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1. 发明专利

DE694483C 未知
公开(公告)号：DE694483C
公开(公告)日：1940-08-02
申请号：DEB0182328
申请日：1938-03-12
申请人： STEPHAN BECK
发明人： BECK STEPHAN
IPC分类号： F28D1/053

2. 发明申请

US20090170089A1 METHODS AND COMPOSITIONS FOR DIFFERENTIATING TISSUES OR CELL TYPES USING EPIGENETIC MARKERS 审中-公开
标题翻译：使用染色体标记分化组织或细胞类型的方法和组合物
公开(公告)号：US20090170089A1
公开(公告)日：2009-07-02
申请号：US12036030
申请日：2008-02-22
申请人： Joern Lewin , Kurt Berlin , Thomas Hildmann , Alexander Olek , Stephan Beck , Karen Novik
发明人： Joern Lewin , Kurt Berlin , Thomas Hildmann , Alexander Olek , Stephan Beck , Karen Novik
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q2600/154 , C12Q2600/16
摘要： The present invention provides, inter alia, a method for generating a genome-wide epigenomic map, comprising a correlation between methylation variable CpG positions (MVP) and genomic DNA sample types. MVP are those CpG positions that show a variable quantitative level of methylation between sample types. Particular genomic regions of interest (ROI) provide preferred marker sequences that comprise multiple, and preferably proximate MVP, and that have novel utility for distinguishing sample types. The epigenic maps have broad utility, for example, in identifying sample types, or for distinguishing between and among sample types. In a preferred embodiment the epigenomic map is based on methylation variable regions (MVP) within the major histocompatibility complex (MHC), and has utility, for example, in identifying the cell or tissue source of a genomic DNA sample, or for distinguishing one or more particular cell or tissue types among other cell or tissue types. Analysis of epigenetic characteristics of one, or of a set of nucleic acid sequences, in the context of an inventive epigenomic map, allows for the determination of an origin of the nucleic acids.
摘要翻译：本发明尤其提供了一种生成全基因组表观遗传学图谱的方法，其包括甲基化可变CpG位点（MVP）和基因组DNA样品类型之间的相关性。 MVP是显示样品类型之间甲基化可变定量水平的那些CpG位置。特定的感兴趣的基因组区域（ROI）提供优选的标记序列，其包含多个，优选接近MVP，并且具有用于区分样品类型的新颖效用。表征性地图具有广泛的用途，例如，在识别样本类型中，或用于区分样本类型和样本类型。在优选的实施方案中，表观基因组图基于主要组织相容性复合物（MHC）内的甲基化可变区（MVP），并且可用于例如鉴定基因组DNA样品的细胞或组织来源，或用于区分一个或更特定的细胞或组织类型与其他细胞或组织类型。在本发明表观遗传学图谱的上下文中，一种或一组核酸序列的表观遗传学特征的分析允许确定核酸的来源。

3. 发明申请

US20090191548A1 METHODS AND NUCLEIC ACIDS FOR THE ANALYSIS OF GENE EXPRESSION ASSOCIATED WITH TISSUE CLASSIFICATION 审中-公开
标题翻译：用于组织分类相关基因表达分析的方法和核酸
公开(公告)号：US20090191548A1
公开(公告)日：2009-07-30
申请号：US12088384
申请日：2006-09-28
申请人： Kurt Berlin , Stephan Beck , Matthias Burger , Rene Cortese , Florian Eckhardt , Carolina Haefliger , Joern Lewin , Fabian Model , Alexander Olek
发明人： Kurt Berlin , Stephan Beck , Matthias Burger , Rene Cortese , Florian Eckhardt , Carolina Haefliger , Joern Lewin , Fabian Model , Alexander Olek
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6881 , C12Q2600/158
摘要： The present application provides methods and nucleic acids the classification of a biological sample. This is achieved by the analysis of the expression status of at least one of the genes selected from Table 1 as disclosed.
摘要翻译：本申请提供了生物样品分类的方法和核酸。通过分析所公开的选自表1中的至少一种基因的表达状态来实现。

4. 发明申请

US20060183128A1 Methods and compositions for differentiating tissues for cell types using epigenetic markers 审中-公开
标题翻译：使用表观遗传标记分化细胞类型的组织的方法和组合物
公开(公告)号：US20060183128A1
公开(公告)日：2006-08-17
申请号：US10641321
申请日：2003-08-12
申请人： Kurt Berlin , Alexander Olek , Stephan Beck , Thomas Hildmann , Joern Lewin , Karen Novik
发明人： Kurt Berlin , Alexander Olek , Stephan Beck , Thomas Hildmann , Joern Lewin , Karen Novik
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6881 , C12Q2600/154 , C12Q2600/16
摘要： The present invention provides, inter alia, a method for generating a genome-wide epigenomic map, comprising a correlation between methylation variable CpG positions (MVP) and genomic DNA sample types. MVP are those CpG positions that show a variable quantitative level of methylation between sample types. Particular genomic regions of interest (ROI) provide preferred marker sequences that comprise multiple, and preferably proximate MVP, and that have novel utility for distinguishing sample types. The epigenic maps have broad utility, for example, in identifying sample types, or for distinguishing between and among sample types. In a preferred embodiment the epigenomic map is based on methylation variable regions (MVP) within the major histocompatibility complex (MHC), and has utility, for example, in identifying the cell or tissue source of a genomic DNA sample, or for distinguishing one or more particular cell or tissue types among other cell or tissue types. Analysis of epigenetic characteristics of one, or of a set of nucleic acid sequences, in the context of an inventive epigenomic map, allows for the determination of an origin of the nucleic acids.
摘要翻译：本发明尤其提供了一种生成全基因组表观遗传学图谱的方法，其包括甲基化可变CpG位点（MVP）和基因组DNA样品类型之间的相关性。 MVP是显示样品类型之间甲基化可变定量水平的那些CpG位置。特定的感兴趣的基因组区域（ROI）提供优选的标记序列，其包含多个，优选接近MVP，并且具有用于区分样品类型的新颖效用。表征性地图具有广泛的用途，例如，在识别样本类型中，或用于区分样本类型和样本类型。在优选的实施方案中，表观基因组图基于主要组织相容性复合物（MHC）内的甲基化可变区（MVP），并且可用于例如鉴定基因组DNA样品的细胞或组织来源，或用于区分一个或更特定的细胞或组织类型与其他细胞或组织类型。在本发明表观遗传学图谱的上下文中，一种或一组核酸序列的表观遗传学特征的分析允许确定核酸的来源。

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