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1. 发明申请

US20070265323A1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS 审中-公开
标题翻译：用于治疗代谢性疾病的化合物
公开(公告)号：US20070265323A1
公开(公告)日：2007-11-15
申请号：US11772556
申请日：2007-07-02
申请人： Shalini Sharma , Reid von Borstel , Kirvin Hodge , Michael Bamat , Stephen Wolpe
发明人： Shalini Sharma , Reid von Borstel , Kirvin Hodge , Michael Bamat , Stephen Wolpe
IPC分类号： A61K31/41 , A61K31/192 , A61P3/10 , A61P7/12 , A61K31/216
CPC分类号： C07B41/12 , A01N37/10 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/235 , A61K31/41 , A61K31/4196 , A61K31/44 , A61K31/445 , A61K31/535 , A61K31/54 , C07C59/68 , C07C59/90 , C07C67/47 , C07C69/738 , C07C209/68 , C07C217/22 , C07C233/31 , C07C233/47 , C07C235/78 , C07C235/84 , C07C259/06 , C07C323/52 , C07C323/59 , C07C2601/02 , C07C2601/04 , C07C2602/04 , C07D213/30 , C07D213/55 , C07D249/10 , C07D249/12 , C07D257/04 , C07D333/16 , C07D333/24 , Y10S514/866
摘要： Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
摘要翻译：公开了可用于治疗各种代谢紊乱（例如胰岛素抵抗综合征，糖尿病，高脂血症，脂肪肝疾病，恶病质，肥胖症，动脉粥样硬化和动脉硬化）的化合物。

2. 发明申请

US20050043218A1 Inhibitor of stem cell proliferation and uses thereof 审中-公开
标题翻译：干细胞增殖抑制剂及其用途
公开(公告)号：US20050043218A1
公开(公告)日：2005-02-24
申请号：US10897005
申请日：2004-07-23
申请人： Irena Tsyrlova , Stephen Wolpe
发明人： Irena Tsyrlova , Stephen Wolpe
IPC分类号： A61K38/00 , A61K38/42 , C07K14/47 , C07K14/475 , C07K14/52 , C07K14/805
CPC分类号： C07K14/805 , A61K38/42 , C07K14/4703 , C07K14/475 , C07K14/52 , A61K2300/00
摘要： Disclosed and claimed are methods for the isolation and use of stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery. Also disclosed and claimed are the inhibitors of stem cell proliferation.
摘要翻译：公开和要求的是用于分离和使用干细胞抑制因子以调节异常干细胞周期和加速化疗后外周血细胞恢复的方法。还公开并要求保护的是干细胞增殖的抑制剂。

3. 发明申请

US20080015209A1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS 审中-公开
标题翻译：用于治疗代谢性疾病的化合物
公开(公告)号：US20080015209A1
公开(公告)日：2008-01-17
申请号：US11841508
申请日：2007-08-20
申请人： Shalini Sharma , Reid von Borstel , Kirvin Hodge , Michael Bamat , Stephen Wolpe
发明人： Shalini Sharma , Reid von Borstel , Kirvin Hodge , Michael Bamat , Stephen Wolpe
IPC分类号： A61K31/192 , A61K31/195 , A61K31/215 , A61K31/216 , A61K31/27 , A61K31/41 , A61K31/4196 , A61K31/44 , A61K31/4439 , A61K31/445 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10
CPC分类号： C07B41/12 , A01N37/10 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/235 , A61K31/41 , A61K31/4196 , A61K31/44 , A61K31/445 , A61K31/535 , A61K31/54 , C07C59/68 , C07C59/90 , C07C67/47 , C07C69/738 , C07C209/68 , C07C217/22 , C07C233/31 , C07C233/47 , C07C235/78 , C07C235/84 , C07C259/06 , C07C323/52 , C07C323/59 , C07C2601/02 , C07C2601/04 , C07C2602/04 , C07D213/30 , C07D213/55 , C07D249/10 , C07D249/12 , C07D257/04 , C07D333/16 , C07D333/24 , Y10S514/866
摘要： Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
摘要翻译：公开了可用于治疗各种代谢紊乱（例如胰岛素抵抗综合征，糖尿病，高脂血症，脂肪肝疾病，恶病质，肥胖症，动脉粥样硬化和动脉硬化）的化合物。

4. 发明申请

US20070105958A1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS 有权
公开(公告)号：US20070105958A1
公开(公告)日：2007-05-10
申请号：US11535779
申请日：2006-09-27
申请人： Shalini Sharma , Reid von Borstel , Kirvin Hodge , Michael Bamat , Stephen Wolpe
发明人： Shalini Sharma , Reid von Borstel , Kirvin Hodge , Michael Bamat , Stephen Wolpe
IPC分类号： A61K31/195
CPC分类号： C07B41/12 , A01N37/10 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/235 , A61K31/41 , A61K31/4196 , A61K31/44 , A61K31/445 , A61K31/535 , A61K31/54 , C07C59/68 , C07C59/90 , C07C67/47 , C07C69/738 , C07C209/68 , C07C217/22 , C07C233/31 , C07C233/47 , C07C235/78 , C07C235/84 , C07C259/06 , C07C323/52 , C07C323/59 , C07C2601/02 , C07C2601/04 , C07C2602/04 , C07D213/30 , C07D213/55 , C07D249/10 , C07D249/12 , C07D257/04 , C07D333/16 , C07D333/24 , Y10S514/866
摘要： Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.

5. 发明申请

US20060166863A1 Inhibitor and stimulator of stem cell proliferation and uses thereof 审中-公开
标题翻译：抑制剂和刺激器的干细胞增殖及其用途
公开(公告)号：US20060166863A1
公开(公告)日：2006-07-27
申请号：US11386736
申请日：2006-03-23
申请人： Stephen Wolpe , Irena Tsyrlova
发明人： Stephen Wolpe , Irena Tsyrlova
IPC分类号： A61K38/42 , C07K14/805
CPC分类号： C07K14/52 , A61K38/00 , C07K14/475 , C07K14/805
摘要： Disclosed and claimed are methods for the isolation and use of stem cell modulating factors for regulating stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery. Also disclosed and claimed are the inhibitors and stimulators of stem cell proliferation.
摘要翻译：公开和要求的是用于分离和使用干细胞调节因子以调节干细胞周期并加速化疗后外周血细胞恢复的方法。还公开并要求保护的是干细胞增殖的抑制剂和刺激剂。

6. 发明申请

US20060014784A1 Compounds for the treatment of metabolic disorders 有权
标题翻译：用于治疗代谢紊乱的化合物
公开(公告)号：US20060014784A1
公开(公告)日：2006-01-19
申请号：US10531618
申请日：2004-04-08
申请人： Kirvin Hodge , Shalini Sharma , Reid Von Borstel , Stephen Wolpe
发明人： Kirvin Hodge , Shalini Sharma , Reid Von Borstel , Stephen Wolpe
IPC分类号： A61K31/195 , A61K31/47
CPC分类号： A61K31/19 , A61K31/195 , A61K31/34 , A61K31/36 , A61K31/47
摘要： Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyper-lipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. Wherein n is 1 or 2; m is 0, 1, 2, 3 or 4; q is 0 or 1; t is 0 or 1; R2 is alkyl having from 1 to 3 carbon atoms; R3 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from: halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono-substituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and 0 and the heteroaromatic ring is covalently bound to the remainder of the compound of formula I by a ring carbon; and R1 is hydrogen or alkyl having 1 or 2 carbon atoms, provided that when m is 0 or 1, R1 is not hydrogen. Alternatively, when R1 is hydrogen, the biologically active agent can be a pharmaceutically acceptable salt of the compound of Formula I.
摘要翻译：公开了可用于治疗诸如胰岛素抵抗综合征，糖尿病，高脂血症，脂肪肝疾病，恶病质，肥胖症，动脉粥样硬化和动脉硬化的各种代谢疾病的药剂。其中n为1或2; m为0,1,2,3或4; q为0或1; t为0或1; R 2是具有1至3个碳原子的烷基; R 3是氢，卤素，具有1至3个碳原子的烷基或具有1至3个碳原子的烷氧基; A是未取代的或被1或2个选自：卤素，具有1或2个碳原子的烷基，全氟甲基，具有1或2个碳原子的烷氧基和全氟甲氧基取代的苯基; 或具有3至6个环碳原子的环烷基，其中环烷基是未取代的或一个或两个环碳独立地被甲基或乙基单取代; 或具有1或2个选自N，S和0的环杂原子的5或6元杂芳环，并且所述杂芳环通过环碳与式I化合物的其余部分共价结合; 并且R 1是氢或具有1或2个碳原子的烷基，条件是当m是0或1时，R 1不是氢。或者，当R 1是氢时，生物活性剂可以是式I化合物的药学上可接受的盐。

7. 发明申请

US20070265322A1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS 有权
公开(公告)号：US20070265322A1
公开(公告)日：2007-11-15
申请号：US11772504
申请日：2007-07-02
申请人： Shalini Sharma , Reid von Borstel , Kirvin Hodge , Michael Bamat , Stephen Wolpe
发明人： Shalini Sharma , Reid von Borstel , Kirvin Hodge , Michael Bamat , Stephen Wolpe
IPC分类号： A61K31/41 , A61K31/192 , A61P3/10 , A61P7/12 , A61K31/216
CPC分类号： C07B41/12 , A01N37/10 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/235 , A61K31/41 , A61K31/4196 , A61K31/44 , A61K31/445 , A61K31/535 , A61K31/54 , C07C59/68 , C07C59/90 , C07C67/47 , C07C69/738 , C07C209/68 , C07C217/22 , C07C233/31 , C07C233/47 , C07C235/78 , C07C235/84 , C07C259/06 , C07C323/52 , C07C323/59 , C07C2601/02 , C07C2601/04 , C07C2602/04 , C07D213/30 , C07D213/55 , C07D249/10 , C07D249/12 , C07D257/04 , C07D333/16 , C07D333/24 , Y10S514/866
摘要： Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.

8. 发明申请

US20060035970A1 Compounds for the treatment of metabolic disorders 失效
公开(公告)号：US20060035970A1
公开(公告)日：2006-02-16
申请号：US10532690
申请日：2003-10-28
申请人： Kirvin Hodge , Shalini Sharma , Reid Von Borstel , Stephen Wolpe
发明人： Kirvin Hodge , Shalini Sharma , Reid Von Borstel , Stephen Wolpe
IPC分类号： A61K31/235 , A61K31/192
CPC分类号： A61K31/235 , A61K31/192 , A61K31/216 , Y10S514/866
摘要： Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.

9. 发明申请

US20070249696A1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS 审中-公开
公开(公告)号：US20070249696A1
公开(公告)日：2007-10-25
申请号：US11772501
申请日：2007-07-02
申请人： Shalini Sharma , Reid von Borstel , Kirvin Hodge , Michael Bamat , Stephen Wolpe
发明人： Shalini Sharma , Reid von Borstel , Kirvin Hodge , Michael Bamat , Stephen Wolpe
IPC分类号： A61K31/19 , A61K31/41 , A61P3/10
CPC分类号： C07B41/12 , A01N37/10 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/235 , A61K31/41 , A61K31/4196 , A61K31/44 , A61K31/445 , A61K31/535 , A61K31/54 , C07C59/68 , C07C59/90 , C07C67/47 , C07C69/738 , C07C209/68 , C07C217/22 , C07C233/31 , C07C233/47 , C07C235/78 , C07C235/84 , C07C259/06 , C07C323/52 , C07C323/59 , C07C2601/02 , C07C2601/04 , C07C2602/04 , C07D213/30 , C07D213/55 , C07D249/10 , C07D249/12 , C07D257/04 , C07D333/16 , C07D333/24 , Y10S514/866
摘要： Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.

10. 发明申请

US20070244172A1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS 失效
公开(公告)号：US20070244172A1
公开(公告)日：2007-10-18
申请号：US11772560
申请日：2007-07-02
申请人： Shalini Sharma , Reid von Borstel , Kirvin Hodge , Michael Bamat , Stephen Wolpe
发明人： Shalini Sharma , Reid von Borstel , Kirvin Hodge , Michael Bamat , Stephen Wolpe
IPC分类号： A61K31/192 , A61K31/165 , A61K31/235 , A61K31/381 , A61K31/41 , A61K31/4196
CPC分类号： C07B41/12 , A01N37/10 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/235 , A61K31/41 , A61K31/4196 , A61K31/44 , A61K31/445 , A61K31/535 , A61K31/54 , C07C59/68 , C07C59/90 , C07C67/47 , C07C69/738 , C07C209/68 , C07C217/22 , C07C233/31 , C07C233/47 , C07C235/78 , C07C235/84 , C07C259/06 , C07C323/52 , C07C323/59 , C07C2601/02 , C07C2601/04 , C07C2602/04 , C07D213/30 , C07D213/55 , C07D249/10 , C07D249/12 , C07D257/04 , C07D333/16 , C07D333/24 , Y10S514/866
摘要： Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.

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