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1. 发明申请

US20090186400A1 Method of Producing S-Adenosyl-L-Methionine-Containing Dry Yeast Having Excellent Storage Stability, the Product Thereof and Composition for Oral Intake 有权
标题翻译：具有优异储存稳定性的S-腺苷-L-含甲硫氨酸的干酵母的生产方法及其产品及口服成分
公开(公告)号：US20090186400A1
公开(公告)日：2009-07-23
申请号：US12300826
申请日：2007-05-15
申请人： Kentarou Takano , Shinyo Gayama
发明人： Kentarou Takano , Shinyo Gayama
IPC分类号： C12N1/02 , C12N1/16
CPC分类号： C12N1/18 , A61K9/1617 , A61K9/19 , C07H19/167 , C12N1/04 , C12P19/40
摘要： A method for producing a dry yeast containing S-adenosyl-L-methionine using a yeast having production capability of S-adenosyl-L-methionine, in which an ascorbic acid compound or a salt thereof is added to a yeast concentrate separated from a fungus culture liquid of the yeast, and the concentrate is then dried, a dry yeast containing SAMe obtained by the production method, and a composition for oral ingestion formed by molding the dry yeast. A method capable of producing a dry yeast containing SAMe in a high concentration excellent in storage stability conveniently at low cost is established, and a dry yeast containing SAMe obtained by the production method and a composition for oral ingestion formed by molding the dry yeast are provided.
摘要翻译：使用具有S-腺苷-L-甲硫氨酸的生产能力的酵母生产含有S-腺苷-L-甲硫氨酸的干酵母的方法，其中将抗坏血酸化合物或其盐加入从真菌分离的酵母浓缩物中培养液，然后干燥浓缩物，通过制备方法得到的含有SAMe的干酵母和通过模制干酵母形成的用于口服摄取的组合物。建立了能够以低成本方便地生产具有优异的储存稳定性高的SAMe的干酵母的方法，并且提供了通过制备方法获得的含有SAMe的干酵母和通过模制干酵母形成的口服摄取组合物。

2. 发明授权

US09404076B2 S-adenosyl-L-methionine-containing dry yeast composition with excellent storage stability and process for producing same 有权
标题翻译：具有优异贮藏稳定性的S-腺苷-L-甲硫氨酸干酵母组合物及其制造方法
公开(公告)号：US09404076B2
公开(公告)日：2016-08-02
申请号：US13639700
申请日：2011-04-05
申请人： Kentarou Takano , Shinyo Gayama
发明人： Kentarou Takano , Shinyo Gayama
IPC分类号： A23L1/28 , A61K36/06 , C12N1/16 , C12P19/40 , C12N1/04
CPC分类号： C12N1/16 , C12N1/04 , C12P19/40
摘要： A dry yeast composition which includes 5-adenosyl-L-methionine and a thickener and has excellent storage stability. A thickener is added to a yeast cell concentrate obtained by culturing yeast which has SAMe-producing ability and collecting the cells, and the resultant mixture is dried. Thus, a dry yeast containing a high concentration of 5-adenosyl-L-methionine which has excellent storage stability and excellent bioabsorbability can be easily and profitably produced. It is hence possible to supply a market with a dry yeast composition that contains a high concentration of 5-adenosyl-L-methionine, which is useful as a water-soluble physiologically active substance, and that has excellent storage stability and bioabsorbability.
摘要翻译：一种干酵母组合物，其包含5-腺苷-L-甲硫氨酸和增稠剂，并且具有优异的储存稳定性。向通过培养具有SAMe产生能力并收集细胞的酵母获得的酵母细胞浓缩物中加入增稠剂，并将所得混合物干燥。因此，可以容易且有利地生产具有优异的储存稳定性和优异的生物吸收性的含有高浓度的5-腺苷-L-甲硫氨酸的干酵母。因此，可以向市场提供含有高浓度的5-腺苷-L-甲硫氨酸的干酵母组合物，其可用作水溶性生理活性物质，并且具有优异的储存稳定性和生物吸收性。

3. 发明授权

US07714166B2 Process for producing carnitinamide 失效
标题翻译：肉碱生产方法
公开(公告)号：US07714166B2
公开(公告)日：2010-05-11
申请号：US11992831
申请日：2006-08-24
申请人： Genki Nogami , Hideo Ikarashi , Shinyo Gayama
发明人： Genki Nogami , Hideo Ikarashi , Shinyo Gayama
IPC分类号： C07C231/00
CPC分类号： B01J23/34 , B01J23/002 , B01J2523/00 , C07C231/06 , B01J2523/13 , B01J2523/55 , B01J2523/72 , B01J2523/54 , B01J2523/43 , C07C237/06
摘要： A process for producing carnitinamide which is an intermediate for production of L-carnitine is provided, which can hydrate carnitine nitrile to form carnitinamide with high selectivity, whereby highly-purified carnitinamide excellent as a substrate for stereoselective hydrolysis by optical resolution or a microorganism is produced in high yield. The process comprises hydrating carnitine nitrile to form carnitinamide using a catalyst containing a manganese oxide, and thus carnitinamide substantially free from by-produced carnitine is produced in high yield, so that carnitinamide of extremely high purity can be obtained through simple and easy crystallization operation.
摘要翻译：提供了生产左旋肉碱的中间体生产肉碱酰胺的方法，其可以以高选择性水合肉碱腈以形成肉碱酰胺，由此产生作为通过光学拆分或微生物进行立体选择性水解的底物的高度纯化的肉碱胺以高产量。该方法包括使用含有氧化锰的催化剂水化肉碱腈以形成肉毒碱，从而以高产率生产基本上不含副产肉碱的肉毒碱，从而可以通过简单且容易的结晶操作获得极高纯度的肉毒碱。

4. 发明授权

US09700629B2 Composition containing S-adenosyl-L-methionine with excellent storage stability 有权
公开(公告)号：US09700629B2
公开(公告)日：2017-07-11
申请号：US14238029
申请日：2012-07-20
申请人： Kentaro Takano , Shinyo Gayama
发明人： Kentaro Takano , Shinyo Gayama
IPC分类号： A61K31/7076 , A61K47/38 , A61K47/42 , A61K47/36 , A61K9/14 , A61K9/16 , A61K9/19 , C12P19/40 , A61K36/064
CPC分类号： A61K47/36 , A61K9/146 , A61K9/1652 , A61K9/1658 , A61K9/19 , A61K31/7076 , A61K36/064 , A61K47/38 , A61K47/42 , C12P19/40
摘要： The present invention relates to a composition including S-adenosyl-L-methionine; and at least one kind of additive selected from carboxymethylcellulose, hydroxypropylcellulose, soybean polysaccharide, casein sodium, and zein, in which S-adenosyl-L-methionine is extracted from S-adenosyl-L-methionine-containing cells obtained by culturing a microorganism having an ability to produce SAMe, and the content of the additive in the composition falls within the range of 0.05 to 15 times by mass of S-adenosyl-L-methionine in the composition. The present invention provides a composition containing a high concentration of S-adenosyl-L-methionine, which is useful as a water-soluble physiologically active substance, and being excellent in storage stability and bioabsorbability. The present invention also relates to a molded article formed by using the composition and a method of producing the composition.

5. 发明申请

US20130028878A1 S-ADENOSYL-L-METHIONINE-CONTAINING DRY YEAST COMPOSITION WITH EXCELLENT STORAGE STABILITY AND PROCESS FOR PRODUCING SAME 有权
标题翻译：具有优异储存稳定性的S-腺苷-L-甲硫氨酸含量干燥组合物及其生产方法
公开(公告)号：US20130028878A1
公开(公告)日：2013-01-31
申请号：US13639700
申请日：2011-04-05
申请人： Kentarou Takano , Shinyo Gayama
发明人： Kentarou Takano , Shinyo Gayama
IPC分类号： A61K36/06 , A23L1/28
CPC分类号： C12N1/16 , C12N1/04 , C12P19/40
摘要： A dry yeast composition which includes 5-adenosyl-L-methionine and a thickener and has excellent storage stability. A thickener is added to a yeast cell concentrate obtained by culturing yeast which has SAMe-producing ability and collecting the cells, and the resultant mixture is dried. Thus, a dry yeast containing a high concentration of 5-adenosyl-L-methionine which has excellent storage stability and excellent bioabsorbability can be easily and profitably produced. It is hence possible to supply a market with a dry yeast composition that contains a high concentration of 5-adenosyl-L-methionine, which is useful as a water-soluble physiologically active substance, and that has excellent storage stability and bioabsorbability.
摘要翻译：一种干酵母组合物，其包含5-腺苷-L-甲硫氨酸和增稠剂，并且具有优异的储存稳定性。向通过培养具有SAMe产生能力并收集细胞的酵母获得的酵母细胞浓缩物中加入增稠剂，并将所得混合物干燥。因此，可以容易且有利地生产具有优异的储存稳定性和优异的生物吸收性的含有高浓度的5-腺苷-L-甲硫氨酸的干酵母。因此，可以向市场提供含有高浓度的5-腺苷-L-甲硫氨酸的干酵母组合物，其可用作水溶性生理活性物质，并且具有优良的储存稳定性和生物吸收性。

6. 发明授权

US08202515B2 Method of producing dry yeast containing S-adenosyl-L-methionine and composition for oral intake 有权
标题翻译：生产含有S-腺苷-L-甲硫氨酸的干酵母的方法和用于口服摄入的组合物
公开(公告)号：US08202515B2
公开(公告)日：2012-06-19
申请号：US12299942
申请日：2007-05-08
申请人： Kentarou Takano , Shinyo Gayama , Toshito Tsuchida
发明人： Kentarou Takano , Shinyo Gayama , Toshito Tsuchida
IPC分类号： A01N63/00
CPC分类号： A61K36/06 , A23L33/14 , A23L33/175 , C12N1/16 , C12P19/40
摘要： A method for producing a dry yeast containing S-adenosyl-L-methionine using a yeast having production capability of S-adenosyl-L-methionine, in which a yeast cell concentrate separated from a cell culture liquid of the yeast is subjected to at least one treatment of (1) a treatment of adding a mineral acid to adjust the pH of the concentrate to 1 to 5, and (2) a treatment of heating the concentrate to 40 to 85° C., and then dried, and a composition for oral ingestion containing a dry yeast produced by the production method, having been molded. A method for producing dry yeast cells containing S-adenosyl-L-methionine, which is useful as a water soluble physiologically active substance, in a high concentration with a good yield at low cost, and a composition for oral ingestion formed by molding a dry yeast produced by the production method can be provided.
摘要翻译：使用具有S-腺苷-L-甲硫氨酸生产能力的酵母生产含有S-腺苷-L-甲硫氨酸的干酵母的方法，其中将从酵母的细胞培养液中分离的酵母细胞浓缩物至少一种处理（1）加入无机酸以将浓缩物的pH调节至1至5的处理，和（2）将浓缩物加热至40至85℃的处理，然后干燥，并将组合物用于口服摄入，其含有通过制造方法生产的干酵母，已经被模制。以低成本以高收率高浓度生产可用作水溶性生理活性物质的S-腺苷-L-甲硫氨酸的干酵母细胞的方法，以及通过模制干燥形成的口服摄取组合物可以提供通过制造方法生产的酵母。

7. 发明申请

US20100075403A1 METHOD FOR PRODUCTION OF DRY YEAST CONTAINING S-ADENOSYL-L-METHIONINE AND HAVING EXCELLENT STORAGE STABILITY, PRODUCT PRODUCED BY THE METHOD, AND MOLDED COMPOSITION OF THE DRY YEAST 有权
标题翻译：生产含有S-腺苷-L-甲硫氨酸的干燥并具有优良储存稳定性的方法，该方法生产的产品和干燥的YEAST的成型组合物
公开(公告)号：US20100075403A1
公开(公告)日：2010-03-25
申请号：US12524050
申请日：2008-01-23
申请人： Kentarou Takano , Shinyo Gayama
发明人： Kentarou Takano , Shinyo Gayama
IPC分类号： C12N1/16
CPC分类号： C12N1/18 , A23L33/13 , A23L33/14 , A23V2002/00 , C12N1/04 , A23V2250/218 , A23V2250/312
摘要： The present invention relates to a method for producing a dry yeast containing S-adenosyl-L-methionine using a yeast having production capability of S-adenosyl-L-methionine, the method containing: adding a cyclodextrin compound to a yeast concentrate obtained from a fungus culture liquid of the yeast; and then drying the concentrate, an SAMe-containing dry yeast obtained by the production method, and a composition formed by molding the dry yeast. According to the present invention, a dry yeast containing S-adenosyl-L-methionine, which is useful as an aqueous physiologically active substance, in a high concentration excellent in storage stability and a composition obtained by molding the dry yeast can be produced conveniently and economically and can be brought into the market.
摘要翻译：本发明涉及使用具有S-腺苷-L-甲硫氨酸生产能力的酵母生产含有S-腺苷-L-甲硫氨酸的干酵母的方法，该方法包括：将环糊精化合物加入到由酵母真菌培养液; 然后干燥浓缩物，通过制备方法获得的含有SAMe的干酵母和通过模制干酵母形成的组合物。根据本发明，可以方便地制造含有S-作为生理活性物质的S-腺苷-L-甲硫氨酸的干酵母，其贮藏稳定性优异的高浓度和通过成型干酵母获得的组合物，在经济上可以进入市场。

8. 发明申请

US20090181001A1 METHOD OF PRODUCING DRY YEAST CONTAINING S-ADENOSYL-L-METHIONINE AND COMPOSITION FOR ORAL INTAKE 有权
标题翻译：生产含有S-腺苷-L-甲硫氨酸的干性酵素的方法和用于口服摄取的组合物
公开(公告)号：US20090181001A1
公开(公告)日：2009-07-16
申请号：US12299942
申请日：2007-05-08
申请人： Kentarou Takano , Shinyo Gayama , Toshito Tsuchida
发明人： Kentarou Takano , Shinyo Gayama , Toshito Tsuchida
IPC分类号： A61K35/66 , C12N1/16
CPC分类号： A61K36/06 , A23L33/14 , A23L33/175 , C12N1/16 , C12P19/40
摘要： A method for producing a dry yeast containing S-adenosyl-L-methionine using a yeast having production capability of S-adenosyl-L-methionine, in which a yeast cell concentrate separated from a cell culture liquid of the yeast is subjected to at least one treatment of (1) a treatment of adding a mineral acid to adjust the pH of the concentrate to 1 to 5, and (2) a treatment of heating the concentrate to 40 to 85° C., and then dried, and a composition for oral ingestion containing a dry yeast produced by the production method, having been molded. A method for producing dry yeast cells containing S-adenosyl-L-methionine, which is useful as a water soluble physiologically active substance, in a high concentration with a good yield at low cost, and a composition for oral ingestion formed by molding a dry yeast produced by the production method can be provided.
摘要翻译：使用具有S-腺苷-L-甲硫氨酸生产能力的酵母生产含有S-腺苷-L-甲硫氨酸的干酵母的方法，其中从酵母的细胞培养液中分离出的酵母细胞浓度至少一种处理（1）加入无机酸以将浓缩物的pH调节至1至5的处理，和（2）将浓缩物加热至40至85℃的处理，然后干燥，并将组合物用于口服摄入，其含有通过制造方法生产的干酵母，已经被模制。以低成本以高收率高浓度生产可用作水溶性生理活性物质的S-腺苷-L-甲硫氨酸的干酵母细胞的方法，以及通过模制干燥形成的口服摄取组合物可以提供通过制造方法生产的酵母。

9. 发明授权

US09200250B2 Method for production of dry yeast containing S-adenosyl-L-methionine and having excellent storage stability, product produced by the method, and molded composition of the dry yeast 有权
标题翻译：生产含有S-腺苷-L-甲硫氨酸的干酵母并具有优异的储存稳定性的方法，通过该方法生产的产品和干酵母的模塑组合物
公开(公告)号：US09200250B2
公开(公告)日：2015-12-01
申请号：US12524050
申请日：2008-01-23
申请人： Kentarou Takano , Shinyo Gayama
发明人： Kentarou Takano , Shinyo Gayama
IPC分类号： C12N1/16 , C12N1/18 , A23L1/30 , C12N1/04
CPC分类号： C12N1/18 , A23L33/13 , A23L33/14 , A23V2002/00 , C12N1/04 , A23V2250/218 , A23V2250/312
摘要： The present invention relates to a method for producing a dry yeast containing S-adenosyl-L-methionine using a yeast having production capability of S-adenosyl-L-methionine, the method containing: adding a cyclodextrin compound to a yeast concentrate obtained from a fungus culture liquid of the yeast; and then drying the concentrate, an SAMe-containing dry yeast obtained by the production method, and a composition formed by molding the dry yeast. According to the present invention, a dry yeast containing S-adenosyl-L-methionine, which is useful as an aqueous physiologically active substance, in a high concentration excellent in storage stability and a composition obtained by molding the dry yeast can be produced conveniently and economically and can be brought into the market.
摘要翻译：本发明涉及使用具有S-腺苷-L-甲硫氨酸生产能力的酵母生产含有S-腺苷-L-甲硫氨酸的干酵母的方法，该方法包括：将环糊精化合物加入到由酵母真菌培养液; 然后干燥浓缩物，通过制备方法获得的含有SAMe的干酵母和通过模制干酵母形成的组合物。根据本发明，可以方便地制造含有S-作为生理活性物质的S-腺苷-L-甲硫氨酸的干酵母，其贮藏稳定性优异的高浓度和通过成型干酵母获得的组合物，在经济上可以进入市场。

10. 发明授权

US09080158B2 Method of producing S-adenosyl-L-methionine-containing dry yeast having excellent storage stability, the product thereof and composition for oral intake 有权
标题翻译：具有优异储存稳定性的含S-腺苷-L-甲硫氨酸的干酵母的制造方法及其口服摄取用组合物
公开(公告)号：US09080158B2
公开(公告)日：2015-07-14
申请号：US12300826
申请日：2007-05-15
申请人： Kentarou Takano , Shinyo Gayama
发明人： Kentarou Takano , Shinyo Gayama
IPC分类号： C12N1/12 , C12N1/20 , A01N63/00 , C12N1/18 , A61K9/16 , A61K9/19 , C07H19/167 , C12N1/04 , C12P19/40
CPC分类号： C12N1/18 , A61K9/1617 , A61K9/19 , C07H19/167 , C12N1/04 , C12P19/40
摘要： A method for producing a dry yeast containing S-adenosyl-L-methionine using a yeast having production capability of S-adenosyl-L-methionine, in which an ascorbic acid compound or a salt thereof is added to a yeast concentrate separated from a fungus culture liquid of the yeast, and the concentrate is then dried, a dry yeast containing SAMe obtained by the production method, and a composition for oral ingestion formed by molding the dry yeast. A method capable of producing a dry yeast containing SAMe in a high concentration excellent in storage stability conveniently at low cost is established, and a dry yeast containing SAMe obtained by the production method and a composition for oral ingestion formed by molding the dry yeast are provided.
摘要翻译：使用具有S-腺苷-L-甲硫氨酸的生产能力的酵母生产含有S-腺苷-L-甲硫氨酸的干酵母的方法，其中将抗坏血酸化合物或其盐加入从真菌分离的酵母浓缩物中培养液，然后干燥浓缩物，通过制备方法得到的含有SAMe的干酵母和通过模制干酵母形成的用于口服摄取的组合物。建立了能够以低成本方便地生产具有优异的储存稳定性高的SAMe的干酵母的方法，并且提供了通过制备方法获得的含有SAMe的干酵母和通过模制干酵母形成的口服摄取组合物。

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