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1. 发明授权

US08394811B2 Hydrazide compounds as thyroid hormone receptor modulators and uses thereof 有权
标题翻译：酰肼化合物作为甲状腺激素受体调节剂及其用途
公开(公告)号：US08394811B2
公开(公告)日：2013-03-12
申请号：US12450922
申请日：2008-04-18
申请人： Herbert H. Samuels , Ruben Abagyan , Matthieu Schapira , Maxim Totrov , Bruce M. Raaka , Stephen R. Wilson , Li Fan , Zhiguo Zhou
发明人： Herbert H. Samuels , Ruben Abagyan , Matthieu Schapira , Maxim Totrov , Bruce M. Raaka , Stephen R. Wilson , Li Fan , Zhiguo Zhou
IPC分类号： A61K31/438 , A61K31/4418 , A61P5/16 , C07D211/70 , C07D471/10
CPC分类号： C07D471/10 , C07D211/70
摘要： A method of identification of compounds that modulate thyroid hormone activity, and the use of such compounds and compositions thereof for such purposes are disclosed. The compounds may be selected from the group consisting of: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to aberrant thyroid hormone activity, such as hyperthyroidism and thyrotoxicosis.
摘要翻译：公开了鉴定调节甲状腺激素活性的化合物的方法，以及这些化合物及其组合物用于此目的的用途。化合物可以选自：化合物可以制备为药物组合物，并且可以用于预防和治疗与异常甲状腺激素活性如甲状腺功能亢进和甲状腺毒症有因果关系的病症。

2. 发明申请

US20110130580A1 USE OF BUCKYSOME OR CARBON NANOTUBE FOR DRUG DELIVERY 审中-公开
标题翻译： BUCKYSOME或碳纳米管用于药物输送的使用
公开(公告)号：US20110130580A1
公开(公告)日：2011-06-02
申请号：US12274089
申请日：2008-11-19
申请人： Andreas Hirsch , Uri Sagman , Stephen R. Wilson
发明人： Andreas Hirsch , Uri Sagman , Stephen R. Wilson
IPC分类号： C07J1/00 , B82Y5/00
CPC分类号： A61K9/127 , A61K9/0092 , A61K47/6923 , A61K47/6925 , A61K47/6949 , A61K49/0004 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/152 , C01B32/174
摘要： Compositions and methods for administering a therapeutic agent to a mammal are disclosed. The compositions comprise either (i) vesicles comprising an amphiphilic substituted fullerene, wherein the therapeutic agent is present in the vesicle interior or between layers of the vesicle wall, (ii) a substituted fullerene, comprising a fullerene core and a functional moiety, wherein the therapeutic agent is associated with the substituted fullerene, or (iii) carbon nanotubes, wherein the therapeutic agent is covalently bonded to the carbon nanotubes.
摘要翻译：公开了向哺乳动物施用治疗剂的组合物和方法。所述组合物包含（i）包含两亲性取代的富勒烯的囊泡，其中所述治疗剂存在于泡囊内部或囊泡壁的层之间，（ii）包含富勒烯核心和功能部分的取代的富勒烯，其中治疗剂与取代的富勒烯相关，或（iii）碳纳米管，其中治疗剂与碳纳米管共价键合。

3. 发明申请

US20110059529A1 METHODS FOR GENETIC PLANT TRANSFORMATION USING WATER-SOLUBLE FULLERENE DERIVATIVES 有权
标题翻译：使用水溶性富勒烯衍生物进行遗传植物转化的方法
公开(公告)号：US20110059529A1
公开(公告)日：2011-03-10
申请号：US12876671
申请日：2010-09-07
申请人： Stephen R. Wilson
发明人： Stephen R. Wilson
IPC分类号： C12N5/04 , A01H1/06
CPC分类号： C12N15/8201
摘要： In various embodiments, methods described herein comprise the use of water-soluble cationic fullerene derivatives for improving plant genetic transformation. Cationic Fullerene derivatives of the invention possess DNA binding and compaction activity and provide a new method to deliver DNA into plant cells for plant transformation. Water-soluble fullerene derivatives of the invention with anionic or non-polar substituents possess antioxidant (free radical scavenging) activity, provide improved yields and efficiency of plant transformation methods such as biolistic, Agrobacterium tumefaciens, or electroporation methods by limiting cellular damage and resulting cell death leading to higher yields of viable transformed cells in the process.
摘要翻译：在各种实施方案中，本文所述的方法包括使用水溶性阳离子富勒烯衍生物来改善植物遗传转化。本发明的阳离子富勒烯衍生物具有DNA结合和压实活性，并提供了将DNA输送到植物转化植物细胞中的新方法。具有阴离子或非极性取代基的本发明的水溶性富勒烯衍生物具有抗氧化（自由基清除）活性，通过限制细胞损伤和产生的细胞提供植物转化方法如生物射弹，根癌土壤杆菌或电穿孔方法的提高的产量和效率死亡导致该过程中可行的转化细胞的产量更高。

4. 发明申请

US20110021630A1 METHOD FOR TREATING WOUNDS BY ADMINISTERING FULLERENES 审中-公开
标题翻译：通过管理富勒烯处理创伤的方法
公开(公告)号：US20110021630A1
公开(公告)日：2011-01-27
申请号：US12921143
申请日：2009-03-03
申请人： Christopher L. Kepley , Robert P. Lenk , Stephen R. Wilson , Zhiguo Zhou
发明人： Christopher L. Kepley , Robert P. Lenk , Stephen R. Wilson , Zhiguo Zhou
IPC分类号： A61K31/225 , C07C69/34 , A61P17/02
CPC分类号： A61K31/04 , A61K31/225
摘要： Disclosed herein are methods for treating wounds. In one embodiment, the method comprises: administering to a subject in need thereof a therapeutically effective amount of a synthetically modified fullerene of the formula Zm—F—Yn wherein F is a fullerene of formula Cp or X@Cp, the fullerene having two opposing poles and an equatorial region; Cp represents a fullerene cage having p carbon atoms, and X@CP represents such a fullerene cage having a chemical group X within the cage; Z and Y are positioned near respective opposite poles of Cp; m=1-5 and Z is a hydrophilic, lipophilic, or amphiphilic chemical moiety; n=1-5 and Y is a lipophilic chemical moiety; p=60-200 and p is an even number; and X, if present, represents one or more metal atoms within the fullerene (F), optionally in the form of a trinitride of formula Gi=1−3Hk=3−iN in which G and H are metal atoms.
摘要翻译：本文公开了治疗伤口的方法。在一个实施方案中，所述方法包括：向有需要的受试者施用治疗有效量的式Zm-F-Yn的合成修饰的富勒烯，其中F是式Cp或X @ Cp的富勒烯，所述富勒烯具有两个相对的两极和赤道地区; Cp表示具有p个碳原子的富勒烯笼，X @ CP表示在保持架内具有化学基团X的这种富勒烯笼; Z和Y位于Cp的相应相对极附近; m = 1-5，Z是亲水性，亲油性或两亲性化学部分; n = 1-5，Y是亲脂性化学部分; p = 60-200，p是偶数; 和X如果存在，则表示富勒烯（F）内的一个或多个金属原子，任选地呈式Gi = 1-3Hk = 3-iN的三氮化硼的形式，其中G和H是金属原子。

5. 发明申请

US20100286182A1 HYDRAZIDE COMPOUNDS AS THYROID HORMONE RECEPTOR MODULATORS AND USES THEREOF 有权
标题翻译：作为甲状腺激素受体调节剂的氢化物化合物及其用途
公开(公告)号：US20100286182A1
公开(公告)日：2010-11-11
申请号：US12450922
申请日：2008-04-18
申请人： Herbert H. Samuels , Ruben Abagyan , Matthieu Schapira , Maxim Totrov , Bruce M. Raaka , Stephen R. Wilson , Li Fan , Zhiguo Zhou
发明人： Herbert H. Samuels , Ruben Abagyan , Matthieu Schapira , Maxim Totrov , Bruce M. Raaka , Stephen R. Wilson , Li Fan , Zhiguo Zhou
IPC分类号： A61K31/438 , A61K31/4418 , C07D471/10 , C07D211/70 , A61P5/16
CPC分类号： C07D471/10 , C07D211/70
摘要： A method of identification of compounds that modulate thyroid hormone activity, and the use of such compounds and compositions thereof for such purposes are disclosed. The compounds may be selected from the group consisting of: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to aberrant thyroid hormone activity, such as hyperthyroidism and thyrotoxicosis.
摘要翻译：公开了鉴定调节甲状腺激素活性的化合物的方法，以及这些化合物及其组合物用于此目的的用途。化合物可以选自：化合物可以制备为药物组合物，并且可以用于预防和治疗与异常甲状腺激素活性如甲状腺功能亢进和甲状腺毒症有因果关系的病症。

6. 发明申请

US20080213324A1 Amphiphilic or lipophilic polar functionalized fullerenes and their uses 有权
标题翻译：两亲或亲脂极性官能化富勒烯及其用途
公开(公告)号：US20080213324A1
公开(公告)日：2008-09-04
申请号：US12073230
申请日：2008-03-03
申请人： Zhiguo Zhou , Robert P. Lenk , Darren Macfarland , Kenneth L. Walker , Jing Zhang , Stephen R. Wilson
发明人： Zhiguo Zhou , Robert P. Lenk , Darren Macfarland , Kenneth L. Walker , Jing Zhang , Stephen R. Wilson
IPC分类号： A61K8/14 , C07F9/06 , A61K9/127 , A61K31/661 , A61K8/55 , A61K38/28 , A61P27/14
CPC分类号： A61K31/661 , A61K8/0208 , A61K8/19 , A61K9/0014 , A61K9/1271 , A61K38/28 , A61Q1/02 , A61Q5/02 , A61Q9/00 , A61Q13/00 , A61Q19/007 , A61K2300/00
摘要： Described herein are synthetically modified fullerene molecules, wherein the fullerene is preferably ellipsoid in shape with an equatorial band and two opposing poles, comprising an adduct at one or both poles, at least one adduct being a hydrophobic chemical moiety capable of anchoring the fullerene on or in a lipid membrane.
摘要翻译：这里描述的是合成改性的富勒烯分子，其中富勒烯优选为具有赤道带和两个相对极的形状的椭圆体，包括一个或两个极处的加合物，至少一个加合物是能够将富勒烯锚定在其上的疏水化学部分在脂质膜中。

7. 发明授权

US07163956B2 Substituted fullerene compositions and their use as antioxidants 有权
标题翻译：取代的富勒烯组合物及其作为抗氧化剂的用途
公开(公告)号：US07163956B2
公开(公告)日：2007-01-16
申请号：US10960449
申请日：2004-10-07
申请人： Stephen R. Wilson , Yi-Zhen Hu , Tong Zhu , Russ Lebovitz
发明人： Stephen R. Wilson , Yi-Zhen Hu , Tong Zhu , Russ Lebovitz
IPC分类号： A61K31/40 , A61K31/95 , C07C63/00 , C07C211/00 , C07D487/00
CPC分类号： B82Y40/00 , A61K8/19 , A61K47/6949 , A61K2800/522 , A61Q19/00 , B82Y5/00 , B82Y30/00 , C01B32/15 , C01B32/152
摘要： This patent discloses a substituted fullerenes, compositions comprising the same, and their use as antioxidants. The substituted fullerenes comprise a fullerene core (Cn) and at least one of: (i) from 1 to 6 (>CX1X2) groups bonded to the fullerene core; (ii) from 1 to 18 —X3 groups bonded to the fullerene core; (iii) from 1 to 6 —X4— groups bonded to the fullerene core; or (iv) from 1 to 6 dendrons bonded to the fullerene core.
摘要翻译：该专利公开了一种取代的富勒烯，包含它们的组合物及其作为抗氧化剂的用途。取代的富勒烯包含富勒烯核（Cn）和至少一个：（i）与富勒烯核键合的1至6个（> X 1，X 2，X 2） ; （ii）与富勒烯核键合的1至18个-X 3+基团; （iii）与富勒烯核键合的1至6个-X 4+基团; 或（iv）1至6个与富勒烯核心结合的树突。

8. 发明授权

US06448412B1 Methods for the preparation and characterization of multi-substituted fullerenes 有权
标题翻译：多取代富勒烯的制备和表征方法
公开(公告)号：US06448412B1
公开(公告)日：2002-09-10
申请号：US09702144
申请日：2000-10-30
申请人： Randall B. Murphy , Stephen R. Wilson , Quing Lu
发明人： Randall B. Murphy , Stephen R. Wilson , Quing Lu
IPC分类号： C07D48700
CPC分类号： G11C13/025 , B82Y10/00 , C07C61/00 , C07C2604/00 , C07D209/58 , C07D213/16 , C07D317/72 , C07D333/08 , C07D487/06 , C40B40/04 , C40B50/08 , C40B50/14 , G11C13/0014 , G11C13/0019 , Y10S977/734 , Y10S977/835 , Y10S977/842 , Y10S977/881
摘要： The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the Cn fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by 3He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.
摘要翻译：本发明涉及新配置的多取代富勒烯衍生物及其制备和使用方法。所述方法包括富勒烯衍生物文库的组合合成，包括以下步骤：通过使Cn富勒烯与两种或多种反应性前体化合物反应形成富勒烯衍生物的混合物，并除去未反应的化合物以产生具有所需活性的富勒烯衍生物。还提供了通过3He核磁共振和电喷雾质谱鉴定和筛选富勒烯组合文库以定义具有最佳期望活性的成员的方法。

9. 发明授权

US5751254A Feed movement mechanism and control system for a multibeam antenna 失效
标题翻译：多波束天线的馈送运动机制和控制系统
公开(公告)号：US5751254A
公开(公告)日：1998-05-12
申请号：US786045
申请日：1997-01-21
申请人： Trevor S. Bird , Mark A. Sprey , Ian J. McInnes , Warren J. Hancock , Stephen R. Wilson
发明人： Trevor S. Bird , Mark A. Sprey , Ian J. McInnes , Warren J. Hancock , Stephen R. Wilson
IPC分类号： H01Q3/18 , H01Q5/45 , H01Q3/12
CPC分类号： H01Q3/18 , H01Q5/45
摘要： A feed transport device for moving a feed within a non-planar focal surface defined by a satellite communications antenna, comprises first and second non-linear rails, and a feed transport unit comprising a feed support member for supporting the feed, and first and second slidable members slidably mounted on said first and second rails respectively to permit each slidable member to slide along the length of its respective rail, wherein one end of the feed support member is pivotally attached, not necessarily about a single pivot axis, to the first slidable member, the other end of the feed support member is both slidably and pivotally, again not necessarily about a single axis, attached to the second slidable member, and the first and second rails are shaped and positioned to maintain the feed in, or near to, said focal plane during movement of the feed support member along the first and second rails. The feed support is provided with transverse sliding rail and a gimbal allows rotation about two perpendicular axes. The shape and position of the first and second rails and the orientation of the feed support member are chosen so as to ensure that the minimum of adjustment of the feed by the servos is required as the feed is moved along the length of the focal surface.
摘要翻译：一种用于移动由卫星通信天线限定的非平面焦点表面内的进给物的进给传送装置，包括第一和第二非直线轨道，以及包括用于支撑进给的进给支撑构件的进给传送单元，以及第一和第二滑动构件分别可滑动地安装在所述第一和第二轨道上，以允许每个可滑动构件沿其相应轨道的长度滑动，其中进给支撑构件的一端可枢转地附接到第一可滑动构件进给支撑构件的另一端既可滑动地又可枢转地，而不一定围绕连接到第二可滑动构件的单个轴线，并且第一和第二轨道成形和定位成将进给物保持在或接近，所述焦平面在所述馈送支撑构件沿着所述第一和第二轨道运动期间。进给支架设有横向滑轨，万向架可绕两个垂直轴线旋转。选择第一和第二轨道的形状和位置以及馈送支撑构件的取向，以便确保当馈电沿着焦点表面的长度移动时，需要通过舵机进行馈送的最小调节。

10. 发明授权

US5635404A Applications of electrospray ionization mass spectrometry to neutral organic molecules including fullerenes 失效
标题翻译：电喷雾离子化质谱法应用于包括富勒烯在内的中性有机分子
公开(公告)号：US5635404A
公开(公告)日：1997-06-03
申请号：US38105
申请日：1993-03-29
申请人： Stephen R. Wilson
发明人： Stephen R. Wilson
IPC分类号： H01J49/04 , G01N24/00
CPC分类号： H01J49/04 , Y10T436/200833 , Y10T436/203332 , Y10T436/23 , Y10T436/235 , Y10T436/24 , Y10T436/25 , Y10T436/25875
摘要： Electrospray ionization mass spectroscopy (ESI-MS) methods, tagging reagents and novel compounds for labeling neutral compounds to provide ionized compounds for mass spectroscopy analysis, and novel compounds discovered using such EES-MS methods, including fulleroids
摘要翻译：电喷雾质谱（ESI-MS）方法，标记试剂和用于标记中性化合物以提供用于质谱分析的电离化合物的新型化合物，以及使用这种EES-MS方法发现的新化合物，包括富勒烯

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