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1. 发明申请

US20180210182A1 AUTOFOCUS IMAGING 审中-公开
公开(公告)号：US20180210182A1
公开(公告)日：2018-07-26
申请号：US15922003
申请日：2018-03-15
申请人： Bas HULSKEN , Sjoerd STALLINGA
发明人： Bas HULSKEN , Sjoerd STALLINGA
IPC分类号： G02B21/24 , H04N3/14 , G02B21/36 , H04N5/232
CPC分类号： G02B21/245 , G02B21/36 , H04N3/1581 , H04N5/2258 , H04N5/23212
摘要： The present invention relates to the field of digital pathology and in particular to whole slide scanners. Autofocus imaging can be performed by sampling a first number of pixels of a primary image sensor which is a time delay integration (TDI) sensor, and sampling a second number of pixels of an autofocus image sensor, wherein the second number is between one quarter and three quarters of the first number. Thus, continuous autofocus for rapid light scanning may be provided based on an additional image sensor that is tilted with respect to the optical axis.

2. 发明授权

US08649581B2 Colour management for biological samples 有权
标题翻译：生物样品的色彩管理
公开(公告)号：US08649581B2
公开(公告)日：2014-02-11
申请号：US13124693
申请日：2009-10-16
申请人： Maarten M. J. W. Van Herpen , Dirk L. J. Vossen , Sjoerd Stallinga , Bernardus H. W. Hendriks , Erik M. H. P. Van Dijk
发明人： Maarten M. J. W. Van Herpen , Dirk L. J. Vossen , Sjoerd Stallinga , Bernardus H. W. Hendriks , Erik M. H. P. Van Dijk
IPC分类号： G06K9/00
CPC分类号： G06T11/001 , H04N1/62
摘要： A method of determining a color transformation for images of biological material includes preparing a first set of biological test objects using a first preparation method, and preparing a second set of biological test objects using a second preparation method. Each test object in the second set of test objects corresponding to a counterpart test object in the first set of test objects, the test object and its counterpart being of the same biological type of material. For each test object in the first and second set of test objects, the color of the test object is determined thereby generating a first and second set of colors The method further includes generating a conversion table indicating a mapping between the colors in the first set of colors and the corresponding colors in the second set of colors. The first and second preparation methods include first and second staining methods, respectively.
摘要翻译：确定生物材料的图像的颜色变换的方法包括使用第一制备方法制备第一组生物测试对象，并使用第二制备方法制备第二组生物测试对象。第二组测试对象中的每个测试对象对应于第一组测试对象中的对应测试对象，测试对象及其对应物具有相同的生物类型的材料。对于第一和第二组测试对象中的每个测试对象，确定测试对象的颜色，从而生成第一和第二组颜色。该方法还包括生成表示第一组中的颜色之间的颜色之间的映射的转换表颜色和相应的颜色在第二组颜色。第一和第二种制备方法分别包括第一和第二染色方法。

3. 发明授权

US08421000B2 Beam shaping without introducing divergence within a light beam 有权
标题翻译：光束成形，而不会在光束内引入发散
公开(公告)号：US08421000B2
公开(公告)日：2013-04-16
申请号：US12743024
申请日：2008-11-20
申请人： Erik Martinus Hubertus Petrus Van Dijk , Sjoerd Stallinga , Dirk Leo Joep Vossen , Marius Iosif Boamfa
发明人： Erik Martinus Hubertus Petrus Van Dijk , Sjoerd Stallinga , Dirk Leo Joep Vossen , Marius Iosif Boamfa
IPC分类号： G02F1/01 , G02B5/30
CPC分类号： G01N21/6458 , G02B5/1833
摘要： An optical beam shaper comprises a polarization-dependent phase adjustment member which applies a phase pattern of equal magnitude and opposite sign to two orthogonal polarization states. In a preferred embodiment the beamer shaper is a dif tractive element made of a birefringent material, such as a photo-polymerizable liquid crystal polymer frozen in a uniaxial alignment, said dif tractive element comprising a plurality of zones, each zone having a stepped thickness defining a plurality of steps. The beam shaper can be used to introduce astigmatism to a polarized light beam or to undo the astigmatism to a beam with an orthogonal polarization state. The beam shaper is advantageously used within a detection device, such as a fluorescence scanner.
摘要翻译：光束整形器包括偏振相关相位调整构件，其对两个正交偏振状态施加相等幅度和相反符号的相位图案。在优选实施例中，光束整形器是由双折射材料制成的吸引元件，例如以单轴取向冷冻的光可聚合液晶聚合物，所述吸引元件包括多个区域，每个区域具有限定多个步骤。光束整形器可用于对偏振光束引入像散或者使具有正交偏振状态的光束的散光消除。光束整形器有利地用在诸如荧光扫描仪的检测装置内。

4. 发明授权

US08119995B2 Device for detection of excitation using a multiple spot arrangement 失效
标题翻译：使用多点排列检测激励的装置
公开(公告)号：US08119995B2
公开(公告)日：2012-02-21
申请号：US11995826
申请日：2006-07-17
申请人： Derk Jan Wilfred Klunder , Levinus Pieter Bakker , Sjoerd Stallinga
发明人： Derk Jan Wilfred Klunder , Levinus Pieter Bakker , Sjoerd Stallinga
IPC分类号： G01J1/58
CPC分类号： G01N21/6452 , G01N21/648 , G01N2021/6478
摘要： The invention relates to a device (1) for detection of excitation (110) using a multiple spot arrangement (60), in which a multiple spot generator (50) is matched to the multiple spot arrangement (60) in such a way that light (100) entering the multiple spot generator (50) will be guided to defined areas on the multiple spot arrangement (60).
摘要翻译：本发明涉及一种用于使用多点排列（60）检测激励（110）的装置（1），其中多点发生器（50）与多点排列（60）匹配，使得光（100）进入多点发生器（50）将被引导到多点布置（60）上的限定区域。

5. 发明申请

US20110019064A1 TWO-DIMENSIONAL ARRAY OF RADIATION SPOTS FOR AN OPTICAL SCANNING DEVICE 审中-公开
标题翻译：用于光学扫描装置的两维辐射阵列阵列
公开(公告)号：US20110019064A1
公开(公告)日：2011-01-27
申请号：US12933166
申请日：2009-03-16
申请人： Sjoerd Stallinga
发明人： Sjoerd Stallinga
IPC分类号： H04N5/225 , G02B21/06
CPC分类号： G02B21/004 , G02B26/10
摘要： The invention relates to an optical scanning device (10) comprising: a spot generator (20) for generating a two-dimensional array (8) of radiation spots at lattice points Pmn=mT1+nT2 (m=1 to L1, n=1 to L2) where T 1 is a first lattice vector and T2 is a second lattice vector, and scanning means for scanning a sample (26) through the array of radiation spots in a scanning direction such that the radiation spots trace essentially equidistant lines (81, 82, 83) relative to the sample. According to the invention, the angle γ between the scanning direction and the first lattice vector T1 is at most as large as the angle between the scanning direction and the second lattice vector T2, and the ratio L1/L2 is less than 0.6. According to a preferred embodiment, L1 differs from Λ by less then 1.0 or L1 equals Λ with a tolerance of 10% or, Λ being defined by √2 D/R=(1+Λ2) Λ, D being the length of a lattice diagonal and R being the resolution. The invention further relates to an optical scanning method.
摘要翻译：本发明涉及一种光学扫描装置（10），包括：点阵发生器（20），用于在格点Pmn = mT1 + nT2（m = 1至L1，n = 1）处产生辐射点的二维阵列（8）到L2），其中T 1是第一晶格矢量，T2是第二晶格矢量;以及扫描装置，用于通过扫描方向上的辐射点阵列扫描样品（26），使得辐射点基本上等距线（81 ，82,83）。根据本发明，扫描方向与第一格子矢量T1之间的角度γ与扫描方向和第二格子矢量T2之间的角度最大，并且比率L1 / L2小于0.6。根据优选实施例，L1与Λ不同于1.0或L1等于Λ，其公差为10％，或Λ由√2D / R =（1 +Λ2）Λ定义，D是格子的长度对角线和R是分辨率。本发明还涉及一种光学扫描方法。

6. 发明申请

US20100277580A1 MULTI-MODAL SPOT GENERATOR AND MULTI-MODAL MULTI-SPOT SCANNING MICROSCOPE 审中-公开
标题翻译：多模式发射器和多模式多点扫描显微镜
公开(公告)号：US20100277580A1
公开(公告)日：2010-11-04
申请号：US12742978
申请日：2008-11-19
申请人： Sjoerd Stallinga , Dirk L.J. Vossen , Levinus P. Bakker , Bas Helsken
发明人： Sjoerd Stallinga , Dirk L.J. Vossen , Levinus P. Bakker , Bas Helsken
IPC分类号： H04N7/18 , G02B27/09 , G02B27/10 , G02B21/06
CPC分类号： G02B21/0032 , G02B27/0087 , G02B27/0905
摘要： The invention relates to a spot generator (10) having: —an entrysurface (12) for receiving an incident light beam (20) and an exit surface (14) for (22, 24) transmitting the light beam, the entry surface defining an entryside (16) and the exit surface defining an exit side (18). According to the invention, the spot generator is designed to modulate the incident light beam to generate on the exit side a first plurality (22) and a second plurality (24) of separate light spots, each light spot belonging to the first plurality having a first angular spectrum and each light spot belonging to the second plurality having a second angular spectrum different than the first angular spectrum. Advantageously, the spot generator comprises a periodic binary phase structure. The invention further relates to a multi-spot scanning microscope and to a method of imaging a microscopic sample.
摘要翻译：本发明涉及一种点发生器（10），具有： - 入射表面（12），用于接收入射光束（20）和用于（22,24）透射光束的出射表面（14），入射表面限定一个入口侧（16）和出口表面限定出口侧（18）。根据本发明，点发生器被设计成调制入射光束，以在出射侧产生第一多个（22）和第二多个（24）个分开的光点，每个属于第一多个光点的光点具有一个第一角谱和属于第二多个的每个光点具有不同于第一角谱的第二角谱。有利地，点发生器包括周期性二进制相位结构。本发明还涉及一种多点扫描显微镜和一种对微观样品进行成像的方法。

7. 发明申请

US20080265175A1 Device for Detection of Excitation Using a Multiple Spot Arrangement 失效
标题翻译：使用多点布置检测激励的装置
公开(公告)号：US20080265175A1
公开(公告)日：2008-10-30
申请号：US11995826
申请日：2006-07-17
申请人： Derk Jan Wilfred Klunder , Levinus Pieter Bakker , Sjoerd Stallinga
发明人： Derk Jan Wilfred Klunder , Levinus Pieter Bakker , Sjoerd Stallinga
IPC分类号： G01J1/58
CPC分类号： G01N21/6452 , G01N21/648 , G01N2021/6478
摘要： The invention relates to a device (1) for detection of excitation (110) using a multiple spot arrangement (60), in which a multiple spot generator (50) is matched to the multiple spot arrangement (60) in such a way that light (100) entering the multiple spot generator (50) will be guided to defined areas on the multiple spot arrangement (60).
摘要翻译：本发明涉及一种用于使用多点排列（60）检测激励（110）的装置（1），其中多点发生器（50）与多点排列（60）匹配，使得光（100）进入多点发生器（50）将被引导到多点布置（60）上的限定区域。

8. 发明申请

US20080253257A1 Phase-Conjugate Read-Out in a Holographic Data Storage 审中-公开
标题翻译：全息数据存储中的相位共轭读取
公开(公告)号：US20080253257A1
公开(公告)日：2008-10-16
申请号：US11570535
申请日：2005-06-20
申请人： Sjoerd Stallinga
发明人： Sjoerd Stallinga
IPC分类号： G11B7/00
CPC分类号： G11B7/0065 , G11C13/042
摘要： The invention relates to a holographic data storage medium (4) in which there are sections (20) which are used for data storage and sections (21) which are not. A diffractive structure (30a, 30b) is provided in respect of one or more of the unused sections (21), possibly at each of the boundaries between the used (20) and unused sections (21) or within the volume of a respective unused section (21) of the data storage volume. During read-out, a reference wave (6) is diffracted by the diffractive structure (30b) such that it enters a used section (20) (from the right) in a direction substantially perpendicular to the optical axis (16) of the signal wave (26). During recording, a reference wave (2) is diffracted by the diffractive structure (30a) such that it enters the used section (20) (from the left) in a direction substantially perpendicular to the optical axes (1b) of the signal wave (1).
摘要翻译：本发明涉及一种全息数据存储介质（4），其中存在用于数据存储的部分（20）和不是的部分（21）。关于一个或多个未使用部分（21），可能在使用的（20）和未使用部分（21）之间的每个边界处或在一个或多个未使用部分（21）的体积内，提供衍射结构（30a，30b）各个未使用部分（21）的数据存储卷。在读出期间，参考波（6）被衍射结构（30b）衍射，使得其在基本上垂直于所述光轴（16）的方向（从右侧）进入使用部分（20）信号波（26）。在记录期间，参考波（2）被衍射结构（30a）衍射，使得其在基本上垂直于信号的光轴（1b）的方向上进入使用部分（20）（从左侧）波（1）。

9. 发明申请

US20080205247A1 Multi-Radiation Beam Optical Scanning Device 审中-公开
标题翻译：多光束光学扫描装置
公开(公告)号：US20080205247A1
公开(公告)日：2008-08-28
申请号：US11913319
申请日：2006-04-26
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Sjoerd Stallinga , Stein Kuiper , Teunis Willem Tukker , Coen Theodorus Hubertus Fransiscus Liedenbaum , Albert Hendrik Jan Immink
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Sjoerd Stallinga , Stein Kuiper , Teunis Willem Tukker , Coen Theodorus Hubertus Fransiscus Liedenbaum , Albert Hendrik Jan Immink
IPC分类号： G11B7/135 , G11B7/125 , G11B7/12
CPC分类号： G11B7/1365 , G11B7/1275 , G11B2007/0006
摘要： An optical scanning device for scanning an information layer (2) of an optical record carrier (3). The device includes a radiation source (7) for providing at least a first radiation beam of a first polarization along a first optical path, and a second radiation beam of a second, different polarization along a second, different optical path. An objective lens system, having an optical axis (19a), is arranged to converge the radiation beams on the information layer A beam-deflecting element (30) comprising a birefringent material is orientated such that each of said polarized radiation beams experiences a different index of refraction upon passing through the birefringent material, and is arranged to refract at least the first radiation beam towards the optical axis.
摘要翻译：一种用于扫描光学记录载体（3）的信息层（2）的光学扫描装置。该装置包括辐射源（7），用于沿着第一光路提供至少第一偏振的第一辐射束，以及沿第二不同光路提供具有第二不同极化的第二辐射束。具有光轴（191a）的物镜系统被布置成将辐射束会聚在信息层上。包括双折射材料的束偏转元件（30）被定向成使得每个所述偏振辐射束经历不同的通过双折射材料时的折射率，并且被设置成至少使第一辐射束朝向光轴折射。

10. 发明申请

US20080141364A1 Method, Apparatus, Device, System, Program, for Calibrating 审中-公开
标题翻译：方法，装置，装置，系统，程序，用于校准
公开(公告)号：US20080141364A1
公开(公告)日：2008-06-12
申请号：US11815019
申请日：2006-01-24
申请人： Boris Skoric , Pim Theo Tuyls , Antonius Hermanus Maria Akkermans , Willem Gerard Ophey , Sjoerd Stallinga
发明人： Boris Skoric , Pim Theo Tuyls , Antonius Hermanus Maria Akkermans , Willem Gerard Ophey , Sjoerd Stallinga
IPC分类号： G06F21/00
CPC分类号： G06F21/34 , G06F21/31 , G06F2221/2103 , G09C1/00 , H04L9/3234 , H04L9/3278 , H04L2209/34
摘要： This invention relates to the use 100 of a challenge-response pair 104, 108 for calibrating a device 101 for authenticating 200 a physical token (102) 102.
摘要翻译：本发明涉及用于校准用于认证物理令牌（102）102的设备101的质询 - 响应对104,108的使用。

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