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1. 发明授权

US4812407A Membrane, system and process for testing substance diffusion through the membrane and method for making the membrane 失效
标题翻译：通过膜测试物质扩散的膜，系统和方法以及制造膜的方法
公开(公告)号：US4812407A
公开(公告)日：1989-03-14
申请号：US038285
申请日：1987-04-14
申请人： Stephan Buchmann , Hans Leuenberger , Claudia Reinke
发明人： Stephan Buchmann , Hans Leuenberger , Claudia Reinke
IPC分类号： G01N13/00 , C12M1/34 , C12M3/06 , G01N33/15
CPC分类号： C12M25/02 , B01D63/087 , B01D69/10 , B01D71/42
摘要： The system for testing the diffusion behavior of a substance comprises a donor compartment detachably mounted on a holding member of a rotor, rotatably around a vertical axis, said donor compartment being bounded at its bottom by a membrane effective to separate the donor compartment from an acceptor compartment. The membrane comprises a flexible carrier of a bio-compatible, lifeless, light permeable material, on which cells constituting a monocellular layer have been cultivated, for example. By determining the time dependent variation of the quantity of a substance passing through the membrane by diffusion, it is possible to determine the coefficient of diffusion and/or the coefficient of permeability of the membrane and of the cell culture provided thereon. By suitable selection of the cells, conditions may be created that closely resemble those that occur during the absorption of the respective substance through the biophase of a living organism.
摘要翻译：用于测试物质的扩散行为的系统包括可拆卸地安装在转子的保持构件上的供体腔，其围绕垂直轴线可旋转，所述供体室在其底部由有效地将供体隔室与受体分隔开的膜隔间膜包括生物相容性，无生命的透光材料的柔性载体，在其上培养构成单细胞层的细胞。通过通过扩散确定通过膜的物质的量的时间依赖性变化，可以确定膜及其上提供的细胞培养物的扩散系数和/或渗透系数。通过细胞的适当选择，可以产生与通过生物体的生物相吸收相应物质期间发生的条件非常相似的条件。

2. 发明授权

US09062014B2 Crystalline forms of (R)-5-[3-chloro-4-(2,3-dihydroxy-propoxy)-benz[Z]ylidene]-2-([Z]-propylimino)-3-0-tolyl-thiazolidin-4-one 有权
标题翻译：（R）-5- [3-氯-4-（2,3-二羟基 - 丙氧基） - 苯并[Z]亚基] -2 - （[Z] - 丙基亚氨基）-3-0-甲苯基 - 噻唑烷 -4-one
公开(公告)号：US09062014B2
公开(公告)日：2015-06-23
申请号：US13125102
申请日：2009-10-19
申请人： Nicholas Bonham , Stephan Buchmann , Alex Eberlin , Christoph Imboden , Markus Von Raumer
发明人： Nicholas Bonham , Stephan Buchmann , Alex Eberlin , Christoph Imboden , Markus Von Raumer
IPC分类号： A61K31/426 , C07D277/54
CPC分类号： C07D277/54 , A61K31/426
摘要： The invention relates to crystalline forms of (R)-5-[3-chloro-4-(2,3-dihydroxy-propoxy)-benz[Z]ylidene]-2-([Z]-propylimino)-3-o-tolyl-thiazolidin-4-one, processes for the preparation thereof, pharmaceutical compositions containing said crystalline forms, and their use as compounds improving vascular function and as immunomodulating agents, either alone or in combination with other active compounds or therapies.
摘要翻译：本发明涉及（R）-5- [3-氯-4-（2,3-二羟基 - 丙氧基） - 苯并[Z]亚基] -2 - （[Z] - 丙基亚氨基）-3- - 甲苯基 - 噻唑烷-4-酮，其制备方法，含有所述结晶形式的药物组合物及其作为改善血管功能的化合物和作为免疫调节剂的用途，单独或与其它活性化合物或疗法组合。

3. 发明申请

US20110196004A1 CRYSTALLINE FORMS OF (R) -5-[3-CHLORO-4-(2,3-DIHYDROXY-PROPOXY)-BENZ [Z] YLIDENE] -2-( [Z]-PROPYLIMINO) -3-0-TOLYL-THIAZOLIDIN-4-ONE 有权
标题翻译：（R）-5- [3-氯-4-（2,3-二羟基 - 丙氧基） - 苯并[Z]哒嗪酮] -2（[Z] - 丙烯酰基）-3-0-戊基 - 噻唑烷的晶体形式 -4-ONE
公开(公告)号：US20110196004A1
公开(公告)日：2011-08-11
申请号：US13125102
申请日：2009-10-19
申请人： Nicholas Bonham , Stephan Buchmann , Alex Eberlin , Christoph Imboden , Markus Von Raumer
发明人： Nicholas Bonham , Stephan Buchmann , Alex Eberlin , Christoph Imboden , Markus Von Raumer
IPC分类号： A61K31/426 , C07D277/34 , A61P37/06 , A61P19/02 , A61P3/10 , A61P17/06 , A61P35/00 , A61P35/04
CPC分类号： C07D277/54 , A61K31/426
摘要： The invention relates to crystalline forms of (R)-5-[3-chloro-4-(2,3-dihydroxy-propoxy)-benz[Z]ylidene]-2-([Z]-propylimino)-3-o-tolyl-thiazolidin-4-one, processes for the preparation thereof, pharmaceutical compositions containing said crystalline forms, and their use as compounds improving vascular function and as immunomodulating agents, either alone or in combination with other active compounds or therapies.
摘要翻译：本发明涉及（R）-5- [3-氯-4-（2,3-二羟基 - 丙氧基） - 苯并[Z]亚基] -2 - （[Z] - 丙基亚氨基）-3- - 甲苯基 - 噻唑烷-4-酮，其制备方法，含有所述结晶形式的药物组合物及其作为改善血管功能的化合物和作为免疫调节剂的用途，单独或与其它活性化合物或疗法组合。

4. 发明申请

US20090023775A1 1-[2-(4-BENZYL-4-HYDROXY-PIPERIDIN-1 -YL )-ETHYL]-3-(2-METHYL-QUINOLIN- 4-YL)- UREA AS CRYSTALLINE SULFATE SALT 有权
标题翻译： 1- [2-（4-苄基-4-羟基 - 哌啶-1-基） - 乙基] -3-（2-甲基喹啉-4-基） - 尿素，为硫酸亚铁盐
公开(公告)号：US20090023775A1
公开(公告)日：2009-01-22
申请号：US11577064
申请日：2005-10-11
申请人： Jean-Michel Bonard , Stephan Buchmann , Stephane Redey , Bertrand Woinet
发明人： Jean-Michel Bonard , Stephan Buchmann , Stephane Redey , Bertrand Woinet
IPC分类号： A61K31/4709 , C07D401/12 , A61P9/10 , A61P35/00
CPC分类号： C07D401/12
摘要： The invention relates to 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea as a crystalline, stoichiometrically defined and non-hygroscopic sulfate salt and a process for its preparation. Further, the present invention relates to the use of said 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea as a crystalline, stoichiometrically defined and non-hygroscopic sulfate salt alone or in combination with other compounds. Further, the present invention relates to formulations of said 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea as a crystalline, stoichiometrically defined and non-hygroscopic sulfate salt in the preparation of pharmaceutical compositions. The invention also relates to the use of such sulfate salts in formulations as neurohormonal antagonists.
摘要翻译：本发明涉及1- [2-（4-苄基-4-羟基 - 哌啶-1-基） - 乙基] -3-（2-甲基 - 喹啉-4-基） - 脲，其结晶，化学计量定义和非吸湿硫酸盐及其制备方法。此外，本发明涉及所述1- [2-（4-苄基-4-羟基 - 哌啶-1-基） - 乙基] -3-（2-甲基 - 喹啉-4-基） - 脲作为结晶，化学计量限定和非吸湿性硫酸盐单独或与其它化合物组合。此外，本发明涉及所述1- [2-（4-苄基-4-羟基 - 哌啶-1-基） - 乙基] -3-（2-甲基 - 喹啉-4-基） - 脲的制剂，为在制备药物组合物中的结晶化学计量限定和非吸湿性硫酸盐。本发明还涉及这种硫酸盐在作为神经激素拮抗剂的制剂中的用途。

5. 发明授权

US06572277B1 Plug connector arrangement for optical fibers 失效
标题翻译：用于光纤的插头连接器布置
公开(公告)号：US06572277B1
公开(公告)日：2003-06-03
申请号：US09762099
申请日：2001-03-29
申请人： Michel Ritter , Armin Reicharz , Josef Warislohner , Michael Steinhauser , Stephan Buchmann
发明人： Michel Ritter , Armin Reicharz , Josef Warislohner , Michael Steinhauser , Stephan Buchmann
IPC分类号： G02B636
CPC分类号： G02B6/4471
摘要： In a plug arrangement for optical waveguides, there is mounted on the end of the cable accommodating the optical waveguide a cable fixing sleeve that is bonded to the outside of the cable. The ends of the plastic fibers of the optical waveguide cladding are brought out of the cable end and laid back onto the external surface of the bonded-on cable fixing sleeve and a further sleeve being pushed onto said cable fixing sleeve, with the plastic fibers of the optical waveguide cladding being clamped and bonded between the two sleeves.
摘要翻译：在用于光波导的插头装置中，安装在电缆的端部上，该电缆容纳光波导，电缆固定套结合到电缆的外部。光波导包层的塑料纤维的端部从电缆端部脱出并放置在接合的电缆固定套的外表面上，另外的套筒被推到所述电缆固定套上，塑料纤维光波导包层被夹紧并结合在两个套筒之间。

6. 发明授权

US5402705A Control device for an electrical household appliance adapted to prepare infusion beverages 失效
标题翻译：适用于制备输液饮料的家用电器的控制装置
公开(公告)号：US5402705A
公开(公告)日：1995-04-04
申请号：US194383
申请日：1994-02-10
申请人： Jean-Philippe Bailleux , Gregor Storsberg , Stephan Buchmann
发明人： Jean-Philippe Bailleux , Gregor Storsberg , Stephan Buchmann
IPC分类号： A47J31/54 , A47J31/00
CPC分类号： A47J31/545
摘要： Control device (1) for an electrical household appliance for the preparation of infusion beverages, having a housing (2) enclosing a reservoir (3) for cold water, a heating plate (4) supported an infusion collector (5), a water heater (6) connected thermally to the plate (4) and having a conduit (6') connected to the cold water reservoir (3) and a rising conduit (6") connected to a water pipe (7) of an infusion filter (8) disposed above the infusion collector (5). An electrical heating resistance (9) for the water heater (6) is connected to an electrical supply circuit (10) switchingly controlled by the device. The device supplies the electrical resistance (9) in a first phase intermittently by current pulses of predetermined duration, separated by pause times also of predetermined duration, and in a second phase supplies the electrical resistance (9) with a direct current.
摘要翻译：用于制备输注饮料的家用电器的控制装置（1），具有包围用于冷水的储存器（3）的壳体（2），支撑着输液收集器（5）的加热板（4），热水器（6），其与板（4）热连接并且具有连接到冷水储存器（3）的导管（6'）和连接到输注过滤器的水管（7）的上升导管（6“） 8）设置在输液收集器（5）上方。用于热水器（6）的电加热电阻（9）连接到由设备切换控制的电源电路（10）。该装置以预定持续时间的电流脉冲间歇地供给电阻（9），并且以预定持续时间的暂停时间分隔，并且在第二阶段中，以直流电提供电阻（9）。

7. 发明授权

US08067601B2 1-[2-(4-benzyl-4-hydroxy-piperidin-1 -yl )-ethyl]-3-(2-methyl-quinolin- 4-yl)- urea as crystalline sulfate salt 有权
标题翻译： 1- [2-（4-苄基-4-羟基 - 哌啶-1-基） - 乙基] -3-（2-甲基 - 喹啉-4-基） - 脲，为结晶硫酸盐
公开(公告)号：US08067601B2
公开(公告)日：2011-11-29
申请号：US11577064
申请日：2005-10-11
申请人： Jean-Michel Bonard , Stephan Buchmann , Stéphane Redey , Bertrand Woinet
发明人： Jean-Michel Bonard , Stephan Buchmann , Stéphane Redey , Bertrand Woinet
IPC分类号： C07D295/00
CPC分类号： C07D401/12
摘要： The invention relates to 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea as a crystalline, stoichiometrically defined and non-hygroscopic sulfate salt and a process for its preparation. Further, the present invention relates to the use of said 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea as a crystalline, stoichiometrically defined and non-hygroscopic sulfate salt alone or in combination with other compounds. Further, the present invention relates to formulations of said 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea as a crystalline, stoichiometrically defined and non-hygroscopic sulfate salt in the preparation of pharmaceutical compositions. The invention also relates to the use of such sulfate salts in formulations as neurohormonal antagonists.
摘要翻译：本发明涉及1- [2-（4-苄基-4-羟基 - 哌啶-1-基） - 乙基] -3-（2-甲基 - 喹啉-4-基） - 脲，其结晶，化学计量定义和非吸湿硫酸盐及其制备方法。此外，本发明涉及所述1- [2-（4-苄基-4-羟基 - 哌啶-1-基） - 乙基] -3-（2-甲基 - 喹啉-4-基） - 脲作为结晶，化学计量限定和非吸湿性硫酸盐单独或与其它化合物组合。此外，本发明涉及所述1- [2-（4-苄基-4-羟基 - 哌啶-1-基） - 乙基] -3-（2-甲基 - 喹啉-4-基） - 脲的制剂，为在制备药物组合物中的结晶化学计量限定和非吸湿性硫酸盐。本发明还涉及这种硫酸盐在作为神经激素拮抗剂的制剂中的用途。

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