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1. 发明申请

US20080193979A1 Method for generating diversity 审中-公开
标题翻译：生成多样性的方法
公开(公告)号：US20080193979A1
公开(公告)日：2008-08-14
申请号：US12011757
申请日：2008-01-28
申请人： Julian Edward Sale , Michael Samuel Neuberger , Sarah Jane Cumbers , Shunichi Takeda
发明人： Julian Edward Sale , Michael Samuel Neuberger , Sarah Jane Cumbers , Shunichi Takeda
IPC分类号： C12P21/04
CPC分类号： C12N15/01 , A01K67/0275 , A01K2217/05 , C07K16/00 , C07K2317/56 , C12N15/1024 , C12N15/1075
摘要： The invention relates to a method for preparing an antibody-producing cell line capable of directed constitutive hypermutation of a specific nucleic acid region, comprising the steps of: a) screening a clonal cell population for V gene diversity; b) isolating one or more cells which display V gene diversity and comparing the rate of accumulation of mutations in the V genes and other genes of the selected cells; and c) selecting a cell in which the rate of V gene mutation exceeds that of other gene mutation.
摘要翻译：本发明涉及一种制备能够引导特异性核酸区域的组成型突变的产生抗体的细胞系的方法，包括以下步骤：a）筛选V基因多样性的克隆细胞群; b）分离显示V基因多样性的一个或多个细胞，并比较V基因和所选细胞的其他基因中突变的积累速率; c）选择V基因突变率超过其他基因突变的细胞。

2. 发明授权

US07368259B2 Method for generating diversity 有权
公开(公告)号：US07368259B2
公开(公告)日：2008-05-06
申请号：US10733532
申请日：2003-12-11
申请人： Julian Edward Sale , Michael Samuel Neuberger , Sarah Jane Cumbers , Shunichi Takeda
发明人： Julian Edward Sale , Michael Samuel Neuberger , Sarah Jane Cumbers , Shunichi Takeda
IPC分类号： C12Q1/04 , C12N15/01 , C12N15/63 , C12N5/08
CPC分类号： C12N15/01 , A01K67/0275 , A01K2217/05 , C07K16/00 , C07K2317/56 , C12N15/1024 , C12N15/1075
摘要： The invention relates to a method for preparing an antibody-producing cell line capable of directed constitutive hypermutation of a specific nucleic acid region, comprising the steps of: a) screening a clonal cell population for V gene diversity; b) isolating one or more cells which display V gene diversity and comparing the rate of accumulation of mutations in the V genes and other genes of the selected cells; and c) selecting a cell in which the rate of V gene mutation exceeds that of other gene mutation.

3. 发明授权

US4638785A Ignition system for internal combustion engines 失效
标题翻译：内燃机点火系统
公开(公告)号：US4638785A
公开(公告)日：1987-01-27
申请号：US827167
申请日：1986-02-07
申请人： Takeshi Matsui , Shunichi Takeda , Tomoatsu Makino
发明人： Takeshi Matsui , Shunichi Takeda , Tomoatsu Makino
IPC分类号： F02P3/045 , F02P3/05 , F02P5/08
CPC分类号： F02P3/0453
摘要： An ignition system for an internal combustion engine is disclosed. The ignition system includes a timing signal detector responsive to the rotation speed of an engine to generate a pulse signal including a leading edge and a trailing edge corresponding to the ignition timing and having a predetermined duty cycle, a triangular wave generator for generating a triangular wave voltage synchronized with the trailing edge of the pulse signal, a voltage storing circuit for storing the voltage level of the triangular wave voltage in synchronism with the leading edge of the pulse signal, a voltage divider for dividing the stored voltage in the voltage storing circuit to generate a reference voltage, a comparator for comparing the reference voltage and the triangular wave voltage to detect a difference therebetween, a charging and discharging controller for correcting the stored voltage in the voltage storing circuit so as to reduce to zero the difference at the leading edge of the pulse signal, a threshold voltage generator for generating a threshold voltage which is offset from the stored voltage by an amount corresponding to the desired dwell time of an ignition coil, and an energization controller for controlling the dwell time of the ignition coil in accordance with the result of a comparison between the threshold voltage and the triangular wave voltage.
摘要翻译：公开了一种用于内燃机的点火系统。点火系统包括响应于发动机的转速的定时信号检测器，以产生包括对应于点火正时的前沿和后沿并具有预定占空比的脉冲信号，用于产生三角波的三角波发生器电压与脉冲信号的后沿同步;电压存储电路，用于与脉冲信号的前沿同步地存储三角波电压的电压电平;分压器，用于将存储电压中的存储电压分压到产生参考电压，比较器，用于比较参考电压和三角波电压以检测它们之间的差;充放电控制器，用于校正电压存储电路中存储的电压，以便将前沿上的差减小到零脉冲信号的阈值电压发生器，用于产生阈值电压w 从存储电压偏移与点火线圈的期望停留时间相对应的量，以及用于根据阈值电压和三角波之间的比较的结果来控制点火线圈的停留时间的通电控制器电压。

4. 发明授权

US07084729B2 Ignition coil 有权
公开(公告)号：US07084729B2
公开(公告)日：2006-08-01
申请号：US11052291
申请日：2005-02-08
申请人： Masahiro Kondo , Kazutoyo Osuka , Shunichi Takeda
发明人： Masahiro Kondo , Kazutoyo Osuka , Shunichi Takeda
IPC分类号： H01F27/02
CPC分类号： F02P3/02 , F02D2400/18 , F02D2400/22 , H01F27/022 , H01F27/40 , H01F38/12 , H01F2038/125
摘要： An ignition coil has a connector electrically connected to an external circuit, an igniter for accommodating a switching element adapted to cause a current supplied from the connector to be intermittent, a primary coil portion for generating a predetermined voltage by the intermittent current, a secondary coil portion for stepping up the generated voltage and applying the resulting voltage to an ignition plug, and a resin insulating material which hardens in between the primary coil portion and the secondary coil portion to ensure insulation between the primary coil portion and the secondary coil portion. An outer shell of the igniter is formed of the resin insulating material.

5. 发明授权

US4307566A Bulky spun yarn and a method for manufacturing the same from a combination of thermally extensible and thermally shrinkable fibers 失效
标题翻译：大型短纤纱及其制造方法由热可伸缩纤维和热收缩纤维组合而成
公开(公告)号：US4307566A
公开(公告)日：1981-12-29
申请号：US114593
申请日：1980-01-23
申请人： Goro Murata , Osamu Wada , Shunichi Takeda
发明人： Goro Murata , Osamu Wada , Shunichi Takeda
IPC分类号： D02G1/18 , D02G3/36 , D02G3/24
CPC分类号： D02G1/18 , D02G3/36 , Y10T428/2922 , Y10T428/2924 , Y10T428/2967 , Y10T428/2969 , Y10T428/2976
摘要： A double layered yarn having a sheath and core structure is prepared through a roving process, drawing process or fine spinning process. The sheath portion of the yarn is composed of staple fibers which have a high thermal shrinkage in boiling water of at least 5%, and the blended fiber ratio of which is between 50% and 25%. The core portion of the yarn is composed of staple fibers which have a property being spontaneously extensible, and the blended fiber ratio of which is between 25% and 75%. The double layered yarn is subjected to a heat treatment in hot water, and a bulky spun yarn which comprises staple fibers A and B is obtained. The staple fibers A are concentrated toward the inside of the bulky spun yarn after they are shrunk. The ends of staple fibers B are held within the inside of the bulky spun yarn, and the intermediate portions of fibers B are bulged as a loop from the body portion of the bulky spun yarn, after the fibers B are spontaneously extended.
摘要翻译：通过粗纱加工，拉伸加工或精纺工艺制备具有鞘芯结构的双层纱线。纱线的鞘部由沸水中的热收缩率高至少5％，混纺纤维比率在50％〜25％之间的短纤维构成。纱线的芯部由具有自发伸长性的短纤维构成，其混纺纤维比例在25％〜75％之间。双层纱线在热水中进行热处理，得到包含短纤维A和B的蓬松的细纱。短纤维A在收缩后集中在大体积细纱的内部。短纤维B的端部保持在大体积细纱的内部，纤维B的中间部分在纤维B自发地延伸之后，作为环状从隆起的细纱的主体部分隆起。

6. 发明授权

US4209559A Linear crystalline terephthalate polyester yarn and textile goods made therefrom 失效
标题翻译：线性结晶对苯二甲酸酯聚酯纱线和由其制成的纺织品
公开(公告)号：US4209559A
公开(公告)日：1980-06-24
申请号：US23918
申请日：1979-03-26
申请人： Osamu Wada , Yoshiyuki Sasaki , Shiro Kumakawa , Akio Kimura , Toshimasa Shimizu , Hiroyuki Nagai , Shunichi Takeda , Takumi Shimazu
发明人： Osamu Wada , Yoshiyuki Sasaki , Shiro Kumakawa , Akio Kimura , Toshimasa Shimizu , Hiroyuki Nagai , Shunichi Takeda , Takumi Shimazu
IPC分类号： D01F6/62 , D03D15/00 , D02G3/02 , B32B3/00 , B32B7/02 , B32B27/36
CPC分类号： D03D15/0061 , D01F6/62 , D03D15/00 , D03D15/0077 , D10B2331/04 , Y10S428/903 , Y10T428/2395 , Y10T428/2904 , Y10T428/2913 , Y10T428/31786 , Y10T442/3146
摘要： Novel polyester filamentary yarn is provided having (a) a fineness of 0.9 denier per filament or less, (b) an amorphous orientation in the range of 30% to 70% and (c) a negative .epsilon..sub.0.2 where said .epsilon..sub.0.2 is a structural integrity parameter. The yarn possesses ameliorated properties regarding a heat-setting property, a raising property, a dimensional stability and a twist resistance. The yarn finds its wide range of usage, for example, silky fabrics with an excellent fullness, pliability and liveliness, raised fabrics with thermally stabilized fluffs protruding straight-forwardly and an extremely soft hand, and uniformly creped fabrics with an improved surface contour are obtained therefrom.
摘要翻译：提供新的聚酯长丝纱线，其具有（a）细丝为0.9旦尼尔/丝或更小，（b）30％至70％范围内的非晶取向和（c）负ε0.2，其中所述ε0.2为结构完整性参数。该纱具有改善的热定形性，提高性，尺寸稳定性和抗扭曲性。纱线的使用范围广泛，例如，具有良好的丰满度，柔韧性和活力的柔滑织物，获得具有热稳定的绒毛的挺起的织物，手感柔软，手感柔软，并且具有改善的表面轮廓的均匀起皱织物由此。

7. 发明授权

US06873238B2 Ignition coil 有权
标题翻译：点火线圈
公开(公告)号：US06873238B2
公开(公告)日：2005-03-29
申请号：US10440126
申请日：2003-05-19
申请人： Masahiro Kondo , Kazutoyo Osuka , Shunichi Takeda
发明人： Masahiro Kondo , Kazutoyo Osuka , Shunichi Takeda
IPC分类号： F02P3/02 , H01F27/02 , H01F27/40 , H01F38/12 , H01F5/00
CPC分类号： F02P3/02 , F02D2400/18 , F02D2400/22 , H01F27/022 , H01F27/40 , H01F38/12 , H01F2038/125
摘要： An ignition coil has a connector electrically connected to an external circuit, an igniter for accommodating a switching element adapted to cause a current supplied from the connector to be intermittent, a primary coil portion for generating a predetermined voltage by the intermittent current, a secondary coil portion for stepping up the generated voltage and applying the resulting voltage to an ignition plug, and a resin insulating material which hardens in between the primary coil portion and the secondary coil portion to ensure insulation between the primary coil portion and the secondary coil portion. An outer shell of the igniter is formed of the resin insulating material.
摘要翻译：点火线圈具有电连接到外部电路的连接器，用于容纳适于使从连接器供给的电流间歇的开关元件的点火器，用于通过间歇电流产生预定电压的初级线圈部分，次级线圈部分，用于升高产生的电压并将所得到的电压施加到火花塞;以及树脂绝缘材料，其在初级线圈部分和次级线圈部分之间硬化，以确保初级线圈部分和次级线圈部分之间的绝缘。点火器的外壳由树脂绝缘材料形成。

8. 发明申请

US20060174858A1 Ignition apparatus for internal combustion engine 有权
公开(公告)号：US20060174858A1
公开(公告)日：2006-08-10
申请号：US11347281
申请日：2006-02-06
申请人： Masami Kojima , Shunichi Takeda , Koukichi Yamada , Atushi Moriyama
发明人： Masami Kojima , Shunichi Takeda , Koukichi Yamada , Atushi Moriyama
IPC分类号： F02P11/00
CPC分类号： F02P3/0435 , H01F27/022 , H01F27/04 , H01F27/40 , H01F38/12
摘要： An ignition apparatus for an internal combustion engine, which is controlled by a control unit, includes a connector, an ignition coil assembly, an igniter and a capacitor. The connector is electrically connected with the control unit, and includes an input terminal, which is electrically connected with the control unit to receive an ignition signal outputted by the control unit. The connector also includes a ground terminal, which is connected with a ground. The igniter includes a switching device that switches a coil current supplied to the ignition coil assembly based on the ignition signal received from the control unit through the connector. The igniter also includes a Zener diode that serves as a protection element of the switching device. The capacitor is provided in parallel with the Zener diode between the input terminal and the ground terminal to form a parallel circuit.

9. 发明申请

US20050146410A1 IGNITION COIL 有权
标题翻译：点火线圈
公开(公告)号：US20050146410A1
公开(公告)日：2005-07-07
申请号：US11052291
申请日：2005-02-08
申请人： Masahiro Kondo , Kazutoyo Osuka , Shunichi Takeda
发明人： Masahiro Kondo , Kazutoyo Osuka , Shunichi Takeda
IPC分类号： F02P3/02 , H01F27/02 , H01F27/40 , H01F38/12
CPC分类号： F02P3/02 , F02D2400/18 , F02D2400/22 , H01F27/022 , H01F27/40 , H01F38/12 , H01F2038/125
摘要： An ignition coil has a connector electrically connected to an external circuit, an igniter for accommodating a switching element adapted to cause a current supplied from the connector to be intermittent, a primary coil portion for generating a predetermined voltage by the intermittent current, a secondary coil portion for stepping up the generated voltage and applying the resulting voltage to an ignition plug, and a resin insulating material which hardens in between the primary coil portion and the secondary coil portion to ensure insulation between the primary coil portion and the secondary coil portion. An outer shell of the igniter is formed of the resin insulating material.
摘要翻译：点火线圈具有电连接到外部电路的连接器，用于容纳适于使从连接器供给的电流间歇的开关元件的点火器，用于通过间歇电流产生预定电压的初级线圈部分，次级线圈部分，用于升高产生的电压并将所得到的电压施加到火花塞;以及树脂绝缘材料，其在初级线圈部分和次级线圈部分之间硬化，以确保初级线圈部分和次级线圈部分之间的绝缘。点火器的外壳由树脂绝缘材料形成。

10. 发明授权

US07107977B2 Ignition apparatus for internal combustion engine 有权
标题翻译：内燃机点火装置
公开(公告)号：US07107977B2
公开(公告)日：2006-09-19
申请号：US11347281
申请日：2006-02-06
申请人： Masami Kojima , Shunichi Takeda , Koukichi Yamada , Atushi Moriyama
发明人： Masami Kojima , Shunichi Takeda , Koukichi Yamada , Atushi Moriyama
IPC分类号： F02P3/055 , H01F38/12
CPC分类号： F02P3/0435 , H01F27/022 , H01F27/04 , H01F27/40 , H01F38/12
摘要： An ignition apparatus for an internal combustion engine, which is controlled by a control unit, includes a connector, an ignition coil assembly, an igniter and a capacitor. The connector is electrically connected with the control unit, and includes an input terminal, which is electrically connected with the control unit to receive an ignition signal outputted by the control unit. The connector also includes a ground terminal, which is connected with a ground. The igniter includes a switching device that switches a coil current supplied to the ignition coil assembly based on the ignition signal received from the control unit through the connector. The igniter also includes a Zener diode that serves as a protection element of the switching device. The capacitor is provided in parallel with the Zener diode between the input terminal and the ground terminal to form a parallel circuit.
摘要翻译：由控制单元控制的用于内燃机的点火装置包括连接器，点火线圈组件，点火器和电容器。连接器与控制单元电连接，并且包括输入端子，其与控制单元电连接以接收由控制单元输出的点火信号。该连接器还包括一个接地端子，与地面连接。点火器包括开关装置，其基于通过连接器从控制单元接收的点火信号来切换提供给点火线圈组件的线圈电流。点火器还包括用作开关装置的保护元件的齐纳二极管。电容器与输入端子和接地端子之间的齐纳二极管并联提供以形成并联电路。

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