专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08133999B2 Process for preparation of 6, 7-bis(2-methoxyethoxy) quinazolin-4-one 有权
标题翻译：制备6,7-双（2-甲氧基乙氧基）喹唑啉-4-酮的方法
公开(公告)号：US08133999B2
公开(公告)日：2012-03-13
申请号：US12484632
申请日：2009-06-15
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Hiroyuki Oda , Shinobu Suzuki
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Hiroyuki Oda , Shinobu Suzuki
IPC分类号： C07D239/72
CPC分类号： C07D239/88 , C07C67/31 , C07C69/92
摘要： 6,7-Bis(2-methoxyethoxy)quinazolin-4-one of formula (5) useful in synthesis of an anti-cancer drug can be prepared by a reaction of ethyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate of formula (4) with an orthoformic acid in the presence of an ammonium acetate:
摘要翻译：可用于合成抗癌药物的式（5）的6,7-双（2-甲氧基乙氧基）喹唑啉-4-酮可以通过2-氨基-4,5-双（2-甲氧基乙氧基）苯甲酸酯与原甲酸在乙酸铵存在下反应：

2. 发明申请

US20100010233A1 PROCESS FOR PREPARING IMIDAZOLIDIN-2,4-DIONE COMPOUND AND METHOD FOR ACQUIRING SOLID STATE 4,5-DIHYDROXY-2-IMIDAZOLIDINONE COMPOUND 失效
标题翻译：制备咪唑啉-2,4-二酮化合物的方法和获得固体状态的4,5-二羟基-2-咪唑啉酮化合物的方法
公开(公告)号：US20100010233A1
公开(公告)日：2010-01-14
申请号：US12373548
申请日：2007-07-13
申请人： Shigeyoshi Nishino , Hidetaka Shima , Tetsuro Shimano , Kimihiko Yoshimura
发明人： Shigeyoshi Nishino , Hidetaka Shima , Tetsuro Shimano , Kimihiko Yoshimura
IPC分类号： C07D233/40
CPC分类号： C07D233/74
摘要： An object of the present invention is to provide an industrially suitable process for preparing an imidazolidin-2,4-dione compound which is safe, simple and easy to prepare the imidazolidin-2,4-dione compound with high yield, which is a useful compound, for example, as a material for decomposing a harmful halogenated aromatic hydrocarbon compound such as dioxin, etc., an electroless silver plating solution for electronic parts, or a diazo copying material, etc. This object can be solved by a process for preparing an imidazolidin-2,4-dione compound which comprises subjecting a 4,5-dihydroxy-2-imidazolidinone compound, (1) to dehydration reaction in the presence of an acid catalyst(s); or (2) to reaction at 100 to 300° C. Or, it can be solved by a process for preparing an imidazolidin-2,4-dione compound which comprises reacting a mixed solution of a urea compound, glyoxal, and a base at 20 to 300° C.Also, an object of the present invention is to provide a method for acquiring a 4,5-dihydroxy-2-imidazolidinone from an aqueous solution containing a 4,5-dihydroxy-2-imidazolidinone by a simple and easy method. This object can be solved by a process for acquiring a solid state 4,5-dihydroxy-2-imidazolidinone compound which comprises mixing an organic solvent with an aqueous solution containing a 4,5-dihydroxy-2-imidazolidinone compound, and subjecting the mixture to azeotropic distillation.
摘要翻译：本发明的目的是提供一种工业上合适的制备咪唑烷-2,4-二酮化合物的方法，该方法安全，简单并且容易以高产率制备咪唑烷-2,4-二酮化合物，其是有用的化合物，例如作为用于分解有害的卤化芳族烃化合物如二恶英等的材料，用于电子部件的无电镀银溶液或重氮复制材料等。该目的可以通过制备方法包括使4,5-二羟基-2-咪唑啉酮化合物（1）在酸催化剂存在下进行脱水反应的咪唑烷-2,4-二酮化合物; 或（2）在100〜300℃下反应，或者可以通过制备咪唑烷-2,4-二酮化合物的方法来解决，该方法包括使脲化合物，乙二醛和碱的混合溶液另外，本发明的目的在于提供一种通过简单且简单的方法从含有4,5-二羟基-2-咪唑啉酮的水溶液中获得4,5-二羟基-2-咪唑烷酮的方法，容易的方法。该目的可以通过获得固体4,5-二羟基-2-咪唑烷酮化合物的方法来解决，该方法包括将有机溶剂与含有4,5-二羟基-2-咪唑烷酮化合物的水溶液混合，并将该混合物共沸蒸馏。

3. 发明申请

US20090306380A1 Process for preparing 4-amino-2-alkylthio-5-pyrimidinecarbaldehyde 审中-公开
标题翻译：制备4-氨基-2-烷硫基-5-嘧啶甲醛的方法
公开(公告)号：US20090306380A1
公开(公告)日：2009-12-10
申请号：US11919179
申请日：2006-04-24
申请人： Shigeyoshi Nishino , Shoji Shikita , Tadashi Murakami
发明人： Shigeyoshi Nishino , Shoji Shikita , Tadashi Murakami
IPC分类号： C07D239/47 , C07C255/07
CPC分类号： C07D239/47 , C07C253/30 , C07C255/15
摘要： Provided are a process for preparing a 4-amino-2-alkylthio-5-pyrimidinecarbaldehyde, which is industrially advantageous in that a 4-amino-2-alkylthio-5-pyrimidinecarbaldehyde can be prepared in high yield in a simple way, an intermediate used in the process, and a process for preparing the intermediate, which is industrially advantageous in that the intermediate can be prepared safely in high yield with ease.The present invention is directed to: a process for preparing an alkali metal salt of 3,3-dialkoxy-2-hydroxymethylenepropanenitrile, comprising reacting at least one nitrile compound selected from the group consisting of a 3,3-dialkoxypropanenitrile and a 3-alkoxy-2-propenenitrile, with a formic acid ester at −10 to 30° C. in the presence of a base comprising an alkali metal; an alkali metal salt of 4-amino-2-mercapto-5-pyrimidinecarbaldehyde; a process for preparing an alkali metal salt of 4-amino-2-mercapto-5-pyrimidinecarbaldehyde, comprising reacting an alkali metal salt of 3,3-dialkoxy-2-hydroxymethylenepropanenitrile with thiourea; a process for preparing a 4-amino-2-alkylthio-5-pyrimidinecarbaldehyde, comprising reacting an alkali metal salt of 4-amino-2-mercapto-5-pyrimidinecarbaldehyde with an alkylating agent; and an use of an alkali metal salt of 4-amino-2-mercapto-5-pyrimidinecarbaldehyde in the preparation of a 4-amino-2-alkylthio-5-pyrimidinecarbaldehyde.
摘要翻译：提供了一种制备4-氨基-2-烷硫基-5-嘧啶甲醛的方法，其工业上有利的是4-氨基-2-烷硫基-5-嘧啶甲醛可以简单的方式以高产率制备，中间体用于制备中间体的方法，其工业上的优点在于可以容易地以高产率安全地制备中间体。本发明涉及：制备3,3-二烷氧基-2-羟基亚甲基丙腈的碱金属盐的方法，包括使至少一种腈化合物与3,3-二烷氧基丙腈和3-烷氧基 -2-丙烯腈与甲酸酯在-10至30℃下在包含碱金属的碱的存在下反应; 4-氨基-2-巯基-5-嘧啶甲醛的碱金属盐; 制备4-氨基-2-巯基-5-嘧啶甲醛的碱金属盐的方法，包括使3,3-二烷氧基-2-羟基亚甲基丙腈的碱金属盐与硫脲反应; 制备4-氨基-2-烷硫基-5-嘧啶甲醛的方法，包括使4-氨基-2-巯基-5-嘧啶甲醛的碱金属盐与烷化剂反应; 以及4-氨基-2-巯基-5-嘧啶甲醛的碱金属盐在制备4-氨基-2-烷硫基-5-嘧啶甲醛中的用途。

4. 发明授权

US07342040B2 5-fluorooxindole-3-carboxylic acid ester 失效
标题翻译： 5-氟羟吲哚-3-羧酸酯
公开(公告)号：US07342040B2
公开(公告)日：2008-03-11
申请号：US11093603
申请日：2005-03-30
申请人： Katsumasa Harada , Shigeyoshi Nishino , Kenji Hirotsu , Shuji Yokoyama , Takeshi Takahashi , Hiroyuki Oda
发明人： Katsumasa Harada , Shigeyoshi Nishino , Kenji Hirotsu , Shuji Yokoyama , Takeshi Takahashi , Hiroyuki Oda
IPC分类号： A61K31/404 , C07D209/04
CPC分类号： C07D209/34 , C07C201/12 , C07C205/56 , C07C255/41 , C07D209/32
摘要： A 5-fluorooxindole-3-carboxylic acid ester represented by a formula (2): wherein R1 is a group selected from the group consisting of an unsubstituted or substituted alkyl group having 1 to 10 carbon atoms, an unsubstituted or substituted cycloalkyl group having 3 to 7 carbon atoms, an aralkyl group having 7 to 10 carbon atoms or an aryl group having 6 to 14 carbon atoms.
摘要翻译：由式（2）表示的5-氟羟吲哚-3-羧酸酯：其中R 1是选自未取代或取代的碳原子数1〜10的烷基，具有3至7个碳原子的未取代或取代的环烷基，具有7至10个碳原子的芳烷基或具有6至14个碳原子的芳基。

5. 发明申请

US20070106083A1 Process for preparing 4-aminotetrahydropyran compound and an acid salt thereof, synthetic intermediate thereof and process for preparing the same 有权
标题翻译：制备4-氨基四氢吡喃化合物及其酸式盐的合成中间体及其制备方法
公开(公告)号：US20070106083A1
公开(公告)日：2007-05-10
申请号：US10564709
申请日：2004-07-14
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Keiji Iwamoto , Takashi Harada , Shinobu Suzuki
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Keiji Iwamoto , Takashi Harada , Shinobu Suzuki
IPC分类号： C07D309/14
CPC分类号： C07D309/10 , C07D309/14
摘要： The present invention relates to a process for preparing 4-aminotetrahydropyran compound and an acid salt thereof represented by the formula (2): wherein R represents a hydrogen atom or a hydrocarbon group, which comprises subjecting a 4-hydrazinotetrahydropyran compound or an acid salt thereof represented by the formula (1): wherein R has the same meaning as defined above, to decomposition reaction in the presence of at least one compound selected from Raney nickel, noble metal catalyst and metal oxide, and a synthetic intermediate thereof and a process for preparing the same.
摘要翻译：本发明涉及一种由式（2）表示的4-氨基四氢吡喃化合物及其酸式盐的制备方法：其中R表示氢原子或烃基，其包括使4-肼基四氢吡喃化合物或其酸式盐由式（1）表示：其中R具有与上述相同的含义，在至少一种选自阮内镍，贵金属催化剂和金属氧化物的化合物及其合成中间体存在下进行分解反应，以及其制备方法准备一样

6. 发明申请

US20060287541A1 Method for producing nitrile compound, carboxylic acid compound or carboxylate compound 有权
标题翻译：腈化合物，羧酸化合物或羧酸酯化合物的制造方法
公开(公告)号：US20060287541A1
公开(公告)日：2006-12-21
申请号：US10572373
申请日：2004-09-17
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Keiji Iwamoto , Takashi Harada
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Keiji Iwamoto , Takashi Harada
IPC分类号： C07D309/14
CPC分类号： C07C253/30 , C07C51/00
摘要： The present invention discloses a process for preparing a nitrile compound, a carboxylic acid compound or a carboxylic acid ester compound represented by the formula (2): wherein R represents a cyano group, a carboxyl group or an ester group, R1 and R2 each represent a group which does not participate in the reaction, which may have a substituent, and R1 and R2 may be combined to each other to form a ring, which comprises subjecting an acetic acid compound represented by the formula (1): wherein R, R1 and R2 have the same meanings as defined above, to decarboxylation in the presence of a metal catalyst.
摘要翻译：本发明公开了一种制备由式（2）表示的腈化合物，羧酸化合物或羧酸酯化合物的方法：其中R表示氰基，羧基或酯基，R 1 R 2和R 2各自表示不参与反应的基团，其可以具有取代基，R 1和R 2， SUP>可以彼此组合以形成环，其包括使由式（1）表示的乙酸化合物：其中R，R 1和R 2，具有与上述相同的含义，在金属催化剂的存在下脱羧。

7. 发明申请

US20060270849A1 Process for producing pyrimidin-4-one compound 审中-公开
标题翻译：制备嘧啶-4-酮化合物的方法
公开(公告)号：US20060270849A1
公开(公告)日：2006-11-30
申请号：US10561042
申请日：2004-06-18
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Shinobu Suzuki
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Shinobu Suzuki
IPC分类号： C07D487/02
CPC分类号： C07D487/04 , C07D239/90 , C07D239/91 , C07D471/04 , C07D495/04
摘要： A pyrimidin-4-one compound can be prepared in a high yield by reacting an aminoarylcarboxylic acid compound with an organic acid compound in the presence of a nitrogen atom-containing compound under relatively simple and moderate reaction conditions.
摘要翻译：通过使氨基芳基羧酸化合物与有机酸化合物在含氮原子化合物的存在下，在相对简单和适中的反应条件下反应，可以高收率地制备嘧啶-4-酮化合物。

8. 发明申请

US20050130995A1 Process for producing 4-aminoquinazoline compound 审中-公开
标题翻译： 4-氨基喹唑啉化合物的制备方法
公开(公告)号：US20050130995A1
公开(公告)日：2005-06-16
申请号：US10503664
申请日：2003-02-06
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Takashi Harada , Hiroyuki Oda
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Takashi Harada , Hiroyuki Oda
IPC分类号： C07D239/88 , C07D239/94 , A61K31/517
CPC分类号： C07D239/88 , C07D239/94
摘要： A 4-aminoquinazoline derivative can be obtained by the steps of reacting quinazolin-4-one or its derivative with a chlorinating agent in a first organic solvent in the presence of an organic base, and subsequently reacting the reaction product with an amine compound represented by the formula R5—NH—R6 (each of R5 and R6 represents hydrogen or an optionally substituted hydrocarbyl group) in the presence of a second organic solvent.
摘要翻译： 4-氨基喹唑啉衍生物可以通过以下步骤获得：将喹唑啉-4-酮或其衍生物与氯化剂在有机碱存在下在第一有机溶剂中反应，然后使反应产物与由式R 5 -NH-R 6（R 5和R 6各自表示氢或任选地取代的烃基）在第二有机溶剂的存在下进行。

9. 发明授权

US06900335B2 Process for producing 5-fluorooxindole and for producing intermediates therefor 失效
标题翻译：制备5-氟羟吲哚的方法及其制备中间体
公开(公告)号：US06900335B2
公开(公告)日：2005-05-31
申请号：US10333316
申请日：2001-07-19
申请人： Katsumasa Harada , Shigeyoshi Nishino , Kenji Hirotsu , Shuji Yokoyama , Takeshi Takahashi , Hiroyuki Oda
发明人： Katsumasa Harada , Shigeyoshi Nishino , Kenji Hirotsu , Shuji Yokoyama , Takeshi Takahashi , Hiroyuki Oda
IPC分类号： C07C205/56 , C07C255/41 , C07D209/32 , C07D209/34
CPC分类号： C07D209/34 , C07C201/12 , C07C205/56 , C07C255/41 , C07D209/32
摘要： The present invention discloses a process for preparing 5-fluorooxindole represented by the formula (3): which comprises (A) a first step of cyclizing 2-(5-fluoro-2-nitrophenyl)malonic acid diester represented by the formula (1): wherein R1 and R2 may be the same or different from each other and each represents a group which does not participate in the reaction, under reductive conditions to form 5-fluorooxindole-3-carboxylic acid ester represented by the formula (2): wherein R1 has he same meaning as defined above, and (B) then, a second step of decarboxylating the 5-fluorooxindole-3-carboxylic acid ester, and a process for preparing its synthetic intermediates.
摘要翻译：本发明公开了一种制备式（3）表示的5-氟羟吲哚的方法：其包括（A）使由式（1）表示的2-（5-氟-2-硝基苯基）丙二酸二酯环化的第一步骤，：其中R 1和R 2彼此可以相同或不同，并且各自代表不参与反应的基团，在还原条件下形成5- 由式（2）表示的氟氧吲哚-3-羧酸酯：其中R 1具有与上述相同的含义，（B）然后，将5-氟羟吲哚-3 - 羧酸酯及其合成中间体的制备方法。

10. 发明申请

US20050080262A1 Process for producing quinazolin-4-one derivative 失效
标题翻译：喹唑啉-4-酮衍生物的制备方法
公开(公告)号：US20050080262A1
公开(公告)日：2005-04-14
申请号：US10502734
申请日：2003-01-28
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Takashi Harada , Hiroyuki Oda , Takeshi Takahashi , Shinobu Suzuki
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Takashi Harada , Hiroyuki Oda , Takeshi Takahashi , Shinobu Suzuki
IPC分类号： C07C201/08 , C07C205/59 , C07C205/60 , C07C227/04 , C07C229/56 , C07C229/64 , C07D239/88 , C07D239/90 , C07D239/72
CPC分类号： C07D239/88 , C07C67/31 , C07C69/92 , C07C201/08 , C07C205/59 , C07C205/60 , C07C227/04 , C07C229/56 , C07C229/64 , C07D239/90
摘要： A process for producing a quinazolin-4-one compound having the formula: [wherein R1, R2, R3 and R4 each represents a group not participating in the below-mentioned reaction, and R1, R2, R3 and R4 can be combined together to form a ring] which comprises reacting an anthranilic acid derivative having the formula: [wherein R5 is a hydrogen atom or a hydrocarbyl group] with a formic acid derivative in the presence of an ammonium carboxylate.
摘要翻译：制备具有下式的喹唑啉-4-酮化合物的方法：其中R 1，R 2，R 3和R 4各自表示不参与下述反应的基团，和 R 1，R 2，R 3和R 4可以组合在一起形成环]，其包括使具有下式的邻氨基苯甲酸衍生物：其中R 5是氢原子或烃基]与甲酸衍生物在羧酸铵存在下反应。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式