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1. 发明授权

US5621095A Cephalosporins 失效
标题翻译：头孢菌素
公开(公告)号：US5621095A
公开(公告)日：1997-04-15
申请号：US594764
申请日：1996-01-31
申请人： Jean-Fran.cedilla.ois Chantot , Solange Gouin d'Ambrieres , Daniel Humbert , Jean-Georges Teutsch
发明人： Jean-Fran.cedilla.ois Chantot , Solange Gouin d'Ambrieres , Daniel Humbert , Jean-Georges Teutsch
IPC分类号： A61K31/54 , A61P31/04 , C07D501/24 , C07D507/00 , C07D513/04 , C07D519/00
CPC分类号： C07D513/04
摘要： The syn isomer of a compound of the formula ##STR1## in the R or S form or a mixture of R and S forms wherein their non-toxic, pharmaceutically acceptable acid addition salts and having antibacterial activity and their preparation wherein the substituents are defined as in the specification.
摘要翻译：具有R或S形式的式I化合物的顺式异构体或R和S形式的混合物，其中其无毒的，药学上可接受的酸加成盐并具有抗菌活性及其制备，其中定义了取代基如说明书中所述。

2. 发明授权

US5385897A 4-thia-1-aza-bicyclo[4,2,0]oct-2-ene derivatives 失效
标题翻译： 4-硫杂-1-氮杂 - 双环[4,2,0]辛-2-烯衍生物
公开(公告)号：US5385897A
公开(公告)日：1995-01-31
申请号：US855324
申请日：1992-03-20
申请人： Jean-Georges Teutsch , Alain Bonnet , Jozsef Aszodi , Solange Gouin d'Ambrieres
发明人： Jean-Georges Teutsch , Alain Bonnet , Jozsef Aszodi , Solange Gouin d'Ambrieres
IPC分类号： C07D513/04 , C07D519/00 , C07D417/12 , A61K31/54
CPC分类号： C07D513/04
摘要： A compound selected from the group consisting of a compound of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## and R.sub.b --NH--, Ra is an organic radical, Ri and Rj are individually selected from the group consisting of hydrogen, aliphatic hydrocarbon, aromatic hydrocarbon and heterocycle or taken together with the nitrogen atom to which they are attached form an optionally substituted ring, Rb is selected from the group consisting of carbocyclic aryl and heterocyclic aryl, both optionally substituted, R.sub.1A is selected from the group consisting of ##STR3## R.sub.A ' and R.sub.B ' are individually selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, Z.sub.A is selected from the group consisting of a simple bond, --O-- and optionally oxidize sulfur, R.sub.3A is selected from the group consisting of optionally substituted carbocyclic aryl and heterocyclic aryl, optionally substitute quaternary ammonium, acetyl, carbamoyl, alkoxycarbonyl, alkyl and haloalkyl of 1 to 4 carbon atoms, --CN and azido, R.sub.4 is selected from the group consisting of hydrogen and methoxy, A is selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, magnesium, --NH.sub.4, an organic amine and esterified carboxy or --COOA is --COO.sup..crclbar., n.sub.2 is an integer from 0 to 2 and their non-toxic, pharmaceutical acceptable acid addition salts having excellent antibiotic activity.
摘要翻译：选自由下列化合物组成的组的化合物：其中R选自由下列组成的组成的组合：IMA和Rb-NH-，R a是有机基团，R 1和R j分别选自氢，脂族烃，芳族烃和杂环或与它们所连接的氮原子一起形成任选取代的环，R b选自碳环芳基和杂环芳基，两者均为任选取代的，R 1A选自由“IMAGE”RA“和”RB“组成的组分别选自氢和1至4个碳原子的烷基，ZA选自简单键，-O-和任选地氧化硫， R3A选自任选取代的碳环芳基和杂环芳基，任选地取代季铵，乙酰基，氨基甲酰基，烷氧基羰基，烷基和卤代烷基1 至4个碳原子，-CN和叠氮基，R 4选自氢和甲氧基，A选自氢，碱金属，碱土金属，镁，-NH 4，有机胺和酯化羧基或-COOA为-COO（ - ），n2为0〜2的整数，其无毒性，药学上可接受的酸加成盐具有优异的抗生素活性。

3. 发明授权

US5663164A 1-dethia-2-thia-cephalosporanic acids 失效
标题翻译： 1-脱硫-2-硫杂 - 头孢菌素酸
公开(公告)号：US5663164A
公开(公告)日：1997-09-02
申请号：US429600
申请日：1995-04-27
申请人： Jean-Georges Teutsch , Alain Bonnet , Jozsef Aszodi , Germain Costerousse , Solange Gouin d'Ambrieres
发明人： Jean-Georges Teutsch , Alain Bonnet , Jozsef Aszodi , Germain Costerousse , Solange Gouin d'Ambrieres
IPC分类号： A61K31/54 , C07C47/198 , C07C59/21 , C07C59/88 , C07C391/02 , C07D205/085 , C07D213/71 , C07D257/04 , C07D285/12 , C07D285/125 , C07D401/04 , C07D403/04 , C07D405/04 , C07D417/12 , C07D417/14 , C07D513/04 , C07D513/14 , C07D519/00 , C07F7/18
CPC分类号： C07D257/04 , C07C323/00 , C07C391/02 , C07C47/198 , C07C59/21 , C07C59/88 , C07D205/085 , C07D213/71 , C07D285/125 , C07D401/04 , C07D403/04 , C07D405/04 , C07D417/12 , C07D417/14 , C07D513/04 , C07D513/14 , C07F7/186
摘要： Novel 1-dethia-2-thia-cephalosporanic acid derivatives of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## Ra is an organic radical, R.sub.i and R.sub.j are individually selected from the group consisting of hydrogen, aliphatic, aromatic and heterocycle or taken together with the nitrogen atom to which they are attached form an optionally substituted cycle or R.sub.b NH--, R.sub.b is optionally substituted carbocyclic or heterocyclic aryl, R.sub.1 and --COM are as defined in the specification, R.sub.4 is hydrogen or methoxy, n.sub.2 is 0, 1 or 2 and their non-toxic, pharmaceutically acceptable acid addition salts in racemic or optically active form having antibiotic activity and their preparation and novel intermediates.
摘要翻译：新颖的1-脱硫-2-硫杂 - 头孢烷酸衍生物，其结构式为：其中R选自由下列组成的组：R a是有机基团，R 1和R j分别选自氢，脂族芳族和杂环或与它们所连接的氮原子一起形成任选取代的环或RbNH-，Rb是任选取代的碳环或杂环芳基，R 1和-COM如本说明书中所定义，R 4是氢或甲氧基，n2为0,1或2及其具有抗生素活性的外消旋或光学活性形式的无毒的药学上可接受的酸加成盐及其制备和新型中间体。

4. 发明授权

US5378697A Cephalosporins 失效
标题翻译：头孢菌素
公开(公告)号：US5378697A
公开(公告)日：1995-01-03
申请号：US903610
申请日：1992-06-24
申请人： Jean-Francois Chantot , Solange Gouin D'Ambrieres , Daniel Humbert , Jean-Georges Teutsch
发明人： Jean-Francois Chantot , Solange Gouin D'Ambrieres , Daniel Humbert , Jean-Georges Teutsch
IPC分类号： A61K31/54 , A61P31/04 , C07D501/24 , C07D507/00 , C07D513/04 , C07D519/00
CPC分类号： C07D513/04
摘要： The syn isomer of a compound of the formula ##STR1## in the R or S form or a mixture of R and S forms and their non-toxic, pharmaceutically acceptable acid addition salts wherein the substituents are defined as in the specification having antibacterial activity and their preparation.
摘要翻译：具有R或S形式的式I化合物的顺式异构体或R和S形式的混合物及其无毒的药学上可接受的酸加成盐，其中取代基如本说明书中具有抗菌活性和他们的准备。

5. 发明授权

US06313305B1 Cephalosporins 失效
标题翻译：头孢菌素
公开(公告)号：US06313305B1
公开(公告)日：2001-11-06
申请号：US08900366
申请日：1997-07-21
申请人： Jozsef Aszodi , Jean-Francois Chantot , Patrick Fauveau , Solange Gouin d'Ambrieres , Daniel Humbert , Christophe Dini
发明人： Jozsef Aszodi , Jean-Francois Chantot , Patrick Fauveau , Solange Gouin d'Ambrieres , Daniel Humbert , Christophe Dini
IPC分类号： C07D28508
CPC分类号： C07D501/00 , C07C45/63 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07C59/64 , C07C69/734 , C07C205/44 , C07C239/20 , C07C255/56 , C07C255/57 , Y02P20/55
摘要： A compound having the formula selected from the group consisting of wherein either R3p and R4p are identical and selected from the group consisting of —OH, protected —OH and acyloxy of 1 to 8 carbon atoms, R2p is selected from the group consisting of —CN, —F, Br and I and R1p and R5p are hydrogen or R5p is —F and R1p and R2p are hydrogen or R1p and R2p are F and R5p is hydrogen, or R4p and R5p are identical and selected from the group consisting of —OH, protected —OH and acyloxy of 1 to 8 carbon atoms, R3p is selected from the group consisting of F and —CN and R1p and R2p are hydrogen, R8 is hydrogen or an amine protective group and R10 is the remainder in which the hydroxy or amino are protected wherein R′1 is selected from the group consisting of alkyl of 1 to 4 carbon atoms, —CN, carboxy and alkoxy carbonyl of 1 to 4 carbon atoms.
摘要翻译：具有选自R3p和R4p中的式的化合物是相同的，并且选自-OH，被保护的-OH和1至8个碳原子的酰氧基，R2p选自-CN， -F，Br和I，R1p和R5p是氢或R5p是-F，R1p和R2p是氢或R1p，R2p是F，R5p是氢，或R4p和R5p是相同的，选自-OH，保护的-OH和1至8个碳原子的酰氧基，R3p选自F和-CN，R1p和R2p是氢，R8是氢或胺保护基，R10是其中羟基或氨基被保护，其中R'1选自1至4个碳原子的烷基，-CN，羧基和1至4个碳原子的烷氧基羰基。

6. 发明授权

US5936083A Cephalosporins 失效
标题翻译：头孢菌素
公开(公告)号：US5936083A
公开(公告)日：1999-08-10
申请号：US625910
申请日：1996-04-01
申请人： Jozsef Aszodi , Jean-Francois Chantot , Solange Gouin D'Ambrieres
发明人： Jozsef Aszodi , Jean-Francois Chantot , Solange Gouin D'Ambrieres
IPC分类号： C07D501/00 , C07D501/22 , C07D501/24 , C07D501/56
CPC分类号： C07D501/00
摘要： A compound selected from the group consisting of a syn isomer of a compound of the formula ##STR1## in the R or S form or in the form of an R, S mixture wherein R us selected from the group consisting of ##STR2## R and R' are individually selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, CO.sub.2 --Q, ##STR3## CH.sub.2 --SQ, Q and Q' are individually hydrogen or alkyl of 1 to 4 carbon atoms, P, P' and P" are individually alkyl of 1 to 4 carbon atoms optionally substituted by one of the substituents R and R' the dotted line indicating that P and P' can optionally form with the nitrogen atom to which they are linked a heterocycle with 5 or 6 links, R.sub.b and R.sub.c are individually selected from the group consisting of an equivalent of an alkali metal, an alkaline earth metal, magnesium, ammonium and an amine organic base or A and A' are the remainder of an easily cleavable ester group or CO.sub.2 A is CO.sub.2 --and the wavy line indicates that CH.sub.2 R.sub.1 is in the E or Z position and their non-toxic, pharmaceutically acceptable acid addition salts having anti-bacterial activity.
摘要翻译：选自R或S形式的式的化合物的顺式异构体或R，S混合物形式的化合物，其中R us选自R和R'的化合物分别选自由氢，1-4个碳原子的烷基，1-4个碳原子的烷氧基，卤素，CO2-Q，CH2-SQ，Q和Q'分别是氢或1-4个碳原子的烷基，P， P'和P“分别是1至4个碳原子的烷基，任选被一个取代基R和R'取代，虚线表示P和P'可以任选地与它们连接的氮原子一起形成杂环与 5或6链，Rb和Rc分别选自碱金属，碱土金属，镁，铵和胺有机碱的当量，A和A'是易裂解酯基的剩余部分或CO 2 A是CO 2 - 而波浪线表示CH 2 R 1在E或Z位置a 它们具有抗菌活性的无毒的，药学上可接受的酸加成盐。

7. 发明授权

US5763617A Cephalosporins 失效
标题翻译：头孢菌素
公开(公告)号：US5763617A
公开(公告)日：1998-06-09
申请号：US769488
申请日：1996-12-18
申请人： Jozsef Aszodi , Jean-Francois Chantot , Patrick Fauveau , Solange Gouin D'Ambrieres , Daniel Humbert , Christophe Dini
发明人： Jozsef Aszodi , Jean-Francois Chantot , Patrick Fauveau , Solange Gouin D'Ambrieres , Daniel Humbert , Christophe Dini
IPC分类号： C07C45/63 , C07C45/67 , C07C45/71 , C07C47/565 , C07C47/575 , C07C59/64 , C07C69/734 , C07C205/44 , C07C239/20 , C07C255/56 , C07C255/57 , C07D277/40 , C07D277/46 , C07D285/08 , C07D409/12 , C07D417/12 , C07D501/00 , C07D501/24
CPC分类号： C07D501/00 , C07C205/44 , C07C239/20 , C07C255/56 , C07C255/57 , C07C45/63 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07C59/64 , C07C69/734 , Y02P20/55
摘要： A syn isomer in (R) or (S) form or a mixture thereof of a compound of the formula ##STR1## syn isomer, in the (R) or (S) form or in the form of an (R,S) mixture, in the form of an integral salt or their salts with organic or mineral acids wherein the substituents are as defined in the application and having antibacterial properties.
摘要翻译：（R）或（S）中的顺式异构体以（R）或（S）形式或（R，S）形式的式（I）异构体的化合物或其混合物形式或其混合物，混合物，其形式为整体盐或其与有机或无机酸的盐，其中取代基如本申请中所定义并具有抗菌性质。

8. 发明授权

US5712266A Cephalosporins 失效
标题翻译：头孢菌素
公开(公告)号：US5712266A
公开(公告)日：1998-01-27
申请号：US453923
申请日：1995-05-30
申请人： Jozsef Aszodi , Jean-Francois Chantot , Patrick Fauveau , Solange Gouin D'Ambrieres , Daniel Humbert , Christophe Dini
发明人： Jozsef Aszodi , Jean-Francois Chantot , Patrick Fauveau , Solange Gouin D'Ambrieres , Daniel Humbert , Christophe Dini
IPC分类号： C07C45/63 , C07C45/67 , C07C45/71 , C07C47/565 , C07C47/575 , C07C59/64 , C07C69/734 , C07C205/44 , C07C239/20 , C07C255/56 , C07C255/57 , C07D277/40 , C07D277/46 , C07D285/08 , C07D409/12 , C07D417/12 , C07D501/00 , C07D501/24
CPC分类号： C07D501/00 , C07C205/44 , C07C239/20 , C07C255/56 , C07C255/57 , C07C45/63 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07C59/64 , C07C69/734 , Y02P20/55
摘要： A syn isomer in (R) or (S) form or a mixture thereof of a compound of the formula ##STR1## syn isomer, in the (R) or (S) form or in the form of an (R,S) mixture, in the form of an internal salt or their salts with organic or mineral acids wherein the substituents are defined as in the application having anti-bacterial properties.
摘要翻译：（R）或（S）中的顺式异构体以（R）或（S）形式或（R，S）形式的式（I）异构体的化合物或其混合物形式或其混合物，混合物，以内盐的形式或其与有机或无机酸的盐形式，其中取代基如本申请中所定义，具有抗细菌性质。

9. 发明授权

US6100404A Erythromycin compounds 失效
标题翻译：红霉素化合物
公开(公告)号：US6100404A
公开(公告)日：2000-08-08
申请号：US780861
申请日：1997-01-09
申请人： Constantin Agouridas , Jean-Francois Chantot , Alexis Denis , Solange Gouin D'Ambrieres , Odile Le Martret
发明人： Constantin Agouridas , Jean-Francois Chantot , Alexis Denis , Solange Gouin D'Ambrieres , Odile Le Martret
IPC分类号： C07D249/18 , A61K31/00 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/00 , A61P31/04 , C07D209/08 , C07D215/02 , C07D215/12 , C07D217/14 , C07D233/61 , C07D233/64 , C07D235/08 , C07D257/04 , C07D277/64 , C07D401/04 , C07D417/04 , C07D471/04 , C07D473/00 , C07D473/04 , C07D495/04 , C07H17/00 , C07H17/08
CPC分类号： C07H17/08 , C07H17/00
摘要： Intermediates for the preparation of compounds selected from the group consisting of a compound of the formula ##STR1## wherein R is ##STR2## n is an integer from 3 to 5, Ar is an optionally substituted heterocyclic selected from the group consisting of
摘要翻译：用于制备选自下式化合物的化合物的中间体其中R为n为3至5的整数，Ar为任选取代的杂环基，其选自

10. 发明授权

US5883248A Cephalosporins 失效
标题翻译：头孢菌素
公开(公告)号：US5883248A
公开(公告)日：1999-03-16
申请号：US903460
申请日：1997-07-30
申请人： Jozsef Aszodi , Jean-Francois Chantot , Patrick Fauveau , Solange Gouin D'Ambrieres , Daniel Humbert , Christophe Dini
发明人： Jozsef Aszodi , Jean-Francois Chantot , Patrick Fauveau , Solange Gouin D'Ambrieres , Daniel Humbert , Christophe Dini
IPC分类号： C07C45/63 , C07C45/67 , C07C45/71 , C07C47/565 , C07C47/575 , C07C59/64 , C07C69/734 , C07C205/44 , C07C239/20 , C07C255/56 , C07C255/57 , C07D277/40 , C07D277/46 , C07D285/08 , C07D409/12 , C07D417/12 , C07D501/00 , C07D501/24
CPC分类号： C07D501/00 , C07C205/44 , C07C239/20 , C07C255/56 , C07C255/57 , C07C45/63 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07C59/64 , C07C69/734 , Y02P20/55
摘要： Novel intermediates of the formula ##STR1## wherein the substituents are defined in the specification.
摘要翻译：式中的取代基在本说明书中定义的新颖的中间体 + TR + TR 。

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