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1. 发明授权

US09597072B2 Method of preparing a packaged antimicrobial medical device 有权
公开(公告)号：US09597072B2
公开(公告)日：2017-03-21
申请号：US13449184
申请日：2012-04-17
申请人： Howard Scalzo , Jerome A. Fischer , Stephen Rothenburger , Robert Cerwin , James R. McDivitt
发明人： Howard Scalzo , Jerome A. Fischer , Stephen Rothenburger , Robert Cerwin , James R. McDivitt
IPC分类号： A61B17/04 , A61B17/06 , A61L17/00 , A61B17/00
CPC分类号： A61B17/06114 , A61B17/06166 , A61B50/00 , A61B2017/00889 , A61L17/005 , A61L2300/202 , A61L2300/404 , A61L2300/606
摘要： A method of making a packaged antimicrobial suture comprising the steps of providing a containment compartment that is substantially free of an antimicrobial agent; positioning a suture within the containment compartment, said suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; placing the containment compartment having the suture in an outer package; and subjecting the outer package, the containment compartment and the suture to time, temperature and pressure conditions sufficient to transfer an effective amount of the antimicrobial agent from the suture to the containment compartment, while retaining an effective amount of said antimicrobial agent on the suture, thereby substantially inhibiting bacterial colonization on the suture and the containment compartment.

2. 发明申请

US20120227360A1 METHOD OF PREPARING AN ANTIMICROBIAL PACKAGED MEDICAL DEVICE 有权
标题翻译：制备抗微生物包装医疗器械的方法
公开(公告)号：US20120227360A1
公开(公告)日：2012-09-13
申请号：US13419377
申请日：2012-03-13
申请人： Howard Scalzo , Jerome A. Fischer , Stephen Rothenburger , Robert Cerwin , James R. McDivitt
发明人： Howard Scalzo , Jerome A. Fischer , Stephen Rothenburger , Robert Cerwin , James R. McDivitt
IPC分类号： B65B55/22
CPC分类号： A61L17/005 , A61B17/06114 , A61B17/06166 , A61B50/00 , A61L2300/202 , A61L2300/404
摘要： A method for making an antimicrobial suture comprising the steps of positioning an antimicrobial agent source within a package comprising an inner surface, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; positioning a medical device within the package; and subjecting the package, the antimicrobial agent source and the medical device to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the medical device, thereby substantially inhibiting bacterial colonization on the medical device.
摘要翻译：一种用于制备抗微生物缝合线的方法，包括以下步骤：将抗微生物剂源定位在包含内表面的包装中，所述抗微生物剂选自卤代羟基醚，酰氧基二苯醚及其组合; 将医疗设备定位在包装内; 以及使所述包装，所述抗微生物剂源和所述医疗装置经受足以将有效量的所述抗微生物剂从所述抗微生物剂来源蒸发转移到所述医疗装置的时间，温度和压力条件，从而基本上抑制所述医疗装置上的细菌定植。

3. 发明授权

US08133437B2 Method of preparing an antimicrobial packaged medical device 有权
标题翻译：制备抗微生物包装医疗器械的方法
公开(公告)号：US08133437B2
公开(公告)日：2012-03-13
申请号：US11301364
申请日：2005-12-13
申请人： Howard Scalzo , Jerome A. Fischer , Stephen Rothenburger , Robert Cerwin , James R. McDivitt
发明人： Howard Scalzo , Jerome A. Fischer , Stephen Rothenburger , Robert Cerwin , James R. McDivitt
IPC分类号： A61L9/00 , A61L2/00 , A61L2/18 , A61L2/20 , B01J7/00 , B65B11/58 , A61B17/06 , A61L17/00
CPC分类号： A61L17/005 , A61B17/06114 , A61B17/06166 , A61B50/00 , A61L2300/202 , A61L2300/404
摘要： A method for making an antimicrobial suture comprising the steps of positioning an antimicrobial agent source within a package comprising an inner surface, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; positioning a medical device within the package; and subjecting the package, the antimicrobial agent source and the medical device to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the medical device, thereby substantially inhibiting bacterial colonization on the medical device. Alternatively, the packaged medical device is produced according to the steps of positioning a medical device within a package; exposing the package having the medical device to an antimicrobial agent source; and subjecting the package having the medical device and the antimicrobial agent source to time, temperature and pressure conditions sufficient to transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the medical device within the package, thereby substantially inhibiting bacterial colonization on the medical device.
摘要翻译：一种用于制备抗微生物缝合线的方法，包括以下步骤：将抗微生物剂源定位在包含内表面的包装中，所述抗微生物剂选自卤代羟基醚，酰氧基二苯醚及其组合; 将医疗设备定位在包装内; 以及使所述包装，所述抗微生物剂源和所述医疗装置经受足以将有效量的所述抗微生物剂从所述抗微生物剂来源蒸发转移到所述医疗装置的时间，温度和压力条件，从而基本上抑制所述医疗装置上的细菌定植。或者，根据将医疗装置定位在包装内的步骤来制造包装的医疗装置; 将具有医疗装置的包装暴露于抗微生物剂源; 以及将具有医疗装置和抗微生物剂源的包装经受足以将有效量的抗微生物剂从抗微生物剂源转移到包装内的医疗装置的时间，温度和压力条件，从而基本上抑制细菌定植医疗装置。

4. 发明申请

US20110076312A1 ANTIMICROBIAL/ANTIBACTERIAL MEDICAL DEVICES COATED WITH TRADITIONAL CHINESE MEDICINES 审中-公开
标题翻译：抗生素/抗生素医疗器械与传统中医药
公开(公告)号：US20110076312A1
公开(公告)日：2011-03-31
申请号：US12569571
申请日：2009-09-29
申请人： Henry Pokropinski, JR. , Jerome A. Fischer , Jerry Jonn , Huimin Wang , Stephen Rothenburger , Xintian Ming
发明人： Henry Pokropinski, JR. , Jerome A. Fischer , Jerry Jonn , Huimin Wang , Stephen Rothenburger , Xintian Ming
IPC分类号： A01N25/08 , A01N65/08 , A01N41/04 , C07C309/17 , A01P1/00 , A61L31/08
CPC分类号： A61L17/005 , A61L17/145 , A61L24/0015 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/404 , A61L2300/622 , Y10T428/2982
摘要： An antimicrobial composition for coating a medical device. The antimicrobial composition includes a polymeric film forming material and an antimicrobial agent comprising a material selected from the group of extract of Houttuynia cordata, sodium houttuyfonate, sodium new houttuyfonate and mixtures thereof. A medical device having an antimicrobial composition that includes a material selected from the group of extract of Houttuynia cordata, sodium houttuyfonate, sodium new houttuyfonate and mixtures thereof and a method for making same are also provided.
摘要翻译：一种用于涂覆医疗装置的抗微生物组合物。抗微生物组合物包括聚合物成膜材料和抗微生物剂，其包含选自鱼腥草提取物，氢化，，酸钠，新型ho，酸钠及其混合物的组合物。本发明提供一种具有抗微生物组合物的医疗装置，其特征在于，具有选自鱼腥草提取物，氢化，，酸钠，新ho，酸钠及其混合物的物质及其制造方法。

5. 发明申请

US20090301033A1 METHOD OF PREPARING A PACKAGED ANTIMICROBIAL MEDICAL DEVICE 有权
标题翻译：制备包装的抗微生物药物装置的方法
公开(公告)号：US20090301033A1
公开(公告)日：2009-12-10
申请号：US12417518
申请日：2009-04-02
申请人： Howard Scalzo , Jerome A. Fischer , Stephen Rothenburger , Robert Cerwin , James R. McDivitt
发明人： Howard Scalzo , Jerome A. Fischer , Stephen Rothenburger , Robert Cerwin , James R. McDivitt
IPC分类号： B65B55/00
CPC分类号： A61B17/06114 , A61B17/06166 , A61B50/00 , A61B2017/00889 , A61L17/005 , A61L2300/202 , A61L2300/404 , A61L2300/606
摘要： A method of making a packaged antimicrobial suture comprising the steps of providing a containment compartment that is substantially free of an antimicrobial agent; positioning a suture within the containment compartment, said suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; placing the containment compartment having the suture in an outer package; and subjecting the outer package, the containment compartment and the suture to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the suture to the containment compartment, while retaining an effective amount of said antimicrobial agent on the suture, thereby substantially inhibiting bacterial colonization on the suture and the containment compartment.
摘要翻译：一种制备包装的抗微生物缝合线的方法，包括以下步骤：提供基本上不含抗微生物剂的容纳隔室; 将缝合线定位在容纳隔室内，所述缝合线包括一个或多个表面，其上设置有抗微生物剂，所述抗微生物剂选自卤代羟基醚，酰氧基二苯醚及其组合; 将具有缝合线的容纳隔室放置在外包装中; 并且将外包装，容纳隔室和缝合线经受足够的时间，温度和压力条件，以将有效量的抗微生物剂从缝线转移到容纳隔室，同时将有效量的所述抗微生物剂保留在缝合线上从而基本上抑制缝合线和容纳隔室上的细菌定植。

6. 发明授权

US08668867B2 Method of preparing an antimicrobial packaged medical device 有权
标题翻译：制备抗微生物包装医疗器械的方法
公开(公告)号：US08668867B2
公开(公告)日：2014-03-11
申请号：US13419377
申请日：2012-03-13
申请人： Howard Scalzo , Jerome A. Fischer , Stephen Rothenburger , Robert Cerwin , James R. McDivitt
发明人： Howard Scalzo , Jerome A. Fischer , Stephen Rothenburger , Robert Cerwin , James R. McDivitt
IPC分类号： A61L9/00 , A61L2/00 , A61L2/18
CPC分类号： A61L17/005 , A61B17/06114 , A61B17/06166 , A61B50/00 , A61L2300/202 , A61L2300/404
摘要： A method for making an antimicrobial suture comprising the steps of positioning an antimicrobial agent source within a package comprising an inner surface, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; positioning a medical device within the package; and subjecting the package, the antimicrobial agent source and the medical device to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the medical device, thereby substantially inhibiting bacterial colonization on the medical device.
摘要翻译：一种用于制备抗微生物缝合线的方法，包括以下步骤：将抗微生物剂源定位在包含内表面的包装中，所述抗微生物剂选自卤代羟基醚，酰氧基二苯醚及其组合; 将医疗设备定位在包装内; 以及使所述包装，所述抗微生物剂源和所述医疗装置经受足以将有效量的所述抗微生物剂从所述抗微生物剂来源蒸发转移到所述医疗装置的时间，温度和压力条件，从而基本上抑制所述医疗装置上的细菌定植。

7. 发明授权

US07513093B2 Method of preparing a packaged antimicrobial medical device 有权
标题翻译：制备包装的抗微生物医疗器械的方法
公开(公告)号：US07513093B2
公开(公告)日：2009-04-07
申请号：US11301365
申请日：2005-12-13
申请人： Howard Scalzo , Jerome A. Fischer , Stephen Rothenburger , Robert Cerwin , James R. McDivitt
发明人： Howard Scalzo , Jerome A. Fischer , Stephen Rothenburger , Robert Cerwin , James R. McDivitt
IPC分类号： B65B11/58 , B65B55/00
CPC分类号： A61B17/06114 , A61B17/06166 , A61B50/00 , A61B2017/00889 , A61L17/005 , A61L2300/202 , A61L2300/404 , A61L2300/606
摘要： A method of making a packaged antimicrobial suture comprising the steps of providing a containment compartment that is substantially free of an antimicrobial agent; positioning a suture within the containment compartment, said suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; placing the containment compartment having the suture in an outer package; and subjecting the outer package, the containment compartment and the suture to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the suture to the containment compartment, while retaining an effective amount of said antimicrobial agent on the suture, thereby substantially inhibiting bacterial colonization on the suture and the containment compartment.
摘要翻译：一种制备包装的抗微生物缝合线的方法，包括以下步骤：提供基本上不含抗微生物剂的容纳隔室; 将缝合线定位在容纳隔室内，所述缝合线包括一个或多个表面，其上设置有抗微生物剂，所述抗微生物剂选自卤代羟基醚，酰氧基二苯醚及其组合; 将具有缝合线的容纳隔室放置在外包装中; 并且将外包装，容纳隔室和缝合线经受足够的时间，温度和压力条件，以将有效量的抗微生物剂从缝线转移到容纳隔室，同时将有效量的所述抗微生物剂保留在缝合线上从而基本上抑制缝合线和容纳隔室上的细菌定植。

8. 发明申请

US20070225220A1 Antimicrobial composition 有权
标题翻译：抗微生物组成
公开(公告)号：US20070225220A1
公开(公告)日：2007-09-27
申请号：US11389824
申请日：2006-03-27
申请人： Xintian Ming , Stephen Rothenburger
发明人： Xintian Ming , Stephen Rothenburger
IPC分类号： A61K38/16 , A61K31/7034 , A61K31/7048 , A61K31/496 , A61K31/4709 , A61K31/43 , A61K31/545 , A61K31/65
CPC分类号： A01N25/30 , A01N37/46 , A01N43/50 , A61K31/43 , A61K31/4709 , A61K31/496 , A61K31/545 , A61K31/65 , A61K31/7034 , A61K31/7048 , Y02A50/473 , A01N43/713 , A01N43/90 , A01N2300/00
摘要： An antimicrobial composition comprising (a) a cationic surfactant derived from the condensation of fatty acids and esterified dibasic amino acids, such as lauric arginate and (b) an antibiotic, such as of β-lactam antibiotics, polypeptides, quinolones. The composition may be used as a stand alone antimicrobial formulation, or in combination with medical articles or medical devices.
摘要翻译：一种抗微生物组合物，其包含（a）衍生自脂肪酸和酯化的二元氨基酸的缩合的阳离子表面活性剂，例如月桂酸海藻酸钠和（b）抗生素，例如β-内酰胺抗生素，多肽，喹诺酮类。组合物可以用作独立的抗微生物制剂，或与医疗制品或医疗装置组合使用。

9. 发明申请

US20060263444A1 Antimicrobial composition 审中-公开
标题翻译：抗微生物组成
公开(公告)号：US20060263444A1
公开(公告)日：2006-11-23
申请号：US11132946
申请日：2005-05-19
申请人： Xintian Ming , Stephen Rothenburger
发明人： Xintian Ming , Stephen Rothenburger
IPC分类号： A61K33/34 , A61K33/24 , A61K33/38 , A61K33/32 , A61K31/4172 , A61K31/22
CPC分类号： A01N43/50 , A01N37/44 , A01N47/44 , A01N59/16 , A01N25/30 , A01N2300/00
摘要： An antimicrobial composition comprising (a) a cationic surfactant derived from the condensation of fatty acids and esterified dibasic amino acids, such as lauric arginate, and (b) an antimicrobial metal, such as elemental silver or alloys thereof or silver compounds. The composition may be used as a stand alone antimicrobial formulation, or in combination with medical articles or medical devices.
摘要翻译：一种抗微生物组合物，其包含（a）衍生自脂肪酸和酯化的二元氨基酸的缩合的阳离子表面活性剂，例如月桂酸海藻酸盐，和（b）抗微生物金属，例如元素银或其合金或银化合物。组合物可以用作独立的抗微生物制剂，或与医疗制品或医疗装置组合使用。

10. 发明申请

US20060091035A1 Method of preparing a packaged antimicrobial medical device 有权
公开(公告)号：US20060091035A1
公开(公告)日：2006-05-04
申请号：US11301365
申请日：2005-12-13
申请人： Howard Scalzo , Jerome Fischer , Stephen Rothenburger , Robert Cerwin , James McDivitt
发明人： Howard Scalzo , Jerome Fischer , Stephen Rothenburger , Robert Cerwin , James McDivitt
IPC分类号： A61B19/02
CPC分类号： A61B17/06114 , A61B17/06166 , A61B50/00 , A61B2017/00889 , A61L17/005 , A61L2300/202 , A61L2300/404 , A61L2300/606
摘要： A method of making a packaged antimicrobial suture comprising the steps of providing a containment compartment that is substantially free of an antimicrobial agent; positioning a suture within the containment compartment, said suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; placing the containment compartment having the suture in an outer package; and subjecting the outer package, the containment compartment and the suture to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the suture to the containment compartment, while retaining an effective amount of said antimicrobial agent on the suture, thereby substantially inhibiting bacterial colonization on the suture and the containment compartment.

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