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1. 发明申请

US20100125941A1 SANITARY WASHING DEVICE 有权
标题翻译：卫浴设备
公开(公告)号：US20100125941A1
公开(公告)日：2010-05-27
申请号：US12600196
申请日：2008-05-14
申请人： Kazuma Shin , Michinori Yananose , Hiroshi Nakamura , Shinji Okano , Osamu Tateishi
发明人： Kazuma Shin , Michinori Yananose , Hiroshi Nakamura , Shinji Okano , Osamu Tateishi
IPC分类号： E03D9/08
CPC分类号： E03D9/08
摘要： A sanitary washing device includes: a water discharge nozzle configured to squirt water from a water discharge port; a first channel configured to guide water supplied from a water supply source to the water discharge nozzle; a first channel opening/closing valve provided in the first channel and configured to control passage of water through the first channel; a heat exchange unit provided in the first channel between the first channel opening/closing valve and the water discharge nozzle and configured to heat water passed therethrough; and a draining device configured to drain water in the heat exchange unit toward the water supply source.
摘要翻译：卫生洗涤装置包括：排水口，其配置成从排水口喷水; 第一通道，其构造成将从供水源供给的水引导到排水喷嘴; 第一通道打开/关闭阀，设置在第一通道中并且构造成控制水通过第一通道; 一个热交换单元，设置在第一通道中的第一通道开/关阀和排水喷嘴之间，并构造成加热通过其中的水; 以及排水装置，其构造成将所述热交换单元中的水朝向所述供水源排出。

2. 发明授权

US06535825B1 Method and device for obtaining calibration data of mechanical press, and load display device for mechanical press 失效
标题翻译：用于获得机械压力机的校准数据的方法和装置，以及用于机械压力机的负载显示装置
公开(公告)号：US06535825B1
公开(公告)日：2003-03-18
申请号：US09631831
申请日：2000-08-03
申请人： Shinji Okano
发明人： Shinji Okano
IPC分类号： G07L100
CPC分类号： B30B15/14 , B30B1/265 , B30B15/0094
摘要： When obtaining load displaying calibration data, first, a reference die height position (a) where a load (F) of a mechanical press (1) comes to minimum load value (Fa) is sought as well as a reference die height position (f) where the load (F) comes to maximum load value (Ff). Then a plurality of intermediate die height positions (b . . . e) are selected between these reference die height positions (a) and (f). Subsequently, a load is imposed on the mechanical press (1) at each of the die height positions (a . . . f) and a pressure sensor (33) senses peak oil pressures (Pa . . . Pf) corresponding to the respective die height positions (a . . . f). Thereafter, relative relationships between load values (Fa . . . Ff) corresponding to the die height positions (a . . . f) and the peak oil pressures (Pa . . . Pf) are obtained as a characteristic curve (B).
摘要翻译：当获得负载显示校准数据时，首先寻求机械压力机（1）的负载（F）达到最小负载值（Fa）的参考模具高度位置（a）以及参考模具高度位置（f ）其中负载（F）达到最大负载值（Ff）。然后在这些参考管芯高度位置（a）和（f）之间选择多个中间管芯高度位置（b。）。随后，在每个模具高度位置（a.f）上对机械压力机（1）施加负载，并且压力传感器（33）感测对应于相应模具的峰值油压（Pa.p.Pf）高度位置（a。。f）。此后，获得与模头高度位置（a.f.）对应的载荷值（Fa。Ff）与峰值油压（Pa.p.Pf）之间的相对关系作为特性曲线（B）。

3. 发明授权

US08701222B2 Sanitary washing device 有权
标题翻译：卫生洗涤装置
公开(公告)号：US08701222B2
公开(公告)日：2014-04-22
申请号：US12600196
申请日：2008-05-14
申请人： Kazuma Shin , Michinori Yananose , Hiroshi Nakamura , Shinji Okano , Osamu Tateishi
发明人： Kazuma Shin , Michinori Yananose , Hiroshi Nakamura , Shinji Okano , Osamu Tateishi
IPC分类号： A47K3/26
CPC分类号： E03D9/08
摘要： A sanitary washing device includes: a water discharge nozzle configured to squirt water from a water discharge port; a first channel configured to guide water supplied from a water supply source to the water discharge nozzle; a first channel opening/closing valve provided in the first channel and configured to control passage of water through the first channel; a heat exchange unit provided in the first channel between the first channel opening/closing valve and the water discharge nozzle and configured to heat water passed therethrough; and a draining device configured to drain water in the heat exchange unit toward the water supply source.
摘要翻译：卫生洗涤装置包括：排水口，其配置成从排水口喷水; 第一通道，其构造成将从供水源供给的水引导到排水喷嘴; 第一通道打开/关闭阀，设置在第一通道中并且构造成控制水通过第一通道; 一个热交换单元，设置在第一通道中的第一通道开/关阀和排水喷嘴之间，并构造成加热通过其中的水; 以及排水装置，其构造成将所述热交换单元中的水朝向所述供水源排出。

4. 发明申请

US20080031855A1 Anticancer Agent Containing Minus-Strand Rna Virus 审中-公开
标题翻译：含有短链RNA病毒的抗癌剂
公开(公告)号：US20080031855A1
公开(公告)日：2008-02-07
申请号：US11630522
申请日：2005-04-28
申请人： Shinji Okano , Yoshikazu Yonemitsu , Katsuo Sueishi , Satoko Shibata , Mamoru Hasegawa , Haruhiko Kondo
发明人： Shinji Okano , Yoshikazu Yonemitsu , Katsuo Sueishi , Satoko Shibata , Mamoru Hasegawa , Haruhiko Kondo
IPC分类号： A61K35/00 , A61P43/00
CPC分类号： A61K35/76 , A61K35/768 , A61K38/179 , A61K38/215 , A61K2039/5154 , C12N2760/18832 , C12N2760/18871
摘要： Minus-strand RNA viruses were found to have an effective tumor-suppressive effect even when they did not carry a therapeutically effective gene. The present invention provides anticancer agents comprising a minus-strand RNA virus. Furthermore, the present invention provides methods for producing the anticancer agents, which comprise the step of mixing a minus-strand RNA virus with pharmaceutically acceptable carriers. Furthermore, the present invention provides methods for suppressing cancer, which comprise the step of administering a minus-strand RNA virus to cancer tissues.
摘要翻译：发现减数RNA病毒即使不携带治疗有效的基因也具有有效的肿瘤抑制作用。本发明提供了包含负链RNA病毒的抗癌剂。此外，本发明提供了制造抗癌剂的方法，其包括将负链RNA病毒与药学上可接受的载体混合的步骤。此外，本发明提供了抑制癌症的方法，其包括向癌组织施用负链RNA病毒的步骤。

5. 发明申请

US20070269414A1 Method for Producing Gene Transferred Denritic Cells 审中-公开
标题翻译：生产基因转移的Denritic细胞的方法
公开(公告)号：US20070269414A1
公开(公告)日：2007-11-22
申请号：US10578085
申请日：2004-10-29
申请人： Shinji Okano , Yoshikazu Yonemitsu , Katsuo Sueishi , Satoko Shibata , Mamoru Hasegawa
发明人： Shinji Okano , Yoshikazu Yonemitsu , Katsuo Sueishi , Satoko Shibata , Mamoru Hasegawa
IPC分类号： A61K48/00 , A61P31/00 , C12N15/00 , C12N5/08
CPC分类号： C12N15/86 , A61K2039/5156 , C12N2510/02 , C12N2760/18843
摘要： The present invention provides a method for introducing a gene into a dendritic cell, which includes the step of contacting a minus-strand RNA virus with a dendritic cell. The present invention also provides a method for producing a gene transferred dendritic cell, which includes the step of contacting a minus-strand RNA virus with a dendritic cell. The present invention also provides gene transferred dendritic cells produced by such methods. Furthermore, the present invention provides a method for activating a dendritic cell, which includes the step of contacting a minus-strand RNA virus with a dendritic cell. The present invention enables efficient gene delivery into dendritic cells. Dendritic cells introduced with antigen gene or cytokine gene are useful as vaccine.
摘要翻译：本发明提供了将基因导入树状细胞的方法，其包括使负链RNA病毒与树突状细胞接触的步骤。本发明还提供了一种转基因树突状细胞的制备方法，其包括将负链RNA病毒与树突状细胞接触的步骤。本发明还提供了通过这些方法产生的基因转移的树突状细胞。此外，本发明提供了激活树突细胞的方法，其包括使负链RNA病毒与树突状细胞接触的步骤。本发明使得有效的基因递送到树突状细胞中。引入抗原基因或细胞因子基因的树突状细胞可用作疫苗。

6. 发明申请

US20080014183A1 Anticancer Agent Containing Dendritic Cell Having Rna Virus Transferred Thereinto 有权
标题翻译：含有转移Rna病毒的树突状细胞的抗癌剂
公开(公告)号：US20080014183A1
公开(公告)日：2008-01-17
申请号：US11630532
申请日：2005-04-28
申请人： Shinji Okano , Yoshikazu Yonemitsu , Katsuo Sueishi , Satoko Shibata , Mamoru Hasegawa , Haruhiko Kondo
发明人： Shinji Okano , Yoshikazu Yonemitsu , Katsuo Sueishi , Satoko Shibata , Mamoru Hasegawa , Haruhiko Kondo
IPC分类号： A61K48/00
CPC分类号： A61K35/76 , A61K35/768 , A61K38/179 , A61K38/215 , A61K2039/5154 , C12N2760/18832 , C12N2760/18871
摘要： The present invention provides anticancer agents comprising dendritic cells introduced with RNA viruses. The present invention also provides methods for producing anticancer agents, which comprise the step of preparing dendritic cells introduced with RNA viruses. The present invention also provides methods for treating cancers using dendritic cells introduced with RNA viruses. The present invention provides effective methods for treating cancers, which use RNA viruses and dendritic cells in combination
摘要翻译：本发明提供包含引入RNA病毒的树突状细胞的抗癌剂。本发明还提供了制备抗癌剂的方法，其包括制备引入RNA病毒的树突状细胞的步骤。本发明还提供了用RNA病毒引入的树突状细胞治疗癌症的方法。本发明提供了组合使用RNA病毒和树突状细胞的治疗癌症的有效方法

7. 发明授权

US08889118B2 Anticancer agent containing dendritic cell having RNA virus transferred thereinto 有权
标题翻译：含有转录有RNA病毒的树突状细胞的抗癌剂
公开(公告)号：US08889118B2
公开(公告)日：2014-11-18
申请号：US11630532
申请日：2005-04-28
申请人： Shinji Okano , Yoshikazu Yonemitsu , Katsuo Sueishi , Satoko Shibata , Mamoru Hasegawa , Haruhiko Kondo
发明人： Shinji Okano , Yoshikazu Yonemitsu , Katsuo Sueishi , Satoko Shibata , Mamoru Hasegawa , Haruhiko Kondo
IPC分类号： A61K48/00 , C12N15/86 , A61K38/21 , A61K38/17 , A61K35/76 , A61K39/00
CPC分类号： A61K35/76 , A61K35/768 , A61K38/179 , A61K38/215 , A61K2039/5154 , C12N2760/18832 , C12N2760/18871
摘要： The present invention provides anticancer agents comprising dendritic cells introduced with RNA viruses. The present invention also provides methods for producing anticancer agents, which comprise the step of preparing dendritic cells introduced with RNA viruses. The present invention also provides methods for treating cancers using dendritic cells introduced with RNA viruses. The present invention provides effective methods for treating cancers, which use RNA viruses and dendritic cells in combination.
摘要翻译：本发明提供包含引入RNA病毒的树突状细胞的抗癌剂。本发明还提供了制备抗癌剂的方法，其包括制备引入RNA病毒的树突状细胞的步骤。本发明还提供了用RNA病毒引入的树突状细胞治疗癌症的方法。本发明提供了组合使用RNA病毒和树突状细胞的治疗癌症的有效方法。

8. 发明申请

US20060104950A1 Methods of Tranducing genes into T cells 审中-公开
标题翻译：将基因导入T细胞的方法
公开(公告)号：US20060104950A1
公开(公告)日：2006-05-18
申请号：US10532172
申请日：2003-10-22
申请人： Shinji Okano , Yoshikazu Yonemitsu , Katsuo Sueishi , Mamoru Hasegawa
发明人： Shinji Okano , Yoshikazu Yonemitsu , Katsuo Sueishi , Mamoru Hasegawa
IPC分类号： A61K48/00 , C12N5/08 , C12N15/86
CPC分类号： C12N15/86 , C12N2760/18843 , C12N2800/30
摘要： The present invention provides methods of transducing a gene into activated T cells comprising the step of contacting a paramyxovirus vector with activated T cells. This invention also provides a method of preparing T cells transduced with a foreign gene comprising the step of contacting a paramyxovirus vector with activated T cells. This invention also provides T cells transduced with a foreign gene prepared by this method. The present invention enables efficient gene transduction specific to activated T cells, and is expected to be applied to immunological modification strategies using T cell-directed gene delivery.
摘要翻译：本发明提供将基因转导到活化的T细胞中的方法，包括使副粘病毒载体与活化的T细胞接触的步骤。本发明还提供了一种制备用外源基因转导的T细胞的方法，包括使副粘病毒载体与活化的T细胞接触的步骤。本发明还提供了通过该方法制备的外源基因转导的T细胞。本发明能够有效地对活化的T细胞进行基因转导，并且预期将其应用于使用T细胞定向基因递送的免疫修饰策略。

9. 发明授权

US06457370B1 Method and device for measuring working force of mechanical press 失效
标题翻译：用于测量机械压力机工作力的方法和装置
公开(公告)号：US06457370B1
公开(公告)日：2002-10-01
申请号：US09556523
申请日：2000-04-21
申请人： Shinji Okano
发明人： Shinji Okano
IPC分类号： G01N300
CPC分类号： G01L5/0076 , B30B15/284
摘要： Pressurized oil is charged into a hydraulic chamber (12) formed within a slide (3) of a mechanical press (1). relationship between a working force (F) during a press working and a pressure (P) of the pressurized oil is preliminarily measured for every predetermined initial pressure of the pressurized oil. A computer (33) stores the measured results as a plurality of pressurizing characteristics (A1), (A2) and (A3). The computer (33) stores through a pressure sensor (27), a pressure of the pressurized oil while a press working is not performed, as a preload pressure (Pa1). And it stores a maximum pressure of the pressurized oil during the press working as a peak pressure (Pb1). It further selects a pressurizing characteristic (A1) corresponding to the preload pressure (Pa1) from among the plurality of pressurizing characteristics and thereafter calculates a working force (F1) based on the selected pressurizing characteristic (A1) and the peak pressure (Pb1).
摘要翻译：加压油被装入形成在机械压力机（1）的滑动件（3）内的液压室（12）中。对于加压油的每个预定的初始压力，预先测定压力加工时的加压力（F）与加压油的压力（P）之间的关系。计算机（33）将测量结果存储为多个加压特性（A1），（A2）和（A3）。计算机（33）通过压力传感器（27）存储加压油的压力，而不进行冲压加工，作为预压力（Pa1）。并且它在压力加工期间存储加压油的最大压力作为峰值压力（Pb1）。从多个加压特性中进一步选择与预压力（Pa1）对应的加压特性（A1），然后基于所选择的加压特性（A1）和峰值压力（Pb1）来计算加压力（F1）。

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