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1. 发明申请

US20070021526A1 Setting time indicator for acrylic bone cement 审中-公开
标题翻译：丙烯酸骨水泥定型时间指示器
公开(公告)号：US20070021526A1
公开(公告)日：2007-01-25
申请号：US11187724
申请日：2005-07-22
申请人： Shulin He , Paul Higham
发明人： Shulin He , Paul Higham
IPC分类号： A61K6/08
CPC分类号： A61L24/001 , A61L24/04 , A61L2430/02 , C08L33/12
摘要： A bone cement has a liquid acrylic monomer component, a powdered acrylic polymer component and beta-carotene (Pro-vitamin A) mixed into one of the liquid or powdered components. The beta-carotene adds a yellowish color to the combined liquid and powdered component. The color disappears on setting of the bone cement.
摘要翻译：骨水泥具有液体丙烯酸单体组分，粉状丙烯酸聚合物组分和β-胡萝卜素（Pro-维生素A），其混合到液体或粉末组分之一中。 β-胡萝卜素对组合的液体和粉末组分添加淡黄色。骨水泥的颜色消失。

2. 发明授权

US08303657B2 Polyethylene cross-linked with an anthocyanin 有权
标题翻译：聚乙烯与花青素交联
公开(公告)号：US08303657B2
公开(公告)日：2012-11-06
申请号：US13115451
申请日：2011-05-25
申请人： Shulin He , Shi-Shen Yau , Aiguo Wang , Daniel E. Lawrynowicz
发明人： Shulin He , Shi-Shen Yau , Aiguo Wang , Daniel E. Lawrynowicz
IPC分类号： A61F2/02
CPC分类号： A61L2/14 , A61L2/08 , A61L2/20 , A61L27/16 , A61L27/505 , C08F10/02 , C08J3/28 , C08L53/00 , C08L2666/02 , C08L23/06
摘要： A method for manufacturing of ultrahigh molecular weight polyethylene (UHMWPE) for implants, where the implants have been machined out of UHMWPE blocks or extruded rods, has anthocyanin dispersely imbedded in the polyethylene. The implant is then exposed to γ ray or electron beam irradiation in an amount of at least 2.5 Mrad followed by a heat treatment to prevent the implant from becoming brittle in the long term as well as to improve strength and wear. The method includes mixing a powder or granulate resin of UHMWPE with an aqueous liquid that contains anthocyanin in a predetermined amount. The water is then evaporated in order to deposit the anthocyanin in a predetermined concentration on the polyethylene particles. The doped UHMWPE particles are compressed into blocks at temperatures in a range of approximately 135° C.-250° C. and pressures in a range of approximately 2-70 MPa. Medical implants are made from the blocks.
摘要翻译：用于植入物的超高分子量聚乙烯（UHMWPE）的制造方法，其中植入物已经由UHMWPE块或挤出棒加工而成，其中花青素分散嵌入聚乙烯中。然后将植入物暴露于至少2.5Mrad的γ射线或电子束照射，然后进行热处理，以防止植入物在长期内变脆，并提高强度和磨损。该方法包括将UHMWPE的粉末或颗粒状树脂与含有预定量的花青素的含水液体混合。然后蒸发水，以将预定浓度的花青素沉积在聚乙烯颗粒上。掺杂的UHMWPE颗粒在约135℃-250℃的温度和约2-70MPa范围内的压力下被压缩成块。医疗植入物由块体制成。

3. 发明申请

US20120187607A1 POLYETHYLENE CROSS-LINKED WITH AN ANTHOCYANIN 有权
标题翻译：聚苯乙烯与蒽醌连接
公开(公告)号：US20120187607A1
公开(公告)日：2012-07-26
申请号：US13399184
申请日：2012-02-17
申请人： Shulin He , Shi-Shen Yau , Aiguo Wang , Daniel E. Lawrynowicz
发明人： Shulin He , Shi-Shen Yau , Aiguo Wang , Daniel E. Lawrynowicz
IPC分类号： B29C35/08
CPC分类号： A61L2/14 , A61L2/08 , A61L2/20 , A61L27/16 , A61L27/505 , C08F10/02 , C08J3/28 , C08L53/00 , C08L2666/02 , C08L23/06
摘要： A method for manufacturing of ultrahigh molecular weight polyethylene (UHMWPE) for implants, where the implants have been machined out of UHMWPE blocks or extruded rods, has anthocyanin dispersely imbedded in the polyethylene. The implant is then exposed to γ ray or electron beam irradiation in an amount of at least 2.5 Mrad followed by a heat treatment to prevent the implant from becoming brittle in the long term as well as to improve strength and wear. The method includes mixing a powder or granulate resin of UHMWPE with an aqueous liquid that contains anthocyanin in a predetermined amount. The water is evaporated in order to deposit the anthocyanin in a predetermined concentration on the polyethylene particles. The doped UHMWPE particles are compressed into blocks at temperatures in a range of approximately 135° C.-250° C. and pressures in a range of approximately 2-70 MPa. Medical implants are made from the blocks.
摘要翻译：用于植入物的超高分子量聚乙烯（UHMWPE）的制造方法，其中植入物已经由UHMWPE块或挤出棒加工而成，其中花青素分散嵌入聚乙烯中。然后将植入物暴露于至少2.5Mrad的γ射线或电子束照射，然后进行热处理，以防止植入物在长期内变脆，并提高强度和磨损。该方法包括将UHMWPE的粉末或颗粒状树脂与含有预定量的花青素的含水液体混合。蒸发水以使以预定浓度的花青素沉积在聚乙烯颗粒上。掺杂的UHMWPE颗粒在约135℃-250℃的温度和约2-70MPa范围内的压力下被压缩成块。医疗植入物由块体制成。

4. 发明授权

US08133436B2 Polyethylene cross-linked with an anthocyanin 有权
公开(公告)号：US08133436B2
公开(公告)日：2012-03-13
申请号：US12221678
申请日：2008-08-05
申请人： Shulin He , Shi-Shen Yau , Aiguo Wang , Daniel E. Lawrynowicz
发明人： Shulin He , Shi-Shen Yau , Aiguo Wang , Daniel E. Lawrynowicz
IPC分类号： A61L2/08 , A61F2/02
CPC分类号： A61L2/14 , A61L2/08 , A61L2/20 , A61L27/16 , A61L27/505 , C08F10/02 , C08J3/28 , C08L53/00 , C08L2666/02 , C08L23/06
摘要： A method for manufacturing of ultrahigh molecular weight polyethylene (UHMWPE) for implants, where the implants have been machined out of UHMWPE blocks or extruded rods, has anthocyanin dispersely imbedded in the polyethylene. The implant is then exposed to γ ray or electron beam irradiation in an amount of at least 2.5 Mrad followed by a heat treatment to prevent the implant from becoming brittle in the long term as well as to improve strength and wear. The method includes mixing a powder or granulate resin of UHMWPE with an aqueous liquid that contains anthocyanin in a predetermined amount. The water is then evaporated in order to deposit the anthocyanin in a predetermined concentration on the polyethylene particles. The doped UHMWPE particles are compressed into blocks at temperatures in a range of approximately 135° C.-250° C. and pressures in a range of approximately 2-70 MPa. Medical implants are made from the blocks.

5. 发明申请

US20110276143A1 SURFACE CROSSLINKED POLYETHYLENE 有权
标题翻译：表面交联聚乙烯
公开(公告)号：US20110276143A1
公开(公告)日：2011-11-10
申请号：US12775789
申请日：2010-05-07
申请人： Shulin He , Zongtao Zhang , Keenan Michael Hanson , Shi-Shen Yau , Daniel E. Lawrynowicz , Aiguo Wang
发明人： Shulin He , Zongtao Zhang , Keenan Michael Hanson , Shi-Shen Yau , Daniel E. Lawrynowicz , Aiguo Wang
IPC分类号： A61F2/30 , B05D7/00 , B05D3/06
CPC分类号： C08J3/245 , A61L27/16 , A61L27/50 , A61L2400/18 , A61L2430/02 , C08J7/123 , C08J2323/06 , C08K5/1545 , C08L23/06
摘要： A method for producing a wear resistant polyethylene medical implant includes forming a medical implant, such as an orthopedic implant, made at least partially of ultra high molecular weight polyethylene (UHMWPE). The polyethylene may be irradiated with gamma ray or e-beam radiation to form free radicals and then crosslinked to eliminate free radicals prior to exposure to oxygen. The so treated bearing surface of the crosslinked polyethylene is then coated with a photoinitiator. Thereafter the bearing material is photocrosslinked with ultra-violet (UV) radiation. The photocrosslinking process can also be applied to non-crosslink UHMWPE.
摘要翻译：用于制造耐磨聚乙烯医疗植入物的方法包括形成至少部分由超高分子量聚乙烯（UHMWPE）制成的医疗植入物，例如矫形植入物。可以用γ射线或电子束辐射照射聚乙烯以形成自由基，然后在暴露于氧气之前进行交联以消除自由基。然后用光引发剂涂覆如此处理的交联聚乙烯的承载表面。此后，轴承材料与紫外（UV）辐射光交联。光交联工艺也可应用于非交联UHMWPE。

6. 发明申请

US20110224325A1 POLYETHYLENE CROSS-LINKED WITH AN ANTHOCYANIN 有权
标题翻译：聚苯乙烯与蒽醌连接
公开(公告)号：US20110224325A1
公开(公告)日：2011-09-15
申请号：US13115451
申请日：2011-05-25
申请人： Shulin He , Shi-Shen Yau , Aiguo Wang , Daniel E. Lawrynowicz
发明人： Shulin He , Shi-Shen Yau , Aiguo Wang , Daniel E. Lawrynowicz
IPC分类号： A61L27/16
CPC分类号： A61L2/14 , A61L2/08 , A61L2/20 , A61L27/16 , A61L27/505 , C08F10/02 , C08J3/28 , C08L53/00 , C08L2666/02 , C08L23/06
摘要： A method for manufacturing of ultrahigh molecular weight polyethylene (UHMWPE) for implants, where the implants have been machined out of UHMWPE blocks or extruded rods, has anthocyanin dispersely imbedded in the polyethylene. The implant is then exposed to γ ray or electron beam irradiation in an amount of at least 2.5 Mrad followed by a heat treatment to prevent the implant from becoming brittle in the long term as well as to improve strength and wear. The method includes mixing a powder or granulate resin of UHMWPE with an aqueous liquid that contains anthocyanin in a predetermined amount. The water is then evaporated in order to deposit the anthocyanin in a predetermined concentration on the polyethylene particles. The doped UHMWPE particles are compressed into blocks at temperatures in a range of approximately 135° C.-250° C. and pressures in a range of approximately 2-70 MPa. Medical implants are made from the blocks.
摘要翻译：用于植入物的超高分子量聚乙烯（UHMWPE）的制造方法，其中植入物已经由UHMWPE块或挤出棒加工而成，其中花青素分散嵌入聚乙烯中。然后将植入物暴露于至少2.5Mrad的γ射线或电子束照射，然后进行热处理，以防止植入物在长期内变脆，并提高强度和磨损。该方法包括将UHMWPE的粉末或颗粒状树脂与含有预定量的花青素的含水液体混合。然后蒸发水，以将预定浓度的花青素沉积在聚乙烯颗粒上。掺杂的UHMWPE颗粒在约135℃-250℃的温度和约2-70MPa范围内的压力下被压缩成块。医疗植入物由块体制成。

7. 发明授权

US06759485B2 Biodegradable poly (propylene fumarate) networks cross linked with poly (propylene fumarate) -diacrylate macromers 有权
标题翻译：与聚（丙烯酸富马酸酯） - 二丙烯酸酯大分子单体交联的可生物降解的聚（丙烯富马酸）网络
公开(公告)号：US06759485B2
公开(公告)日：2004-07-06
申请号：US10127117
申请日：2002-04-22
申请人： Shulin He , Michael J. Yaszemski , Antonios G. Mikos
发明人： Shulin He , Michael J. Yaszemski , Antonios G. Mikos
IPC分类号： C08L6706
CPC分类号： C08L67/06 , A61L27/18 , A61L27/50 , A61L27/58 , C08G63/676 , C08G63/918 , C08G81/025 , C08L67/07 , Y10S530/812 , Y10S530/815 , C08L67/00 , C08L71/02
摘要： A network consisting essentially of poly(propylene fumarate) cross linked with diacrylate and a method for making same.
摘要翻译：基本上由二丙烯酸交联的聚（丙烯酸富马酸酯）组成的网络及其制备方法。

8. 发明授权

US08415406B2 Setting time indicator for acrylic bone cement 有权
标题翻译：丙烯酸骨水泥定型时间指示器
公开(公告)号：US08415406B2
公开(公告)日：2013-04-09
申请号：US11653654
申请日：2007-01-16
申请人： Shulin He , Matthew P. Poggie
发明人： Shulin He , Matthew P. Poggie
IPC分类号： A61K6/083 , A61F2/28 , C08F2/50
CPC分类号： A61L24/001 , A61L24/04 , A61L2430/02 , C08L33/12 , A61K6/083
摘要： A bone cement has a liquid acrylic monomer component, a powdered acrylic polymer component and yellowish beta-carotene (Pro-vitamin A) mixed into one of the liquid or powdered component and FDC blue No. 2 Lake powder mixed into the powdered component. The beta-carotene and FDC blue adds a greenish (yellow plus blue) color to the combined liquid and powdered component. The yellowish color disappears on setting of the bone cement leaving the cement blue.
摘要翻译：骨水泥具有液体丙烯酸单体组分，粉末丙烯酸聚合物组分和混合成粉末状组分之一的液体或粉末组分之一的淡黄色β-胡萝卜素（Pro-维生素A）和FDC蓝色2号Lake粉末。 β-胡萝卜素和FDC蓝色对组合的液体和粉末组分增加了绿色（黄色和蓝色）的颜色。在水泥蓝色的骨水泥凝固时，黄色消失。

9. 发明授权

US08241564B1 Polyethylene cross-linked with an anthocyanin 有权
标题翻译：聚乙烯与花青素交联
公开(公告)号：US08241564B1
公开(公告)日：2012-08-14
申请号：US13399184
申请日：2012-02-17
申请人： Shulin He , Shi-Shen Yau , Aiguo Wang , Daniel E. Lawrynowicz
发明人： Shulin He , Shi-Shen Yau , Aiguo Wang , Daniel E. Lawrynowicz
IPC分类号： A61L2/00 , A61F2/02
CPC分类号： A61L2/14 , A61L2/08 , A61L2/20 , A61L27/16 , A61L27/505 , C08F10/02 , C08J3/28 , C08L53/00 , C08L2666/02 , C08L23/06
摘要： A method for manufacturing of ultrahigh molecular weight polyethylene (UHMWPE) for implants, where the implants have been machined out of UHMWPE blocks or extruded rods, has anthocyanin dispersely imbedded in the polyethylene. The implant is then exposed to γ ray or electron beam irradiation in an amount of at least 2.5 Mrad followed by a heat treatment to prevent the implant from becoming brittle in the long term as well as to improve strength and wear. The method includes mixing a powder or granulate resin of UHMWPE with an aqueous liquid that contains anthocyanin in a predetermined amount. The water is evaporated in order to deposit the anthocyanin in a predetermined concentration on the polyethylene particles. The doped UHMWPE particles are compressed into blocks at temperatures in a range of approximately 135° C.-250° C. and pressures in a range of approximately 2-70 MPa. Medical implants are made from the blocks.
摘要翻译：用于植入物的超高分子量聚乙烯（UHMWPE）的制造方法，其中植入物已经由UHMWPE块或挤出棒加工而成，其中花青素分散嵌入聚乙烯中。然后将植入物暴露于至少2.5Mrad的γ射线或电子束照射，然后进行热处理，以防止植入物在长期内变脆，并提高强度和磨损。该方法包括将UHMWPE的粉末或颗粒状树脂与含有预定量的花青素的含水液体混合。蒸发水以使以预定浓度的花青素沉积在聚乙烯颗粒上。掺杂的UHMWPE颗粒在约135℃-250℃的温度和约2-70MPa范围内的压力下被压缩成块。医疗植入物由块体制成。

10. 发明申请

US20100036491A1 Polyethylene cross-linked with an anthocyanin 有权
标题翻译：聚乙烯与花青素交联
公开(公告)号：US20100036491A1
公开(公告)日：2010-02-11
申请号：US12221678
申请日：2008-08-05
申请人： Shulin He , Shi-Shen Yau , Aiguo Wang
发明人： Shulin He , Shi-Shen Yau , Aiguo Wang
IPC分类号： A61F2/02 , C08F269/00 , A61L2/08 , A61L2/00 , A61L2/16 , A61L2/14
CPC分类号： A61L2/14 , A61L2/08 , A61L2/20 , A61L27/16 , A61L27/505 , C08F10/02 , C08J3/28 , C08L53/00 , C08L2666/02 , C08L23/06
摘要： A method for manufacturing of ultrahigh molecular weight polyethylene (UHMWPE) for implants, where the implants have been machined out of UHMWPE blocks or extruded rods, has anthocyanin dispersely imbedded in the polyethylene. The implant is then exposed to γ ray or electron beam irradiation in an amount of at least 2.5 Mrad followed by a heat treatment to prevent the implant from becoming brittle in the long term as well as to improve strength and wear. The method includes mixing a powder or granulate resin of UHMWPE with an aqueous liquid that contains anthocyanin in a predetermined amount. The water is then evaporated in order to deposit the anthocyanin in a predetermined concentration on the polyethylene particles. The doped UHMWPE particles are compressed into blocks at temperatures in a range of approximately 135° C.-250° C. and pressures in a range of approximately 2-70 MPa. Medical implants are made from the blocks.
摘要翻译：用于植入物的超高分子量聚乙烯（UHMWPE）的制造方法，其中植入物已经由UHMWPE块或挤出棒加工而成，其中花青素分散嵌入聚乙烯中。然后将植入物以至少2.5Mrad的量暴露于γ射线或电子束照射，然后进行热处理，以防止植入物在长期内变脆，并且改善强度和磨损。该方法包括将UHMWPE的粉末或颗粒状树脂与含有预定量的花青素的含水液体混合。然后蒸发水，以将预定浓度的花青素沉积在聚乙烯颗粒上。掺杂的UHMWPE颗粒在约135℃-250℃的温度和约2-70MPa范围内的压力下被压缩成块。医疗植入物由块体制成。

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