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1. 发明授权

US08759295B2 Peptide-peptidase inhibitor conjugates and methods of using same 失效
标题翻译：肽肽酶抑制剂缀合物及其使用方法
公开(公告)号：US08759295B2
公开(公告)日：2014-06-24
申请号：US12785396
申请日：2010-05-21
申请人： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
发明人： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
IPC分类号： A61K38/26 , C07K14/605 , C07K19/00 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12
CPC分类号： A61K47/48246 , A61K47/545 , A61K47/55 , A61K47/64
摘要： Peptide-peptidase inhibitor conjugate molecules are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.
摘要翻译：公开了肽 - 肽酶抑制剂缀合物分子。这些缀合物分子可用作治疗和预防代谢和心血管疾病，病症和病症的药剂。这些疾病，病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病以及其它与糖尿病有关的疾病。

2. 发明申请

US20140058070A1 C-TERMINAL AMIDATION OF POLYPEPTIDES 有权
标题翻译：聚氨酯的C-末端氨基化
公开(公告)号：US20140058070A1
公开(公告)日：2014-02-27
申请号：US13822821
申请日：2011-09-08
申请人： Chengzao Sun , Behrouz Bruce Forood , Gary Luo , Soumitra S. Ghosh
发明人： Chengzao Sun , Behrouz Bruce Forood , Gary Luo , Soumitra S. Ghosh
IPC分类号： C07K1/00
CPC分类号： C07K1/003 , C07C211/27 , C07D311/88 , C07K1/107
摘要： There are provided compounds and methods for amidating the C-terminus of a polypeptide. The method include reacting a polypeptide which includes a C-terminal thioester or C-terminal selenoester with any one of a defined set of auxiliary molecules under conditions suitable to produce a polypeptide adduct which includes the auxiliary molecule chemically bound at the C-terminal of the polypeptide. In the subsequent step, the auxiliary molecule is removed from the C-terminal of the polypeptide adduct under conditions suitable to produce an amidated polypeptide.
摘要翻译：提供了用于酰胺化多肽的C末端的化合物和方法。该方法包括在适于产生多肽加合物的条件下使包含C-末端硫酯或C-末端硒酸酯的多肽与定义的一组辅助分子中的任一个反应，所述多肽加合物包括在C末端化学结合的辅助分子多肽。在随后的步骤中，辅助分子在适于产生酰胺化多肽的条件下从多肽加合物的C-末端去除。

3. 发明授权

US08642544B2 N-terminus conformationally constrained GLP-1 receptor agonist compounds 有权
标题翻译： N末端构象约束的GLP-1受体激动剂化合物
公开(公告)号：US08642544B2
公开(公告)日：2014-02-04
申请号：US13260702
申请日：2010-03-26
申请人： Josue Alfaro-Lopez , Abhinandini Sharma , Soumitra S. Ghosh
发明人： Josue Alfaro-Lopez , Abhinandini Sharma , Soumitra S. Ghosh
IPC分类号： A61K38/26 , A61K38/16 , A61K38/00
CPC分类号： C07K14/605 , A61K38/00 , C07K14/46
摘要： The disclosure provides N-terminus conformationally constrained compounds, which may comprise peptide mimetics and/or amino acid substitutions, which may be used in peptides, such as GLP-1 receptor agonist compounds, to induce a β-turn secondary structure at the N-terminus. The N-terminus conformationally constrained compounds may be used for research purposes; to produce GLP-1 receptor agonist compounds having improved GLP-1 receptor binding activity, enzymatic stability, or in vivo glucose lowering activity; and to develop GLP-1 receptor agonist compounds which have fewer amino acid residues. The disclosure also provides GLP-1 receptor agonist compounds, such as exendins, exendin analogs, GLP-1 (7-37), GLP-1 (7-37) analogs, comprising the N-terminus conformationally constrained compounds. The compounds are useful for treating various diseases, such as diabetes and obesity. The disclosure also provides methods for chemically synthesizing the N-terminus conformationally constrained compounds.
摘要翻译：本公开提供了可以包含肽模拟物和/或氨基酸取代的N末端构象约束的化合物，其可以用于肽，例如GLP-1受体激动剂化合物，以在N-末端诱导β-匝二次结构，终点。 N末端构象约束化合物可用于研究目的; 以产生具有改善的GLP-1受体结合活性，酶稳定性或体内葡萄糖降低活性的GLP-1受体激动剂化合物; 并开发具有较少氨基酸残基的GLP-1受体激动剂化合物。本公开还提供了GLP-1受体激动剂化合物，例如包含N末端构象约束的化合物的毒蜥外泌肽，毒蜥外泌肽类似物，GLP-1（7-37），GLP-1（7-37）类似物。该化合物可用于治疗各种疾病，如糖尿病和肥胖症。本公开还提供了化学合成N末端构象约束化合物的方法。

4. 发明授权

US08598120B2 Methods for treatment using amylin family peptides 失效
标题翻译：使用胰岛淀粉样多肽家族肽治疗的方法
公开(公告)号：US08598120B2
公开(公告)日：2013-12-03
申请号：US13364250
申请日：2012-02-01
申请人： Christopher J. Soares , Michael R. Hanley , Diana Y. Lewis , David G. Parkes , Carolyn M. Jodka , Kathryn S. Prickett , Soumitra S. Ghosh , Christine M. Mack , Qing Lin
发明人： Christopher J. Soares , Michael R. Hanley , Diana Y. Lewis , David G. Parkes , Carolyn M. Jodka , Kathryn S. Prickett , Soumitra S. Ghosh , Christine M. Mack , Qing Lin
IPC分类号： A61K38/16 , A61P3/04 , A61P5/22 , C07K14/435 , C07K19/00
CPC分类号： C07K14/575
摘要： The present invention relates to novel compounds having a function of a peptide in the amylin family, related nucleic acids, expression constructs, host cells, and processes production of the compounds. The compounds of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.
摘要翻译：本发明涉及在胰岛淀粉样多肽家族中具有肽功能的新化合物，相关核酸，表达构建体，宿主细胞，并且处理化合物的生产。本发明的化合物包括一个或多个氨基酸序列修饰。此外，公开了治疗和预防代谢紊乱如肥胖，糖尿病和增加的心血管风险的方法和组合物。

5. 发明授权

US08497240B2 DPP-IV resistant GIP hybrid polypeptides with selectable properties 有权
标题翻译：具有可选性质的DPP-IV抗性GIP杂交多肽
公开(公告)号：US08497240B2
公开(公告)日：2013-07-30
申请号：US12377856
申请日：2007-08-17
申请人： Odile Esther Levy , Alain D. Baron , Lawrence J. D'Souza , Mary Erickson , Soumitra S. Ghosh , Michael R. Hanley , Samuel Janssen , Carolyn M. Jodka , Diana Y. Lewis , Christine M. Mack , David G. Parkes , Richard A. Pittner , Christopher J. Soares , Ved Srivastava , Andrew A. Young , Thao Le
发明人： Odile Esther Levy , Alain D. Baron , Lawrence J. D'Souza , Mary Erickson , Soumitra S. Ghosh , Michael R. Hanley , Samuel Janssen , Carolyn M. Jodka , Diana Y. Lewis , Christine M. Mack , David G. Parkes , Richard A. Pittner , Christopher J. Soares , Ved Srivastava , Andrew A. Young , Thao Le
IPC分类号： A61K38/00 , A61K38/16 , A61K38/26
CPC分类号： C07K14/47 , A61K38/00 , C07K14/575 , C07K14/57563 , C07K14/605 , C07K2319/00
摘要： The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
摘要翻译：本发明一般涉及具有可选性质的新型GIP类似物和GIP杂合多肽，其可用作治疗和预防代谢性疾病和病症的药剂，例如可通过控制血浆葡萄糖水平，胰岛素水平和/或胰岛素分泌，正性肌力作用，分解代谢作用降低，胃排空减慢。这些病症和障碍包括但不限于高血压，血脂异常，心血管疾病，饮食失调，重症监护，胰岛素抵抗，肥胖症和任何类型的糖尿病，包括1型，2型和妊娠糖尿病。

6. 发明授权

US08114958B2 Amylin family peptides 失效
标题翻译：淀粉蛋白家族肽
公开(公告)号：US08114958B2
公开(公告)日：2012-02-14
申请号：US10589054
申请日：2005-02-11
申请人： Christopher J. Soares , Michael R. Hanley , Diana Y. Lewis , David Geoffrey Parkes , Carolyn M. Jodka , Kathryn S. Prickett , Soumitra S. Ghosh , Christine Marie Mack , Qing Lin
发明人： Christopher J. Soares , Michael R. Hanley , Diana Y. Lewis , David Geoffrey Parkes , Carolyn M. Jodka , Kathryn S. Prickett , Soumitra S. Ghosh , Christine Marie Mack , Qing Lin
IPC分类号： C07K19/00 , C07K14/435 , A61K38/16 , A61P3/04
CPC分类号： C07K14/575
摘要： The present invention relates to obesity related polypeptides (ORPs), related nucleic acids, expression constructs, host cells, and processes production of the obesity related polypeptides. The ORPs of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.
摘要翻译：本发明涉及肥胖相关多肽（ORPs），相关核酸，表达构建体，宿主细胞，并且涉及肥胖相关多肽的产生。本发明的ORP包括一个或多个氨基酸序列修饰。此外，公开了治疗和预防代谢紊乱如肥胖，糖尿病和增加的心血管风险的方法和组合物。

7. 发明申请

US20100292172A1 Peptide-Peptidase Inhibitor Conjugates and Methods of Using Same 失效
标题翻译：肽肽酶抑制剂缀合物及其使用方法
公开(公告)号：US20100292172A1
公开(公告)日：2010-11-18
申请号：US12785396
申请日：2010-05-21
申请人： SOUMITRA S. GHOSH , JOSUE ALFARO-LOPEZ , LAWRENCE J. D'SOUZA , ODILE ESTHER LEVY , QING LIN , CHRISTOPHER J. SOARES
发明人： SOUMITRA S. GHOSH , JOSUE ALFARO-LOPEZ , LAWRENCE J. D'SOUZA , ODILE ESTHER LEVY , QING LIN , CHRISTOPHER J. SOARES
IPC分类号： A61K38/17 , C07K14/575 , C07K14/46 , A61K38/22 , A61P1/00 , A61P9/00
CPC分类号： A61K47/48246 , A61K47/545 , A61K47/55 , A61K47/64
摘要： Peptide-peptidase inhibitor conjugate molecules are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.
摘要翻译：公开了肽 - 肽酶抑制剂缀合物分子。这些缀合物分子可用作治疗和预防代谢和心血管疾病，病症和病症的药剂。这些疾病，病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病以及其它与糖尿病有关的疾病。

8. 发明申请

US20100099619A1 PANCREATIC POLYPEPTIDE FAMILY MOTIFS, POLYPEPTIDES AND METHODS COMPRISING THE SAME 有权
标题翻译：胰蛋白多糖家族动物，聚合物及其包含的方法
公开(公告)号：US20100099619A1
公开(公告)日：2010-04-22
申请号：US12640352
申请日：2009-12-17
申请人： Odile Esther Levy , Carolyn M. Jodka , Soumitra S. Ghosh , David G. Parkes , Richard A. Pittner , Lawrence J. D'Souza , John S. Ahn , Kathryn S. Prickett , Jonathan David Roth , Sean H. Adams
发明人： Odile Esther Levy , Carolyn M. Jodka , Soumitra S. Ghosh , David G. Parkes , Richard A. Pittner , Lawrence J. D'Souza , John S. Ahn , Kathryn S. Prickett , Jonathan David Roth , Sean H. Adams
IPC分类号： A61K38/16 , C07K14/00 , A61P3/00
CPC分类号： C07K14/575 , A61K38/00 , C07K14/475
摘要： The present invention provides novel Pancreatic Polypeptide Family (“PPF”) polypeptides and methods for their use.
摘要翻译：本发明提供新型胰腺多肽家族（“PPF”）多肽及其使用方法。

9. 发明申请

US20090186817A1 PEPTIDE-PEPTIDASE INHIBITOR CONJUGATES AND METHODS OF USING SAME 审中-公开
标题翻译：肽类肽抑制剂结合体及其使用方法
公开(公告)号：US20090186817A1
公开(公告)日：2009-07-23
申请号：US12293389
申请日：2007-03-21
申请人： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
发明人： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
IPC分类号： A61K38/22 , C07K2/00 , C07K14/575
CPC分类号： A61K47/545 , A61K47/55 , A61K47/64
摘要： Peptide-peptidase inhibitor conjugate molecules are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.
摘要翻译：公开了肽 - 肽酶抑制剂缀合物分子。这些缀合物分子可用作治疗和预防代谢和心血管疾病，病症和病症的药剂。这些疾病，病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病以及其它与糖尿病有关的疾病。

10. 发明申请

US20080207501A1 Amylin Family Polypeptide-6 (Afp-6) Analogs and Methods of Making and Using Them 失效
标题翻译： Amylin家族多肽-6（Afp-6）类似物及其制备和使用方法
公开(公告)号：US20080207501A1
公开(公告)日：2008-08-28
申请号：US11664750
申请日：2005-10-11
申请人： Mary Erickson , Ved Srivastava , Sarah McQuaid , Andrew A. Young , Richard A. Pittner , Soumitra S. Ghosh
发明人： Mary Erickson , Ved Srivastava , Sarah McQuaid , Andrew A. Young , Richard A. Pittner , Soumitra S. Ghosh
IPC分类号： A61K38/16 , C07K14/00 , A61P9/00 , A61P3/00
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention relates to Amylin Family Polypeptide-6 (AFP-6) analogs, which include derivatives and fragments, related nucleic acids, expression constructs, host cells, and processes for recombinant production of the AFP-6 analogs. The AFP-6 analogs of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent conditions such as metabolic and cardiovascular disorders, e.g., obesity, diabetes, metabolic syndrome, myocardial ischemia, and increased cardiovascular risk.
摘要翻译：本发明涉及淀粉蛋白家族多肽-6（AFP-6）类似物，其包括衍生物和片段，相关核酸，表达构建体，宿主细胞和用于重组生产AFP-6类似物的方法。本发明的AFP-6类似物包括一个或多个氨基酸序列修饰。此外，公开了治疗和预防诸如代谢和心血管疾病如肥胖症，糖尿病，代谢综合征，心肌缺血和增加的心血管风险的病症的方法和组合物。

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