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1. 发明授权

US09056886B2 Guanosine-rich modified oligonucleotides and antiproliferative activity thereof 有权
标题翻译：富含肌氨酸的修饰的寡核苷酸及其抗增殖活性
公开(公告)号：US09056886B2
公开(公告)日：2015-06-16
申请号：US13381326
申请日：2010-06-29
申请人： Soo Jin Lee , Sung Hwan Moon
发明人： Soo Jin Lee , Sung Hwan Moon
IPC分类号： C07H19/173 , C07H21/00
CPC分类号： C07H19/173 , C07H21/00
摘要： The present invention relates to a novel modified oligonucleotide comprising at least one guanosine molecule and a modified nucleic acid with therapeutic efficacies. The present invention also relates to a pharmaceutical composition having cell apoptotic activity against cancer cells for preventing or treating cancer comprising a guanosine-rich modified oligonucleotide with at least one therapeutically effective modified nucleic acid (N), or its pharmaceutically acceptable salt as active ingredient.
摘要翻译：本发明涉及包含至少一种鸟苷分子和具有治疗功效的修饰的核酸的新型修饰寡核苷酸。本发明还涉及具有细胞凋亡活性的药物组合物，其具有用于预防或治疗癌症的细胞凋亡活性，其包含富含鸟嘌呤的修饰的寡核苷酸与至少一种治疗有效的修饰的核酸（N）或其药学上可接受的盐作为活性成分。

2. 发明授权

US08138337B2 Reverse-turn mimetics and method relating thereto 有权
标题翻译：反转模拟物及其相关方法
公开(公告)号：US08138337B2
公开(公告)日：2012-03-20
申请号：US12649161
申请日：2009-12-29
申请人： Sung Hwan Moon , Jae Uk Chung , Sung Chan Lee , Masakatsu Eguchi , Michael Kahn , Kwang Won Jeong , Cu Nguyen , Soo Jin Lee
发明人： Sung Hwan Moon , Jae Uk Chung , Sung Chan Lee , Masakatsu Eguchi , Michael Kahn , Kwang Won Jeong , Cu Nguyen , Soo Jin Lee
IPC分类号： C07D487/04 , A61K31/53 , A61P19/02 , A61P35/00
CPC分类号： C07D487/04 , A61K31/53
摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins as well as their prodrugs are disclosed. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds and prodrugs for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.
摘要翻译：公开了模拟生物活性肽和蛋白质的逆转转区域的二级结构及其前药的构象约束化合物。这种反转模拟结构和前药在广泛的领域中具有实用性，包括用作诊断和治疗剂。还公开了包含本发明的反转模拟结构的文库以及用于筛选其的方法以鉴定生物活性成员。本发明还涉及这些化合物和前药用于抑制或治疗由Wnt信号传导途径调节的疾病如癌症，特别是结肠直肠癌，与血管成形术相关的再狭窄，多囊肾病，异常血管生成疾病，类风湿性关节炎疾病，结节性硬化综合征，阿尔茨海默氏病，过度头发生长或损失，或溃疡性结肠炎。

3. 发明申请

US20110130339A1 COSMETIC COMPOSITION FOR SKIN CELL REGENERATION MIMICKING EXTRACELLULAR MATRIX 有权
标题翻译：化妆品组合物用于皮肤细胞再生复合细胞基质
公开(公告)号：US20110130339A1
公开(公告)日：2011-06-02
申请号：US12955301
申请日：2010-11-29
申请人： Mi Jin KIM , Jong Won Shim , Yong Jin Kim , Eun Jung An , Chan Woo Lee , Soo Jin Lee , Jin Woong Kim
发明人： Mi Jin KIM , Jong Won Shim , Yong Jin Kim , Eun Jung An , Chan Woo Lee , Soo Jin Lee , Jin Woong Kim
IPC分类号： A61K8/67 , A61Q19/08
CPC分类号： A61K8/64 , A61K8/19 , A61K8/27 , A61K8/67 , A61K8/735 , A61K2800/592 , A61Q19/08
摘要： The present invention relates to a cosmetic composition which mimics the extracellular matrix to stimulate the regeneration of skin cells, and more particularly to a cosmetic composition which contains active ingredients consisting of low-molecular-weight materials, which easily permeate through the skin, at a composition ratio similar to that in the extracellular matrix. The cosmetic composition stimulates the repair of the skin to maintain homeostasis and is effective for the regeneration of skin cells.
摘要翻译：本发明涉及一种化妆品组合物，其模拟细胞外基质以刺激皮肤细胞的再生，更具体地涉及一种化妆品组合物，其含有由容易渗透皮肤的低分子量材料组成的活性成分组成比与细胞外基质相似。化妆品组合物刺激皮肤的修复以维持体内平衡，并且对皮肤细胞的再生是有效的。

4. 发明授权

US07932384B2 Reverse-turn mimetics and method relating thereto 有权
标题翻译：反转模拟物及其相关方法
公开(公告)号：US07932384B2
公开(公告)日：2011-04-26
申请号：US12510107
申请日：2009-07-27
申请人： Sung Hwan Moon , Jae Uk Chung , Sung Chan Lee , Masakatsu Eguchi , Michael Kahn , Kwang Won Jeong , Cu Nguyen , Soo Jin Lee
发明人： Sung Hwan Moon , Jae Uk Chung , Sung Chan Lee , Masakatsu Eguchi , Michael Kahn , Kwang Won Jeong , Cu Nguyen , Soo Jin Lee
IPC分类号： C07D487/04 , A61K31/53 , A61P19/02 , A61P35/00
CPC分类号： C07D487/04 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/53 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.
摘要翻译：公开了模拟生物活性肽和蛋白质的反转转区的二级结构的构象约束化合物。这种反转模拟结构在广泛的领域中具有实用性，包括用作诊断和治疗剂。还公开了包含本发明的反转模拟结构的文库以及用于筛选其的方法以鉴定生物活性成员。本发明还涉及这种化合物用于抑制或治疗由Wnt信号传导途径调节的疾病，例如癌症，特别是结肠直肠癌，与血管成形术，多囊肾病，异常血管生成疾病，类风湿性关节炎疾病，结节性硬化综合征相关的再狭窄，阿尔茨海默氏病，过度毛发生长或损失，或溃疡性结肠炎。

5. 发明申请

US20100222303A1 REVERSE-TURN MIMETICS AND METHOD RELATING THERETO 有权
公开(公告)号：US20100222303A1
公开(公告)日：2010-09-02
申请号：US12649161
申请日：2009-12-29
申请人： Sung Hwan Moon , Jae Uk Chung , Sung Chan Lee , Masakatsu Eguchi , Michael Kahn , Kwang Won Jeong , Cu Nguyen , Soo Jin Lee
发明人： Sung Hwan Moon , Jae Uk Chung , Sung Chan Lee , Masakatsu Eguchi , Michael Kahn , Kwang Won Jeong , Cu Nguyen , Soo Jin Lee
IPC分类号： A61K31/675 , C07D487/04 , A61K31/53 , A61K31/4985 , C07D413/14 , A61K31/5377 , C07D265/36 , A61K31/538 , A61P19/02
CPC分类号： C07D487/04 , A61K31/53
摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins as well as their prodrugs are disclosed. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds and prodrugs for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

6. 发明授权

US07289086B2 Image data correction method and apparatus for plasma display panel, and plasma display panel device having the apparatus 失效
标题翻译：用于等离子体显示面板的图像数据校正方法和装置，以及具有该装置的等离子体显示面板装置
公开(公告)号：US07289086B2
公开(公告)日：2007-10-30
申请号：US10779793
申请日：2004-02-18
申请人： Soo-Jin Lee
发明人： Soo-Jin Lee
IPC分类号： G09G3/28
CPC分类号： G09G3/2022 , G09G3/2944 , G09G2320/0233 , G09G2320/0242 , G09G2320/0285 , G09G2360/16
摘要： An image data correction method and apparatus for a plasma display panel, and a plasma display panel device having the apparatus. The image data correction method calculates a load factor of video signals fed into a plasma display panel, and determines an automatic power control level corresponding to the calculated load factor. The method further involves generating sustain pulse information and the number of subfields and selecting a correction table corresponding to the number of subfields and the automatic power control level from the memory. Then, the image data is corrected with reference to the correction table. By this image data correction, white chromaticity can be maintained constantly while enhancing the color reproducibility of each subfield.
摘要翻译：一种用于等离子体显示面板的图像数据校正方法和装置，以及具有该装置的等离子体显示面板装置。图像数据校正方法计算馈送到等离子体显示面板中的视频信号的负载因子，并且确定与所计算的负载系数对应的自动功率控制电平。该方法还包括产生维持脉冲信息和子场数，并从存储器中选择与子场数量和自动功率控制电平相对应的校正表。然后，参考校正表来校正图像数据。通过该图像数据校正，可以在增强每个子场的颜色再现性的同时保持白色色度。

7. 发明申请

US20050088372A1 Plasma display panel, and apparatus and method for driving the same 失效
标题翻译：等离子体显示面板及其驱动装置及方法
公开(公告)号：US20050088372A1
公开(公告)日：2005-04-28
申请号：US10968163
申请日：2004-10-20
申请人： Soo-Jin Lee , Im-Su Choi
发明人： Soo-Jin Lee , Im-Su Choi
IPC分类号： G09G3/20 , G06F3/147 , G09F9/313 , G09G3/28 , G09G3/288 , G09G3/291 , G09G3/294 , G09G3/298 , G09G5/10 , H01J17/49
CPC分类号： G09G3/294 , G09G3/2037 , G09G2320/0266 , G09G2320/0673 , G09G2360/16
摘要： Disclosed is a plasma display panel, and an apparatus and method for driving the same. In the method of the present invention, an image signal is received and gamma-corrected according to a gamma correction curve. The gamma-corrected image signal is generated as subfield data according to the subfield generating compression curve. The average signal level of the image signal is calculated and correction according to an average signal level correction inverse curve is performed regarding the generation of the subfields for each gray level, and a sustain electrode driving signal and a scan electrode driving signal corresponding to the average signal level are output.
摘要翻译：公开了一种等离子体显示面板及其驱动装置和方法。在本发明的方法中，根据伽马校正曲线接收图像信号并进行伽马校正。根据子场产生压缩曲线，产生伽马校正图像信号作为子场数据。计算图像信号的平均信号电平，并根据对于每个灰度级的子场的生成执行平均信号电平校正反向曲线的校正，以及对应于平均值的维持电极驱动信号和扫描电极驱动信号输出信号电平。

8. 发明申请

US20120202981A1 NOVEL GUANOSINE-RICH MODIFIED OLIGONUCLEOTIDES AND ANTIPROLIFERATIVE ACTIVITY THEREOF 有权
标题翻译：新型冠心病修饰寡核苷酸及其抗增殖活性
公开(公告)号：US20120202981A1
公开(公告)日：2012-08-09
申请号：US13381326
申请日：2010-06-29
申请人： Soo Jin Lee , Sung Hwan Moon
发明人： Soo Jin Lee , Sung Hwan Moon
IPC分类号： C07H21/00
CPC分类号： C07H19/173 , C07H21/00
摘要： The present invention relates to a novel modified oligonucleotide comprising at least one guanosine molecule and a modified nucleic acid with therapeutic efficacies. The present invention also relates to a pharmaceutical composition having cell apoptotic activity against cancer cells for preventing or treating cancer comprising a guanosine-rich modified oligonucleotide with at least one therapeutically effective modified nucleic acid (N), or its pharmaceutically acceptable salt as active ingredient.
摘要翻译：本发明涉及包含至少一种鸟苷分子和具有治疗功效的修饰的核酸的新型修饰寡核苷酸。本发明还涉及具有细胞凋亡活性的药物组合物，其具有用于预防或治疗癌症的细胞凋亡活性，其包含富含鸟嘌呤的修饰的寡核苷酸与至少一种治疗有效的修饰的核酸（N）或其药学上可接受的盐作为活性成分。

9. 发明授权

US07566711B2 Reverse-turn mimetics and method relating thereto 有权
标题翻译：反转模拟物及其相关方法
公开(公告)号：US07566711B2
公开(公告)日：2009-07-28
申请号：US11108164
申请日：2005-04-15
申请人： Sung Hwan Moon , Jae Uk Chung , Sung Chan Lee , Masakatsu Eguchi , Michael Kahn , Kwang Won Jeong , Cu Nguyen , Soo Jin Lee
发明人： Sung Hwan Moon , Jae Uk Chung , Sung Chan Lee , Masakatsu Eguchi , Michael Kahn , Kwang Won Jeong , Cu Nguyen , Soo Jin Lee
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/53 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.
摘要翻译：公开了模拟生物活性肽和蛋白质的反转转区的二级结构的构象约束化合物。这种反转模拟结构在广泛的领域中具有实用性，包括用作诊断和治疗剂。还公开了包含本发明的反转模拟结构的文库以及用于筛选其的方法以鉴定生物活性成员。本发明还涉及这种化合物用于抑制或治疗由Wnt信号传导途径调节的疾病，例如癌症，特别是结肠直肠癌，与血管成形术，多囊肾病，异常血管生成疾病，类风湿性关节炎疾病，结节性硬化综合征相关的再狭窄，阿尔茨海默氏病，过度毛发生长或损失，或溃疡性结肠炎。

10. 发明申请

US20060033684A1 Plasma display panel method and apparatus for preventing after-image on the plasma display panel 失效
公开(公告)号：US20060033684A1
公开(公告)日：2006-02-16
申请号：US11252405
申请日：2005-10-17
申请人： Soo-Jin Lee , Woo-Jin Kim , Im-Su Choi
发明人： Soo-Jin Lee , Woo-Jin Kim , Im-Su Choi
IPC分类号： G09G3/28
CPC分类号： G09G3/2007 , G09G3/296 , G09G2320/0257 , G09G2320/0626 , G09G2360/16
摘要： An after-image prevention apparatus and method for a plasma display panel having a plurality of address electrodes and a plurality of scan and sustain electrodes arranged in pairs and in a zigzag pattern. An average signal level until the current frame from currently input picture data and an average signal level of each cell until the previous frame as stored in a memory section is calculated. The average signal level is compared with the picture data. An attenuation coefficient is generated corresponding to the difference between the average signal level and the picture data. The picture data is multiplied by the attenuation coefficient to output correction data, thereby preventing an after-image phenomenon on the plasma display panel.

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