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1. 发明申请

US20070179096A1 Pharmaceutical Formulation 审中-公开
标题翻译：药物配方
公开(公告)号：US20070179096A1
公开(公告)日：2007-08-02
申请号：US11734823
申请日：2007-04-13
申请人： Soren Bjorn , Hans Sorensen , Peter Langballe , Silke Larsen , Kristen Ebbehoj , Birthe Hamsen
发明人： Soren Bjorn , Hans Sorensen , Peter Langballe , Silke Larsen , Kristen Ebbehoj , Birthe Hamsen
IPC分类号： A61K38/27 , A61K31/4172
CPC分类号： A61K9/19 , A61K9/0019 , A61K31/4172 , A61K38/27 , A61K47/02 , A61K47/10 , A61K47/183 , A61K47/26
摘要： The invention relates to aqueous pharmaceutical formulations comprising human growth hormone, histidine, poloxamer, phenol, and mannitol.
摘要翻译：本发明涉及包含人生长激素，组氨酸，泊洛沙姆，苯酚和甘露醇的含水药物制剂。

2. 发明申请

US20060205036A1 Coagulation Factor VII polypeptides 审中-公开
标题翻译：凝血因子VII多肽
公开(公告)号：US20060205036A1
公开(公告)日：2006-09-14
申请号：US11367189
申请日：2006-03-03
申请人： Henrik Ostergaard , Soren Bjorn , Egon Persson
发明人： Henrik Ostergaard , Soren Bjorn , Egon Persson
IPC分类号： C12P21/04 , C07H21/04 , A61K38/36 , C07K14/745
CPC分类号： C07K14/745 , A61K38/00 , C12N9/6437 , C12N9/647 , C12Y304/21021
摘要： The present invention relates to novel coagulation Factor VII polypeptides, polynucleotide constructs encoding such polypeptides, as well as vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions, uses and methods of treatment.
摘要翻译：本发明涉及新型凝血因子VII多肽，编码这种多肽的多核苷酸构建体，以及包含和表达多核苷酸，药物组合物，用途和治疗方法的载体和宿主细胞。

3. 发明申请

US20090227504A1 Pegylated Factor VII Glycoforms 失效
标题翻译：聚乙二醇化因子VII糖酵解
公开(公告)号：US20090227504A1
公开(公告)日：2009-09-10
申请号：US12371156
申请日：2009-02-13
申请人： Niels Kristian Klausen , Soren Bjorn , Carsten Behrens , Patrick William Garibay
发明人： Niels Kristian Klausen , Soren Bjorn , Carsten Behrens , Patrick William Garibay
IPC分类号： A61K38/16 , C07K14/00
CPC分类号： A61K38/4846 , A61K47/60 , C07K14/755
摘要： The invention concerns a preparation comprising a plurality of Factor VII polypeptides or Factor VII-related polypeptides, wherein the polypeptides comprise asparagine-linked and/or serine-linked oligosaccharide chains, and wherein at least one oligosaccharide group is covalently attached to at least one polymeric group.
摘要翻译：本发明涉及包含多个因子VII多肽或因子VII相关多肽的制剂，其中所述多肽包含天冬酰胺连接和/或丝氨酸连接的寡糖链，并且其中至少一个寡糖基团共价连接至至少一个聚合物组。

4. 发明申请

US20060019881A1 Human spasmolytic polypeptide in glycosylated form 审中-公开
公开(公告)号：US20060019881A1
公开(公告)日：2006-01-26
申请号：US11184451
申请日：2005-07-19
申请人： Lars Thim , Kjeld Norris , Fanny Norris , Soren Bjorn , Mogens Christensen , Per Nielsen
发明人： Lars Thim , Kjeld Norris , Fanny Norris , Soren Bjorn , Mogens Christensen , Per Nielsen
IPC分类号： A61K38/17 , C07K14/47
CPC分类号： C07K14/575 , A61K38/00
摘要： Human spasmolytic polypeptide (HSP) which has the amino acid sequence Glu Lys Pro Ser Pro Cys Gln Cys Ser Arg Leu Ser Pro His Asn Arg Thr Asn Cys Gly Phe Pro Gly Ile Thr Ser Asp Gln Cys Phe Asp Asn Gly Cys Cys Phe Asp Ser Ser Val Thr Gly Val Pro Trp Cys Phe His Pro Leu Pro Lys Gln Glu Ser Asp Gln Cys Val Met Glu Val Ser Asp Arg Arg Asn Cys Gly Tyr Pro Gly Ile Ser Pro Glu Glu Cys Ala Ser Arg Lys Cys Cys Phe Ser Asn Phe Ile Phe Glu Val Pro Trp Cys Phe Phe Pro Asn Ser Val Glu Asp Cys His Tyr or a functionally equivalent homologue thereof, characterized by being in glycosylated form.

5. 发明申请

US20060199763A1 Derivatives of GLP-1 analogs 审中-公开
公开(公告)号：US20060199763A1
公开(公告)日：2006-09-07
申请号：US11008743
申请日：2004-12-09
申请人： Liselotte Knudsen , Per Huusfeldt , Per Nielsen , Niels Kaarsholm , Helle Olsen , Soren Bjorn , Freddy Pedersen , Kjeld Madsen
发明人： Liselotte Knudsen , Per Huusfeldt , Per Nielsen , Niels Kaarsholm , Helle Olsen , Soren Bjorn , Freddy Pedersen , Kjeld Madsen
IPC分类号： A61K38/22 , A61K31/4439 , A61K31/426
CPC分类号： C11D3/168 , A61K31/426 , A61K31/4439 , A61K38/2264 , A61K38/26 , A61K38/28 , A61K45/06 , A61K47/24 , C07K14/605 , C11D3/0063 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition comprising a GLP-1 derivative having a lipophilic substituent; and a surfactant.

6. 发明申请

US20060198819A1 Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest 审中-公开
标题翻译：使用半乳糖氧化酶选择性地将量角器分子缀合到具有治疗兴趣的蛋白质
公开(公告)号：US20060198819A1
公开(公告)日：2006-09-07
申请号：US11339752
申请日：2006-01-25
申请人： Carsten Behrens , Patrick Garibay , Magali Zundel , Niels Klausen , Soren Bjorn
发明人： Carsten Behrens , Patrick Garibay , Magali Zundel , Niels Klausen , Soren Bjorn
IPC分类号： A61K38/28 , A61K38/22 , A61K38/37 , A61K38/26 , A61K38/20 , A61K38/19 , A61K38/16 , C07K14/54 , C07K14/53 , C07K14/62 , C07K14/42 , C07K14/51
CPC分类号： C12P21/005 , A61K47/549 , A61K47/60 , C12N9/6437
摘要： This invention relates to novel compounds, methods for selective chemical conjugation of protractor molecules and the use thereof for diagnostic and/or therapeutic purposes.
摘要翻译：本发明涉及新化合物，量角器分子的选择性化学共轭的方法及其用于诊断和/或治疗目的的用途。

7. 发明申请

US20060154319A1 Inhibition of bradykinin release 审中-公开
标题翻译：抑制缓激肽释放
公开(公告)号：US20060154319A1
公开(公告)日：2006-07-13
申请号：US11248110
申请日：2005-10-11
申请人： Hans Flodgaard , Lennart Lindbom , Soren Bjorn
发明人： Hans Flodgaard , Lennart Lindbom , Soren Bjorn
IPC分类号： A61K38/17 , G01N33/537 , G01N33/53 , G01N33/543
CPC分类号： A61K38/57 , G01N33/5064 , G01N2333/575 , G01N2333/96433
摘要： The invention is related to a method for treating or preventing a disorder resulting from the release of bradykinin in said mammal, particularly a mammal which produces a HBP which binds to a HBP antagonist, e.g. a monoclonal antibody that binds to at least one epitope of human HBP, comprising administering to said mammal a HBP antagonist in an amount effective to decrease the release of bradykinin in a mammal. Furthermore, the invention is directed to methods and kits for determining if a mammal produces HBP that binds to a HBP antagonist, e.g., a monoclonal antibody that binds to at least one epitope of human HBP and a method for detecting an antagonist of HBP.
摘要翻译：本发明涉及用于治疗或预防所述哺乳动物，特别是产生结合HBP拮抗剂的HBP的哺乳动物例如缓释肽释放引起的疾病的方法，例如，与人类HBP的至少一个表位结合的单克隆抗体，包括向所述哺乳动物施用有效降低哺乳动物缓激肽释放量的HBP拮抗剂。此外，本发明涉及用于确定哺乳动物是否产生结合HBP拮抗剂的HBP的方法和试剂盒，例如与人HBP的至少一个表位结合的单克隆抗体和检测HBP拮抗剂的方法。

8. 发明申请

US20060018831A1 TF binding agent and use thereof 审中-公开
标题翻译： TF结合剂及其用途
公开(公告)号：US20060018831A1
公开(公告)日：2006-01-26
申请号：US11186669
申请日：2005-07-21
申请人： Hesse Birger , Andreas Kjaer , Henning Stennicke , Soren Bjorn
发明人： Hesse Birger , Andreas Kjaer , Henning Stennicke , Soren Bjorn
IPC分类号： A61K51/00 , C07K14/755
CPC分类号： A61K51/088 , C12N9/6437 , C12Y304/21021
摘要： This invention relates to novel compounds, which bind to tissue factor and the use thereof for diagnostic and/or therapeutic purposes.
摘要翻译：本发明涉及结合组织因子的新化合物及其用于诊断和/或治疗目的的用途。

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