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1. 发明授权

US07332586B2 Nanoparticle delivery vehicle 失效
标题翻译：纳米颗粒递送载体
公开(公告)号：US07332586B2
公开(公告)日：2008-02-19
申请号：US10192393
申请日：2002-07-10
申请人： Stefan Franzen , Daniel L. Feldheim , Alexander G. Tkachenko , Marisha L. Godek , Joseph A. Ryan , Stefan Franzen, legal representative
发明人： Miles F. Anderson
IPC分类号： C07K17/00 , C07K17/02 , C07K17/06 , C07K17/14 , A61K9/14
CPC分类号： A61K49/0047 , A61K9/5115 , A61K48/0025 , C12N15/88 , Y02A50/471 , Y10S977/773
摘要： A nanoparticle delivery vehicle, comprising a nanoparticle, an active agent and a nuclear localization signal and methods of modulating gene expression and protein expression employing the nanoparticle delivery vehicle. A representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter of about 30 nm or less, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the nucleus of a target cell. Another representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter greater than or equal to about 30 nm, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the cytoplasm of a cell.
摘要翻译：包含纳米颗粒，活性剂和核定位信号的纳米颗粒递送载体以及使用纳米颗粒递送载体调节基因表达和蛋白质表达的方法。代表性的方法包括提供包含直径约30nm或更小的纳米颗粒的纳米颗粒递送载体，活性剂和核定位信号; 并使靶细胞与纳米颗粒递送载体接触，由此将活性剂递送至靶细胞的细胞核。另一种代表性的方法包括提供包含直径大于或等于约30nm的纳米颗粒的纳米颗粒递送载体，活性剂和核定位信号; 并使靶细胞与纳米颗粒递送载体接触，由此将活性剂递送至细胞的细胞质。

2. 发明授权

US09061076B2 Viral nanoparticle cell-targeted delivery platform 有权
标题翻译：病毒纳米颗粒细胞靶向递送平台
公开(公告)号：US09061076B2
公开(公告)日：2015-06-23
申请号：US12601736
申请日：2008-05-22
申请人： Stefan Franzen , Richard Guenther , Steven A. Lommel , LiNa Loo
发明人： Stefan Franzen , Richard Guenther , Steven A. Lommel , LiNa Loo
IPC分类号： A61K31/704 , A61P35/00 , A61K51/00 , C12N15/09 , A61K47/48 , A61K9/51 , B82Y5/00 , C12N7/00
CPC分类号： A61K47/48776 , A61K9/5184 , A61K47/6425 , A61K47/645 , A61K47/6901 , B82Y5/00 , C12N7/00 , C12N15/09 , C12N2770/38023 , C12N2770/38043 , C12N2799/02 , C12N2810/855
摘要： This invention is a process for the manufacture of a plant viral capsid to be used for the targeted delivery of therapeutics to diseased cells. The process uses a plant virus as the starting material. The choice of the plant virus overcomes a problem in the manufacture of a uniform starting material. The final product has an advantage over other plant virus-based delivery systems in that the plant virus selected has a natural structure that is resistant to breakdown during the delivery process. This system takes advantage of the reversible divalent cation switch that this capsid employs to assemble and disassemble.
摘要翻译：本发明是一种用于制造用于向病变细胞靶向递送治疗剂的植物病毒衣壳的方法。该过程使用植物病毒作为起始材料。植物病毒的选择克服了制造均匀原料的问题。最终产品优于其他基于植物病毒的递送系统，因为所选择的植物病毒具有在递送过程中耐破坏的天然结构。该系统利用该衣壳用于组装和拆卸的可逆二价阳离子开关。

3. 发明授权

US08674146B2 Method for producing alkylene oxide addition products 失效
标题翻译：生产环氧烷加成产物的方法
公开(公告)号：US08674146B2
公开(公告)日：2014-03-18
申请号：US12440461
申请日：2007-08-29
申请人： Stefan Franzen , Franz Büttgen , Ingomar Mrozek , Bernhard Gutsche
发明人： Stefan Franzen , Franz Büttgen , Ingomar Mrozek , Bernhard Gutsche
IPC分类号： C07C41/02 , C07C41/03 , B01J8/00
CPC分类号： C07C41/02 , B01J19/0093 , B01J2219/00783 , B01J2219/00788 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/0086 , B01J2219/00867 , B01J2219/00869 , B01J2219/00873 , B01J2219/00889 , C07C41/03 , C07C213/04 , C08G65/2696 , C11D1/44 , C11D1/72 , C11D1/74 , C07C43/11
摘要： The invention relates to a method for producing alkylene oxide addition products by reaction of compounds having a nucleophilic center with alkylene oxides in a reactor having a large inner surface. The invention is characterized in that the reaction is carried out exclusively in the liquid phase.
摘要翻译：本发明涉及通过在具有大内表面的反应器中使具有亲核中心的化合物与烯化氧反应制备环氧烷加成产物的方法。本发明的特征在于反应仅在液相中进行。

4. 发明申请

US20120039799A1 VIRAL NANOPARTICLE CELL-TARGETED DELIVERY PLATFORM 有权
标题翻译： VIRAL NANOPARTICLE细胞定向递送平台
公开(公告)号：US20120039799A1
公开(公告)日：2012-02-16
申请号：US12601736
申请日：2008-05-22
申请人： Stefan Franzen , Richard Guenther , Steven A. Lommel , LiNa Loo
发明人： Stefan Franzen , Richard Guenther , Steven A. Lommel , LiNa Loo
IPC分类号： A61K9/00 , A61K31/704 , A61P35/00 , A61K51/00
CPC分类号： A61K47/48776 , A61K9/5184 , A61K47/6425 , A61K47/645 , A61K47/6901 , B82Y5/00 , C12N7/00 , C12N15/09 , C12N2770/38023 , C12N2770/38043 , C12N2799/02 , C12N2810/855
摘要： This invention is a process for the manufacture of a plant viral capsid to be used for the targeted delivery of therapeutics to diseased cells. The process uses a plant virus as the starting material. The choice of the plant virus overcomes a problem in the manufacture of a uniform starting material. The final product has an advantage over other plant virus-based delivery systems in that the plant virus selected has a natural structure that is resistant to breakdown during the delivery process. This system takes advantage of the reversible divalent cation switch that this capsid employs to assemble and disassemble.
摘要翻译：本发明是一种用于制造用于向病变细胞靶向递送治疗剂的植物病毒衣壳的方法。该过程使用植物病毒作为起始材料。植物病毒的选择克服了制造均匀原料的问题。最终产品优于其他基于植物病毒的递送系统，因为所选择的植物病毒具有在递送过程中耐破坏的天然结构。该系统利用该衣壳用于组装和拆卸的可逆二价阳离子开关。

5. 发明授权

US08273925B2 Method and device for the production of alkylene oxide addition products 有权
标题翻译：用于生产环氧烷加成产物的方法和装置
公开(公告)号：US08273925B2
公开(公告)日：2012-09-25
申请号：US12524172
申请日：2007-12-08
申请人： Stefan Franzen , Thomas Koelker
发明人： Stefan Franzen , Thomas Koelker
IPC分类号： C07C29/00 , B01J19/00
CPC分类号： C08G65/2609 , C08G65/2615 , C08G65/2621 , C08G65/2696
摘要： A method for the production of alkylene oxide addition products comprising (i) charging a stirred reactor with a starting compound capable of adding on or inserting alkylene oxides, introducing at least one alkylene oxide plus a different diluent gas, wherein a portion of said alkylene oxide reacts in a liquid phase with said starting compound, and the remaining alkylene oxide together with said diluent gas forms a gas phase above the liquid phase, (ii) continuously drawing off said liquid phase from the bottom of the reactor via an outlet stub, and recycling to the top of the reactor via an external circulation system, which comprises at least one heat exchanger and at least one Venturi nozzle within said external circulation system, and (iii) metering said gas phase comprising alkylene oxide into said Venturi nozzle via a vacuum line.
摘要翻译：一种用于生产环氧烷加成产物的方法，包括（i）向搅拌反应器中加入能够加入或插入烯化氧的起始化合物，引入至少一种环氧烷加上不同的稀释气体，其中一部分所述环氧烷烃在液相中与所述起始化合物反应，剩余的环氧烷与所述稀释气体一起在液相上形成气相，（ii）经由出口残渣从反应器的底部连续地抽出液相，以及通过外部循环系统再循环到反应器的顶部，外部循环系统包括至少一个热交换器和在所述外部循环系统内的至少一个文丘里喷嘴，以及（iii）通过真空将所述包含环氧烷的气相计量到所述文丘里喷嘴中线。

6. 发明授权

US07868161B2 Photocrosslinking probes and uses of the same 失效
标题翻译：光交联探针及其用途
公开(公告)号：US07868161B2
公开(公告)日：2011-01-11
申请号：US11496264
申请日：2006-07-31
申请人： Stefan Franzen , Bohdan Skalski
发明人： Stefan Franzen , Bohdan Skalski
IPC分类号： C07H21/00 , C07H21/04
CPC分类号： C07D495/14 , C07H21/04 , C12Q1/6813 , C12Q1/6816 , C12Q2523/313 , C12Q2523/101 , C12Q2563/107 , C12Q2525/117
摘要： A method of detecting a target nucleic acid is disclosed, the method comprising detecting the presence of a fluorescent covalent crosslinked product from non-fluorescent precursors. The fluorescent covalent crosslinked product comprises a novel fluorophore structure. Also described are methods of synthesizing probe molecules that can form fluorescent covalent crosslinked products with nucleic acid targets and arrays comprising such probes.
摘要翻译：公开了一种检测靶核酸的方法，该方法包括检测来自非荧光前体的荧光共价交联产物的存在。荧光共价交联产物包含新的荧光团结构。还描述了合成探针分子的方法，所述探针分子可以与核酸靶和包含这种探针的阵列形成荧光共价交联产物。

7. 发明申请

US20100000881A1 Electrochemical detection of nucleic acid hybridization 审中-公开
标题翻译：电化学检测核酸杂交
公开(公告)号：US20100000881A1
公开(公告)日：2010-01-07
申请号：US10978678
申请日：2004-11-01
申请人： Stefan Franzen , Daniel Feldheim
发明人： Stefan Franzen , Daniel Feldheim
IPC分类号： C12Q1/68 , G01N27/26
CPC分类号： C12Q1/6825 , C12Q2563/113 , C12Q2565/607
摘要： A nucleic acid hybridization detection assay is carried out at an electrode. A solid electrode, such as an indium tin oxide electrode, is modified by capture probes comprising single-stranded oligonucleotides immobilized to the surface of the electrode. In some embodiments using sandwich assay methodology, the capture probes hybridize complementary target nucleic acid sequences, which in turn are bound to detection probes comprising nanoparticle-oligonucleotide conjugates comprising target-complementary oligonucleotides. In some embodiments, detection probes comprise nanoparticles attached to molecules comprising one partner of a ligand-binding pair (e.g., streptavidin), while target sequences comprise the other partner of the ligand-binding pair (e.g., biotin). When the assay is carried out in the presence of a redox mediator, redox reactions catalyzed, and/or facilitated and/or enhanced by the presence of nanoparticles generate electrons that are transferred to the electrode, resulting in a detectable electrical signal.
摘要翻译：在电极上进行核酸杂交检测测定。诸如氧化铟锡电极的固体电极通过包含固定在电极表面上的单链寡核苷酸的捕获探针进行修饰。在使用夹心测定方法的一些实施方案中，捕获探针杂交互补的靶核酸序列，其又与包含靶互补寡核苷酸的纳米颗粒 - 寡核苷酸缀合物的检测探针结合。在一些实施方案中，检测探针包含与包含配体结合对（例如链霉亲和素）的一个配偶体的分子连接的纳米颗粒，而靶序列包含配体结合对（例如生物素）的另一个配偶体。当在氧化还原介体的存在下进行测定时，通过纳米颗粒的存在而催化和/或促进和/或增强的氧化还原反应产生转移到电极的电子，产生可检测的电信号。

8. 发明申请

US20090253944A1 Process for Preparing Alkylene Oxides 有权
标题翻译：制备环氧烷的方法
公开(公告)号：US20090253944A1
公开(公告)日：2009-10-08
申请号：US12295679
申请日：2007-03-23
申请人： Bernhard Gutsche , Bernd Fabry , Stefan Franzen
发明人： Bernhard Gutsche , Bernd Fabry , Stefan Franzen
IPC分类号： C07C29/04
CPC分类号： C07D301/12 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00862 , B01J2219/00867 , B01J2219/00869 , B01J2219/00889 , C07D301/14
摘要： The invention provides a process for preparing ethylene oxide and/or propylene oxide by contacting ethylene and/or propylene with an oxidizing agent, wherein (i) the reaction takes place in a microreaction system (p-reactor) and (ii) the oxidizing agent used is a peroxo compound.
摘要翻译：本发明提供了通过使乙烯和/或丙烯与氧化剂接触来制备环氧乙烷和/或环氧丙烷的方法，其中（i）反应在微反应系统（p反应器）中进行，和（ii）氧化剂使用过氧化合物。

9. 发明申请

US20070082349A1 Photocrosslinking probes and uses of the same 失效
标题翻译：光交联探针及其用途
公开(公告)号：US20070082349A1
公开(公告)日：2007-04-12
申请号：US11496264
申请日：2006-07-31
申请人： Stefan Franzen , Bohdan Skalski
发明人： Stefan Franzen , Bohdan Skalski
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C07D495/14 , C07H21/04 , C12Q1/6813 , C12Q1/6816 , C12Q2523/313 , C12Q2523/101 , C12Q2563/107 , C12Q2525/117
摘要： A method of detecting a target nucleic acid is disclosed, the method comprising detecting the presence of a fluorescent covalent crosslinked product from non-fluorescent precursors. The fluorescent covalent crosslinked product comprises a novel fluorophore structure. Also described are methods of synthesizing probe molecules that can form fluorescent covalent crosslinked products with nucleic acid targets and arrays comprising such probes.
摘要翻译：公开了一种检测靶核酸的方法，该方法包括检测来自非荧光前体的荧光共价交联产物的存在。荧光共价交联产物包含新的荧光团结构。还描述了合成探针分子的方法，所述探针分子可以与核酸靶和包含这种探针的阵列形成荧光共价交联产物。

10. 发明申请

US20110218349A1 Method for Producing Alkylene Oxide Addition Products 审中-公开
标题翻译：生产环氧丙烷添加剂的方法
公开(公告)号：US20110218349A1
公开(公告)日：2011-09-08
申请号：US12440459
申请日：2007-08-29
申请人： Stefan Franzen , Bernhard Gutsche , Bernd Fabry , Eik Ulf Mahnke
发明人： Stefan Franzen , Bernhard Gutsche , Bernd Fabry , Eik Ulf Mahnke
IPC分类号： C07D301/10
CPC分类号： C07C41/03 , C07D301/10 , C08G65/2603 , C08G65/2609 , C08G65/2696 , C07C43/11
摘要： The invention relates to a method for producing alkylene oxide addition products. The method according to the invention is characterized by (a) contacting ethylene and/or propylene with an oxidizing agent in a first structured reactor (“μ reactor”) and (b) feeding the ethylene oxide and/or propylene oxide so obtained, optionally after purification, to a second structured reactor where it is reacted with a compound having a nucleophilic molecular group.
摘要翻译：本发明涉及一种生产环氧烷加成产物的方法。根据本发明的方法的特征在于：（a）在第一结构化反应器（“μ反应器”）中将乙烯和/或丙烯与氧化剂接触，和（b）将如此获得的环氧乙烷和/或环氧丙烷纯化后的第二结构反应器与其具有亲核分子基团的化合物反应。

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