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1. 发明授权

US5469860A Fine needle aspiration cytology device syringe holder 失效
标题翻译：细针抽吸细胞学装置注射器支架
公开(公告)号：US5469860A
公开(公告)日：1995-11-28
申请号：US331283
申请日：1994-10-27
申请人： Stephen A. De Santis
发明人： Stephen A. De Santis
IPC分类号： A61B10/00 , A61B10/02 , A61B17/00
CPC分类号： A61B10/0283
摘要： A fine needle aspiration cytology device for extracting tissue samples for cytologic evaluation is disclosed. The device comprises a handle and generally U-shaped slide member with trigger attachable thereto. The handle is designed and configured to releasably engage a conventional syringe. The slide is designed to slidably engage with the handle and is provided with a slot at the base thereof for retaining the plunger of the When interconnected, the slide may move in forward or rearward positions relative the handle and further, when interconnected with a syringe, may selectively control the axial position of the plunger relative the syringe. In a preferred embodiment, the device is further provided with a manually adjustable locking detent mechanism that may releasably maintain the handle and slide in rigid connection.
摘要翻译：公开了一种用于提取组织样本用于细胞学评估的细针穿刺细胞学装置。该装置包括手柄和大致U形的滑动构件，其具有可附接到其上的触发器。手柄设计和构造成可释放地接合常规注射器。滑动件被设计成与手柄可滑动地接合并且在其底部设置有狭槽，用于保持当柱塞相互连接时，滑块可以相对于手柄向前或向后移动，并且当与注射器互连时，可以相对于注射器选择性地控制柱塞的轴向位置。在优选实施例中，该装置还设置有可手动调节的锁定棘爪机构，其可释放地保持手柄并且以刚性连接的方式滑动。

2. 发明授权

US06725083B1 Tissue site markers for in VIVO imaging 有权
标题翻译：用于VIVO成像的组织位点标记
公开(公告)号：US06725083B1
公开(公告)日：2004-04-20
申请号：US09717909
申请日：2000-11-20
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
IPC分类号： A61B1900
CPC分类号： A61M37/0069 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/08021 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.
摘要翻译：本发明涉及活检部位标记和标记活组织检查部位的方法，使得活检腔的位置通过常规成像方法，特别是通过超声成像容易看到。本发明的活检部位标记物具有高的超声反射率，从小标记物呈现出实质的声学特征，以避免在随后的成像研究中掩盖诊断组织特征，并且可以容易地与生物特征区分开来。本发明的活检部位标记物的几个公开的实施方案具有放置在组织部位中的声阻抗的高对比度，以便有效地反射和散射超声能量，并且优选地包括气体填充的内部孔。标记可以具有不均匀的表面轮廓以增强声学特征。标记具有在医学成像期间可识别人造的特征形式。可以将活检部位标记物精确地固定到活检部位，以便当放置放置器械被取出时以及随后移动或操纵标记的组织时抵抗活组织腔的迁移。

3. 发明授权

US08224424B2 Tissue site markers for in vivo imaging 有权
标题翻译：用于体内成像的组织位点标记
公开(公告)号：US08224424B2
公开(公告)日：2012-07-17
申请号：US12460052
申请日：2009-07-13
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
IPC分类号： A61B5/00 , A61B6/00 , A61B19/00
CPC分类号： A61M37/0069 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/08021 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.
摘要翻译：本发明涉及活检部位标记和标记活组织检查部位的方法，使得活检腔的位置通过常规成像方法，特别是通过超声成像容易看到。本发明的活检部位标记物具有高的超声反射率，从小标记物呈现出实质的声学特征，以避免在随后的成像研究中掩盖诊断组织特征，并且可以容易地与生物特征区别开来。本发明的活检部位标记物的几个公开的实施方案具有放置在组织部位中的声阻抗的高对比度，以便有效地反射和散射超声能量，并且优选地包括气体填充的内部孔。标记可以具有不均匀的表面轮廓以增强声学特征。标记具有在医学成像期间可识别人造的特征形式。可以将活检部位标记物精确地固定到活检部位，以便当放置放置器械被取出时以及随后标记的组织被移动或操纵时抵抗从活检腔的迁移。

4. 发明授权

US06993375B2 Tissue site markers for in vivo imaging 有权
公开(公告)号：US06993375B2
公开(公告)日：2006-01-31
申请号：US10823053
申请日：2004-04-12
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
IPC分类号： A61B19/00
CPC分类号： A61M37/0069 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/08021 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.

5. 发明授权

US5560373A Needle core biopsy instrument with durable or disposable cannula assembly 失效
标题翻译：针芯活检器具耐用或一次性插管组装
公开(公告)号：US5560373A
公开(公告)日：1996-10-01
申请号：US417750
申请日：1995-04-06
申请人： Stephen A. De Santis
发明人： Stephen A. De Santis
IPC分类号： A61B10/00 , A61B10/02
CPC分类号： A61B10/0283
摘要： A needle core biopsy instrument/extractor for extracting a tissue sample via needle aspiration is disclosed. The extractor comprises a first cannula having a sharpened, beveled cutting tip and biopsy reservoir formed on it distal end. The proximal end of the first cannula is in fluid communication with a conventional syringe such that when the plunger of the syringe is retracted via manipulation o the extractor, a vacuum is created within the biopsy reservoir of the first cannula Axially mounted about the first cannula is a second cutting cannula which is designed and configured to selectively cover and uncover the distal end of the first cannula. A biasing member, preferably a spring, is provided to urge the second cannula forward about the distal end of the first cannula. The syringe, coaxially positioned first and second cannulas, and biasing member are contained within an introducer which is preferably designed and configured to be manipulated by one hand. The handle slide and lever of the device are oriented in such a way as to allow the retention of tissue via vacuum and the severing of the specimen by the second cannula to be exactly timed by cam operation.
摘要翻译：公开了一种用于通过针抽吸提取组织样本的针芯活检器械/提取器。提取器包括第一套管，其具有形成在其远端上的锋利的，倾斜的切割尖端和活检池。第一插管的近端与常规注射器流体连通，使得当注射器的柱塞通过操作提取器缩回时，在第一套管的活检储存器内产生真空，轴向安装在第一套管周围是第二切割套管被设计和构造成选择性地覆盖和露出第一套管的远端。提供偏置构件，优选地为弹簧，以将第二套管向前推动围绕第一套管的远端。注射器，同轴定位的第一和第二插管以及偏置构件被包含在引导器内，该导引器优选地被设计和构造成用一只手操纵。该装置的手柄滑动件和杠杆被定向成允许通过真空保持组织，并且通过第二套管将试样切断以通过凸轮操作精确定时。

6. 发明申请

US20100010342A1 Tissue site markers for in vivo imaging 有权
标题翻译：用于体内成像的组织位点标记
公开(公告)号：US20100010342A1
公开(公告)日：2010-01-14
申请号：US12460052
申请日：2009-07-13
申请人： Fred H. Burbank , Paul Lubock , Micheal L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
发明人： Fred H. Burbank , Paul Lubock , Micheal L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
IPC分类号： A61B8/14
CPC分类号： A61M37/0069 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/08021 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.
摘要翻译：本发明涉及活检部位标记和标记活组织检查部位的方法，使得活检腔的位置通过常规成像方法，特别是通过超声成像容易看到。本发明的活检部位标记物具有高的超声反射率，从小标记物呈现出实质的声学特征，以避免在随后的成像研究中掩盖诊断组织特征，并且可以容易地与生物特征区别开来。本发明的活检部位标记物的几个公开的实施方案具有放置在组织部位中的声阻抗的高对比度，以便有效地反射和散射超声能量，并且优选地包括气体填充的内部孔。标记可以具有不均匀的表面轮廓以增强声学特征。标记具有在医学成像期间可识别人造的特征形式。可以将活检部位标记物精确地固定到活检部位，以便当放置放置器械被取出时以及随后移动或操纵标记的组织时抵抗活组织腔的迁移。

7. 发明授权

US07565191B2 Tissue site markers for in vivo imaging 有权
标题翻译：用于体内成像的组织位点标记
公开(公告)号：US07565191B2
公开(公告)日：2009-07-21
申请号：US11238201
申请日：2005-09-29
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
IPC分类号： A61B19/00
CPC分类号： A61M37/0069 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/08021 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.
摘要翻译：本发明涉及活检部位标记和标记活组织检查部位的方法，使得活检腔的位置通过常规成像方法，特别是通过超声成像容易看到。本发明的活检部位标记物具有高的超声反射率，从小标记物呈现出实质的声学特征，以避免在随后的成像研究中掩盖诊断组织特征，并且可以容易地与生物特征区别开来。本发明的活检部位标记物的几个公开的实施方案具有放置在组织部位中的声阻抗的高对比度，以便有效地反射和散射超声能量，并且优选地包括气体填充的内部孔。标记可以具有不均匀的表面轮廓以增强声学特征。标记具有在医学成像期间可识别人造的特征形式。可以将活检部位标记物精确地固定到活检部位，以便当放置放置器械被取出时以及随后移动或操纵标记的组织时抵抗活组织腔的迁移。

8. 发明授权

US07047063B2 Tissue site markers for in vivo imaging 有权
公开(公告)号：US07047063B2
公开(公告)日：2006-05-16
申请号：US10658911
申请日：2003-09-10
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick , Frank Louw , Stephen A. De Santis
IPC分类号： A61B19/00
CPC分类号： A61M37/0069 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/08021 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.

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