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2. 发明授权

US4835158A Isoquinoline derivatives 失效
标题翻译：异喹啉衍生物
公开(公告)号：US4835158A
公开(公告)日：1989-05-30
申请号：US120654
申请日：1987-11-16
申请人： Gordon H. Phillipps , Stanley F. Dyke , Esme J. Bailey , Peter D. Howes , David I. C. Scopes
发明人： Gordon H. Phillipps , Stanley F. Dyke , Esme J. Bailey , Peter D. Howes , David I. C. Scopes
IPC分类号： C07D471/04 , C07D471/14
CPC分类号： C07D471/04 , C07D471/14
摘要： Pharmaceutical compositions for combatting cancer comprising a compound of formula (I) ##STR1## (wherein R.sup.1 represents a hydrogen atom or a C.sub.1-4 alkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkynyl group;R.sup.2 represents a hydrogen atom or a hydroxyl, C.sub.1-4 alkoxy or C.sub.2-4 alkanoyloxy group;R.sup.3 represents a hydrogen atom, or (when R.sup.2 is other than a hydrogen atom) optionally a hydroxyl, C.sub.1-4 alkoxy or C.sub.2-4 alkanoyloxy group, or R.sup.2 and R.sup.3 together represent a methylenedioxy group;R.sup.4 represents a hydrogen or halogen atom or a C.sub.1-3 alkyl group or a phenyl group optionally substituted by a halogen atom or a hydroxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or C.sub.1-4 alkanoyloxy group; and the ring A represents a group of formula ##STR2## where R.sup.5 and R.sup.6 each represent a hydrogen atom or a hydroxyl, C.sub.1-4 alkoxy or C.sub.1-4 alkanoyloxy group,R.sup.7 and R.sup.8 each represents a hydrogen atom or a methyl group, and one of X, X.sup.1, X.sup.2 and X.sup.3 represents a nitrogen atom and the others represent --CH-- groups; with the proviso that where Arepresents a group of formula (i) at least one of R.sup.1 to R.sup.6 represents other than a hydrogen atom) together with at least one pharmaceutical carrier or excipient.
摘要翻译：包括式（I）化合物（I）（其中R1表示氢原子或C1-4烷基，C2-4烯基或C2-4炔基; R2表示氢原子或羟基，C 1-4烷氧基或C 2-4烷酰氧基; R 3表示氢原子，或（当R 2不是氢原子时）任选的羟基，C 1-4烷氧基或C 2-4烷酰氧基，或R 2和R 3 一起代表亚甲二氧基; R4代表氢或卤原子或C1-3烷基或任选被卤素原子或羟基，C1-4烷基，C1-4烷氧基或C1-4烷酰氧基取代的苯基; 并且环A表示式为“IMAGE”的基团，其中R 5和R 6各自表示氢原子或羟基，C 1-4烷氧基或C 1-4烷酰氧基，R 7和R 8各自表示氢原子或甲基， X，X 1，X 2和X 3中的一个表示氮原子，其余的表示-CH-基团;条件是其中A代表（i）R 1至R 6中的至少一个表示除氢原子以外的基团）以及至少一种药物载体或赋形剂。

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