专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008117061A3 TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS 审中-公开
标题翻译：四氢叶酸作为肿瘤生长抑制剂
公开(公告)号：WO2008117061A3
公开(公告)日：2009-05-14
申请号：PCT/GB2008001072
申请日：2008-03-27
申请人： STERIX LTD , JOURDAN FABRICE , KIMBERLEY MERIEL , LEESE MATTHEW , POTTER BARRY VICTOR LLOYD , PUROHIT ATUL , REED MICHAEL JOHN
发明人： JOURDAN FABRICE , KIMBERLEY MERIEL , LEESE MATTHEW , POTTER BARRY VICTOR LLOYD , PUROHIT ATUL , REED MICHAEL JOHN
IPC分类号： A61K31/40 , A61K31/403 , A61K31/435 , A61K31/47 , A61K31/55 , A61P35/00
CPC分类号： A61K31/40 , A61K31/403 , A61K31/435 , A61K31/47 , A61K31/55
摘要： The present invention provides a compound of Formula (I) or Formula (Il) wherein A is selected from CR10R11, -S(=O)2-, -NR12-,and C=O, wherein R10 and R11 independently selected from H, -OH, hydrocarbyl, -CN, -NO2, and halogens, R12 is selected from H and hydrocarbyl; B is selected from (CR13R14)1-3, C=O, CR15R16C=O, -S(=O)2-, -NR17- and -NR18-C(=O)-, wherein each of R13, R14, R15 and R16 is independently selected from H, -OH, hydrocarbyl, -CN, -NO2, and halogens, R17 and R18 are independently selected from H and hydrocarbyl; R1 is selected from OH, O-hydrocarbyl, O-heterohydrocarbyl, -SO2-hydrocarbyl, -CH=CH2, halogen, -OSO2NR19R20, -C(=O)-NR21R22, -NR23-C(=O)H and -NR35R36; wherein each of R19, R20, R21, R22, R23, R35 and R36 is independently is selected from H and hydrocarbyl; R2 is selected from H, -O-hydrocarbyl, -S-hydrocarbyl, hydrocarbyl, -CN, -NO2, and halogens, R3 is selected from Formula (A), Formula (B), Formula (C), Formula (D) wherein each of R4, R5, R6, R7 and R8 is independently selected from H, -OH, hydrocarbyl, -O-hydrocarbyl, -COOH or an ester thereof, halocarbyl, -O-halocarbyl, acyl, -O-acyl, -NR29-acyl, -O-SO2NR19R20, -NR30R31, -NR32SO2R33, -CN, -NO2, and halogens, R9 is selected from H and hydrocarbyl, and each R29 to R33 is independently selected from H and hydrocarbyl; and wherein two or more of R4, R5, R6, R7, R8 and R9 may together form a ring; wherein when R1 is OH and R3 is of Formula (D), (i) at least one of R4, R5, R6, R7 and R8 is independently selected from halocarbyl, -O-halocarbyl, -O-acyl, -NR29-acyl, -O- SO2NR19R20, -NR30R31, -NR32SO2R33, -CN, and halogens, or (ii) two or more of R4, R5, R6, R7 and R8 together form a ring, or (iii) at least three of R4, R5, R6, R7 and R8 are independently selected from -OH, hydrocarbyl, -O-hydrocarbyl, halocarbyl, -O-halocarbyl, -O-acyl, -NR29-acyl, -O-SO2NR19R20, -NR30R31, -NR32SO2R33, -CN, -NO2, and halogens; wherein h is an optional bond, wherein G is CR24R25, wherein R24 and R25 independently selected from H, -OH, hydrocarbyl, -CN, -NO2, and halogens, or wherein when h is present G is CR24, wherein R24 is selected from H, -OH, hydrocarbyl, -CN, -NO2, and halogens; n is 0, 1 or 2, each D is independently selected from O, NR26 and CR27R28, wherein each R26 is independently selected from H and hydrocarbyl; and each R27 and R28 is independently selected from H, -OH, hydrocarbyl, -CN, -NO2, and halogens.
摘要翻译：本发明提供式（I）或式（II）的化合物，其中A选自CR 10 R 11，-S（= O）2 - ， - NR 12 - 和C = O，其中R 10和R 11独立地选自H， -OH，烃基，-CN，-NO 2和卤素，R 12选自H和烃基; B选自（CR13R14）1-3，C = O，CR15R16C = O，-S（= O）2-，-NR17-和-NR18-C（= O） - ，其中R13，R14，R15 并且R 16独立地选自H，-OH，烃基，-CN，-NO 2和卤素，R 17和R 18独立地选自H和烃基; R 1选自OH，O-烃基，O-杂烃基，-SO 2 - 烃基，-CH = CH 2，卤素，-OSO 2 NR 19 R 20，-C（= O）-NR 21 R 22，-NR 23 -C（= O）H和-NR 35 R 36 ; 其中R19，R20，R21，R22，R23，R35和R36各自独立地选自H和烃基; R2选自H，-O-烃基，-S-烃基，烃基，-CN，-NO 2和卤素，R 3选自式（A），式（B），式（C），式（D）其中R4，R5，R6，R7和R8各自独立地选自H，-OH，烃基，-O-烃基，-COOH或其酯，卤代羰基，-O-卤代羰基，酰基，-O-酰基， NR29-酰基，-O-SO2NR19R20，-NR30R31，-NR32SO2R33，-CN，-NO2和卤素，R9选自H和烃基，每个R29至R33独立地选自H和烃基; 并且其中R4，R5，R6，R7，R8和R9中的两个或更多个可以一起形成环; 其中当R 1是OH且R 3具有式（D）时，（i）R 4，R 5，R 6，R 7和R 8中的至少一个独立地选自卤代烃基，-O-卤代羰基，-O-酰基，-NR 29 - ，-O-SO 2 NR 19 R 20，-NR 30 R 31，-NR 32 SO 2 R 33，-CN和卤素，或（ii）R4，R5，R6，R7和R8中的两个或更多个一起形成环，或（iii） R5，R6，R7和R8独立地选自-OH，烃基，-O-烃基，卤代烃基，-O-卤代烃基，-O-酰基，-NR29-酰基，-O-SO2NR19R20，-NR30R31，-NR32SO2R33， CN，-NO 2和卤素; 其中h是任选的键，其中G是CR 24 R 25，其中R 24和R 25独立地选自H，-OH，烃基，-CN，-NO 2和卤素，或其中当存在h时，G是CR 24，其中R 24选自 H，-OH，烃基，-CN，-NO 2和卤素; n是0,1或2，每个D独立地选自O，NR 26和CR 27 R 28，其中每个R 26独立地选自H和烃基; 并且每个R 27和R 28独立地选自H，-OH，烃基，-CN，-NO 2和卤素。

2. 发明专利

JP2009215317A Steroid sulfamate, method for producing it, and use thereof 审中-公开
标题翻译：甾体磺酸盐，其生产方法及其用途
公开(公告)号：JP2009215317A
公开(公告)日：2009-09-24
申请号：JP2009154427
申请日：2009-06-29
申请人： Sterix Ltd , ステリックスリミテッド
发明人： KASCH HELMUT , SCHUHMANN WINFRIED , ROEMER JOHANNES , STEINBACH JOERG
IPC分类号： A61K51/00 , C07J31/00 , A61K31/565 , A61K31/58 , A61P5/30 , A61P15/12 , A61P35/00 , A61P43/00 , C07J41/00 , C07J53/00 , C07J63/00 , C07J71/00 , C07J73/00
CPC分类号： C07J53/004 , C07J63/008 , C07J71/0031 , Y02P20/55
摘要： PROBLEM TO BE SOLVED: To provide a sulfatase inhibitor which needs a compound limiting or preventing the usage of estrogen in hormone-dependent tumor, and does not have an estrogenic active component.
SOLUTION: The invention relates to a new estratriene expressed by general formula (I) which contains several sulfamoyloxy groups per molecule (m=1-5). They are produced by reacting an appropriate steroid alcohol with sulfamoyl chloride or n-alkyl chloride or alkanoylsulfamoyl chloride in the presence of a buffer or a base. The compounds of formula (I) are characterized by high sulfatase activity and are therefore suitable for the treatment of diseases responding to sulfatase inhibition. The high target specificity of the inventive compounds in relation to sulfatase and estrogen transcription assays enable the compounds, which are provided with a radiolabel e.g. [
18 F] fluorine instead of F, to be used as potential markers in tumor diagnosis.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种硫酸酯酶抑制剂，其需要化合物限制或防止激素依赖性肿瘤中雌激素的使用，并且不具有雌激素活性成分。解决方案：本发明涉及由通式（I）表示的新的雌三烯，其每分子含有若干氨磺酰氧基（m = 1-5）。它们通过在缓冲液或碱的存在下使适当的类固醇与氨磺酰氯或正烷基氯或烷酰基氨磺酰氯反应来制备。式（I）化合物的特征在于高硫酸酯酶活性，因此适用于治疗对硫酸酯酶抑制作用的疾病。本发明化合物相对于硫酸酯酶和雌激素转录测定的高目标特异性使得能够提供放射性标记的化合物。 [SP 18] F]氟代替F，用作肿瘤诊断中的潜在标志物。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2003176297A STEROID SULFATASE INHIBITOR 审中-公开
公开(公告)号：JP2003176297A
公开(公告)日：2003-06-24
申请号：JP2002355920
申请日：2002-12-06
申请人： STERIX LTD
发明人： REED MICHAEL JOHN , POTTER BARRY VICTOR LLOYD
IPC分类号： A61K31/565 , A61K31/00 , A61K31/145 , A61K31/56 , A61K31/566 , A61K31/567 , A61K31/5685 , A61P5/30 , A61P5/32 , A61P5/36 , A61P35/00 , A61P43/00 , C07C307/02 , C07J1/00 , C07J31/00 , C07J41/00 , C07J43/00 , C12N9/16
摘要： PROBLEM TO BE SOLVED: To provide a pharmaceutical composition which is effective on the treatments of estrogen-dependent tumors. SOLUTION: This pharmaceutical composition comprises a pharmaceutically acceptable carrier or diluent and a compound which contains a ring system and a sulfamate group of the formula [R 1 and R 2 are each independently selected from H, an alkyl, an alkenyl, a cycloalkyl, or an aryl, provided that at least one of R 1 and R 2 is H; the compound is an inhibitor of an enzyme (E.C.3.1.6.2) having a steroid sulfatase activity; and if the sulfamate group of the compound is replaced with a sulfate group to form a sulfate compound and incubated with a steroid sulfatase enzyme (E.C.3.1.6.2) at a pH 7.4 and 37°C, it provides a K m value of less than 50 μM. COPYRIGHT: (C)2003,JPO

4. 发明专利

JP2014040488A 1,2,4-triazole derivative including sulfamate group as aromatase inhibitor 审中-公开
标题翻译： 1,2,4-三唑衍生物，其中包含磺酰胺类作为芳香酶抑制剂
公开(公告)号：JP2014040488A
公开(公告)日：2014-03-06
申请号：JP2013249821
申请日：2013-12-03
申请人： Sterix Ltd , ステリックスリミテッド
发明人： POTTER BARRY VICTOR LLOYD , WOO LOK WAI LAWRENCE , PUROHIT ATUL , READ MICHAEL J , BUBERT CHRISTIAN , SUTCLIFFE OLIVER BROOK
IPC分类号： C07D249/08 , C12Q1/02 , A61K31/4196 , A61K31/423 , A61K31/424 , A61K31/428 , A61K45/00 , A61P1/02 , A61P1/04 , A61P1/14 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/00 , A61P9/10 , A61P11/02 , A61P11/06 , A61P13/00 , A61P13/12 , A61P15/00 , A61P15/06 , A61P15/18 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P21/04 , A61P25/00 , A61P25/06 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D249/14 , C07D413/12 , C07D417/12 , C07D521/00 , C12Q1/34
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D413/12 , C07D417/12
摘要： PROBLEM TO BE SOLVED: To provide a new compound appropriate for inhibiting the steroid sulfatase activity and the aromatase activity.SOLUTION: A compound represented by formula (I) is provided, where each T represents a bond with one of H, hydrocarbyl, -F-R- and D, E, P, or Q, or forms into a ring together with one of P and Q; Z is a proper atom having a valence of m; D, E, and F are proper linker groups independent from each other, and for Z of nitrogen, E is other than CHand C=O; P, Q, and R are ring systems independent from each other; and at least Q includes a sulfamate group.
摘要翻译：要解决的问题：提供适合于抑制类固醇硫酸酯酶活性和芳香酶活性的新化合物。溶液：提供由式（I）表示的化合物，其中每个T表示与H，烃基，-FR之一的键 - 和D，E，P或Q，或与P和Q之一形成环; Z是具有m价的适当原子; D，E和F是相互独立的适当的连接基团，对于氮的Z，E不是CH且C = O; P，Q和R是彼此独立的环系; 并且至少Q包括氨基磺酸酯基团。

5. 发明专利

JP2010195819A 1,2,4-triazole derivative containing sulfamate group as aromatase inhibitor 有权
标题翻译：含有磺酰胺的1,2,4-三唑衍生物作为芳香酶抑制剂
公开(公告)号：JP2010195819A
公开(公告)日：2010-09-09
申请号：JP2010108842
申请日：2010-05-10
申请人： Sterix Ltd , ステリックスリミテッド
发明人： POTTER BARRY VICTOR LLOYD , WOO LOK WAI LAWRENCE , PUROHIT ATUL , READ MICHAEL J , BUBERT CHRISTIAN , SUTCLIFFE OLIVER BROOK
IPC分类号： C07D249/08 , C12Q1/02 , A61K31/4196 , A61K31/423 , A61K31/424 , A61K31/428 , A61K45/00 , A61P1/02 , A61P1/04 , A61P1/14 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/00 , A61P9/10 , A61P11/02 , A61P11/06 , A61P13/00 , A61P13/12 , A61P15/00 , A61P15/06 , A61P15/18 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P21/04 , A61P25/00 , A61P25/06 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D249/14 , C07D413/12 , C07D417/12 , C07D521/00 , C12Q1/34
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D413/12 , C07D417/12
摘要： PROBLEM TO BE SOLVED: To provide a new compound suitable for the inhibition of steroidsulfatase activity and aromatase activity. SOLUTION: This compound expressed by formula I [wherein, Ts are each H, hydrocarbyl, -F-R- or a bond with one of D, E, P or Q, or forms a ring together with one of P and Q; Z is a suitable atom having m-atomic valences; D, E and F are each independently a suitable linker group, and in the case that the Z is nitrogen, E is other than CH 2 and C=O; P, Q and R are each independently a ring system; and at least Q contains a sulfamate group] is provided. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供适合于抑制类固醇硫酸酯酶活性和芳香酶活性的新化合物。解决方案：由式I表示的化合物[其中，Ts各自为H，烃基，-F-R-或与D，E，P或Q之一的键，或与P和Q之一形成环; Z是具有m原子价的合适原子; D，E和F各自独立地为合适的连接基团，并且在Z为氮的情况下，E不是CH 2，且C = O; P，Q和R各自独立地是环系; 并且至少Q含有氨基磺酸酯基]。版权所有（C）2010，JPO＆INPIT

6. 发明申请

WO2009106817A3 1 IBETA- HYDROXYSTEROID DEHYDROGENASE INHIBITORS 审中-公开
标题翻译： 1 IBETA-羟基甾体脱氢酶抑制剂
公开(公告)号：WO2009106817A3
公开(公告)日：2009-12-03
申请号：PCT/GB2009000518
申请日：2009-02-25
申请人： STERIX LTD , VICKER NIGEL , SU XIANGDONG , PRADAUX-CAGGIANO FABIENNE , POTTER BARRY VICTOR LLOYD
发明人： VICKER NIGEL , SU XIANGDONG , PRADAUX-CAGGIANO FABIENNE , POTTER BARRY VICTOR LLOYD
IPC分类号： C07D213/30 , C07D213/32 , C07D213/34 , C07D213/50 , C07D213/61 , C07D213/65 , C07D213/68 , C07D213/70 , C07D213/71 , C07D213/80 , C07D213/82 , C07D213/89 , C07D233/84 , C07D235/28 , C07D249/12
CPC分类号： C07D233/84 , C07D213/30 , C07D213/32 , C07D213/34 , C07D213/50 , C07D213/61 , C07D213/65 , C07D213/68 , C07D213/70 , C07D213/71 , C07D213/80 , C07D213/82 , C07D213/89 , C07D235/28 , C07D249/12 , C07D257/04 , C07D285/125 , C07D285/135 , C07D405/04 , C07D409/04
摘要： There is provided a compound of formula R1-CO-X-Y-Z-R2 wherein X and Z are each optional groups independently selected from saturated or unsaturated carbon chains having a length of 1 to 3 carbons; Y is SO, S, SO2, CH=CH, CH2CH2 or O; R1 is selected from the following groups (A) wherein - - - denotes the point of attachment; R2 is a heteroaryl group comprising an optionally substituted 5 or 6 membered ring, which ring contains only carbon and at least one nitrogen, or contains only carbon, and at least two nitrogens and at least one sulphur; and wherein (i) when R1 is group (B) and -CO-X-Y-Z- is CO-CH2-SO, CO-CH2-S, or CO-CH2-SO2, R2 is other than group (C) and; (ii) when R1 is group (D) and -CO-X-Y-Z- is -CO-CH2-O-, R2 is other than group (E).
摘要翻译：提供式R1-CO-X-Y-Z-R2的化合物，其中X和Z各自是任选的独立地选自具有1至3个碳原子的饱和或不饱和碳链的基团; Y是SO，S，SO 2，CH = CH，CH 2 CH 2或O; R1选自以下组（A），其中 - - - 表示连接点; R2是包含任选取代的5或6元环的杂芳基，该环仅含有碳和至少一个氮，或仅含有碳，以及至少两个氮和至少一个硫; 并且其中（i）当R 1为基团（B）且-CO-X-Y-Z-为CO-CH 2 SO，CO-CH 2 -S或CO-CH 2 -SO 2时，R 2为（C）（ⅱ）当R 1为基团（D）且-CO-X-Y-Z-为-CO-CH 2 -O-时，R 2为（E）基团。

7. 发明申请

WO2004085457A3 17BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS 审中-公开
标题翻译： 17BETA-HYDROXYSTERIDID DEHYDROGENASE抑制剂
公开(公告)号：WO2004085457A3
公开(公告)日：2005-02-03
申请号：PCT/GB2004001234
申请日：2004-03-22
申请人： STERIX LTD , VICKER NIGEL , LAWRENCE HARSHANI RITHMA RUCHI , ALLAN GILLIAN MARGARET , BUBERT CHRISTIAN , FISCHER DELPHINE SOPHIE MARION , PUROHIT ALAN , REED MICHAEL JOHN , POTTER BARRY VICTOR LLOYD
发明人： VICKER NIGEL , LAWRENCE HARSHANI RITHMA RUCHI , ALLAN GILLIAN MARGARET , BUBERT CHRISTIAN , FISCHER DELPHINE SOPHIE MARION , PUROHIT ALAN , REED MICHAEL JOHN , POTTER BARRY VICTOR LLOYD
IPC分类号： A61K31/56 , A61K31/566 , C07J20060101 , C07J41/00 , C07J71/00
CPC分类号： C07J71/00 , C07J41/00
摘要： There is provided a compound of Formula (I) wherein (I) R is a selected from (i) an alkyloxyalkyl group (ii) a nitrile group, and wherein R is capable of forming a hydrogen bond (iii) alkylaryl group, wherein the aryl group is substituted by other than a C1-10 group (iv) alkenylaryl group wherein the aryl group is substituted (v) alkyiheteroaryl group, wherein when heteroaryl group comprises only C and N in the ring, the aryl group is substituted by other than a methyl group (vi) alkenylheteroaryl group, (vii) =N-O-alkyl or =N-O-H group (viii) branched alkenyl (ix) alkyl-alcohol group (x) amide or alkylamide wherein (a) the alkyl of the alkylamide is - CH2- or -CH2CH2-, (b) the amide is di-substituted and/or (c) the amide is substituted with at least one of a I kyl heterocycle group, al ke nyl heterocycle group, alkylheteroaryl group, alkenylheteroaryl group, heteroaryl group, alkylamine group, alkyloxyalkyl group, alkylaryl group, straight or branched alkyl group, (xi) -CHO so that R, together with R3 provide the enol tautomer (a); OR R1 together with R form (xii) a pyrazole wherein (a) R is =N-0-alkyl or =N-0-H group, (b) the pyrazole is substituted with one of alkyl-OH group, alkyl ester group, alkyloxyalkyl. group, branched alkyl group, and an amide and/or (c) the 2 position is substituted with a group selected from -OH and -0-hydrocarbyl (xiii) a heteroaryl ring to provide a compound of the formula (b); (II) R is selected from groups capable of forming a hydrogen bond, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group and a sulphonamide group; and (III) R is selected from -OH, =O, or a -C(=O)- mimetic.
摘要翻译：提供式（I）的化合物，其中（I）R 1选自（i）烷氧基烷基（ii）腈基，并且其中R 2能够形成氢键（iii ）烷基芳基，其中芳基被除了其中芳基被取代的（C）芳基取代的（C 1 -C 6）烯基芳基以外的其它芳基取代;（ⅴ）芳基杂芳基，其中当杂芳基仅在环中仅包含C和N时，芳基（vii）= NO-烷基或= NOH基（viii）支链烯基（ix）烷基醇基（x）酰胺或烷基酰胺，其中（a）烷基的烷基酰胺是-CH 2 - 或-CH 2 CH 2 - ，（b）酰胺是二取代的，和/或（c）酰胺被I烷基杂环基，烯基杂环基，烷基杂芳基中的至少一个取代，烯基杂芳基，杂芳基，烷基胺基，烷氧基烷基，烷基芳基，直链或支链烷基，（xi）-CHO so t 与R 3一起提供烯醇互变异构体（a）; 或R 1与R 3一起形成（xii）吡唑，其中（a）R 4是= N-O-烷基或= N-O-H基，（b）吡唑被烷基 - OH基，烷基酯基，烷氧基烷基。基团，支链烷基和酰胺和/或（c）2位被选自-OH和-O-烃基（xiii）杂芳基环的基团取代，以提供式（b）的化合物; （II）R 2选自能够形成氢键的基团，氨基磺酸酯基团，膦酸酯基团，硫代膦酸酯基团，磺酸酯基团和磺酰胺基团; 和（III）R 3选自-OH，= O或-C（= O） - 模拟物。

8. 发明申请

WO0066095A3 USE OF ESTRONE DERIVATIVES AS ANTITUMOUR AGENTS 审中-公开
标题翻译：使用ESTRONE衍生物作为抗菌剂
公开(公告)号：WO0066095A3
公开(公告)日：2001-08-09
申请号：PCT/GB0001661
申请日：2000-04-28
申请人： STERIX LTD , REED MICHAEL JOHN , POTTER BARRY VICTOR LLOYD
发明人： REED MICHAEL JOHN , POTTER BARRY VICTOR LLOYD
IPC分类号： A61K31/352 , A61K31/565 , A61P35/00 , C07J1/00
CPC分类号： A61K31/566 , A61K31/352 , A61K31/565
摘要： There is provided use of a cyclic compound or a pharmaceutically active salt thereof in the manufacture of a medicament to prevent and/or inhibit and/or arrest cell cycling, wherein the cyclic compound comprises at least one ring, wherein Group I and Group II, independently of each other, are attached to a ring of the cyclic compound; wherein Group I is a hydrocarbyl or an oxyhydrocarbyl group; and wherein Group II is a group of formula (I), X is P or S; when X is P, Y is =O or S, Z is -OH and R is hydrocarbyl or H; when X is S, Y is =O, Z is =O, and R is hydrocarbyl or N(R1)(R2), wherein each of R1 and R2 is independently selected from H or a hydrocarbyl group.
摘要翻译：提供环状化合物或其药物活性盐在制备用于预防和/或抑制和/或阻止细胞循环的药物中的用途，其中所述环状化合物包含至少一个环，其中第I组和第II组，彼此独立地连接到环状化合物的环上; 其中组I是烃基或氧代烃基; 并且其中II族是式（I）的基团，X是P或S; 当X为P时，Y为= O或S，Z为-OH，R为烃基或H; 当X为S时，Y为= O，Z为= O，R为烃基或N（R1）（R2），其中R1和R2各自独立地选自H或烃基。

9. 发明申请

WO2008065428A3 STEROID SULPHATASE INHIBITORS FOR TREATING HORMONE DEPENDENT CANCER 审中-公开
标题翻译：用于治疗依赖于雄激素的癌症的甾体硫酸酯酶抑制剂
公开(公告)号：WO2008065428A3
公开(公告)日：2008-07-31
申请号：PCT/GB2007004612
申请日：2007-11-30
申请人： STERIX LTD , REED MICHAEL JOHN , PUROHIT ATUL , FOSTER PAUL ALEXANDER , NEWMAN SIMON PAUL , WOO LOK WAI LAWRENCE , POTTER BARRY VICTOR LLOYD
发明人： REED MICHAEL JOHN , PUROHIT ATUL , FOSTER PAUL ALEXANDER , NEWMAN SIMON PAUL , WOO LOK WAI LAWRENCE , POTTER BARRY VICTOR LLOYD
IPC分类号： A61K31/37 , A61P35/00
CPC分类号： A61K31/37
摘要： There is provided use of a compound capable of inhibiting a steroid sulphatase enzyme (E.C.3.1.6.2) in the manufacture of a medicament for the treatment of cancer, wherein the cancer is of a type in which the cancer cells overexpress aromatase enzyme.
摘要翻译：提供能够抑制类固醇硫酸酯酶（E.C.3.1.6.2）的化合物在制备用于治疗癌症的药物中的用途，其中癌症是癌细胞过度表达芳香酶的类型。

10. 发明申请

WO02072084A2 GLYCYRRHETINIC ACID DERIVATIVES, PROGESTERONE AND PROGESTERONE DERIVATIVES AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT TO INHIBIT 11BETA-HYDROXYSTEROID DEHYDROGENASE ACTIVITY 审中-公开
标题翻译：甘氨酸衍生物，前列腺素和孕酮衍生物及其用于制造药物以抑制11BETA-羟基脱氢酶脱氢酶活性的用途
公开(公告)号：WO02072084A2
公开(公告)日：2002-09-19
申请号：PCT/GB0201060
申请日：2002-03-07
申请人： STERIX LTD , POTTER BARRY VICTOR LLOYD , PUROHIT ATUL , REED MICHAEL JOHN , VICKER NIGEL
发明人： POTTER BARRY VICTOR LLOYD , PUROHIT ATUL , REED MICHAEL JOHN , VICKER NIGEL
IPC分类号： A61K31/19 , A61K31/57 , A61P5/38 , A61P5/44 , A61P5/46 , C07D213/40 , C07D295/13 , C07D295/182 , C07J7/00 , C07J9/00 , C07J51/00 , A61K31/16 , A61K31/165 , A61K31/215 , A61K31/4402 , A61K31/5375 , A61K31/5685 , C07C62/32 , C07C62/34 , C07C62/38 , C07C69/753 , C07C235/40
CPC分类号： C07D213/40 , A61K31/19 , A61K31/57 , C07D295/13 , C07D295/182 , C07J7/00 , C07J9/00 , C07J51/00
摘要： The present invention provides use of a compound in the manufacture of a medicament to inhibit 11 beta -HSD activity, wherein the compound is selected from glycyrrhetinic acid derivatives, progesterone and progesterone derivatives.
摘要翻译：本发明提供化合物在制备抑制11β-HSD活性的药物中的用途，其中该化合物选自甘草次酸衍生物，孕酮和孕酮衍生物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式