprising a photosensitive cyclopropenone.
摘要翻译：氧代吲哚啉和氧代吲哚ium嗪染料可用作照相材料和作为图像染料的方法。这些染料通过感光环丙烯酮与吡啶化合物的反应在照相材料的未曝光区域，特别是光热照相材料中形成。氧化吲哚啉和氧代吲哚ium嗪染料可以通过（1）光敏环丙烯酮与吡啶化合物的反应和（2）所得产物与形成成色剂的反应形成。将照相材料成像曝光，然后加热至加工温度以形成染料图像。或者，通过将至少一种反应物吸收到包含光敏环丙烯酮的照相材料中来制备氧代取代二氮杂和氧代吲哚ium嗪染料。

8. 发明申请

US20080133933A1 Key sequence rhythm recognition system and method 审中-公开
标题翻译：关键序列节律识别系统及方法
公开(公告)号：US20080133933A1
公开(公告)日：2008-06-05
申请号：US11810193
申请日：2007-06-04
申请人： Steven L. Bender
发明人： Steven L. Bender
IPC分类号： H04K1/00 , H04L9/00
CPC分类号： G06F21/316
摘要： A user recognition and identification system and method is presented in which text entered by a user at a keyboard is evaluated against previously recorded keystrokes by the user for the presence of repeatable patterns that are unique to an individual.
摘要翻译：呈现用户识别和识别系统和方法，其中用户在键盘输入的文本被评估为用户对于个体独特的可重复模式的存在的先前记录的击键。

9. 发明授权

US06500948B1 Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof 失效
标题翻译：金属蛋白酶抑制剂 - 其组合物，用途，制备及其中间体
公开(公告)号：US06500948B1
公开(公告)日：2002-12-31
申请号：US09675555
申请日：2000-09-29
申请人： Scott E. Zook , Raymond Dagnino, Jr. , Michael E. Deason , Steven L. Bender , Michael J. Melnick
发明人： Scott E. Zook , Raymond Dagnino, Jr. , Michael E. Deason , Steven L. Bender , Michael J. Melnick
IPC分类号： C07D41700
CPC分类号： C07D401/12 , C07D239/04 , C07D241/04 , C07D279/12 , C07D417/12
摘要： The invention relates to compounds of the formula 1: wherein: Z is O or S; V is a divalent radical which together with C* and N forms a ring having six ring atoms, where each of said ring atoms other than C* and N independently is unsubstituted or substituted by a suitable substituent, and at least one of said other ring atoms is a heteroatom selected from O, N and S, and the remainder are carbon atoms; and Ar is an aryl or heteroaryl group; and pharmaceutically acceptable prodrugs, salts and solvates thereof. The invention further relates to pharmaceutically acceptable prodrugs, salts and solvates of these compounds. The invention also relates to methods of inhibiting the activity of metalloproteinases by administering a compound of the formula I or a prodrug, salt of solvate thereof. The invention further relates to pharmaceutical compositions comprising an effective amount of these compounds, prodrugs, salts, and solvates. The invention still further relates to methods and intermediates useful for preparing these compounds, prodrugs, salts, and solvates.
摘要翻译：本发明涉及式1化合物：其中：Z为O或S; V是与C *和N一起形成具有六个环原子的环的二价基团，其中除C *和N之外的所述环原子各自独立地是未取代的或被合适的取代基取代，并且所述另一个环中的至少一个原子是选自O，N和S的杂原子，其余为碳原子; Ar为芳基或杂芳基; 其药学上可接受的前药，其盐和溶剂化物。本发明还涉及这些化合物的药学上可接受的前药，盐和溶剂化物。本发明还涉及通过给予式I化合物或其前药，其溶剂合物的盐来抑制金属蛋白酶的活性的方法。本发明还涉及包含有效量的这些化合物，前药，盐和溶剂合物的药物组合物。本发明还涉及可用于制备这些化合物，前药，盐和溶剂合物的方法和中间体。

10. 依法登记的发明

USH1992H1 Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their pharmaceutical uses 有权
公开(公告)号：USH1992H1
公开(公告)日：2001-09-04
申请号：US09372064
申请日：1999-08-11
申请人： Steven L. Bender , Arlindo L. Castelhano
发明人： Steven L. Bender , Arlindo L. Castelhano
IPC分类号： C07D21132
摘要： The present invention relates to compounds of formula I: wherein Ar is an aryl group or a heteroaryl group; X is —NH—OH or —OH; R1 is H, —CH(R3)(R4), —C(O)R3, a cycloalkyl group, a heterocycloalkyl group, an aryl group, or a heteroaryl group, wherein R3 is H or any suitable substituent and R4 is H, an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, or a heteroaryl group; R2 is CH2-R5, wherein R5 is H or any suitable substituent, or wherein R5 and R4 are optionally substituted carbon atoms singly- or double-bonded to one another; and pharmaceutically acceptable prodrugs, salts, and solvates thereof. The invention further relates to methods of using these compounds, particularly as metalloproteinase inhibitors.

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