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1. 发明公开

EP1066391A2 ANTIGEN PREPARATION AND USE 审中-公开
标题翻译：融合蛋白含有乳多空病毒的主要衣壳蛋白的序列
公开(公告)号：EP1066391A2
公开(公告)日：2001-01-10
申请号：EP99913478.6
申请日：1999-03-29
申请人： Stanley, Margaret Anne , Zhang, Wei
发明人： Stanley, Margaret Anne , Zhang, Wei
IPC分类号： C12N15/62 , C12N5/10 , C12N7/01 , C12N7/02 , C07K14/025 , C07K19/00 , A61K39/12
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N7/00 , C12N2710/14143 , C12N2710/20022 , C12N2710/20023
摘要： Modified virus-like particles (VLPs) can comprise fusion proteins having sequence from a major coat protein of a papovavirus, e.g. L1 protein of HPV 16 or 18, in which the N-terminal of the sequence derived from the major coat protein is fused to a further peptide sequence. The VLPs can contain a full sequence of an L1 protein, or an L1 sequence with an N-terminal deletion, or an L1 sequence with an aminoacid substitution mutation, and optionally a C-terminal L1 sequence deletion. The peptide sequence fused to the N-terminal can be immunogenic e.g. from a protein of a pathogen such as a virus. The further peptide sequence can provide a binding domain for affinity purification of the VLP. Modified VLPs can retain the native conformation of the VLP structure while also presenting to the immune system of a subject immunised with the modified VLPs an epitope present on an N-terminal extension of the major coat protein sequence. Corresponding polynucleotides, expression vectors, plasmids, vectors and cells containing such polynucleotides are disclosed.

2. 发明专利

AU3159499A Antigen preparation and use 未知
公开(公告)号：AU3159499A
公开(公告)日：1999-10-18
申请号：AU3159499
申请日：1999-03-29
申请人： STANLEY MARGARET ANNE , ZHANG WEI
发明人： STANLEY MARGARET ANNE , ZHANG WEI
IPC分类号： A61K39/00 , C07K14/025 , C12N7/04 , C12N15/62 , A61K39/12 , C07K19/00 , C12N5/10 , C12N7/01 , C12N7/02

3. 发明申请

WO9950424A3 FUSION PROTEIN COMPRISING A SEQUENCE FROM A MAJOR COAT PROTEIN OF A PAPOVAVIRUS 审中-公开
标题翻译：融合蛋白包含来自斑马鱼的主要涂层蛋白的序列
公开(公告)号：WO9950424A3
公开(公告)日：1999-12-02
申请号：PCT/GB9900978
申请日：1999-03-29
申请人： STANLEY MARGARET ANNE , ZHANG WEI
发明人： STANLEY MARGARET ANNE , ZHANG WEI
IPC分类号： A61K39/00 , C07K14/025 , C12N7/04 , C12N15/62 , A61K39/12 , C07K19/00 , C12N5/10 , C12N7/01 , C12N7/02
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N7/00 , C12N2710/14143 , C12N2710/20022 , C12N2710/20023
摘要： Modified virus-like particles (VLPs) can comprise fusion proteins having sequence from a major coat protein of a papovavirus, e.g. L1 protein of HPV 16 or 18, in which the N-terminal of the sequence derived from the major coat protein is fused to a further peptide sequence. The VLPs can contain a full sequence of an L1 protein, or an L1 sequence with an N-terminal deletion, or an L1 sequence with an aminoacid substitution mutation, and optionally a C-terminal L1 sequence deletion. The peptide sequence fused to the N-terminal can be immunogenic e.g. from a protein of a pathogen such as a virus. The further peptide sequence can provide a binding domain for affinity purification of the VLP. Modified VLPs can retain the native conformation of the VLP structure while also presenting to the immune system of a subject immunised with the modified VLPs an epitope present on an N-terminal extension of the major coat protein sequence. Corresponding polynucleotides, expression vectors, plasmids, vectors and cells containing such polynucleotides are disclosed.
摘要翻译：修饰的病毒样颗粒（VLP）可以包含具有来自乳头瘤病毒的主要外壳蛋白的序列的融合蛋白，例如。 HPV 16或18的L1蛋白质，其中源自主要外壳蛋白的序列的N末端与另一个肽序列融合。 VLP可以含有L1蛋白或具有N-末端缺失的L1序列或具有氨基酸取代突变的L1序列和任选的C末端L1序列缺失的完整序列。融合到N-末端的肽序列可以是免疫原性的来自病原体如蛋白质的病毒。另外的肽序列可以提供VLP的亲和纯化的结合结构域。修饰的VLP可以保留VLP结构的天然构象，同时还向被修饰的VLP免疫的受试者的免疫系统呈递存在于主要外壳蛋白序列的N末端延伸上的表位。公开了相应的多核苷酸，表达载体，质粒，载体和含有这种多核苷酸的细胞。

4. 发明申请

WO1996029091A1 TREATMENT OF PAPILLOMAVIRUS-ASSOCIATED LESIONS USING INTERLEUKIN-12 审中-公开
标题翻译：使用INTERLEUKIN-12治疗斑马鱼相关性淋巴结
公开(公告)号：WO1996029091A1
公开(公告)日：1996-09-26
申请号：PCT/GB1996000686
申请日：1996-03-22
申请人： CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED , STANLEY, Margaret, Anne , SCARPINI, Cinzia, Giuseppina
发明人： CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED
IPC分类号： A61K38/20
CPC分类号： A61K39/12 , A61K38/208 , A61K48/00 , A61K2039/55538 , C12N2710/20034
摘要： Interleukin-12 (IL-12) or a functional analogue thereof, or a polynucleotide encoding IL-12 or encoding a functional analogue thereof, is used as a therapeutic material or adjuvant in treating papillomavirus-associated lesions e.g. warts due to HPV 6 and/or 11, e.g. condylomaacuminata. IL-12 or a vector encoding it for endogenous production can be used together with a vaccine such as a papillomavirus antigen, or a vector encoding a papillomavirus antigen.
摘要翻译：白细胞介素-12（IL-12）或其功能类似物，或编码IL-12或编码其功能类似物的多核苷酸，用作治疗性乳头瘤病毒相关病变的治疗材料或佐剂。由于HPV 6和/或11引起的疣，例如 condylomaacuminata。可以将IL-12或编码其用于内源性产生的载体与疫苗如乳头瘤病毒抗原或编码乳头瘤病毒抗原的载体一起使用。

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