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1. 发明授权

US06900026B2 Methods for identifying compounds as antioxidants 失效
标题翻译：鉴定化合物作为抗氧化剂的方法
公开(公告)号：US06900026B2
公开(公告)日：2005-05-31
申请号：US10039869
申请日：2001-11-09
申请人： Douglas C. Wallace , Simon Melov , James D. Crapo , Brian J. Day
发明人： Douglas C. Wallace , Simon Melov , James D. Crapo , Brian J. Day
IPC分类号： A61K49/00 , C12N9/02 , C12N15/85 , C12Q1/34
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , A61K49/0008 , C12N9/0089
摘要： The present application describes methods for the testing of compounds of potential usefulness as therapeutic antioxidants and/or as therapeutic free radical scavengers. The animal model for testing such compounds is the Sod2CJE homozygous Manganese Superoxide Dismutase-deficient mouse. When pups of these mice are treated with certain antioxidants, they survive past about 7 days of age, and later develop characteristic histological changes and characteristic neurobehavioral disorders. Those treated mice can be further treated with test compounds which may or may not cross the blood brain barrier, and the life span and physical and neurobehavioral characteristics of those mice provide information about the potential utility of the test compound as a therapeutic antioxidant. Phenotypes of the treated mice allow conclusions regarding targeted areas of the brain and thus, applications to particular disorders such as Parkinsonism.
摘要翻译：本申请描述了测试作为治疗性抗氧化剂和/或作为治疗性自由基清除剂的潜在有用性的化合物的方法。用于测试这些化合物的动物模型是Sod2CJE纯合的锰超氧化物歧化酶缺陷型小鼠。当这些小鼠的幼仔用某些抗氧化剂处理时，它们可以在约7天龄之后存活，并且随后发展特征性组织学变化和特征性神经行为障碍。那些治疗的小鼠可以进一步用可能或不可能穿过血脑屏障的测试化合物进行治疗，并且这些小鼠的寿命和物理和神经行为特征提供了关于测试化合物作为治疗性抗氧化剂的潜在效用的信息。经处理的小鼠的表型允许关于脑的目标区域的结论，因此可以应用于特定疾病如帕金森综合征。

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