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1. 发明申请

US20110295362A1 PROSTHESIS FOR RETRIEVAL AND DEPLOYMENT 有权
标题翻译：重新检索和部署
公开(公告)号：US20110295362A1
公开(公告)日：2011-12-01
申请号：US12954541
申请日：2010-11-24
申请人： Matthew J. Finch , Edward McNamara , Stephen J. Forcucci , Hiroatsu Sugimoto
发明人： Matthew J. Finch , Edward McNamara , Stephen J. Forcucci , Hiroatsu Sugimoto
IPC分类号： A61F2/24
CPC分类号： A61B17/0057 , A61B6/12 , A61B6/4423 , A61B8/0841 , A61B2017/00252 , A61B2017/00526 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , A61B2017/00867 , A61B2560/063 , A61F2/2412 , Y10T29/49002 , Y10T29/49005 , Y10T29/53843 , Y10T29/53909 , Y10T29/53913
摘要： The present disclosure relates to devices and methods for implanting a prosthesis into a heart of a mammal, such as a person. The disclosure includes a prosthesis that acts as a pressure vent between the left and right atria of the heart. The disclosure also includes a mounting tool for mounting the prosthesis onto a loading tool, the loading tool useful for loading the prosthesis onto a device for delivering the prosthesis into the patient's heart. Control devices and methods for using these devices are also disclosed. The intracardiac pressure vents disclosed allow sufficient flow from the left atrium to the right atrium to relieve elevated left atrial pressure and resulting patient symptoms. The devices also limit the amount of flow from the right atrium to the left atrium to minimize the potential for thrombi or other embolic material from entering arterial circulation.
摘要翻译：本公开涉及用于将假体植入哺乳动物（例如人）的心脏中的装置和方法。该公开内容包括用作心脏左心房和右心房之间的压力通气口的假体。本公开还包括用于将假体安装到装载工具上的安装工具，所述装载工具可用于将假体装载到用于将假体递送到患者心脏的装置上。还公开了用于使用这些装置的控制装置和方法。所公开的心内压力通风口允许从左心房到右心房的足够的流动，以缓解升高的左心房压力和导致的患者症状。这些装置还限制从右心房到左心房的流量，以最小化血栓或其他栓塞物质进入动脉循环的可能性。

2. 发明申请

US20100256548A1 DEVICES, SYSTEMS AND METHODS TO TREAT HEART FAILURE 有权
标题翻译：装置，系统和治疗心脏衰竭的方法
公开(公告)号：US20100256548A1
公开(公告)日：2010-10-07
申请号：US12719833
申请日：2010-03-08
申请人： Edward McNamara , David Celermajer , Stephen J. Forcucci , Hiroatsu Sugimoto
发明人： Edward McNamara , David Celermajer , Stephen J. Forcucci , Hiroatsu Sugimoto
IPC分类号： A61F2/24
CPC分类号： A61B17/02 , A61B17/0057 , A61B2017/00252 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61B2017/0237 , A61F2/06 , A61F2/24 , A61F2/2412 , A61F2/2442 , A61F2/2475 , A61M27/002
摘要： Several unique intracardiac pressure vents, placement catheters, methods of placement and methods of treating heart failure are presented. The intracardiac pressure vents presented allow sufficient flow from the left atrium to the right atrium to relieve elevated left atrial pressure and resulting patient symptoms. In an aspect of the invention, the interatrial device comprises portions that are more flexible or less flexible than another portion of the device.
摘要翻译：介绍了几种独特的心内压力通气口，放置导管，放置方法和治疗心力衰竭的方法。所提供的心内压力通风口允许从左心房到右心房的足够的流动，以缓解升高的左心房压力和导致的患者症状。在本发明的一个方面中，所述室间装置包括比装置的另一部分更柔性或更不灵活的部分。

3. 发明授权

US06629987B1 Catheter positioning systems 失效
标题翻译：导管定位系统
公开(公告)号：US06629987B1
公开(公告)日：2003-10-07
申请号：US09364520
申请日：1999-07-30
申请人： Richard A. Gambale , Stephen J. Forcucci , Chirag B. Shah , Michael F. Weiser , Sean Forde
发明人： Richard A. Gambale , Stephen J. Forcucci , Chirag B. Shah , Michael F. Weiser , Sean Forde
IPC分类号： A61M2900
CPC分类号： A61M25/04 , A61B2017/3488 , A61M25/0084 , A61M2025/0087
摘要： The present invention provides a catheter positioning system which serves to control and stabilize a distal end of a catheter at a treatment site within a patient so that a medical procedure can be performed with accuracy. Generally, the positioning system operates by providing a deformable mechanical members at the distal end of the catheter which can be operated from the proximal end of the catheter to extend radially outward to engage surrounding tissue adjacent to treatment site. In one embodiment of the invention a flexible superstructure comprising the plurality of flexible veins extending longitudinally along the distal end of the catheter can be deformed to bow radially outward to engage surrounding tissue. The distal tip of the catheter joined to one of the veins was correspondingly displaced or rotated angularly as the veins bow outward. In another embodiment radially projecting fingers are joined to the distal end of the catheter, which remain retracted during navigation of the catheter to the treatment site then are extended outward to penetrate the tissue and secure the catheter at the treatment site upon being actuated from the proximal end of the catheter by a physician. Methods of positioning a catheter are also disclosed. The inventive device and method are particularly useful in catheter based procedures carried out in large body lumens or in cavities of body organs. In particular, the invention may be useful in delivering implants percutaneously through the left ventricle into the myocardium of the heart.
摘要翻译：本发明提供了一种导管定位系统，其用于控制和稳定患者内的治疗部位处的导管的远端，使得可以精确地执行医疗程序。通常，定位系统通过在导管的远端处提供可变形的机械构件来操作，该可变形机械构件可以从导管的近端操作以径向向外延伸以接合邻近治疗部位的周围组织。在本发明的一个实施例中，包括沿着导管的远端纵向延伸的多个柔性静脉的柔性上部结构可以变形以径向向外弯曲以接合周围的组织。当静脉向外弯曲时，连接到静脉中的一个静脉的导管的远端相应地位移或旋转。在另一个实施例中，径向突出的指状物连接到导管的远端，导管的远端在导管导航到治疗部位期间保持缩回，然后向外延伸以穿透组织，并且在从近端致动时将导管固定在治疗部位导管的末端由医师。还公开了定位导管的方法。本发明的装置和方法特别适用于在大体腔或身体器官腔中进行的基于导管的程序。特别地，本发明可用于将植入物通过左心室经皮穿入心脏心肌。

4. 发明授权

US06331185B1 Flexible vascular inducing implants 失效
公开(公告)号：US06331185B1
公开(公告)日：2001-12-18
申请号：US09164163
申请日：1998-09-30
申请人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Richard T. Choh , Sean Forde
发明人： Richard A. Gambale , Stephen J. Forcucci , Michael F. Weiser , Richard T. Choh , Sean Forde
IPC分类号： A61F206
摘要： Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to be flexible so that they compress and expand with corresponding movement of the surrounding tissue into which they are implanted. The flow of blood into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth, a healing process that leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.

5. 发明授权

US6110144A Method and apparatus for regulating the fluid flow rate to and preventing over-pressurization of a balloon catheter 失效
标题翻译：用于调节流体流速并防止球囊导管过度加压的方法和装置
公开(公告)号：US6110144A
公开(公告)日：2000-08-29
申请号：US359805
申请日：1999-07-26
申请人： Richard T. Choh , John R. Fagan , Stephen J. Forcucci
发明人： Richard T. Choh , John R. Fagan , Stephen J. Forcucci
IPC分类号： A61F2/958 , A61M29/00
CPC分类号： A61M25/10184 , A61M25/1018 , A61M2025/0001 , A61M2025/105
摘要： The invention relates to an apparatus and method for limiting the pressure of inflation fluid injected into a drug delivery catheter balloon, while permitting continuous and uninterrupted flow of such fluid to the balloon. The apparatus includes an elongated hollow housing having a fluid entrance, a fluid exit and a bore extending therebetween which forms an interconnecting chamber and passageway. A piston and piston shaft assembly is disposed inside the housing and is longitudinally movable within the chamber. The piston and piston shaft assembly is biased against the fluid pressure of the fluid entering the housing by a spring. The piston shaft has a distal end which extends toward the passageway inlet. As the incoming fluid pressure increases and approaches the predetermined maximum pressure level of the apparatus, the piston shaft distal end moves within the chamber against the biasing force of the spring toward a position adjacent the passageway inlet. When the incoming fluid pressure reaches and exceeds the predetermined maximum pressure level, the piston shaft distal end enters and extends into the passageway, thereby forming an annulus within the passageway. The annulus functions to restrict the flow rate and limit the pressure of the fluid exiting the housing and entering the catheter balloon.
摘要翻译：本发明涉及一种用于限制注射到药物递送导管球囊中的充气流体的压力的装置和方法，同时允许这种流体连续且不间断地流入气囊。该装置包括细长的中空壳体，其具有流体入口，流体出口和在其间延伸的孔，其形成互连室和通道。活塞和活塞轴组件设置在壳体内部并且可在腔室内纵向移动。活塞和活塞轴组件被抵抗通过弹簧进入壳体的流体的流体压力而偏置。活塞轴具有朝向通道入口延伸的远端。当进入的流体压力增加并且接近装置的预定最大压力水平时，活塞轴远端抵抗弹簧的偏置力抵抗通道入口附近的位置移动。当进入的流体压力达到并超过预定的最大压力水平时，活塞轴远端进入并延伸到通道中，从而在通道内形成环形空间。环的作用是限制流速并限制离开壳体并进入导管气囊的流体的压力。

6. 发明授权

US5993416A Method and apparatus for regulating the fluid flow rate to and preventing over-pressurization of a balloon catheter 失效
公开(公告)号：US5993416A
公开(公告)日：1999-11-30
申请号：US7427
申请日：1998-01-15
申请人： Richard T. Choh , John R. Fagan , Stephen J. Forcucci
发明人： Richard T. Choh , John R. Fagan , Stephen J. Forcucci
IPC分类号： A61F2/958 , A61M29/00
CPC分类号： A61M25/10184 , A61M25/1018 , A61M2025/0001 , A61M2025/105
摘要： The invention relates to an apparatus and method for limiting the pressure of inflation fluid injected into a drug delivery catheter balloon, while permitting continuous and uninterrupted flow of such fluid to the balloon. The apparatus includes an elongated hollow housing having a fluid entrance, a fluid exit and a bore extending therebetween which forms an interconnecting chamber and passageway. A piston and piston shaft assembly is disposed inside the housing and is longitudinally movable within the chamber. The piston and piston shaft assembly is biased against the fluid pressure of the fluid entering the housing by a spring. The piston shaft has a distal end which extends toward the passageway inlet. As the incoming fluid pressure increases and approaches the predetermined maximum pressure level of the apparatus, the piston shaft distal end moves within the chamber against the biasing force of the spring toward a position adjacent the passageway inlet. When the incoming fluid pressure reaches and exceeds the predetermined maximum pressure level, the piston shaft distal end enters and extends into the passageway, thereby forming an annulus within the passageway. The annulus functions to restrict the flow rate and limit the pressure of the fluid exiting the housing and entering the catheter balloon.

7. 发明授权

US10045766B2 Intra-atrial implants to directionally shunt blood 有权
公开(公告)号：US10045766B2
公开(公告)日：2018-08-14
申请号：US13298926
申请日：2011-11-17
申请人： Edward McNamara , David Celermajer , Stephen J. Forcucci , Hiroatsu Sugimoto , Matthew J. Finch
发明人： Edward McNamara , David Celermajer , Stephen J. Forcucci , Hiroatsu Sugimoto , Matthew J. Finch
IPC分类号： A61F2/02 , A61B17/02 , A61B17/00 , A61F2/06 , A61F2/24 , A61M27/00
CPC分类号： A61B17/02 , A61B17/0057 , A61B2017/00252 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61B2017/0237 , A61F2/06 , A61F2/24 , A61F2/2412 , A61F2/2442 , A61F2/2475 , A61M27/002
摘要： Several unique intracardiac pressure vents, placement catheters, methods of placement and methods of treating heart failure are presented. The intracardiac pressure vents presented allow sufficient flow from the left atrium to the right atrium to relieve elevated left atrial pressure and resulting patient symptoms but also limit the amount of flow from the right atrium to the left atrium to minimize the potential for thrombus or other embolic material from entering the arterial circulation.

8. 发明申请

US20160022970A1 DEVICES AND METHODS FOR TREATING HEART FAILURE 审中-公开
标题翻译：用于治疗心脏衰竭的装置和方法
公开(公告)号：US20160022970A1
公开(公告)日：2016-01-28
申请号：US14807544
申请日：2015-07-23
申请人： Stephen J. FORCUCCI , Matthew J. FINCH , Christopher J. MAGNIN , Edward I. McNAMARA , Carol A. DEVELLIAN
发明人： Stephen J. FORCUCCI , Matthew J. FINCH , Christopher J. MAGNIN , Edward I. McNAMARA , Carol A. DEVELLIAN
IPC分类号： A61M27/00 , A61F2/24
CPC分类号： A61M27/002 , A61B17/0218 , A61B17/11 , A61B2017/00252 , A61B2017/00575 , A61B2017/00592 , A61B2017/00601 , A61B2017/00606 , A61B2017/00623 , A61B2090/3966 , A61F2/0063 , A61F2/24 , A61F2/2478 , A61F2002/0072 , A61F2002/249 , A61M2205/04 , A61M2210/125
摘要： A device for implanting into an atrial septum of a patient. In some embodiments, the device has a core region to be disposed in an opening in the atrial septum; a distal retention region adapted to engage tissue on a left atrial side of the septal wall; a proximal retention region adapted to engage tissue on a right atrial side of the septal wall; and a retrieval region comprising a plurality of retrieval members, each retrieval member comprising a connector at a proximal end, the connector being adapted to connect to a delivery system. The device has a delivery configuration and a deployed configuration, the core region, distal retention region and proximal retention region each having a smaller diameter in the delivery configuration than in the deployed configuration, the retrieval member connectors being disposed proximal to and radially outward from the opening in the deployed configuration.
摘要翻译：用于植入患者的房间隔的装置。在一些实施例中，该装置具有芯区域，以被设置在心房隔膜的开口中; 远端保持区域，其适于接合隔膜壁的左心房侧上的组织; 适于接合隔膜壁的右心房侧上的组织的近端保持区域; 以及包括多个检索构件的检索区域，每个检索构件包括在近端处的连接器，所述连接器适于连接到传送系统。该装置具有输送构型和展开构造，该芯部区域，远端保持区域和近侧保持区域各自在输送构造中具有比在展开构造中更小的直径，该回收构件连接器设置在邻近和径向向外的位置在部署配置中打开。

9. 发明申请

US20150148731A1 METHODS AND DEVICES FOR INTRA-ATRIAL SHUNTS HAVING ADJUSTABLE SIZES 有权
标题翻译：具有可调节尺寸的内窥镜的方法和装置
公开(公告)号：US20150148731A1
公开(公告)日：2015-05-28
申请号：US14612022
申请日：2015-02-02
申请人： Edward I. MCNAMARA , Michael W. SUTHERLAND , Matthew J. FINCH , Stephen J. FORCUCCI , John MITZEL , David S. CELERMAJER , Hiroatsu SUGIMOTO
发明人： Edward I. MCNAMARA , Michael W. SUTHERLAND , Matthew J. FINCH , Stephen J. FORCUCCI , John MITZEL , David S. CELERMAJER , Hiroatsu SUGIMOTO
IPC分类号： A61M27/00
CPC分类号： A61B17/0057 , A61B2017/00247 , A61B2017/00575 , A61B2017/00584 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , A61F2/91 , A61F2/915 , A61F2002/075
摘要： Devices and methods for treating heart disease by normalizing elevated blood pressure in the left and right atria of a heart of a mammal are disclosed. Devices may include an adjustable hydraulic diameter shunt portion which can be manually adjusted in vivo. Methods are provided for adjusting the flow rate of the devices in vivo.
摘要翻译：公开了通过使哺乳动物的心脏的左心房和右心房升高的血压正常化来治疗心脏病的装置和方法。设备可以包括可在体内手动调节的可调节的水力直径分流部分。提供了用于调节器件体内流速的方法。

10. 发明授权

US08157860B2 Devices, systems and methods to treat heart failure 有权
标题翻译：用于治疗心力衰竭的装置，系统和方法
公开(公告)号：US08157860B2
公开(公告)日：2012-04-17
申请号：US12719843
申请日：2010-03-08
申请人： Edward McNamara , David Celermajer , Stephen J. Forcucci , Hiroatsu Sugimoto , Matthew J. Finch
发明人： Edward McNamara , David Celermajer , Stephen J. Forcucci , Hiroatsu Sugimoto , Matthew J. Finch
IPC分类号： A61F2/06 , A61F2/82
CPC分类号： A61B17/02 , A61B17/0057 , A61B2017/00252 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61B2017/0237 , A61F2/06 , A61F2/24 , A61F2/2412 , A61F2/2442 , A61F2/2475 , A61M27/002
摘要： Several unique intracardiac pressure vents, placement catheters, methods of placement and methods of treating heart failure are presented. The intracardiac pressure vents presented allow sufficient flow from the left atrium to the right atrium to relieve elevated left atrial pressure and resulting patient symptoms but also limit the amount of flow from the right atrium to the left atrium to minimize the potential for thrombus or other embolic material from entering the arterial circulation.
摘要翻译：介绍了几种独特的心内压力通气口，放置导管，放置方法和治疗心力衰竭的方法。所提供的心内压力通风口允许从左心房到右心房的足够的流量以缓解升高的左心房压力并导致患者症状，但也限制从右心房到左心房的流量，以使血栓或其他栓塞的可能性最小化材料进入动脉循环。

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