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1. 发明申请

US20060111299A1 Compositions and methods for treating atherosclerosis 失效
标题翻译：治疗动脉粥样硬化的组合物和方法
公开(公告)号：US20060111299A1
公开(公告)日：2006-05-25
申请号：US11268690
申请日：2005-11-07
申请人： Robert Kisilevsky , Shui-Pang Tam , John Ancsin , Zongchao Jia
发明人： Robert Kisilevsky , Shui-Pang Tam , John Ancsin , Zongchao Jia
IPC分类号： A61K38/10 , C07K7/08
CPC分类号： C07K14/4711 , A61K38/00 , C07K7/08 , C07K14/775
摘要： Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity and/or inhibit acyl CoA:cholesterol acyl transferase activity. Methods of using these compositions in the treatment and/or prevention of atherosclerosis as well as coronary heart disease and cardiovascular disease are also provided.
摘要翻译：提供哺乳动物血清淀粉样蛋白A同种型2.1（SAA2.1）的选定结构域的肽和模拟物及其化合物及其组合物，其增强对巨噬细胞胆固醇酯水解酶活性的影响和/或抑制酰基CoA：胆固醇酰基转移酶活性。还提供了使用这些组合物治疗和/或预防动脉粥样硬化以及冠心病和心血管疾病的方法。

2. 发明申请

US20110268768A1 Compositions and Methods for Treating Atherosclerosis 审中-公开
标题翻译：治疗动脉粥样硬化的组合物和方法
公开(公告)号：US20110268768A1
公开(公告)日：2011-11-03
申请号：US12950389
申请日：2010-11-19
申请人： Robert Kisilevsky , Shui-Pang Tam , John B. Ancsin , Zongchao Jia
发明人： Robert Kisilevsky , Shui-Pang Tam , John B. Ancsin , Zongchao Jia
IPC分类号： A61K38/10 , C07K14/00 , A61P9/10 , A61P9/00 , A61P3/06 , C07K7/00 , A61K9/00
CPC分类号： C07K7/08 , A61K38/00 , C07K14/775
摘要： Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity and/or inhibit acyl CoA:cholesterol acyl transferase activity. Methods of using these compositions in the treatment and/or prevention of atherosclerosis as well as coronary heart disease and cardiovascular disease are also provided.
摘要翻译：提供哺乳动物血清淀粉样蛋白A同种型2.1（SAA2.1）的选定结构域的肽和模拟物及其化合物及其组合物，其增强对巨噬细胞胆固醇酯水解酶活性的影响和/或抑制酰基CoA：胆固醇酰基转移酶活性。还提供了使用这些组合物治疗和/或预防动脉粥样硬化以及冠心病和心血管疾病的方法。

3. 发明申请

US20100279926A1 Compositions and Methods for Treating Atherosclerosis 失效
标题翻译：治疗动脉粥样硬化的组合物和方法
公开(公告)号：US20100279926A1
公开(公告)日：2010-11-04
申请号：US12701709
申请日：2010-02-08
申请人： Robert Kisilevsky , Shui-Pang Tam , John B. Ancsin , Zongchao Jia
发明人： Robert Kisilevsky , Shui-Pang Tam , John B. Ancsin , Zongchao Jia
IPC分类号： A61K38/00 , A61P9/10 , A61P9/00
CPC分类号： C07K14/4711 , A61K38/00 , C07K7/08 , C07K14/775
摘要： Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity and/or inhibit acyl CoA:cholesterol acyl transferase activity. Methods of using these compositions in the treatment and/or prevention of atherosclerosis as well as coronary heart disease and cardiovascular disease are also provided.
摘要翻译：提供哺乳动物血清淀粉样蛋白A同种型2.1（SAA2.1）的选定结构域的肽和模拟物及其化合物及其组合物，其增强对巨噬细胞胆固醇酯水解酶活性的影响和/或抑制酰基CoA：胆固醇酰基转移酶活性。还提供了使用这些组合物治疗和/或预防动脉粥样硬化以及冠心病和心血管疾病的方法。

4. 发明申请

US20080221028A1 Compositions and Methods for Treating Atherosclerosis 审中-公开
标题翻译：治疗动脉粥样硬化的组合物和方法
公开(公告)号：US20080221028A1
公开(公告)日：2008-09-11
申请号：US11872309
申请日：2007-10-15
申请人： Robert Kisilevsky , Shui-Pang Tam , John B. Ancsin , Zongchao Jia
发明人： Robert Kisilevsky , Shui-Pang Tam , John B. Ancsin , Zongchao Jia
IPC分类号： A61K38/16 , A61K38/10 , A61K38/02 , A61P9/10
CPC分类号： C07K7/08 , A61K38/00 , C07K14/775
摘要： Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity and/or inhibit acyl CoA:cholesterol acyl transferase activity. Methods of using these compositions in the treatment and/or prevention of atherosclerosis as well as coronary heart disease and cardiovascular disease are also provided.
摘要翻译：提供哺乳动物血清淀粉样蛋白A同种型2.1（SAA2.1）的选定结构域的肽和模拟物及其化合物及其组合物，其增强对巨噬细胞胆固醇酯水解酶活性的影响和/或抑制酰基CoA：胆固醇酰基转移酶活性。还提供了使用这些组合物治疗和/或预防动脉粥样硬化以及冠心病和心血管疾病的方法。

5. 发明授权

US07291590B2 Compositions and methods for treating atherosclerosis 有权
标题翻译：治疗动脉粥样硬化的组合物和方法
公开(公告)号：US07291590B2
公开(公告)日：2007-11-06
申请号：US10866330
申请日：2004-06-10
申请人： Robert Kisilevsky , Shui-Pang Tam , John B. Ancsin , Zongchao Jia
发明人： Robert Kisilevsky , Shui-Pang Tam , John B. Ancsin , Zongchao Jia
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： C07K7/08 , A61K38/00 , C07K14/775
摘要： Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity and/or inhibit acyl CoA:cholesterol acyl transferase activity. Methods of using these compositions in the treatment and/or prevention of atherosclerosis as well as coronary heart disease and cardiovascular disease are also provided.
摘要翻译：提供哺乳动物血清淀粉样蛋白A同种型2.1（SAA2.1）的选定结构域的肽和模拟物及其化合物及其组合物，其增强对巨噬细胞胆固醇酯水解酶活性的影响和/或抑制酰基CoA：胆固醇酰基转移酶活性。还提供了使用这些组合物治疗和/或预防动脉粥样硬化以及冠心病和心血管疾病的方法。

6. 发明授权

US6120994A Antioxidant responsive element 失效
标题翻译：抗氧化反应元件
公开(公告)号：US6120994A
公开(公告)日：2000-09-19
申请号：US862431
申请日：1997-05-23
申请人： Shui-Pang Tam
发明人： Shui-Pang Tam
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6897
摘要： The present invention relates, in general, to antioxidant responsive elements (AREs). In particular, the present invention relates to a DNA construct comprising an ARE having the DNA sequence 5'-RGR AC NNN GCT-3' (SEQ ID NO: 1) operably linked to a heterologous protein coding sequence; cells and non-human organisms comprising the DNA construct; a method of screening for a compound that increases transcription of an MRNA regulated by an antioxidant responsive element; and a purified compound that binds to an antioxidant responsive element.
摘要翻译：本发明一般涉及抗氧化反应元件（ARE）。特别地，本发明涉及包含与异源蛋白质编码序列可操作地连接的具有DNA序列5'-RGRACNNN GCT-3'（SEQ ID NO：1）的ARE的DNA构建体。包含DNA构建体的细胞和非人生物; 筛选增加由抗氧化剂反应元件调节的MRNA的转录的化合物的方法; 和与抗氧化反应元件结合的纯化化合物。

7. 发明授权

US5994061A DNA constructs and methods for screening for increased expression of human apo AI gene 失效
标题翻译：用于筛选人apo AI基因表达增加的DNA构建体和方法
公开(公告)号：US5994061A
公开(公告)日：1999-11-30
申请号：US536559
申请日：1995-09-29
申请人： Shui-Pang Tam , Xia Zhang
发明人： Shui-Pang Tam , Xia Zhang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6897
摘要： Methods for screening for a drug that increases expression of the human apolioprotein (apo) AI gene and related DNA constructs. A first method has the steps of: (a) introducing into mammalian cells a DNA construct including, functionally joined together in the 5'.fwdarw.3' direction of transcription, (i) at least one copy of a drug-responsive element (DRE) having at least about 80% homology with the DNA sequence 5'-G/C N T/G A/G GCTGGG-3', (ii) a heterologous promoter, (iii) a reporter gene and (iv) an untranslated region including a functional polyadenylation signal; (b) growing a first culture of the cells in the absence of drug; (c) lysing the first culture to produce a first extract; (d) assaying the first extract for activity of a protein encoded by the reporter gene; (e) growing a second culture of the cells in the presence of the drug; (f) lysing the second culture to produce a second extract; (g) assaying the second extract for activity of the protein encoded by the reporter gene; and (h) comparing the activities of the first extract and the second extract. A second method uses a different DNA construct including (i) a promoter region of the human apo AI gene including at least one copy of a drug-responsive element (DRE) having at least about 80% homology with the DNA sequence 5'-G/C N T/G A/G GCTGGG-3', (ii) a reporter gene and (iii) an untranslated region including a functional polyadenylation signal. A third method involves stably maintaining the introduced DNA in the cells.
摘要翻译：筛选增加人apolioprotein（apo）AI基因和相关DNA构建体表达的药物的方法。第一种方法具有以下步骤：（a）向哺乳动物细胞中引入包括在转录的5''3'方向上功能连接在一起的DNA构建体，（i）至少一个药物反应元件（DRE ）具有与DNA序列5'-G / CNT / GA / G GCTGGG-3'至少约80％的同源性，（ii）异源启动子，（iii）报告基因和（iv）非翻译区，多聚腺苷酸化信号; （b）在没有药物的情况下培养细胞的第一培养物; （c）裂解第一培养物以产生第一提取物; （d）测定第一提取物对报道基因编码的蛋白质的活性; （e）在药物存在下培养细胞的第二培养物; （f）裂解第二培养物以产生第二提取物; （g）测定第二提取物对报道基因编码的蛋白质的活性; 和（h）比较第一提取物和第二提取物的活性。第二种方法使用不同的DNA构建体，其包括（i）人apo AI基因的启动子区域，包括与DNA序列5'-G具有至少约80％同源性的药物应答元件（DRE）的至少一个拷贝 / CNT / GA / G GCTGGG-3'，（ii）报告基因和（iii）包含功能多聚腺苷酸化信号的非翻译区。第三种方法包括稳定地将引入的DNA保持在细胞中。

8. 发明授权

US07700544B2 Compositions and methods for treating atherosclerosis 失效
标题翻译：治疗动脉粥样硬化的组合物和方法
公开(公告)号：US07700544B2
公开(公告)日：2010-04-20
申请号：US11268690
申请日：2005-11-07
申请人： Robert Kisilevsky , Shui-Pang Tam , John B. Ancsin , Zongchao Jia
发明人： Robert Kisilevsky , Shui-Pang Tam , John B. Ancsin , Zongchao Jia
IPC分类号： A61K38/10 , C07K7/08
CPC分类号： C07K14/4711 , A61K38/00 , C07K7/08 , C07K14/775
摘要： Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity and/or inhibit acyl CoA:cholesterol acyl transferase activity. Methods of using these compositions in the treatment and/or prevention of atherosclerosis as well as coronary heart disease and cardiovascular disease are also provided.
摘要翻译：提供哺乳动物血清淀粉样蛋白A同种型2.1（SAA2.1）的选定结构域的肽和模拟物及其化合物及其组合物，其增强对巨噬细胞胆固醇酯水解酶活性的影响和/或抑制酰基CoA：胆固醇酰基转移酶活性。还提供了使用这些组合物治疗和/或预防动脉粥样硬化以及冠心病和心血管疾病的方法。

9. 发明申请

US20090016956A1 Labeled Macrophages and Methods of Use Thereof 审中-公开
标题翻译：标记的巨噬细胞及其使用方法
公开(公告)号：US20090016956A1
公开(公告)日：2009-01-15
申请号：US12110865
申请日：2008-04-28
申请人： Robert Bender , Allan M. Green , Perry Kim , Robert Kisilevsky , Douglas S. McNair , Shui-pang Tam
发明人： Robert Bender , Allan M. Green , Perry Kim , Robert Kisilevsky , Douglas S. McNair , Shui-pang Tam
IPC分类号： A61K51/02 , C12N5/00 , A61K49/00 , C12Q1/02 , A61K35/12
CPC分类号： G01N33/5055 , G01N33/92 , G01N2500/00
摘要： Methods of making and using labeled macrophages are described.
摘要翻译：描述了制备和使用标记的巨噬细胞的方法。

10. 发明授权

US08703698B2 Compositions and methods for treating atherosclerosis 失效
标题翻译：治疗动脉粥样硬化的组合物和方法
公开(公告)号：US08703698B2
公开(公告)日：2014-04-22
申请号：US12701709
申请日：2010-02-08
申请人： Robert Kisilevsky , Shui-Pang Tam , John B. Ancsin , Zongchao Jia
发明人： Robert Kisilevsky , Shui-Pang Tam , John B. Ancsin , Zongchao Jia
IPC分类号： A61K38/00 , A61K38/16 , A61K38/10
CPC分类号： C07K14/4711 , A61K38/00 , C07K7/08 , C07K14/775
摘要： Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity and/or inhibit acyl CoA:cholesterol acyl transferase activity. Methods of using these compositions in the treatment and/or prevention of atherosclerosis as well as coronary heart disease and cardiovascular disease are also provided.
摘要翻译：提供哺乳动物血清淀粉样蛋白A同种型2.1（SAA2.1）的选定结构域的肽和模拟物及其化合物及其组合物，其增强对巨噬细胞胆固醇酯水解酶活性的影响和/或抑制酰基CoA：胆固醇酰基转移酶活性。还提供了使用这些组合物治疗和/或预防动脉粥样硬化以及冠心病和心血管疾病的方法。

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