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1. 发明专利

HRP980143A2 4,4-DISUBSTITUTED-3,4-DIHYDRO-2 (1H)-QUINAZOLINONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS 未知
公开(公告)号：HRP980143A2
公开(公告)日：1999-02-28
申请号：HRP980143
申请日：1998-03-19
申请人： SOO SUNG KO
发明人： KO SOO SUNG
IPC分类号： A61K31/517 , A61K31/519 , A61P31/18 , A61P43/00 , C07D239/80 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D491/056 , C07D239/00
摘要： The present invention relates to 4,4-disubstituted-3,4-dihydro-2(1H)-quinazolines of formula (I), or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.

2. 发明授权

US09187437B2 Substituted oxadiazole compounds 有权
标题翻译：取代的恶二唑化合物
公开(公告)号：US09187437B2
公开(公告)日：2015-11-17
申请号：US13825595
申请日：2011-09-23
申请人： Jagabandhu Das , Soo Sung Ko
发明人： Jagabandhu Das , Soo Sung Ko
IPC分类号： C07D271/06 , C07D271/12 , C07D413/00 , C07D498/00 , C07D413/04 , C07D413/14 , A61K31/44 , A61K31/41 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/12
CPC分类号： C07D271/06 , C07D413/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/12
摘要： Disclosed are compounds of Formula (I): or stereoisomers, N-oxides, salts, or prodrugs thereof; wherein: Ring A is phenyl or 5- to 6-membered heteroaryl; (i) R1 and R2 are independently C1-C4 alkyl; or (ii) R1 and R2 together with the carbon atom to which they are attached, form a cyclic group; Q is phenyl or 5- to 6-membered heteroaryl substituted with zero to 3 substituents; and R3, L1, L2, and n are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
摘要翻译：公开了式（I）的化合物：其立体异构体，N-氧化物，盐或前药; 其中：环A是苯基或5-至6-元杂芳基; （i）R 1和R 2独立地为C 1 -C 4烷基; 或（ii）R 1和R 2与它们所连接的碳原子一起形成环状基团; Q为苯基或被0至3个取代基取代的5至6元杂芳基; 并且R3，L1，L2和n在本文中定义。还公开了使用这种化合物作为G蛋白偶联受体S1P1的选择性激动剂的方法，以及包含这些化合物的药物组合物。这些化合物可用于治疗，预防或减缓各种治疗领域（例如自身免疫疾病和血管疾病）中的疾病或病症的进展。

3. 发明授权

US5683999A Cyclic urea HIV protease inhibitors 失效
标题翻译：环状尿素蛋白酶抑制剂
公开(公告)号：US5683999A
公开(公告)日：1997-11-04
申请号：US613554
申请日：1996-03-11
申请人： Prabhakar Kondaji Jadhav , Soo Sung Ko
发明人： Prabhakar Kondaji Jadhav , Soo Sung Ko
IPC分类号： C07D243/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D519/00 , A61K31/55
CPC分类号： C07D401/12 , C07D243/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： This invention relates to substituted cyclic ureas and derivatives thereof, including compounds of formula (II): ##STR1## said compounds being useful as inhibitors of HIV protease. The present invention also relates to pharmaceutical compositions comprising such compounds and to method of using these compounds for the treatment HIV infection. The present invention also relates to the use of such compounds in processes for the identification of HIV protease inhibitors and for the inhibition or detection of HIV in a bodily fluid sample.
摘要翻译：本发明涉及取代的环脲和其衍生物，包括式（II）的化合物：（II）所述化合物可用作HIV蛋白酶的抑制剂。本发明还涉及包含这些化合物的药物组合物以及使用这些化合物治疗HIV感染的方法。本发明还涉及这种化合物在鉴定HIV蛋白酶抑制剂和用于抑制或检测体液样品中的HIV的方法中的用途。

4. 发明授权

US5874430A 4,4-disubstitued-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as HIV reverse transcriptase inhibitors and intermediates and processes for making the same 失效
标题翻译：可用作HIV逆转录酶抑制剂的4,4-二取代-1,4-二氢-2H-3,1-苯并恶嗪-2-酮及其制备方法
公开(公告)号：US5874430A
公开(公告)日：1999-02-23
申请号：US942031
申请日：1997-10-01
申请人： David Donald Christ , Anthony Joseph Cocuzza , Soo Sung Ko , Jay Andrew Markwalder , Abdul Ezaz Mutlib , Rodney Lawrence Parsons, Jr. , Mona Patel , Steven Paul Seitz
发明人： David Donald Christ , Anthony Joseph Cocuzza , Soo Sung Ko , Jay Andrew Markwalder , Abdul Ezaz Mutlib , Rodney Lawrence Parsons, Jr. , Mona Patel , Steven Paul Seitz
IPC分类号： C07D265/18 , A61K31/535 , A61K265/18
CPC分类号： C07D265/18
摘要： The present invention relates to benzoxazinones of formula I: ##STR1## or stereoisomeric forms or mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, methods of using the same for treating viral infection or as an assay standard or reagent, and intermediates and processes for making the same.
摘要翻译：本发明涉及式I的苯并恶嗪酮：其可用作HIV逆转录酶抑制剂的立体异构形式或其混合物或其药学上可接受的盐形式，以及包含其的药物组合物和诊断试剂盒，方法使用它们来治疗病毒感染或作为测定标准或试剂，以及用于制备其的中间体和方法。

5. 发明申请

US20130190361A1 SUBSTITUTED OXADIAZOLE COMPOUNDS 有权
标题翻译：取代的氧化氮化合物
公开(公告)号：US20130190361A1
公开(公告)日：2013-07-25
申请号：US13825595
申请日：2011-09-23
申请人： Jagabandhu Das , Soo Sung Ko
发明人： Jagabandhu Das , Soo Sung Ko
IPC分类号： C07D271/06 , C07D417/04 , C07D413/10 , C07D413/04 , C07D417/12
CPC分类号： C07D271/06 , C07D413/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/12
摘要： Disclosed are compounds of Formula (I): or stereoisomers, N-oxides, salts, or prodrugs thereof; wherein: Ring A is phenyl or 5- to 6-membered heteroaryl; (i) R1 and R2 are independently C1-C4 alkyl; or (ii) R1 and R2 together with the carbon atom to which they are attached, form a cyclic group; Q is phenyl or 5- to 6-membered heteroaryl substituted with zero to 3 substituents; and R3, L1, L2, and n are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
摘要翻译：公开了式（I）的化合物：其立体异构体，N-氧化物，盐或前药; 其中：环A是苯基或5-至6-元杂芳基; （i）R 1和R 2独立地为C 1 -C 4烷基; 或（ii）R 1和R 2与它们所连接的碳原子一起形成环状基团; Q为苯基或被0至3个取代基取代的5至6元杂芳基; 并且R3，L1，L2和n在本文中定义。还公开了使用这种化合物作为G蛋白偶联受体S1P1的选择性激动剂的方法，以及包含这些化合物的药物组合物。这些化合物可用于治疗，预防或减缓各种治疗领域（例如自身免疫疾病和血管疾病）中的疾病或病症的进展。

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