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    • 1. 发明授权
    • Airless, non-clogging tip assembly and device
    • 无气塞,不堵塞头组件和装置
    • US09022975B2
    • 2015-05-05
    • US13611511
    • 2012-09-12
    • John GoodmanSonia MartinsJoseph B. Bilotta
    • John GoodmanSonia MartinsJoseph B. Bilotta
    • A61B17/00B01F5/06B01F13/00B05B15/02B05B1/32
    • A61B17/00491A61B2017/00495B01F5/0683B01F5/069B01F13/0023B01F2215/0039B05B1/323B05B15/528
    • The invention described herein is a device for dripping a tissue sealant and/or adhesive that comprises a) first and second barrels or syringes that contain first and second biocomponents that are disposed between proximal and distal ends; b) a plunger in each barrel and c) a drip tip comprising i) a support having distal and proximal ends and at least two fluid passageways from the distal to the proximal end that are in fluid communication with one of the barrels of the dispensing device on the proximal end; and ii) an endcap that fits over the support having at least two flexible hinges. The present invention is also directed to an assembly for mixing and drip dispensing two reactive biologic components as tissue sealant and/or hemostatic agent and to methods for delivering biologic components to achieve hemostasis and/or tissue sealant by drip dispensing from the device described above.
    • 本文描述的本发明是用于滴落组织密封剂和/或粘合剂的装置,其包括:a)第一和第二桶或注射器,其包含设置在近端和远端之间的第一和第二生物组分; b)每个筒体中的柱塞,c)滴头,其包括i)具有远端和近端的支撑件和从远端至近端的至少两个流体通道,其与分配装置的一个管道流体连通 在近端; 以及ii)装配在具有至少两个柔性铰链的支撑件上的端盖。 本发明还涉及一种用于混合和滴注两种反应性生物组分作为组织密封剂和/或止血剂的组合物,以及用于通过从上述装置滴注分泌生物组分以实现止血和/或组织密封剂的方法。
    • 2. 发明授权
    • Hemostatic compositions and devices
    • 止血组合物和装置
    • US08119160B2
    • 2012-02-21
    • US11078049
    • 2005-03-11
    • Dwayne Lee LooneyGuanghui ZhangSonia Martins
    • Dwayne Lee LooneyGuanghui ZhangSonia Martins
    • A61K9/16B01D39/00B01D15/00
    • A61L24/104A61L24/0036A61L24/102
    • The present inventions includes a plurality of packed particles that contain interstitial pores, where the interstitial pores have a pore volume and a median pore diameter effective to provide improved absorption of physiological fluids or an aqueous media when placed in contact therewith, compared to a plurality of unpacked particles of the same material, where the particles are made of a biocompatible material and hemostatic agents and have an average diameter suitable for use in providing hemostasis to a site of a body of a mammal requiring hemostasis, hemostatic compositions containing such plurality of packed particles, methods of making such particles and compositions and medical devices suitable for delivering and containing the hemostatic plurality of particles and/or composition to a site of a body.
    • 本发明包括多个包含间质孔的填充颗粒,其中间隙孔具有孔容积和中值孔径,其有效地提供改善的生理流体吸收或与其接触时的水性介质,与多个 相同材料的未包装的颗粒,其中颗粒由生物相容性材料和止血剂制成,并且具有适合用于向要求止血的哺乳动物的身体的部位提供止血的平均直径,含有这种多个包装颗粒的止血组合物 制备这种颗粒和组合物的方法以及适于将止血多个颗粒和/或组合物输送并包含在身体部位的医疗装置。
    • 5. 发明申请
    • Airless, Non-Clogging Tip Assembly and Device
    • 无气塞,非堵塞尖端装配和装置
    • US20140074154A1
    • 2014-03-13
    • US13611511
    • 2012-09-12
    • John GoodmanSonia MartinsJoseph B. Bilotta
    • John GoodmanSonia MartinsJoseph B. Bilotta
    • A61B17/00
    • A61B17/00491A61B2017/00495B01F5/0683B01F5/069B01F13/0023B01F2215/0039B05B1/323B05B15/528
    • The invention described herein is a device for dripping a tissue sealant and/or adhesive that comprises a) first and second barrels or syringes that contain first and second biocomponents that are disposed between proximal and distal ends; b) a plunger in each barrel and c) a drip tip comprising i) a support having distal and proximal ends and at least two fluid passageways from the distal to the proximal end that are in fluid communication with one of the barrels of the dispensing device on the proximal end; and ii) an endcap that fits over the support having at least two flexible hinges. The present invention is also directed to an assembly for mixing and drip dispensing two reactive biologic components as tissue sealant and/or hemostatic agent and to methods for delivering biologic components to achieve hemostasis and/or tissue sealant by drip dispensing from the device described above.
    • 本文描述的本发明是用于滴落组织密封剂和/或粘合剂的装置,其包括:a)第一和第二桶或注射器,其包含设置在近端和远端之间的第一和第二生物组分; b)每个筒体中的柱塞,c)滴头,其包括i)具有远端和近端的支撑件和从远端至近端的至少两个流体通道,其与分配装置的一个管道流体连通 在近端; 以及ii)装配在具有至少两个柔性铰链的支撑件上的端盖。 本发明还涉及一种用于混合和滴注两种反应性生物组分作为组织密封剂和/或止血剂的组合物,以及用于通过从上述装置滴注分泌生物组分以实现止血和/或组织密封剂的方法。
    • 6. 发明申请
    • Hemostatic compositions and devices
    • 止血组合物和装置
    • US20050284809A1
    • 2005-12-29
    • US11078049
    • 2005-03-11
    • Dwayne LooneyGuanghui ZhangSonia Martins
    • Dwayne LooneyGuanghui ZhangSonia Martins
    • A61L24/00A61L24/10B01D15/00
    • A61L24/104A61L24/0036A61L24/102
    • The present inventions includes a plurality of packed particles that contain interstitial pores, where the interstitial pores have a pore volume and a median pore diameter effective to provide improved absorption of physiological fluids or an aqueous media when placed in contact therewith, compared to a plurality of unpacked particles of the same material, where the particles are made of a biocompatible material and hemostatic agents and have an average diameter suitable for use in providing hemostasis to a site of a body of a mammal requiring hemostasis, hemostatic compositions containing such plurality of packed particles, methods of making such particles and compositions and medical devices suitable for delivering and containing the hemostatic plurality of particles and/or composition to a site of a body.
    • 本发明包括多个包含间质孔的填充颗粒,其中间隙孔具有孔容积和中值孔径,其有效地提供改善的生理流体吸收或与其接触时的水性介质,与多个 相同材料的未包装的颗粒,其中颗粒由生物相容性材料和止血剂制成,并且具有适合用于向要求止血的哺乳动物的身体的部位提供止血的平均直径,含有这种多个包装颗粒的止血组合物 制备这种颗粒和组合物的方法以及适于将止血多个颗粒和/或组合物输送并包含在身体部位的医疗装置。