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1. 发明申请

US20060024230A1 Customized therapeutics and in situ diagnostics 审中-公开
标题翻译：定制治疗和原位诊断
公开(公告)号：US20060024230A1
公开(公告)日：2006-02-02
申请号：US10668044
申请日：2003-09-22
申请人： Cynthia Bamdad , Shoshana Bamdad Shendelman
发明人： Cynthia Bamdad , Shoshana Bamdad Shendelman
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： G01N33/585 , A61K47/6923 , B82Y5/00 , B82Y15/00 , B82Y30/00 , G01N33/5438 , G01N2610/00
摘要： Customized therapeutics and in situ diagnostics for patient therapy and diagnosis takes advantage of tools including techniques for derivatizing colloids with self-assembled monolayers. This provides the capability of a wide variety of assays including chemical or biochemical agent/agent interaction studies. Bio-derivatized colloids, with or without signaling entities, are used to probe interactions with species on non-colloidal structures. The invention provides techniques for immobilizing colloidal particles on a wide variety of non-colloidal structures. Included is the ability to decorate a variety of non-colloidal structures including beads, with colloids as a detectable assay. This allows, in many cases, assays detectable via the unaided human eye, as well as assays detectable via automated determination of a change of interaction of electromagnetic radiation with the colloids, e.g., absorption, light-scattering, and the like.
摘要翻译：用于患者治疗和诊断的定制治疗和原位诊断利用工具，包括用自组装单层衍生胶体的技术。这提供了各种测定的能力，包括化学或生物化学试剂/药物相互作用研究。具有或不具有信号传导实体的生物衍生胶体用于探测与非胶体结构物质的相互作用。本发明提供了将胶体颗粒固定在各种非胶体结构上的技术。包括装饰各种非胶体结构（包括珠粒）的能力，胶体作为可检测的测定法。这在许多情况下允许通过无辅助人眼可检测的测定，以及通过自动测定电磁辐射与胶体的相互作用变化（例如吸收，光散射等）可检测的测定。

2. 发明申请

US20050064446A1 Detection of binding species with colloidal and non-colloidal structures 审中-公开
标题翻译：用胶体和非胶体结构检测结合物种
公开(公告)号：US20050064446A1
公开(公告)日：2005-03-24
申请号：US10763810
申请日：2004-01-23
申请人： Cynthia Bamdad , Shoshana Bamdad Shendelman
发明人： Cynthia Bamdad , Shoshana Bamdad Shendelman
IPC分类号： G01N33/543 , C12Q1/68 , G01N33/53
CPC分类号： B82Y30/00 , B82Y15/00 , G01N33/54313
摘要： The invention provides novel techniques for determining the interaction between binding partners. The first binding partner is immobilized to a surface or a colloid and a second binding partner immobilized to a surface or a colloid. Non-specific binding techniques, including a SAM, provide for the immobilization of a wide variety of species. A mixture may be separated into various components and these components may then be fastened to either the colloids or the surfaces. Binding interaction between the binding partners may be determined through a variety of assays.
摘要翻译：本发明提供用于确定结合配偶体之间相互作用的新技术。第一结合配偶体固定在固定在表面或胶体上的表面或胶体和第二结合配偶体上。包括SAM在内的非特异性结合技术提供了多种物种的固定。混合物可以分成各种组分，然后这些组分可以被固定到胶体或表面。结合配偶体之间的结合相互作用可以通过多种测定来确定。

3. 发明申请

US20110250616A1 ELECTROACTIVE SURFACE-CONFINABLE MOLECULES 审中-公开
标题翻译：电动表面可分配的分子
公开(公告)号：US20110250616A1
公开(公告)日：2011-10-13
申请号：US13164712
申请日：2011-06-20
申请人： Cynthia C. BAMDAD , Shoshana Bamdad Shendelman , Michael Frid
发明人： Cynthia C. BAMDAD , Shoshana Bamdad Shendelman , Michael Frid
IPC分类号： G01N33/543 , C07F17/02
CPC分类号： B82Y15/00 , B82Y30/00 , C07F17/02 , G01N33/582 , G01N2800/52
摘要： The invention provides compositions, kits, methods, and species that include electroactive entities which can serve as signaling entities in chemical and/or biochemical assays. The electroactive species can be metallocenes, such as ferrocenes, including substituents that affect the oxidation/reduction potential (redox potential) of the species. By controlling the redox potential of the species, multiple species can be used in a single assay, each species having a different redox potential, for simultaneous signaling of different binding events. Additionally, species having redox potentials lower than 490 mV can be provided, allowing signaling within a potential range easily detectable in the presence of biological fluids.
摘要翻译：本发明提供组合物，试剂盒，方法和物种，其包括可用作化学和/或生物化学测定中的信号实体的电活性实体。电活性物质可以是茂金属，例如二茂铁，包括影响物质的氧化/还原电位（氧化还原电位）的取代基。通过控制物种的氧化还原电位，可以在单个测定中使用多种物质，每种物质具有不同的氧化还原电位，用于同时发信号通知不同的结合事件。另外，可以提供具有低于490mV的氧化还原电位的物质，使得在生物流体存在下容易检测到的潜在范围内的信号传导。

4. 发明申请

US20050202402A1 Tandem signaling assay 审中-公开
标题翻译：串联信号测定
公开(公告)号：US20050202402A1
公开(公告)日：2005-09-15
申请号：US10927780
申请日：2004-08-27
申请人： Cynthia Bamdad , Shoshana Bamdad Shendelman
发明人： Cynthia Bamdad , Shoshana Bamdad Shendelman
IPC分类号： G01N33/543 , G01N33/569 , G01N33/58 , G01N33/78 , C12Q1/00
CPC分类号： B82Y30/00 , B82Y15/00 , G01N33/54326 , G01N33/5438 , G01N33/56966 , G01N33/585 , G01N33/78 , G01N2458/30 , G01N2500/00
摘要： Chemical, biological, and/or biochemical assays of the invention utilize intermediate binding entities for binding interactions. For example, a colloid particle carrying a species that could harm a component in the assay is allowed to binding interact in the assay only after other, more sensitive components have finished their binding interactions. In another example, multi-step binding interactions are used where single-step interactions could be used, so as to reduce false positives.
摘要翻译：本发明的化学，生物和/或生物化学测定利用中间结合实体来结合相互作用。例如，只有在其他更敏感的组分完成了其结合相互作用之后，才允许携带可能损害测定中组分的物质的胶体颗粒在测定中结合相互作用。在另一个实例中，使用多步结合相互作用，其中可以使用单步相互作用，以便减少假阳性。

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