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1. 发明授权

US06329539B1 Prostagladin derivatives 有权
标题翻译：前列腺素衍生物
公开(公告)号：US06329539B1
公开(公告)日：2001-12-11
申请号：US09701187
申请日：2000-11-27
申请人： Fumie Sato , Tohru Tanami , Kazuya Kameo , Kenji Yamada , Shigeru Okuyama , Naoya Ono
发明人： Fumie Sato , Tohru Tanami , Kazuya Kameo , Kenji Yamada , Shigeru Okuyama , Naoya Ono
IPC分类号： C07C5900
CPC分类号： A61K31/5575 , A61K31/557 , C07C405/00 , Y10S514/923
摘要： A prostaglandin derivative represented by the formula: wherein X is a halogen atom, n is an integer of 1 to 5, R1 is a C3-10 cycloalkyl group, a C3-10 cycloalkyl group substituted with C1-4 alkyl group(s), a C4-13 cycloalkylalkyl group, a C5-10 alkyl group, a C5-10 alkenyl group, a C5-10 alkynyl group or a bridged cyclic hydrocarbon group, and R2 is a hydrogen atom, a C1-10 alkyl group or a C3-10 cycloalkyl group, or a pharmaceutically acceptable salt thereof.
摘要翻译：由下式表示的前列腺素衍生物：其中X为卤素原子，n为1〜5的整数，R1为C3-10环烷基，被C1-4烷基取代的C3-10环烷基， C 5-10烷基，C5-10烯基，C5-10炔基或桥连环烃基，R2是氢原子，C1-10烷基或C3 -10环烷基，或其药学上可接受的盐。

2. 发明授权

US5058196A Electric infrared heater having a gas permeable electroformed porous metallic panel coated with a porous ceramic far-infrared radiating layer 失效
标题翻译：具有涂覆有多孔陶瓷远红外辐射层的透气电铸多孔金属面板的电红外加热器
公开(公告)号：US5058196A
公开(公告)日：1991-10-15
申请号：US352227
申请日：1989-05-15
申请人： Kisaku Nakamura , Shigeru Okuyama , Eiji Owada , Yoshihiro Nishibori
发明人： Kisaku Nakamura , Shigeru Okuyama , Eiji Owada , Yoshihiro Nishibori
IPC分类号： F24C7/04 , F24H3/04
CPC分类号： F24H3/0405 , F24C7/043
摘要： An electric far-infrared heater has a plate-like porous metallic panel formed by an electroforming process installed in a box-like housing over an electric heating element therein. The panel is heated by the element and has its outer surface covered by a porous ceramic far-infrared emitting layer of Al.sub.2 O.sub.3, TiO.sub.2, Cr.sub.2 O.sub.3, MgO, ZrO.sub.2, SiO.sub.2 or mixtures thereof. A stream of gas supplied to the interior of the housing is heated by the element and passes through the porous panel and far-infrared layer for discharge onto the object being heated.
摘要翻译：电远红外加热器具有通过电铸工艺形成的板状多孔金属板，该电铸工艺安装在盒式壳体中，电气加热元件中。面板由元件加热，其外表面被Al2O3，TiO2，Cr2O3，MgO，ZrO2，SiO2的多孔陶瓷远红外发射层或其混合物覆盖。供给到壳体内部的气体流被元件加热，并通过多孔板和远红外层，以排放到被加热物体上。

3. 发明授权

US07183322B2 Remedy for hypertension 失效
标题翻译：补救高血压
公开(公告)号：US07183322B2
公开(公告)日：2007-02-27
申请号：US10504585
申请日：2003-02-17
申请人： Noriyuki Miyata , Shigeru Okuyama , Teisuke Takahashi , Kenzo Takahashi
发明人： Noriyuki Miyata , Shigeru Okuyama , Teisuke Takahashi , Kenzo Takahashi
IPC分类号： A61K31/135
CPC分类号： A61K31/136
摘要： A therapeutic agent for hypertension, which comprises as an active ingredient a compound capable of inhibiting Na+/Ca2+ exchanger 1.
摘要翻译：一种高血压治疗剂，其包含作为活性成分的能够抑制Na + + / Ca 2+交换体1的化合物。

4. 发明授权

US06187781B1 4-Tetrahydropyridylpyrimidine derivatives 失效
标题翻译： 4-四氢吡啶基嘧啶衍生物
公开(公告)号：US06187781B1
公开(公告)日：2001-02-13
申请号：US09381462
申请日：1999-09-21
申请人： Atsuro Nakazato , Toshihito Kumagai , Taketoshi Okubo , Izumi Aibe , Hideo Tanaka , Shigeyuki Chaki , Shigeru Okuyama , Kazuyuki Tomisawa
发明人： Atsuro Nakazato , Toshihito Kumagai , Taketoshi Okubo , Izumi Aibe , Hideo Tanaka , Shigeyuki Chaki , Shigeru Okuyama , Kazuyuki Tomisawa
IPC分类号： C07D40144
CPC分类号： C07D401/04 , C07D405/14 , C07D409/14
摘要： A 4-tetrahydropyridylpyrimidine compound represented by formula (I): wherein Ar represents a phenyl group substituted with 1 to 3 substituents selected from a halogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, and a trifluoromethyl group, a phenyl group, a thienyl group or a furanyl group; R1 represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an amino group or an amino group substituted with 1 or 2 alkyl groups having 1 to 5 carbon atoms; R2 represents an alkyl group having 1 to 5 carbon atoms, a cycloalkylalkyl group having 4 to 7 carbon atoms, an alkenyl group having 2 to 5 carbon atoms or an alkynyl group having 2 to 5 carbon atoms; and X1, X2, and X3, which may be the same or different, each represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, an alkylthio group having 1 to 5 carbon atoms, an amino group or an amino group substituted with 1 or 2 alkyl groups having 1 to 5 carbon atoms, or a pharmaceutically acceptable salt thereof. The 4-Tetrahydropyridylpyrimidine compound finds utility in the treatment of diseases in which CRF is implicated.
摘要翻译：由式（I）表示的4-四氢吡啶基嘧啶化合物：其中Ar表示被1至3个选自卤素原子，具有1至5个碳原子的烷基，具有1至5个碳原子的烷氧基的取代基取代的苯基，和三氟甲基，苯基，噻吩基或呋喃基; R1表示氢原子，碳原子数1〜5的烷基，氨基或被1〜2个碳原子数1〜2的烷基取代的氨基。 R2表示碳原子数1〜5的烷基，碳原子数4〜7的环烷基烷基，碳原子数2〜5的烯基或碳原子数2〜5的炔基。 X 1，X 2和X 3可以相同或不同，分别表示氢原子，卤素原子，碳原子数1〜5的烷基，碳原子数1〜5的烷氧基，烷硫基， 1至5个碳原子的氨基或被1或2个具有1至5个碳原子的烷基取代的氨基，或其药学上可接受的盐。 4-四氢吡啶基嘧啶化合物可用于治疗涉及CRF的疾病。

5. 发明申请

US20050203189A1 Remedies for chronic kidney diseases 审中-公开
标题翻译：慢性肾脏疾病的补救措施
公开(公告)号：US20050203189A1
公开(公告)日：2005-09-15
申请号：US10502547
申请日：2003-01-24
申请人： Noriyuki Miyata , Shigeru Okuyama , Teisuke Takahashi
发明人： Noriyuki Miyata , Shigeru Okuyama , Teisuke Takahashi
IPC分类号： A61K31/00 , A61K31/09 , A61P13/12 , A61K31/135
CPC分类号： A61K31/00 , A61K31/09
摘要： A therapeutic agent for chronic kidney diseases, which comprises as an active ingredient a compound capable of inhibiting Na+/Ca2+ exchanger 1.
摘要翻译：作为慢性肾脏疾病的治疗剂，其包含能够抑制Na + / ATP2 +交换体1的化合物作为活性成分。

6. 发明授权

US5496829A Use of 2-nitroxyethyl (+)apovincaminate 失效
标题翻译：使用2-氨基乙基（+）氨基乙酸盐
公开(公告)号：US5496829A
公开(公告)日：1996-03-05
申请号：US244330
申请日：1994-05-24
申请人： Shigeru Okuyama , Susumu Otomo , Yutaka Kawashima , Katsuo Hatayama
发明人： Shigeru Okuyama , Susumu Otomo , Yutaka Kawashima , Katsuo Hatayama
IPC分类号： A61K31/475 , A61K31/44
CPC分类号： A61K31/475
摘要： 2-nitroxyethyl (+)apovincaminate is used as an agent for relieving disturbance of consciousness and as a narcotic antagonist.
摘要翻译： PCT No.PCT / JP94 / 01601 Sec。 371日期：1994年5月24日 102（e）日期1994年5月24日PCT提交1992年12月8日PCT公布。公开号WO93 / 11765 日期：1993年6月24日，2-氨基乙基（+）脱氨基甲酸酯被用作缓解意识紊乱和麻醉拮抗剂的药剂。

7. 发明授权

US4120139A Cable making apparatus 失效
标题翻译：电缆制造设备
公开(公告)号：US4120139A
公开(公告)日：1978-10-17
申请号：US819035
申请日：1977-07-25
申请人： Shinichi Terasawa , Akitoshi Okamura , Shigeru Okuyama , Takehiko Nishiyama , Tadao Nishida
发明人： Shinichi Terasawa , Akitoshi Okamura , Shigeru Okuyama , Takehiko Nishiyama , Tadao Nishida
IPC分类号： H01B13/02 , D07B3/00 , D07B7/02 , D07B7/14 , D01H13/02 , D01H13/04
CPC分类号： D07B7/02 , D07B3/00 , D07B7/14
摘要： Improvements in apparatus for the manufacture of a cable by laying or assemblying pre-twisted outer strands around a pre-twisted core. For smooth transmission of the pre-twist through the core length from a pay-out reel to a laying die, a series of interspaced pairs of opposed guide rollers are disposed along the path of the core to engage the same therebetween. Further, for smooth transmission of the pre-twists through the lengths of the outer strands from respective pay-out reels to the laying die, a series of interspaced tapered guide rollers are disposed along a curve in the path of each outer strand. At least some of the tapered guide rollers are set an an angle to the axial direction of the outer strand being fed thereover and, preferably, further to the direction normal to the vertical plane containing the curve in the outer strand path.
摘要翻译：通过将预先扭绞的外股线围绕预捻芯线布置或组装来制造电缆的装置的改进。为了将预捻通过芯长度从发放卷轴平稳地传递到铺设模具，沿着芯的路径布置一系列相对的导向辊的间隔隔开的一对相互对置的导向辊以在其间相互接合。此外，为了通过外股线从相应的放出卷轴到敷设模具的长度的平稳传递，沿着每条外股线的路径中的曲线设置一系列间隔的锥形导向辊。至少一些锥形导向辊与外部线材的轴向方向成一角度，并且优选地设置成垂直于包含外部股线路径中的曲线的垂直平面的方向。

8. 发明授权

US07307101B2 Use of 20-HETE synthesizing enzyme inhibitors as therapy for cerebral vascular disease 失效
标题翻译：使用20-HETE合成酶抑制剂作为脑血管病的治疗
公开(公告)号：US07307101B2
公开(公告)日：2007-12-11
申请号：US09937946
申请日：2001-09-06
申请人： Richard J. Roman , David R. Harder , Noriyuki Miyata , Masakazu Sato , Kazuya Kameo , Shigeru Okuyama
发明人： Richard J. Roman , David R. Harder , Noriyuki Miyata , Masakazu Sato , Kazuya Kameo , Shigeru Okuyama
IPC分类号： A01N37/34 , A61K37/275 , C12N9/10
CPC分类号： A61K31/15 , A61K31/20 , A61K31/4164 , A61K31/4192 , A61K48/00
摘要： A method for treating cerebral vascular diseases in a human or non-human animal is disclosed. The method involves inhibiting 20-HETE synthesizing enzyme activity sufficiently to increase or prevent a decrease in cerebral blood flow in the human or non-human animal.
摘要翻译：公开了一种用于治疗人或非人动物的脑血管疾病的方法。所述方法包括充分抑制20-HETE合成酶活性以增加或防止人或非人动物中脑血流量的降低。

9. 发明申请

US20050153871A1 Use of 20-hete synthesizing enzyme inhibitors as therapy for cerebral vascular disease 失效
标题翻译：使用20-mL合成酶抑制剂作为脑血管病的治疗
公开(公告)号：US20050153871A1
公开(公告)日：2005-07-14
申请号：US09937946
申请日：2001-09-06
申请人： Richard Roman , David Harder , Noriyuki Miyata , Masakazu Sato , Kazuya Kameo , Shigeru Okuyama
发明人： Richard Roman , David Harder , Noriyuki Miyata , Masakazu Sato , Kazuya Kameo , Shigeru Okuyama
IPC分类号： A61K45/00 , A61K31/15 , A61K31/155 , A61K31/18 , A61K31/20 , A61K31/4164 , A61K31/4174 , A61K31/4192 , A61K31/7105 , A61K31/711 , A61K38/54 , A61K39/395 , A61K48/00 , A61P9/00 , A61P9/10 , A61P25/00 , A61P25/06 , A61P25/14 , A61P25/16 , A61P25/28 , A61P31/00 , A61P31/04 , A61P43/00
CPC分类号： A61K31/15 , A61K31/20 , A61K31/4164 , A61K31/4192 , A61K48/00
摘要： A method for treating cerebral vascular diseases in a human or non-human animal is disclosed. The method involves inhibiting 20-HETE synthesizing enzyme activity sufficiently to increase or prevent a decrease in cerebral blood flow in the human or non-human animal.
摘要翻译：公开了一种用于治疗人或非人动物的脑血管疾病的方法。所述方法包括充分抑制20-HETE合成酶活性以增加或防止人或非人动物中脑血流量的降低。

10. 发明申请

US20050038259A1 Hydroxyeicosenoic acid anaglogs 审中-公开
标题翻译：羟基二十碳烯酸anaglogs
公开(公告)号：US20050038259A1
公开(公告)日：2005-02-17
申请号：US10489205
申请日：2002-09-09
申请人： John Falck , Noriyuki Miyata , Naoya Ono , Tomomichi Chonan , Hitomi Hirano , Yoshihisa Toda , Tohru Tanami , Shigeru Okuyama
发明人： John Falck , Noriyuki Miyata , Naoya Ono , Tomomichi Chonan , Hitomi Hirano , Yoshihisa Toda , Tohru Tanami , Shigeru Okuyama
IPC分类号： C07D277/20 , A61K31/047 , A61K31/08 , A61K31/16 , A61K31/18 , A61K31/185 , A61K31/201 , A61K31/231 , A61K31/275 , A61K31/41 , A61K31/426 , A61P1/02 , A61P1/04 , A61P1/16 , A61P1/18 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P11/08 , A61P13/12 , A61P15/00 , A61P15/06 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/04 , A61P37/02 , A61P37/06 , A61P43/00 , C07C33/04 , C07C33/044 , C07C33/42 , C07C59/01 , C07C59/42 , C07C59/46 , C07C59/60 , C07C69/708 , C07C69/732 , C07C235/28 , C07C255/15 , C07C255/16 , C07C259/06 , C07C309/08 , C07C309/10 , C07C309/20 , C07C309/23 , C07C309/24 , C07C309/68 , C07C311/04 , C07C311/17 , C07C311/51 , C07C317/44 , C07C323/52 , C07C323/66 , C07D257/04 , C07D277/34 , C07D277/12 , C11C3/00
CPC分类号： C07D257/04 , C07C33/044 , C07C33/423 , C07C33/426 , C07C59/42 , C07C59/46 , C07C59/60 , C07C69/708 , C07C235/28 , C07C255/15 , C07C259/06 , C07C309/10 , C07C309/20 , C07C309/23 , C07C309/24 , C07C309/68 , C07C311/17 , C07C311/51 , C07C317/44 , C07C323/52 , C07C323/66 , C07C2601/08 , C07C2601/14 , C07D277/34
摘要： A hydroxyeicosenoic acid analog represented by the following Formula (I), the bond ≡ represents a cis-vinylene group or an ethynylene group; Y represents CH2, O or S(O)p wherein p is 0, 1 or 2; m represents an integer of 1 to 4 inclusive; n represents an integer of 0 to 3 inclusive; the sum of m and n is an integer of 3 to 7 inclusive; R1 represents a C1-4 alkyl group or a C3-8 cycloalkyl group; R2 represents a hydrogen atom or a methyl group; R3 represents COR4, a nitrile group, a halogen atom, a tetrazole group or a thiazolidinedione group; R4 represents OR6, NHR6, N(OH)R6, NHSO2R5, glycerol or functionalized glycerols; R5 represents a C1-15 alkyl group, a C6-10 aryl group or a C7-14 aryl group substituted with alkyl groups, halogens or amino groups; R6 represents a hydrogen, a C1-10 alkyl group or a C1-10 alkyl group substituted with a hydroxyl group, or a pharmaceutically acceptable salt or hydrate thereof. The compounds of the present invention are useful as an elastase release inhibitor.
摘要翻译：由下式（I）表示的羟基二十碳烯酸类似物，键=表示顺式亚乙烯基或亚乙炔基; Y表示CH 2，O或S（O）p，其中p为0,1或2; m表示1〜4的整数， n表示0〜3的整数， m和n的和为3〜7的整数， R 1表示C 1-4烷基或C 3-8环烷基; R 2表示氢原子或甲基; R 3表示COR 4，腈基，卤素原子，四唑基或噻唑烷二酮基; R 4表示OR 6，NHR 6，N（OH）R 6，NHSO 2 R 5，甘油或官能化甘油; R 5代表C1-15烷基，C6-10芳基或被烷基，卤素或氨基取代的C7-14芳基; R 6表示氢，C 1-10烷基或被羟基取代的C 1-10烷基，或其药学上可接受的盐或水合物。本发明的化合物可用作弹性蛋白酶释放抑制剂。

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