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1. 发明申请

US20070264627A1 Retrovirus from the HIV group and its use 审中-公开
标题翻译：来自HIV组的逆转录病毒及其用途
公开(公告)号：US20070264627A1
公开(公告)日：2007-11-15
申请号：US11634155
申请日：2006-12-06
申请人： Lutz Guertler , Josef Eberle , Albrecht Brunn , Stefan Knapp , Hans-Peter Hauser
发明人： Lutz Guertler , Josef Eberle , Albrecht Brunn , Stefan Knapp , Hans-Peter Hauser
IPC分类号： C12Q1/70 , C12N7/00
CPC分类号： G01N33/56988 , A61K39/00 , C07K14/005 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , C12Q1/703
摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
摘要翻译：公开了一种新型免疫缺陷病毒，其名称为MVP-5180/91，并且已经在欧洲动物细胞培养物收集库（ECACC）V 920 52 318下保藏。可从其中获得的特征性抗原，其中可以用于检测与免疫缺陷病相关的逆转录病毒的抗体，以及病毒的DNA和氨基酸序列也被公开。

2. 发明申请

US20050053920A1 Retrovirus from the HIV group and its use 审中-公开
标题翻译：来自HIV组的逆转录病毒及其用途
公开(公告)号：US20050053920A1
公开(公告)日：2005-03-10
申请号：US10829442
申请日：2004-04-22
申请人： Lutz Guertler , Josef Eberle , Albrecht Brunn , Stefan Knapp , Hans-Peter Hauser
发明人： Lutz Guertler , Josef Eberle , Albrecht Brunn , Stefan Knapp , Hans-Peter Hauser
IPC分类号： A61K39/21 , A61K39/00 , A61P31/12 , A61P31/18 , C07K14/00 , C07K14/155 , C07K14/16 , C12N5/02 , C12N7/00 , C12N7/01 , C12N15/09 , C12N15/48 , C12P21/02 , C12Q1/68 , C12Q1/70 , G01N33/53 , G01N33/569 , G01N33/68
CPC分类号： G01N33/56988 , A61K39/00 , C07K14/005 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , C12Q1/703
摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
摘要翻译：公开了一种新型免疫缺陷病毒，其名称为MVP-5180/91，并且已经在欧洲动物细胞培养物收集库（ECACC）V 920 52 318下保藏。可从其中获得的特征性抗原，其中可以用于检测与免疫缺陷病相关的逆转录病毒的抗体，以及病毒的DNA和氨基酸序列也被公开。

3. 发明授权

US06531587B2 Retrovirus from the HIV group and its use 失效
公开(公告)号：US06531587B2
公开(公告)日：2003-03-11
申请号：US09886150
申请日：2001-06-22
申请人： Lutz G. Guertler , Josef Eberle , Albrecht V. Brunn , Stefan Knapp , Hans-Peter Hauser
发明人： Lutz G. Guertler , Josef Eberle , Albrecht V. Brunn , Stefan Knapp , Hans-Peter Hauser
IPC分类号： C07H2104
CPC分类号： G01N33/56988 , A61K39/00 , C07K14/005 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , C12Q1/703
摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.

4. 发明授权

US06528626B2 Retrovirus from the HIV group and its use 失效
公开(公告)号：US06528626B2
公开(公告)日：2003-03-04
申请号：US09886156
申请日：2001-06-22
申请人： Lutz G. Guertler , Josef Eberle , Albrecht v. Brunn , Stefan Knapp , Hans-Peter Hauser
发明人： Lutz G. Guertler , Josef Eberle , Albrecht v. Brunn , Stefan Knapp , Hans-Peter Hauser
IPC分类号： C07K1600
CPC分类号： G01N33/56988 , A61K39/00 , C07K14/005 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , C12Q1/703
摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.

5. 发明授权

US5159062A Signal peptide for the secretion of peptides in Escherichia coli 失效
标题翻译：用于分离ESCHERICHIA COLI的肽的信号肽
公开(公告)号：US5159062A
公开(公告)日：1992-10-27
申请号：US467551
申请日：1990-01-19
申请人： Stefan Knapp , Egon Amann , Karl-Josef Abel
发明人： Stefan Knapp , Egon Amann , Karl-Josef Abel
IPC分类号： C12N15/09 , C07H21/04 , C07K14/195 , C07K14/235 , C07K14/41 , C12N1/21 , C12N15/62 , C12N15/70 , C12P21/02 , C12Q1/68 , C12R1/19
CPC分类号： C07K14/235 , C12N15/625 , C12N15/70 , C07K2319/034 , Y10S530/825
摘要： The invention relates to a new signal peptide from Bordetella pertussis with the amino acid sequence M K K W F V A A G I G A G L L M L S S A A and to particularly suitable expression vectors with whose aid such signal sequences can be found and/or evaluated.
摘要翻译：本发明涉及来自百日咳杆菌的新信号肽，其具有氨基酸序列M K K W F V A A G I G A G L L M L S S A A，并且涉及可以发现和/或评估这些信号序列的特别合适的表达载体。

6. 发明申请

US20070105219A1 Retrovirus from the HIV group and its use 审中-公开
公开(公告)号：US20070105219A1
公开(公告)日：2007-05-10
申请号：US11634254
申请日：2006-12-06
申请人： Lutz Guertler , Josef Eberle , Albrecht Brunn , Stefan Knapp , Hans-Peter Hauser
发明人： Lutz Guertler , Josef Eberle , Albrecht Brunn , Stefan Knapp , Hans-Peter Hauser
IPC分类号： C12Q1/68 , C12N5/06 , C12N5/16
CPC分类号： G01N33/56988 , A61K39/00 , C07K14/005 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , C12Q1/703
摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.

7. 发明授权

US5429097A Device for feeding vapors of a fuel tank into an internal combustion engine 失效
标题翻译：将燃料箱的蒸汽进入内燃机的装置
公开(公告)号：US5429097A
公开(公告)日：1995-07-04
申请号：US160998
申请日：1993-12-03
申请人： Jurgen Wojts-Saary , Joachim Heinemann , Reinhard Tinz , Stefan Knapp
发明人： Jurgen Wojts-Saary , Joachim Heinemann , Reinhard Tinz , Stefan Knapp
IPC分类号： B60K15/035 , F02M25/08 , F02M33/02
CPC分类号： B60K15/03519 , F02M25/0809 , F02M25/0836 , Y10T137/87877
摘要： A device for feeding the vapors present in the free space of a fuel tank into the intake manifold of an internal combustion engine wherein the free space and the intake manifold are connected by a line in which an activated carbon container and a stop valve are connected in series, the activated carbon container being connected with the atmosphere by a vent line and the vent line can be closed by a vent line valve. The device further comprises an excess pressure valve and/or a vacuum valve which may be in the same housing as the vent line valve.
摘要翻译：一种用于将存在于燃料箱的自由空间中的蒸气供给到内燃机的进气歧管中的装置，其中自由空间和进气歧管通过连接有活性炭容器和截止阀的管路相连接系列中，活性炭容器通过排气管线与大气连接，排气管线可以通过排气阀门关闭。该装置还包括过压阀和/或真空阀，其可以在与排气管线阀相同的壳体中。

8. 发明授权

US06548635B1 Retrovirus from the HIV type O and its use (MVP-2901/94) 有权
标题翻译： HIV型O型逆转录病毒及其用途（MVP-2901/94）
公开(公告)号：US06548635B1
公开(公告)日：2003-04-15
申请号：US09610271
申请日：2000-07-06
申请人： Hans-Peter Hauser , Stefan Knapp , Stefan Brust , Lutz G. Gürtler , Josef Eberle , Lazare Kaptue , Léopold Achengui Zekeng
发明人： Hans-Peter Hauser , Stefan Knapp , Stefan Brust , Lutz G. Gürtler , Josef Eberle , Lazare Kaptue , Léopold Achengui Zekeng
IPC分类号： A61K3804
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , Y10S435/974 , Y10S435/975 , Y10S530/812
摘要： A novel HIV type O immunodeficiency virus is disclosed which has the designation MVP-2901/94 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 950121601. The characteristic antigens which can be obtained from the virus and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the partial DNA and amino acid sequences of the virus.
摘要翻译：公开了一种新型HIV型O免疫缺陷病毒，其命名为MVP-2901/94，并已经在欧洲动物细胞培养物保藏中心（ECACC）VAL 950121601中保藏。可以从病毒获得的特征性抗原并且还可以用于检测与免疫缺陷病相关的抗逆转录病毒的抗体，以及病毒的部分DNA和氨基酸序列。

9. 发明授权

US06335158B2 Methodologies for the detection of human immunodeficiency virus nucleic acids employing oligonucleotide primer derived from the HIV-1 MVP5180/91 genome 有权
标题翻译：使用衍生自HIV-1 MVP5180 / 91基因组的寡核苷酸引物检测人类免疫缺陷病毒核酸的方法
公开(公告)号：US06335158B2
公开(公告)日：2002-01-01
申请号：US09131551
申请日：1998-08-10
申请人： Stefan Brust , Stefan Knapp , Manfred Gerken , Lutz G. Guertler
发明人： Stefan Brust , Stefan Knapp , Manfred Gerken , Lutz G. Guertler
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K39/00 , C07K16/1045 , C07K2317/21 , C12N2740/16022 , C12N2740/16122 , C12N2740/16134 , C12Q1/703
摘要： The present invention is directed toward nucleic-acid based methodologies for the detection of human immunodeficiency virus (HIV) nucleic acids in a sample. A novel HIV-1 isolate, designated MVP5180/91, was isolated from a West African Cameroonian patient with immunodeficiency. Nucleic acid and amino acid sequence comparisons of this isolate, with other HIV-1 strains of subtypes A-E and HIV-2 isolates, demonstrated that this virus shares only limited homology with other known HIV-1 and -2 isolates. However, this virus does display some genetic relatedness to another Cameroonian isolate designated ANT-70. These viruses form the basis for a new HIV-1 group which has been designated subtype O. An immunologically important epitope, corresponding to amino acids 601-623 of the MVP5180/91 transmembrane envelope glycoprotein, was identified. Labeled nucleic acids can be prepared from the nucleotide sequence encoding this region and employed in standard hybridization assays to detect HIV-1 nucleic acids. Alternatively, oligonucleotide primers can also be prepared from this region and employed in polymerase chain reaction (PCR) assays to detect viral-specific nucleic acids.
摘要翻译：本发明涉及用于检测样品中的人类免疫缺陷病毒（HIV）核酸的基于核酸的方法。从具有免疫缺陷的西非喀麦隆患者中分离出一种名为MVP5180 / 91的新型HIV-1分离株。该分离株与其他HIV-1亚型A-E和HIV-2分离株的核酸和氨基酸序列比较表明，该病毒与其他已知的HIV-1和-2分离株仅具有有限的同源性。然而，这种病毒确实显示与另一个指定为ANT-70的喀麦隆分离株有一些遗传相关性。这些病毒构成了已被指定为亚型O的新的HIV-1组的基础。鉴定了与MVP5180 / 91跨膜包膜糖蛋白的氨基酸601-623相当的免疫重要的表位。标记的核酸可以从编码该区域的核苷酸序列制备，并用于标准杂交测定以检测HIV-1核酸。或者，也可以从该区域制备寡核苷酸引物，并用于聚合酶链反应（PCR）测定中以检测病毒特异性核酸。

10. 发明授权

US06277561B1 Diagnostic assay for detection of HIV 失效
标题翻译：用于检测HIV的诊断测定
公开(公告)号：US06277561B1
公开(公告)日：2001-08-21
申请号：US09109916
申请日：1998-07-02
申请人： Lutz G. Guertler , Josef Eberle , Albrecht v. Brunn , Stefan Knapp , Hans-Peter Hauser
发明人： Lutz G. Guertler , Josef Eberle , Albrecht v. Brunn , Stefan Knapp , Hans-Peter Hauser
IPC分类号： C12Q170
CPC分类号： G01N33/56988 , A61K39/00 , C07K14/005 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , C12Q1/703
摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 92 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immuno-deficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
摘要翻译：公开了一种新型免疫缺陷病毒，其具有命名为MVP-5180/91，并且已经保藏在欧洲动物细胞培养物库（ECACC）的第V 920 92 318号下。可从其中获得的特征性抗原，其中可以用于检测与免疫缺陷相关的逆转录病毒的抗体，还公开了病毒的DNA和氨基酸序列。

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