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1. 发明专利

NZ545922A Adjustable shims for levelling machine base with screw located between two half wedges, one with a thread and other with a pocket 未知
公开(公告)号：NZ545922A
公开(公告)日：2007-09-28
申请号：NZ54592206
申请日：2006-03-15
申请人： SHUYI ZHANG , SHAOSONG ZHANG
发明人： ZHANG SHUYI , ZHANG SHAOSONG
IPC分类号： F16M7/00 , E02D35/00 , F16M13/00
摘要： A first wedge 1 has a long half screw thread 4 and sits against a second wedge 2 of identical included angle which has a half cylinder pocket 6 and a half cylinder hole 4a. A screw 3 drivable by an Allen key sits between the first and second wedge. The distance between upper and lower surfaces 8,9 of the shim is thus adjustable by turning the screw 3.

2. 发明授权

US08519168B2 Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds 有权
标题翻译：用于合成1,2-取代的3,4-二氧代-1-环丁烯化合物的方法和中间体
公开(公告)号：US08519168B2
公开(公告)日：2013-08-27
申请号：US12665913
申请日：2008-07-01
申请人： Xiaoyong Fu , Frank Bruno Guenter , Agnes S. Kim-Meade , Kenneth Stanley Matthews , Mathew Thomas Maust , Gerald Werne , Jason L. Winters , Jianguo Yin , Shuyi Zhang , David J. Moloznik
发明人： Xiaoyong Fu , Frank Bruno Guenter , Agnes S. Kim-Meade , Kenneth Stanley Matthews , Mathew Thomas Maust , Timothy L. McAllister , Gerald Werne , Jason L. Winters , Jianguo Yin , Shuyi Zhang
IPC分类号： C07D307/40
CPC分类号： C07D307/52 , C07C231/12 , C07C237/44
摘要： This application discloses a novel process for the preparation of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds, which have utility, for example, in the treatment of CXC chemokine-mediated diseases, and intermediates useful in the synthesis thereof.
摘要翻译：本申请公开了一种制备1,2-取代的3,4-二氧代-1-环丁烯化合物的新方法，其可用于例如治疗CXC趋化因子介导的疾病，以及可用于其合成的中间体。

3. 发明授权

US09116300B2 Multi-mode interferometer techniques 有权
标题翻译：多模干涉仪技术
公开(公告)号：US09116300B2
公开(公告)日：2015-08-25
申请号：US13146308
申请日：2010-06-25
申请人： Yanqing Lu , Shuyi Zhang , Qi Zhong , Fei Xu , Xiaowen Lin , Wei Hu
发明人： Yanqing Lu , Shuyi Zhang , Qi Zhong , Fei Xu , Xiaowen Lin , Wei Hu
IPC分类号： G02B6/26 , G02B6/293 , G01N21/45 , G02B6/02 , G02B6/255 , G01J9/00 , G02B6/14
CPC分类号： G02B6/29344 , G01J2009/004 , G01N21/45 , G02B6/02295 , G02B6/14 , G02B6/2551 , G02B6/262
摘要： Technologies are generally described for techniques useful in an interferometer system. In some examples, a system may include a first waveguide effective to propagate a first wave in a first mode. In some examples, the system may include a second waveguide effective to, in response to the first wave, propagate second and third waves in second and third modes, respectively. In some examples, the second waveguide may be effective to reflect the second and third waves off a reflection surface to produce first, second, third and fourth reflected waves. In some examples, the second waveguide may be effective to propagate the first and third reflected waves in the second mode and propagate the second and fourth reflected waves in the third mode.
摘要翻译：技术通常描述用于干涉仪系统中的技术。在一些示例中，系统可以包括有效地在第一模式中传播第一波的第一波导。在一些示例中，系统可以包括有效响应于第一波的第二波导，其分别在第二和第三模式中传播第二和第三波。在一些示例中，第二波导可以有效地将第二和第三波从反射表面反射以产生第一，第二，第三和第四反射波。在一些示例中，第二波导可以有效地在第二模式中传播第一和第三反射波，并且在第三模式中传播第二和第四反射波。

4. 发明授权

US07910775B2 Synthesis of 2-Hydroxy-N,N-dimethyl-3-[[2-[[1(R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide 有权
标题翻译：合成2-羟基-N，N-二甲基-3 - [[2 - [[1（R） - （5-甲基-2-呋喃基）丙基]氨基] -3,4-二氧代-1-环丁烯-1 - 基]氨基]苯甲酰胺
公开(公告)号：US07910775B2
公开(公告)日：2011-03-22
申请号：US12253356
申请日：2008-10-17
申请人： Jianguo Yin , Xiaoyong Fu , Shuyi Zhang , Timothy L. McAllister , Agnes S. Kim-Meade , Jason L. Winters , Anantha Sudhakar , Doris P. Schumacher
发明人： Jianguo Yin , Xiaoyong Fu , Shuyi Zhang , Timothy L. McAllister , Agnes S. Kim-Meade , Jason L. Winters , Anantha Sudhakar , Doris P. Schumacher
IPC分类号： C07C231/02 , C07C233/05
CPC分类号： C07D307/52 , C07C235/60
摘要： Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1-C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
摘要翻译：公开了制备式I化合物的方法：使用式II，Q和XI或XII的化合物：其中A选自Br，Cl和I（其中Br优选）; R表示（C1-C10）烷基。还公开了在所公开的方法中制备的中间体化合物。

5. 发明申请

US20080279822A1 Crystalline Polymorphs of a CXC-Chemokine Receptor Ligand 有权
标题翻译： CXC趋化因子受体配体的晶体多晶型物
公开(公告)号：US20080279822A1
公开(公告)日：2008-11-13
申请号：US12174470
申请日：2008-07-16
申请人： Mengwei Hu , Younong Yu , Michael Dwyer , Arthur Taveras , Agnes Kim-Meade , Jianguo Yin , Xiaoyong Fu , Timothy McAllister , Shuyi Zhang , Kevin Klopfer
发明人： Mengwei Hu , Younong Yu , Michael Dwyer , Arthur Taveras , Agnes Kim-Meade , Jianguo Yin , Xiaoyong Fu , Timothy McAllister , Shuyi Zhang , Kevin Klopfer
IPC分类号： A61K31/341 , C07D307/54 , A61P25/00 , A61P29/00 , A61P35/00 , A61P11/00 , A61P31/12 , A61P19/02 , A61K39/395 , A61K31/519 , A61K31/52 , A61K38/21
CPC分类号： C07D307/52
摘要： The present invention relates to four distinct crystalline polymorphs of a monohydrate of Compound A having the following chemical structure: Compound A. These four polymorphic forms, herein referred to as Forms I, II III and IV are active as a CXC-chemokine receptor ligands. The invention is further directed to formulations, methods of treatment, and processes of synthesis of these polymorphic forms.
摘要翻译：本发明涉及具有以下化学结构的化合物A的一水合物的四种不同的结晶多晶型物：化合物A.这四种多晶型物，本文称为形式I，II III和IV作为CXC-趋化因子受体配体是有活性的。本发明进一步涉及这些多晶形式的制剂，治疗方法和合成方法。

6. 发明授权

US08207221B2 Crystalline polymorphs of a CXC-chemokine receptor ligand 有权
标题翻译： CXC-趋化因子受体配体的结晶多晶型物
公开(公告)号：US08207221B2
公开(公告)日：2012-06-26
申请号：US12174470
申请日：2008-07-16
申请人： Mengwei Hu , Younong Yu , Michael P. Dwyer , Arthur G. Taveras , Agnes Kim-Meade , Jianguo Yin , Xiaoyong Fu , Timothy L. McAllister , Shuyi Zhang , Kevin Klopfer
发明人： Mengwei Hu , Younong Yu , Michael P. Dwyer , Arthur G. Taveras , Agnes Kim-Meade , Jianguo Yin , Xiaoyong Fu , Timothy L. McAllister , Shuyi Zhang , Kevin Klopfer
IPC分类号： A61K31/341 , C07D307/504
CPC分类号： C07D307/52
摘要： The present invention relates to four distinct crystalline polymorphs of a monohydrate of Compound A having the following chemical structure: These four polymorphic forms, herein referred to as Forms I, II, III and IV are active as a CXC-chemokine receptor ligands. The invention is further directed to formulations, methods of treatment, and processes of synthesis of these polymorphic forms.
摘要翻译：本发明涉及具有以下化学结构的化合物A的一水合物的四种不同的结晶多晶型物：这四种多晶型物，在本文中称为形式I，II，III和IV，作为CXC-趋化因子受体配体是有活性的。本发明进一步涉及这些多晶形式的制剂，治疗方法和合成方法。

7. 发明授权

US07374781B2 Sustained release formulations containing acetaminophen and tramadol 失效
标题翻译：含有对乙酰氨基酚和曲马多的缓释制剂
公开(公告)号：US07374781B2
公开(公告)日：2008-05-20
申请号：US10664451
申请日：2003-09-20
申请人： Shuyi Zhang , Jin Wang
发明人： Shuyi Zhang , Jin Wang
IPC分类号： A61K9/48 , A61K9/54 , A61K9/56
CPC分类号： A61K9/209 , A61K9/4808 , A61K9/5084 , A61K31/167 , A61K31/485 , A61K2300/00
摘要： A sustained release formulation as a unit dose contains 100 mg-1000 mg of Acetaminophen and 15 mg-150 mg of tramadol hydrochloride, which comprises of 1) an immediate release portion comprising of 25%-75% of the total effective amount of drug in the dosage form and 2) a sustained release portion comprising of a) 25%-75% of the total effective amount of drugs in the dosage form; b) 6%-50% of gelling polymers of the total formulation, and c) optionally an enteric coating at a level of 5%-40% of the total formulation. The set forth formulation dissolves 25%-60% of the total drug in the first hour, 50%-90% of the total drug in the first four hours and not less than 80% of the total drug in the first 12 hours using USP dissolution method II at 50 rpm.
摘要翻译：作为单位剂量的持续释放制剂含有100mg-1000mg的对乙酰氨基酚和15mg-150mg的盐酸曲马多，其包含1）一个即时释放部分，其包含药物总有效量的25％-75％剂型和2）持续释放部分，其包含a）剂型总有效量的25％-75％; b）总制剂的6％-50％的胶凝聚合物，和c）任选的肠溶衣，其含量为总制剂的5％-40％。所述配方在第一小时内溶解总药物的25％-60％，在前12小时内溶解总药物的50％-90％，并且在前12小时内使用USP溶解不少于总药物的80％溶解方法II在50rpm下。

8. 发明授权

US07985860B2 Process and intermediates for the synthesis of 2-(quinolin-5-yl)-4,5 disubstituted-azole derivatives 失效
标题翻译：用于合成2-（喹啉-5-基）-4,5二取代 - 唑衍生物的方法和中间体
公开(公告)号：US07985860B2
公开(公告)日：2011-07-26
申请号：US11891348
申请日：2007-08-10
申请人： Timothy D. Cutarelli , Xiaoyong Fu , Timothy L. McAllister , Michael R. Reeder , Jianguo Yin , Kelvin H. Yong , Shuyi Zhang
发明人： Timothy D. Cutarelli , Xiaoyong Fu , Timothy L. McAllister , Michael R. Reeder , Jianguo Yin , Kelvin H. Yong , Shuyi Zhang
IPC分类号： C07D215/38
CPC分类号： C07D413/04 , C07C271/22 , C07D413/14
摘要： This application discloses a novel process to synthesize 2-(Quinolin-5yo)-4,5-Disubstituted-Azole derivatives, which may be used, for example, as PDE IV inhibitor compounds in pharmaceutical preparations.
摘要翻译：本申请公开了一种合成2-（喹啉-5-基）-4,5-二取代 - 唑衍生物的新方法，其可用作药物制剂中的PDE IV抑制剂化合物。

9. 发明授权

US07462740B2 Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[[1(r)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide 有权
标题翻译：合成2-羟基-N，正二甲基-3 - [[2 - [[1（R） - （5-甲基-2-呋喃基）丙基]氨基] -3,4-二氧代-1-环丁烯-1 - 基]氨基]苯甲酰胺
公开(公告)号：US07462740B2
公开(公告)日：2008-12-09
申请号：US11430687
申请日：2006-05-09
申请人： Jianguo Yin , Xiaoyong Fu , Shuyi Zhang , Timothy L. McAllister , Agnes S. Kim-Meade , Jason L. Winters , Anantha Sudhakar , Doris P. Schumacher
发明人： Jianguo Yin , Xiaoyong Fu , Shuyi Zhang , Timothy L. McAllister , Agnes S. Kim-Meade , Jason L. Winters , Anantha Sudhakar , Doris P. Schumacher
IPC分类号： C07C231/02 , C07C233/65
CPC分类号： C07D307/52 , C07C235/60
摘要： Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1-C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
摘要翻译：公开了制备式I化合物的方法：使用式II，Q和XI或XII的化合物：其中A选自Br，Cl和I（其中Br优选）; R表示（C1-C10）烷基。还公开了在所公开的方法中制备的中间体化合物。

10. 发明申请

US20080045718A1 Process and intermediates for the synthesis of 2-(quinolin-5-yl)-4,5 disubstituted-azole derivatives 失效
标题翻译：用于合成2-（喹啉-5-基）-4,5二取代 - 唑衍生物的方法和中间体
公开(公告)号：US20080045718A1
公开(公告)日：2008-02-21
申请号：US11891348
申请日：2007-08-10
申请人： Timothy Cutarelli , Xiaoyong Fu , Timothy McAllister , Michael Reeder , Jianguo Yin , Kelvin Yong , Shuyi Zhang
发明人： Timothy Cutarelli , Xiaoyong Fu , Timothy McAllister , Michael Reeder , Jianguo Yin , Kelvin Yong , Shuyi Zhang
IPC分类号： C07D401/04 , C07C69/34 , C07D401/14 , C07C69/76
CPC分类号： C07D413/04 , C07C271/22 , C07D413/14
摘要： This application discloses a novel process to synthesize 2-(Quinolin-5yo)-4,5-Disubstituted-Azole derivatives, which may be used, for example, as PDE IV inhibitor compounds in pharmaceutical preparations.
摘要翻译：本申请公开了一种合成2-（喹啉-5-基）-4,5-二取代 - 唑衍生物的新方法，其可用作药物制剂中的PDE IV抑制剂化合物。

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