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1. 发明授权

US08895498B2 GIP and exendin hybrid polypeptides 有权
标题翻译： GIP和毒蜥外泌肽杂合多肽
公开(公告)号：US08895498B2
公开(公告)日：2014-11-25
申请号：US13591677
申请日：2012-08-22
申请人： Odile Esther Levy , Alain D. Baron , Lawrence J. D'Souza , Mary Erickson , Soumitra G. Ghosh , Michael R. Hanley , Samuel Janssen , Carolyn M. Jodka , Diana Y. Lewis , Christine M. Mack , David G. Parkes , Richard A. Pittner , Christopher J. Soares , Ved Srivastava , Andrew A. Young , Thao Le
发明人： Odile Esther Levy , Alain D. Baron , Lawrence J. D'Souza , Mary Erickson , Soumitra G. Ghosh , Michael R. Hanley , Samuel Janssen , Carolyn M. Jodka , Diana Y. Lewis , Christine M. Mack , David G. Parkes , Richard A. Pittner , Christopher J. Soares , Ved Srivastava , Andrew A. Young , Thao Le
IPC分类号： A61K38/00 , A61P3/10 , C07K7/06 , C07K14/575
CPC分类号： C07K14/575 , A61K38/00 , C07K7/06 , C07K14/605
摘要： The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
摘要翻译：本发明一般涉及具有可选性质的新型GIP类似物和GIP杂合多肽，其可用作治疗和预防代谢性疾病和病症的药剂，例如可通过控制血浆葡萄糖水平，胰岛素水平和/或胰岛素分泌，正性肌力作用，分解代谢作用降低，胃排空减慢。这些病症和障碍包括但不限于高血压，血脂异常，心血管疾病，饮食失调，重症监护，胰岛素抵抗，肥胖症和任何类型的糖尿病，包括1型，2型和妊娠糖尿病。

2. 发明申请

US20140329752A1 PEPTIDE ANTAGONISTS OF THE CALCITONIN CGRP FAMILY OF PEPTIDE HORMONES AND THEIR USE 有权
标题翻译：肽激素CGRP家族肽肽拮抗剂及其使用
公开(公告)号：US20140329752A1
公开(公告)日：2014-11-06
申请号：US13821936
申请日：2013-01-25
申请人： Christopher J. Soares
发明人： Christopher J. Soares
IPC分类号： C07K14/575
CPC分类号： C07K14/57527 , A61K38/00 , A61K38/225 , A61K38/23 , C07K14/585
摘要： The embodiments provide a modified calcitonin gene-related peptide antagonist including an N-terminal fragment of modified calcitonin gene-related peptide or related protein family member where at least two residues of the N-terminal fragment are cysteine (Cys) and at least one amino acid comprises a non-threonine substitution of a threonine (Thr) residue; a central core where the central core comprises an oc-helix; and a C-terminal fragment of modified calcitonin gene-related peptide or related protein family member comprising a C-terminal amide and where at least one amino acid of the C-terminal fragment is phenylalanine (Phe), proline (Pro), tyrosine (Tyr) or hydroxyproline (Hyp) or pharmaceutically acceptable salt thereof, as well as compositions, including pharmaceutical compositions, comprising a subject peptide. The embodiments further provide treatment methods, including methods of treating a migraine, the methods generally involving administering to an individual in need thereof an effective amount of a subject peptide or composition.
摘要翻译：实施方案提供了修饰的降钙素基因相关肽拮抗剂，其包括修饰的降钙素基因相关肽或相关蛋白家族成员的N末端片段，其中N-末端片段的至少两个残基是半胱氨酸（Cys）和至少一个氨基酸包括苏氨酸（Thr）残基的非苏氨酸取代; 中心芯，其中心芯包含α-螺旋; 和包含C-末端酰胺的修饰的降钙素基因相关肽或相关蛋白家族成员的C末端片段，其中C-末端片段的至少一个氨基酸是苯丙氨酸（Phe），脯氨酸（Pro），酪氨酸（ Tyr）或羟脯氨酸（Hyp）或其药学上可接受的盐，以及包含受试肽的组合物，包括药物组合物。实施方案进一步提供治疗方法，包括治疗偏头痛的方法，所述方法通常涉及向有需要的个体施用有效量的受试肽或组合物。

3. 发明申请

US20140066370A1 Polypeptide Conjugate 审中-公开
标题翻译：多肽缀合物
公开(公告)号：US20140066370A1
公开(公告)日：2014-03-06
申请号：US13511201
申请日：2010-11-23
申请人： Behrouz Bruce Forood , Soumitra S. Ghosh , James L. Trevaskis , Chengzao Sun , Odile Esther Levy , Lawrence J. D'Souza , Christopher J. Soares
发明人： Behrouz Bruce Forood , Soumitra S. Ghosh , James L. Trevaskis , Chengzao Sun , Odile Esther Levy , Lawrence J. D'Souza , Christopher J. Soares
IPC分类号： C07K14/605
CPC分类号： C07K14/605 , A61K38/00 , A61K47/54 , A61K47/542 , A61K47/554 , A61K47/60 , A61K47/64 , A61K47/643 , C07K14/575 , C07K14/57563 , C07K14/585
摘要： The disclosure provides Polypeptide Conjugates with multiple improved pharmacological and pharmacokinetic properties and their use in treating various diseases and conditions, such as diabetes and/or obesity.
摘要翻译：本公开提供多肽缀合物具有多种改善的药理学和药代动力学性质及其在治疗各种疾病和病症如糖尿病和/或肥胖症中的用途。

4. 发明授权

US08598314B2 Peptide-peptidase-inhibitor conjugates and methods of making and using same 失效
标题翻译：肽 - 肽酶 - 抑制剂缀合物及其制备和使用方法
公开(公告)号：US08598314B2
公开(公告)日：2013-12-03
申请号：US12680539
申请日：2008-09-26
申请人： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
发明人： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
IPC分类号： A61K38/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： A61K47/64 , A61K47/545 , A61K47/55
摘要： Peptide-peptidase inhibitor conjugate molecules and methods of manufacture thereof are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.
摘要翻译：公开了肽肽酶抑制剂缀合物分子及其制备方法。这些缀合物分子可用作治疗和预防代谢和心血管疾病，病症和病症的药剂。这些疾病，病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病以及其它与糖尿病有关的疾病。

5. 发明授权

US08076288B2 Hybrid polypeptides having glucose lowering activity 有权
标题翻译：具有葡萄糖降低活性的杂交多肽
公开(公告)号：US08076288B2
公开(公告)日：2011-12-13
申请号：US11206903
申请日：2005-08-17
申请人： Odile Esther Levy , Michael R. Hanley , Carolyn M. Jodka , Diana Y. Lewis , Christopher J. Soares , Soumitra S. Ghosh , Lawrence J. D'Souza , David G. Parkes , Christine M. Mack
发明人： Odile Esther Levy , Michael R. Hanley , Carolyn M. Jodka , Diana Y. Lewis , Christopher J. Soares , Soumitra S. Ghosh , Lawrence J. D'Souza , David G. Parkes , Christine M. Mack
IPC分类号： A61K38/00 , A61K38/26
CPC分类号： C07K14/605 , A61K9/0019 , A61K9/19 , A61K38/00 , C07K5/1013 , C07K5/1024 , C07K14/575 , C07K14/58
摘要： The present invention relates generally to novel, selectable hybrid polypeptides useful as agents for the treatment and prevention of metabolic diseases and disorders which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, such as diabetes and diabetes-related conditions. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
摘要翻译：本发明一般涉及可用作治疗和预防代谢性疾病和病症的新颖的可选择的杂交多肽，其可通过控制血浆葡萄糖水平，胰岛素水平和/或胰岛素分泌而减轻，所述胰岛素分泌如糖尿病和糖尿病相关条件。这些病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病，包括1型，2型和妊娠糖尿病。

6. 发明申请

US20090036364A1 GIP ANALOG AND HYBRID POLYPEPTIDES WITH SELECTABLE PROPERTIES 失效
标题翻译：具有可选性能的GIP模拟和混合多糖
公开(公告)号：US20090036364A1
公开(公告)日：2009-02-05
申请号：US11816095
申请日：2006-02-10
申请人： Odile Esther Levy , Alain D. Baron , Lawrence J D'Souza , Mary Erickson , Soumitra S. Ghosh , Michael R. Hanley , Samuel Janssen , Carolyn M. Jodka , Diana Y. Lewis , Christine M. Mack , David G. Parkes , Richard A. Pittner , Christopher J. Soares , Ved Srivastava , Andrew A. Young
发明人： Odile Esther Levy , Alain D. Baron , Lawrence J D'Souza , Mary Erickson , Soumitra S. Ghosh , Michael R. Hanley , Samuel Janssen , Carolyn M. Jodka , Diana Y. Lewis , Christine M. Mack , David G. Parkes , Richard A. Pittner , Christopher J. Soares , Ved Srivastava , Andrew A. Young
IPC分类号： A61K38/22 , C07K14/47 , A61P3/10
CPC分类号： C07K14/575 , C07K14/605 , C07K2319/00
摘要： The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
摘要翻译：本发明一般涉及具有可选性质的新型GIP类似物和GIP杂合多肽，其可用作治疗和预防代谢性疾病和病症的药剂，例如可通过控制血浆葡萄糖水平，胰岛素水平和/或胰岛素分泌，正性肌力作用，分解代谢作用降低，胃排空减慢。这些病症和障碍包括但不限于高血压，血脂异常，心血管疾病，饮食失调，重症监护，胰岛素抵抗，肥胖症和任何类型的糖尿病，包括1型，2型和妊娠糖尿病。

7. 发明申请

US20080312157A1 GIP ANALOG AND HYBRID POLYPEPTIDES WITH SELECTABLE PROPERTIES 有权
标题翻译：具有可选性能的GIP模拟和混合多糖
公开(公告)号：US20080312157A1
公开(公告)日：2008-12-18
申请号：US11840921
申请日：2007-08-17
申请人： Odile Esther Levy , Alain D. Baron , Lawrence J. D'Souza , Mary Erickson , Soumitra S. Ghosh , Michael R. Hanley , Samuel Janssen , Carolyn M. Jodka , Diana Y. Lewis , Christine M. Mack , David G. Parkes , Richard A. Pittner , Christopher J. Soares , Ved Srivastava , Andrew A. Young , Thao Le
发明人： Odile Esther Levy , Alain D. Baron , Lawrence J. D'Souza , Mary Erickson , Soumitra S. Ghosh , Michael R. Hanley , Samuel Janssen , Carolyn M. Jodka , Diana Y. Lewis , Christine M. Mack , David G. Parkes , Richard A. Pittner , Christopher J. Soares , Ved Srivastava , Andrew A. Young , Thao Le
IPC分类号： A61K38/00 , C07K7/00 , A61P1/00
CPC分类号： C07K14/575 , A61K38/00 , C07K7/06 , C07K14/605
摘要： The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
摘要翻译：本发明一般涉及具有可选性质的新型GIP类似物和GIP杂合多肽，其可用作治疗和预防代谢性疾病和病症的药剂，例如可通过控制血浆葡萄糖水平，胰岛素水平和/或胰岛素分泌，正性肌力作用，分解代谢作用降低，胃排空减慢。这些病症和障碍包括但不限于高血压，血脂异常，心血管疾病，饮食失调，重症监护，胰岛素抵抗，肥胖症和任何类型的糖尿病，包括1型，2型和妊娠糖尿病。

8. 发明授权

US5261923A Method and apparatus for continuous circular capsulorehexis 失效
标题翻译：连续循环切除术的方法和装置
公开(公告)号：US5261923A
公开(公告)日：1993-11-16
申请号：US872442
申请日：1992-04-23
申请人： Christopher J. Soares
发明人： Christopher J. Soares
IPC分类号： A61F9/007 , A61F9/00
CPC分类号： A61F9/00754
摘要： A surgical instrument adapted to pass through a superior limbal incision and fit behind the cornea for making a continuous circular incision about the anterior pole of the lens capsule in extracapsular cataract extractions and phacoemulsification. The surgical instrument includes a rotating blade disposed at one end and adapted to rotate about 360.degree.. The instrument is fixed with respect to the lens capsule by a peg extending from the rotation axis of the blade. A method for making the circular incision is also disclosed.
摘要翻译：外科手术器械适于通过上角膜切口并适合于角膜后方，用于在囊外白内障摘除和晶状体乳化过程中围绕镜片囊的前极进行连续的圆形切口。手术器械包括设置在一端并适于旋转约360度的旋转刀片。仪器通过从叶片的旋转轴线延伸的栓头相对于镜片胶囊固定。还公开了一种用于制作圆形切口的方法。

9. 发明申请

US20130184203A1 GLP-1 RECEPTOR AGONIST COMPOUNDS HAVING STABILIZED REGIONS 有权
标题翻译：具有稳定区域的GLP-1受体激动剂化合物
公开(公告)号：US20130184203A1
公开(公告)日：2013-07-18
申请号：US13812445
申请日：2011-07-27
申请人： Josue Alfaro-Lopez , Abhinandini Sharma , Christopher J. Soares , Eugene Coats , Soumitra S. Ghosh
发明人： Josue Alfaro-Lopez , Abhinandini Sharma , Christopher J. Soares , Eugene Coats , Soumitra S. Ghosh
IPC分类号： C07K14/605
CPC分类号： C07K14/605 , A61K38/00 , Y02E50/343
摘要： The disclosure provides GLP-1 receptor agonist compounds having stabilized regions corresponding to alpha-helical regions of the natural peptide compounds. The disclosure also provides benzamide-containing exendin-4 analogs and alkene-constrained exendin-4 analogs, both of which have stabilized regions corresponding to alpha-helical regions of exendin-4.
摘要翻译：本公开提供了具有对应于天然肽化合物的α-螺旋区域的稳定区域的GLP-1受体激动剂化合物。本公开还提供含有苯甲酰胺的毒蜥外泌肽-4类似物和烯烃受限的毒蜥外泌肽-4类似物，两者都具有对应于毒蜥外泌肽-4的α-螺旋区域的稳定区域。

10. 发明申请

US20120253023A1 HYBRID POLYPEPTIDES WITH SELECTABLE PROPERTIES 有权
标题翻译：具有可选性能的混合聚合物
公开(公告)号：US20120253023A1
公开(公告)日：2012-10-04
申请号：US13323608
申请日：2011-12-12
申请人： Odile Esther LEVY , Michael R. Hanley , Carolyn M. Jodka , Diana Y. Lewis , Christopher J. Soares , Soumitra S. Ghosh , Lawrence J. D'Souza , David G. Parkes , Christine M. Mack
发明人： Odile Esther LEVY , Michael R. Hanley , Carolyn M. Jodka , Diana Y. Lewis , Christopher J. Soares , Soumitra S. Ghosh , Lawrence J. D'Souza , David G. Parkes , Christine M. Mack
IPC分类号： C07K19/00
CPC分类号： C07K14/605 , A61K9/0019 , A61K9/19 , A61K38/00 , C07K5/1013 , C07K5/1024 , C07K14/575 , C07K14/58
摘要： The present invention relates generally to novel, selectable hybrid polypeptides useful as agents for the treatment and prevention of metabolic diseases and disorders which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, such as diabetes and diabetes-related conditions. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
摘要翻译：本发明一般涉及可用作治疗和预防代谢性疾病和病症的新颖的可选择的杂交多肽，其可通过控制血浆葡萄糖水平，胰岛素水平和/或胰岛素分泌而减轻，所述胰岛素分泌如糖尿病和糖尿病相关条件。这些病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病，包括1型，2型和妊娠糖尿病。

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