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1. 发明授权

US09115129B2 Substituted pyrido[2,3-B]pyrazines as IP receptor agonists 有权
标题翻译：取代的吡啶并[2,3-B]吡嗪作为IP受体激动剂
公开(公告)号：US09115129B2
公开(公告)日：2015-08-25
申请号：US14371585
申请日：2013-01-11
申请人： Steven John Charlton , Catherine Leblanc , Stephen Carl McKeown
发明人： Steven John Charlton , Catherine Leblanc , Stephen Carl McKeown
IPC分类号： A61K31/4985 , C07D487/04 , C07D471/04
CPC分类号： C07D471/04 , A61K31/4985
摘要： The present invention provides substituted pyrido[2,3-b]pyrazines which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Pharmaceutical compositions comprising such substituted pyride[2,3-b]pyrazines are also encompassed.
摘要翻译：本发明提供活化IP受体的取代的吡啶并[2,3-b]吡嗪。激活IP受体信号通路可用于治疗多种形式的PAH，肺纤维化，并在动物模型和患者的各种器官的纤维化病症中发挥有益作用。还包括包含这种取代的吡啶并[2,3-b]吡嗪的药物组合物。

2. 发明申请

US20130102611A1 IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS 有权
标题翻译： IP受体激动剂杂环化合物
公开(公告)号：US20130102611A1
公开(公告)日：2013-04-25
申请号：US13388819
申请日：2011-07-14
申请人： Steven John Charlton , Catherine Leblanc , Stephen Carl McKeown
发明人： Steven John Charlton , Catherine Leblanc , Stephen Carl McKeown
IPC分类号： C07D471/04
CPC分类号： A61K31/4985 , A61K31/4375 , C07D471/04
摘要： The present invention provides heterocyclic derivatives which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Pharmaceutical compositions comprising such derivatives are also encompassed. Examples of compounds of the invention include the compounds according to Formula Ia, or a pharmaceutically acceptable salt thereof, and the compounds of the examples.
摘要翻译：本发明提供活化IP受体的杂环衍生物。激活IP受体信号通路可用于治疗多种形式的PAH，肺纤维化，并在动物模型和患者的各种器官的纤维化病症中发挥有益作用。还包括包含这些衍生物的药物组合物。本发明化合物的实例包括根据式Ia的化合物或其药学上可接受的盐，以及实施例的化合物。

3. 发明授权

US5916831A Carburetor 失效
标题翻译：化油器
公开(公告)号：US5916831A
公开(公告)日：1999-06-29
申请号：US646305
申请日：1997-03-14
申请人： Dennis John Jager , Steven John Charlton , John Slowley
发明人： Dennis John Jager , Steven John Charlton , John Slowley
IPC分类号： F02M19/02 , F02B43/00 , F02M19/035 , F02M21/04
CPC分类号： F02M19/035 , F02M21/047 , F02M35/10262 , F02B43/00 , Y02T10/146 , Y02T10/32
摘要： A carburetor (2) to supply a mixture of fuel gas and combustion air to a reciprocating internal combustion engine. The carburetor has a venturi (4) and a throttle (10) including a throttle valve (24). A tear-drop shaped obstruction (36) is mounted in the venturi throat (18) on diametrically opposed radial arms (66). The narrowest part of the tubular gap (46) between the walls of venturi (4) and the obstruction (36) is at gap (48). A continuous slot (50) in the throat wall (18) encircles the obstruction and opens into gap (48). Another continuous slot (70) encircling the obstruction (36) is formed therein and also opens into the gap (48). Fuel gas is supplied to the slots (50 and 70) through passages (52, 74 and 72).
摘要翻译： PCT No.PCT / GB94 / 02536 Sec。 371日期1997年3月14日 102（e）1997年3月14日PCT PCT 1994年11月17日PCT公布。出版物WO95 / 14164 日期1995年5月26日化油器（2）向往复式内燃机供给燃料气体和燃烧空气的混合物。化油器具有文丘里管（4）和包括节流阀（24）的节流阀（10）。泪滴形阻塞物（36）安装在径向相对的径向臂（66）上的文丘里喉部（18）中。文氏管（4）的壁与阻塞物（36）之间的管状间隙（46）中最窄的部分处于间隙（48）。喉部壁（18）中的连续狭槽（50）围绕障碍物并且打开到间隙（48）中。围绕障碍物（36）的另一连续槽（70）形成在其中并且还通向间隙（48）。燃料气体通过通道（52,74和72）供应到狭槽（50和70）。

4. 发明申请

US20150376183A1 IP Receptor Agonist Heterocyclic Compounds 有权
标题翻译： IP受体激动剂杂环化合物
公开(公告)号：US20150376183A1
公开(公告)日：2015-12-31
申请号：US14767500
申请日：2014-02-11
申请人： Rebecca BUTLER , Catherine LEBLANC , Stephen Carl MICKEOWN , Steven John CHARLTON
发明人： Rebecca Butler , Catherine LEBLANC , Stephen Carl McKeown , Steven John Charlton
IPC分类号： C07D471/04 , A61K31/4375
CPC分类号： C07D471/04 , A61K31/4375
摘要： The present invention provides heterocyclic derivatives which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译：本发明提供活化IP受体的杂环衍生物。激活IP受体信号通路可用于治疗多种形式的PAH，肺纤维化，并在动物模型和患者的各种器官的纤维化病症中发挥有益作用。还包括包含这些衍生物的药物组合物。

5. 发明授权

US09127067B2 Methods of treatment using chemokine receptor binding polypeptides 有权
标题翻译：使用趋化因子受体结合多肽的治疗方法
公开(公告)号：US09127067B2
公开(公告)日：2015-09-08
申请号：US14065679
申请日：2013-10-29
申请人： Michelle Bradley , Steven John Charlton , Karen Cromie , Bruno Dombrecht , Soren Steffensen , Gino Anselmus Van Heeke
发明人： Zarin Brown , Michelle Bradley , Steven John Charlton , Karen Cromie , Bruno Dombrecht , Soren Steffensen , Gino Anselmus Van Heeke
IPC分类号： A61K39/395 , C07K16/28 , C07K16/46
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/569 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.
摘要翻译：本发明涉及针对或特异性结合趋化因子受体CXCR2的多肽，特别涉及能够调节CXCR2信号转导的多肽。本发明还涉及能够表达本发明多肽的核酸，载体和宿主细胞，包含多肽的药物组合物以及用于治疗涉及CXCR2异常功能的疾病的所述多肽和组合物的用途。

6. 发明授权

US08754085B2 Pyrido[2,3-b]pyrazine compounds useful as IP receptor agonist 有权
标题翻译：可用作IP受体激动剂的吡啶并[2,3-b]吡嗪化合物
公开(公告)号：US08754085B2
公开(公告)日：2014-06-17
申请号：US13388819
申请日：2011-07-14
申请人： Steven John Charlton , Catherine Leblanc , Stephen Carl McKeown
发明人： Steven John Charlton , Catherine Leblanc , Stephen Carl McKeown
IPC分类号： A61K31/495
CPC分类号： A61K31/4985 , A61K31/4375 , C07D471/04
摘要： The present invention provides heterocyclic derivatives which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Pharmaceutical compositions comprising such derivatives are also encompassed. Examples of compounds of the invention include the compounds according to Formula Ia, or a pharmaceutically acceptable salt thereof, and the compounds of the examples.
摘要翻译：本发明提供活化IP受体的杂环衍生物。激活IP受体信号通路可用于治疗多种形式的PAH，肺纤维化，并在动物模型和患者的各种器官的纤维化病症中发挥有益作用。还包括包含这些衍生物的药物组合物。本发明化合物的实例包括根据式Ia的化合物或其药学上可接受的盐，以及实施例的化合物。

7. 发明申请

US20140050736A1 CHEMOKINE RECEPTOR BINDING POLYPEPTIDES 审中-公开
标题翻译：化合物受体结合多肽
公开(公告)号：US20140050736A1
公开(公告)日：2014-02-20
申请号：US14065679
申请日：2013-10-29
申请人： Michelle BRADLEY , Zarin BROWN , Steven John CHARLTON , Karen CROMIE , Bruno DOMBRECHT , Soren STEFFENSEN , Gino Anselmus VAN HEEKE
发明人： Michelle BRADLEY , Zarin BROWN , Steven John CHARLTON , Karen CROMIE , Bruno DOMBRECHT , Soren STEFFENSEN , Gino Anselmus VAN HEEKE
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/569 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.
摘要翻译：本发明涉及针对或特异性结合趋化因子受体CXCR2的多肽，特别涉及能够调节CXCR2信号转导的多肽。本发明还涉及能够表达本发明多肽的核酸，载体和宿主细胞，包含多肽的药物组合物以及用于治疗涉及CXCR2异常功能的疾病的所述多肽和组合物的用途。

8. 发明申请

US20140243346A1 IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译： IP受体激动剂杂环化合物
公开(公告)号：US20140243346A1
公开(公告)日：2014-08-28
申请号：US14265943
申请日：2014-04-30
申请人： Steven John CHARLTON , Catherine LEBLANC , Stephen Carl McKEOWN
发明人： Steven John CHARLTON , Catherine LEBLANC , Stephen Carl McKEOWN
IPC分类号： A61K31/4985 , A61K31/4375 , C07D471/04
CPC分类号： A61K31/4985 , A61K31/4375 , C07D471/04
摘要： The present invention provides heterocyclic derivatives which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Pharmaceutical compositions comprising such derivatives are also encompassed. Examples of compounds of the invention include the compounds according to Formula Ia, or a pharmaceutically acceptable salt thereof, and the compounds of the examples.
摘要翻译：本发明提供活化IP受体的杂环衍生物。激活IP受体信号通路可用于治疗多种形式的PAH，肺纤维化，并在动物模型和患者的各种器官的纤维化病症中发挥有益作用。还包括包含这些衍生物的药物组合物。本发明化合物的实例包括根据式Ia的化合物或其药学上可接受的盐，以及实施例的化合物。

9. 发明授权

US08591896B2 Chemokine receptor binding polypeptides 有权
公开(公告)号：US08591896B2
公开(公告)日：2013-11-26
申请号：US13290175
申请日：2011-11-07
申请人： Michelle Bradley , Zarin Brown , Steven John Charlton , Karen Cromie , Bruno Dombrecht , Soren Steffensen , Gino Van Heeke
发明人： Michelle Bradley , Zarin Brown , Steven John Charlton , Karen Cromie , Bruno Dombrecht , Soren Steffensen , Gino Van Heeke
IPC分类号： A61K39/395 , C07K16/46 , C12N15/13 , C12N15/62 , C12N5/10
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/569 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.

10. 发明申请

US20170101476A1 CHEMOKINE RECEPTOR BINDING POLYPEPTIDES 审中-公开
公开(公告)号：US20170101476A1
公开(公告)日：2017-04-13
申请号：US14751417
申请日：2015-06-26
申请人： Michelle BRADLEY , Zarin BROWN , Steven John CHARLTON , Karen CROMIE , Bruno DOMBRECHT , Soren STEFFENSEN , Gino Anselmus VAN HEEKE
发明人： Michelle BRADLEY , Zarin BROWN , Steven John CHARLTON , Karen CROMIE , Bruno DOMBRECHT , Soren STEFFENSEN , Gino Anselmus VAN HEEKE
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/569 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.

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